Dolan et al.SI Fig. 1

Keywords

PFAMPANTHER MFPANTHER INTERPRO

GO Molecular Function

GO Cellular Component

COG OntologyCOG NameBLOCKS

Electronic Supplementary Material (ESI) for Molecular BioSystemsThis journal is © The Royal Society of Chemistry 2013

CYTOPLASMIC_PARTCYTOPLASM

EXTRACELLULAR_REGIONEXTRACELLULAR_SPACE

EXTRACELLULAR_REGION_PARTGO.0005615.extracellular.space

GO.0044421.extracellular.region.partINTRACELLULAR_ORGANELLE_PART

ORGANELLE_PARTCYTOSKELETON

INTRACELLULAR_NON_MEMBRANE_BOUND_ORGANELLENON_MEMBRANE_BOUND_ORGANELLE

GO.0005856.cytoskeletonGO.0015630.microtubule.cytoskeleton

GO.0005813.centrosomeGO.0005815.microtubule.organizing.center

CYTOSKELETAL_PARTCENTROSOME

MICROTUBULE_ORGANIZING_CENTERREACTOME_CELL_CYCLE

REACTOME_CELL_CYCLE_MITOTICREACTOME_MITOTIC_G2_G2_M_PHASES

REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMESREACTOME_RECRUITMENT_OF_MITOTIC_CENTROSOME_PROTEINS_AND_COMPLEXES

NUCLEUSBIOPOLYMER_METABOLIC_PROCESS

RNA_METABOLIC_PROCESSNUCLEOBASENUCLEOSIDENUCLEOTIDE_AND_NUCLEIC_ACID_METABOLIC_PROCESS

SIGNAL_TRANSDUCTIONCOG1196..Smc..Chromosome.segregation.ATPases

Cell.division.and.chromosome.partitioningENDOPLASMIC_RETICULUM

ANATOMICAL_STRUCTURE_MORPHOGENESISMULTICELLULAR_ORGANISMAL_DEVELOPMENT

SYSTEM_DEVELOPMENTANATOMICAL_STRUCTURE_DEVELOPMENT

PROTEIN_METABOLIC_PROCESSCELLULAR_PROTEIN_METABOLIC_PROCESS

CELLULAR_MACROMOLECULE_METABOLIC_PROCESSREACTOME_IMMUNE_SYSTEM

KEGG_COMPLEMENT_AND_COAGULATION_CASCADESREACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT

REACTOME_REGULATION_OF_COMPLEMENT_CASCADEREACTOME_COMPLEMENT_CASCADE

PROTEIN_COMPLEXKEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION

KEGG_FOCAL_ADHESIONREACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE

REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALINGKEGG_REGULATION_OF_ACTIN_CYTOSKELETON

ER_GOLGI_INTERMEDIATE_COMPARTMENTGO.0005793.ER.Golgi.intermediate.compartment

REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALLREACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING

REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS

KEGG_SPLICEOSOMEIPB002017.Spectrin.repeatACTIN_CYTOSKELETON

ACTIN_BINDINGCYTOSKELETAL_PROTEIN_BINDING

REACTOME_NEPHRIN_INTERACTIONSREACTOME_CELL_CELL_COMMUNICATION

REACTOME_APOPTOSISREACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS

REACTOME_APOPTOTIC_EXECUTION_PHASEPROTEIN_C_TERMINUS_BINDING

REACTOME_CTNNB1_PHOSPHORYLATION_CASCADEKEGG_THYROID_CANCER

KEGG_PROSTATE_CANCERKEGG_ENDOMETRIAL_CANCERKEGG_COLORECTAL_CANCER

DNA_BINDINGGO.0016607.nuclear.speck

NUCLEAR_PARTMEMBRANE_ENCLOSED_LUMEN

ORGANELLE_LUMENMACROMOLECULAR_COMPLEX_ASSEMBLY

PROTEIN_RNA_COMPLEX_ASSEMBLYRIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS_AND_ASSEMBLY

PROTEIN_HETERODIMERIZATION_ACTIVITYPROTEIN_DIMERIZATION_ACTIVITY

CYTOSKELETON_ORGANIZATION_AND_BIOGENESISORGANELLE_ORGANIZATION_AND_BIOGENESIS

REACTOME_HEMOSTASISREACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION

GO.0030247.polysaccharide.bindingGO.0001871.pattern.bindingGO.0008201.heparin.binding

GO.0005539.glycosaminoglycan.bindingREACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS

GO.0005543.phospholipid.bindingGO.0042627.chylomicron

GO.0034358.plasma.lipoprotein.particleGO.0032994.protein.lipid.complex

GO.0034361.very.low.density.lipoprotein.particleGO.0034385.triglyceride.rich.lipoprotein.particle

RECEPTOR_BINDINGENDOCYTIC_VESICLE

VESICLECYTOPLASMIC_VESICLE

CYTOPLASMIC_MEMBRANE_BOUND_VESICLEMEMBRANE_BOUND_VESICLE

REACTOME_PPARA_ACTIVATES_GENE_EXPRESSIONCELLULAR_LIPID_METABOLIC_PROCESS

STEROL_BINDINGSTEROID_BINDING

KEGG_PPAR_SIGNALING_PATHWAYLIPID_BINDING

LIPID_TRANSPORTLIPID_HOMEOSTASIS

CDC42_PROTEIN_SIGNAL_TRANSDUCTIONREACTOME_HDL_MEDIATED_LIPID_TRANSPORT

SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTIONRHO_PROTEIN_SIGNAL_TRANSDUCTIONRAS_PROTEIN_SIGNAL_TRANSDUCTIONGO.0034364.high.density.lipoprotein.particle

PHOSPHOLIPID_BINDINGGO.0070325.lipoprotein.receptor.binding

REACTOME_LIPID_DIGESTION_MOBILIZATION_AND_TRANSPORTREACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT

REACTOME_LIPOPROTEIN_METABOLISM APOA1

APOE

APOA5

APOH

APOB

NPM

1PC

NT

SDC

CAG

8C

EP63PC

M1

CTN

NB1

IQG

AP2U

TRN

TPM4

SPTAN1

PIK3R1

FN1

TF FGB

NU

CB1

NU

CB2

ROC

K1D

STSM

C1A

CBX5

DD

X24C

OPS2

GATAD

2AZN

F638C

FHC

4AC

3SER

PIND

1H

RG

TCF7L2

TRIP11

RN

ASET2ADAREIF4G

2PAIP1SPG

7PD

IA6FBXO

3TSG

101H

MG

CR

CU

L7AG

GF1

SCP2

SLMAP

OPTN

KTN1

GATM

WBP11

MYH

14M

YCBP2

IFT88C

ALCO

CO

2D

DX3X

STX8M

PHO

SPH9

GLR

X5G

OLG

A2N

ID1

LOC

100133511C

OPS3

TNFR

SF10BC

CD

C88C

ITSN2

SNX14

SESTD1

RLF

FAM123B

ELAVL1D

DX5

HSPA8

Dolan et alSI Fig. 2

Electronic Supplementary Material (ESI) for Molecular BioSystemsThis journal is © The Royal Society of Chemistry 2013

MST1SLMAP

TFFBXO3ITSN2

SESTD1

CEP63EHMT2

FN1

GOLGA2

SERPIND1

TRIM62

GLRX5NPM1

ADAR

C3

LOC100133511

STX8PMS2L11

EIF3L

IQGAP2

APOA5

GATC

GATM

CCDC66

TRIP11

MYH14

SPG7

PAIP1

CTNNB1

DST

DDX3X

HCV NS3

CCDC88C

APOB

APOA1

COPS2

C4A

TNFRSF10B

HCV NS2

HCV NS5A

HSPA8

GORASP2

RBM10

TSG101

MPHOSPH9

IFT88

APOE

CBX5

RNASET2

PCNT

SDCCAG8

DDX5

FAM123B

RILPL2

CUL7

AGGF1

SPTAN1

SCP2TPM4PDIA6

ZNF638ZNF195

GATAD2AOPTNPHF14

PIK3R1HMGCR

COPS3

ROCK1

RLF

ELAVL1

NUCB1

WBP11

DENV NS2B

DENV NS4A

DENV NS3

DENV NS1

DENV M

ANKRD50

NID1

SRFBP1

FGB

DDX24

KTN1

MYCBP2

EIF4G2

CALCOCO2

WWC1

LOC728047

LAMB1

C14orf94

FYB

KIF1B

KNG1

UBXD4

MAP3K7IP2

TAX1BP1

GPR81UTRN

NUCB2

SMC1A

HCV E2

HCV NS5B

PCM1

TCF7L2

HCV NS4B

PTBP1

RAI14ZBTB8OSAKAP8LUACA

DCTN2EMILIN1

FUNDC1FUNDC2

GOLGB1LOC642846

PDCD6IPPRDX6

SNX14

APOHCFHHRG

GREB1N4BP2L2ATXN2L

CIC

PGK1KRT8

SEC31ADSCR3

DENV NS4B

DCTN1

GCAKAP1

DENV NS2A

GOLSYN

AKR7A3

FGA

SFRS11

STAT2

HOOK1

SCLT1

PSMD1

UBE2I

BMS1SYNE2

TP53BP2LOC643696

VPS37ATTC1

MATR3ERC1

AKAP9SYNE1

CROPALDH3A2DCUN1D4

CALRCAT

CNOT1

PIAS1NUP50

SPTBN2

COL12A1

PECI

KPNA3

ZNF688

DENV NS5

NUMA1

CGNL1CEP135

HCV Core

COBLL1EID1

Dolan et al. SI Fig. 3

N = 38

(Khadka et al.) (Dolan et al.)

N = 56

N = 67

Electronic Supplementary Material (ESI) for Molecular BioSystemsThis journal is © The Royal Society of Chemistry 2013

Dolan et alSI Fig. 4

HCV

DAVID

All H

CV

Targ

ets

All D

ENV

Targ

ets

All F

lavi

Targ

ets

HC

V U

niqu

eTa

rget

s

Shar

edTa

rget

s

DEN

V U

niqu

eTa

rget

s

DENV

HCV Functional Profile

DENV Functional Profile

Flaviviridae Functional Profile

Comparison of Unique and Shared Host

Functions

DAVID

(Fig. 7C)

(Fig. 7B)

(Fig. 7A)

Electronic Supplementary Material (ESI) for Molecular BioSystemsThis journal is © The Royal Society of Chemistry 2013

Dolan et al.SI Fig. 5

A.

B.

Cel

lula

r ATP

Lev

els

(RLU

)M

TT (O

D45

0)

Electronic Supplementary Material (ESI) for Molecular BioSystemsThis journal is © The Royal Society of Chemistry 2013