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MICHIGAN TECHNOLOGY TRI-CORRIDOR FUND REQUEST FOR PROPOSALS FISCAL YEAR 2005 COMPETITION Briefing Session October 26, 2004 4:00 - 5:30 pm South Lecture Hall Med Sci II

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MICHIGAN TECHNOLOGY TRI-CORRIDOR FUND

REQUEST FOR PROPOSALS FISCAL YEAR 2005

COMPETITION

MICHIGAN TECHNOLOGY TRI-CORRIDOR FUND

REQUEST FOR PROPOSALS FISCAL YEAR 2005

COMPETITION

Briefing SessionOctober 26, 2004

4:00 - 5:30 pmSouth Lecture Hall Med Sci

II

Briefing SessionOctober 26, 2004

4:00 - 5:30 pmSouth Lecture Hall Med Sci

II

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MTTC FUND RFPMTTC FUND RFP

Funding Categories Category I (basic research fund): For

basic research in health-related areas with eventual application to life sciences industry and product development. Eligible applicants include Michigan

universities and nonprofit research institutes.

Should enhance the research capacity and activity of the state to attract or develop companies, researchers, or students to Michigan.

Preference given to multi-institution, multi-disciplinary research centers.

Funding Categories Category I (basic research fund): For

basic research in health-related areas with eventual application to life sciences industry and product development. Eligible applicants include Michigan

universities and nonprofit research institutes.

Should enhance the research capacity and activity of the state to attract or develop companies, researchers, or students to Michigan.

Preference given to multi-institution, multi-disciplinary research centers.

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MTTC FUND RFPMTTC FUND RFP

Funding Categories (cont’d) Category II (applied research fund):

To fund collaborative translational research, testing, or develop of emerging discoveries in life sciences. Eligible applicants include

universities, nonprofit research institutes, and private research facilities.

Funding Categories (cont’d) Category II (applied research fund):

To fund collaborative translational research, testing, or develop of emerging discoveries in life sciences. Eligible applicants include

universities, nonprofit research institutes, and private research facilities.

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MTTC FUND RFPMTTC FUND RFP

Funding Categories (cont’d) Category III (commercialization

development fund): To fund collaborative translational research, testing, or develop of emerging discoveries in life sciences. Category III A (commercialization

services): Provides funding for specific business services to the entrepreneurial community involved in life sciences commercialization.

Eligible applicants include universities and businesses.

Aimed at supporting unique business growth, attraction, and develop services that are specific to the life sciences sector.

Funding Categories (cont’d) Category III (commercialization

development fund): To fund collaborative translational research, testing, or develop of emerging discoveries in life sciences. Category III A (commercialization

services): Provides funding for specific business services to the entrepreneurial community involved in life sciences commercialization.

Eligible applicants include universities and businesses.

Aimed at supporting unique business growth, attraction, and develop services that are specific to the life sciences sector.

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MTTC FUND RFPMTTC FUND RFP

Funding Categories (cont’d) Category III B (commercialization

investment program): Provides funding to companies positioned to commercialize products or services in the life sciences area.

Eligible applicants are companies only.

Funds to provide a competitive advantage for Michigan companies by providing an investment that aims to catalyze market penetration efforts and progress toward long-term sustainable growth.

Funding Categories (cont’d) Category III B (commercialization

investment program): Provides funding to companies positioned to commercialize products or services in the life sciences area.

Eligible applicants are companies only.

Funds to provide a competitive advantage for Michigan companies by providing an investment that aims to catalyze market penetration efforts and progress toward long-term sustainable growth.

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MTTC FUND RFPMTTC FUND RFP

Program Timeline Program Timeline

Nov. 17, 2004 Pre-proposal submission due date

Nov. 29, 2004 - Jan. 21, 2005

Independent peer-review of pre-proposals

Feb. 3, 2005 Invitation to full proposal

Mar. 9, 2005 Full proposal submission due date

Mar. 18 - Jun. 3, 2005 Independent mail review of full proposals including the interview process and final report submitted to MEDC

Jun. 3, 2005 Final funding recommendations received

Jun. 14, 2005 Steering Committee meeting (award decisions)

Jun. 15 - Sep. 15, 2005 Contract negotiations

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MTTC FUND RFPMTTC FUND RFP Eligibility As a “nonprofit research institution in Michigan”

or as a “private research facility in Michigan,” the PI for the project must be a full-time employee of an organization whose core activity is research and/or development. The principal site for the project is MI, and the facility must be owned by the applicant or by a project collaborator.

As a “Michigan-based for-profit company,” the PI must be a full-time employee of a for-profit company who will be located primarily for the duration of the project at the principal site at which the project will be conducted. The company must have a major share of business activity in Michigan. Majority of economic benefits must accrue within MI.

Eligibility As a “nonprofit research institution in Michigan”

or as a “private research facility in Michigan,” the PI for the project must be a full-time employee of an organization whose core activity is research and/or development. The principal site for the project is MI, and the facility must be owned by the applicant or by a project collaborator.

As a “Michigan-based for-profit company,” the PI must be a full-time employee of a for-profit company who will be located primarily for the duration of the project at the principal site at which the project will be conducted. The company must have a major share of business activity in Michigan. Majority of economic benefits must accrue within MI.

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MTTC FUND RFPMTTC FUND RFP

Eligibility (cont’d) Previous years’ MLSC or MTTC fund

awardees are eligible but must provide a detailed update of their program accomplishments to date in the new application

If additional funds for the same project are sought applicant must demonstrate significant progress on project

Eligibility is determined at the time of award, i.e., can apply from out-of-state if plan to move to MI at time of award.

Eligibility (cont’d) Previous years’ MLSC or MTTC fund

awardees are eligible but must provide a detailed update of their program accomplishments to date in the new application

If additional funds for the same project are sought applicant must demonstrate significant progress on project

Eligibility is determined at the time of award, i.e., can apply from out-of-state if plan to move to MI at time of award.

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MTTC FUND RFPMTTC FUND RFP

Collaboration Category I (basic research fund),

Category III (commercialization development fund): Collaboration is highly encouraged.

Category II (applied research fund): Must include high-value collaboration between the eligible applicant and the collaborating entity.

Must document prior or planned genuine productive collaboration such as: commitment of resources (e.g., time, money, facilities, equipment, intellectual property) or performance of specific aims.

Collaboration Category I (basic research fund),

Category III (commercialization development fund): Collaboration is highly encouraged.

Category II (applied research fund): Must include high-value collaboration between the eligible applicant and the collaborating entity.

Must document prior or planned genuine productive collaboration such as: commitment of resources (e.g., time, money, facilities, equipment, intellectual property) or performance of specific aims.

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MTTC FUND RFPMTTC FUND RFP

Qualifying Research Fields Qualifying life sciences fields include

pharmaceuticals, medical devices, instrumentation, diagnostics, biotechnology, and research and ancillary services.

Proposals may employ various biological models and organisms.

Proposals can have cross-over applications to advanced automotive and homeland security sectors including sensors and measurement devices, biosensing, antitoxins, food and water safety and security, and surveillance/detection.

Qualifying Research Fields Qualifying life sciences fields include

pharmaceuticals, medical devices, instrumentation, diagnostics, biotechnology, and research and ancillary services.

Proposals may employ various biological models and organisms.

Proposals can have cross-over applications to advanced automotive and homeland security sectors including sensors and measurement devices, biosensing, antitoxins, food and water safety and security, and surveillance/detection.

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MTTC FUND RFPMTTC FUND RFP

Qualifying Research Fields (cont’d) May include technology such as

microsystems, MEMs, nanotechnology, and information technology.

MAY NOT include proposals for education, training of personnel, curriculum development, or projects that address health care delivery, public health, epidemiology, natural resources management, agriculture, or ecology.

Qualifying Research Fields (cont’d) May include technology such as

microsystems, MEMs, nanotechnology, and information technology.

MAY NOT include proposals for education, training of personnel, curriculum development, or projects that address health care delivery, public health, epidemiology, natural resources management, agriculture, or ecology.

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MTTC FUND RFPMTTC FUND RFP

Organizational Contributions/Match Each of the participating organizations

must provide a specific contribution to the project. For example: use of personnel, space,

facilities; indirect cost sharing. Each proposal must include a cash

match For non-profits any source can provide

the cash match For profits must supply a cash match

from a qualified investor• III A proposal must get some of the cash

from the recipients of the services they provide

Organizational Contributions/Match Each of the participating organizations

must provide a specific contribution to the project. For example: use of personnel, space,

facilities; indirect cost sharing. Each proposal must include a cash

match For non-profits any source can provide

the cash match For profits must supply a cash match

from a qualified investor• III A proposal must get some of the cash

from the recipients of the services they provide

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MTTC FUND RFPMTTC FUND RFP

Review Process Phase I: Pre-proposal submission and

competitive review by independent peer review agency.

Phase II: Selected pre-proposal applicants will be invited to submit full proposals which will undergo competitive peer review.

Phase III: Selected full proposal applicants will be invited for an interview conducted by the independent peer-review agency (expert peer panel).

Final funding decisions to be made by the Steering Committee based upon the Phase III competition.

Review Process Phase I: Pre-proposal submission and

competitive review by independent peer review agency.

Phase II: Selected pre-proposal applicants will be invited to submit full proposals which will undergo competitive peer review.

Phase III: Selected full proposal applicants will be invited for an interview conducted by the independent peer-review agency (expert peer panel).

Final funding decisions to be made by the Steering Committee based upon the Phase III competition.

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MTTC FUND RFPMTTC FUND RFP

Award Type and Terms of Award $26.5 million available for the MTTC

competition. No specific funding request limitations. Funding for up to three years. Grant awards available to applicants from

Michigan universities and Michigan not-for-profit research institutes.

Awards given to for-profit organizations will be in the form of a loan or an equity investment.

Indirect cost rate: 20% (excluding equipment, patient care cost, consultant/consortium cost, subcontracts, building alternations and renovations.)

Award Type and Terms of Award $26.5 million available for the MTTC

competition. No specific funding request limitations. Funding for up to three years. Grant awards available to applicants from

Michigan universities and Michigan not-for-profit research institutes.

Awards given to for-profit organizations will be in the form of a loan or an equity investment.

Indirect cost rate: 20% (excluding equipment, patient care cost, consultant/consortium cost, subcontracts, building alternations and renovations.)

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MTTC FUND RFPMTTC FUND RFP

Pre-Proposal Submission Pre-proposal application system can

be accessed at: http://medc.michigan.org/TTC

Application includes ten steps: Project information Project director information Budget information Applicant organization information Authorized representative information Executive summary (250 word limit) Comments Key Personnel for applicant organization Collaborating organization(s) information Submission of PDF file (Pre-proposal and

biographical sketches)

Pre-Proposal Submission Pre-proposal application system can

be accessed at: http://medc.michigan.org/TTC

Application includes ten steps: Project information Project director information Budget information Applicant organization information Authorized representative information Executive summary (250 word limit) Comments Key Personnel for applicant organization Collaborating organization(s) information Submission of PDF file (Pre-proposal and

biographical sketches)

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MTTC FUND RFPMTTC FUND RFP

Basic Research Fund Proposal Review Criteria and WeightingBasic Research Fund Proposal Review Criteria and Weighting

Criterion WeightingScientific and technical quality of proposed research

20%

Feasibility of proposed work with time/funds available

15%

Economic impact on Michigan 15%

Team qualifications/quality of collaborative efforts/expertise of collaborative team and organizational commitments

20%

Quality of project match and potential of project to leverage additional resources

20%

Quality of intellectual property plan 10%

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MTTC FUND RFPMTTC FUND RFP

Applied Research Fund Proposal Review Criteria and WeightingApplied Research Fund Proposal Review Criteria and Weighting

Criterion WeightingResearch concept quality, application focus, and commercial contribution

20%

Articulation of path to market, market potential, and quality of marketing plan

30%

Economic impact on Michigan 15%

Team qualifications/quality of collaborative efforts/expertise of collaborative team

10%

Quality of project match and potential of project to leverage resources

15%

Quality of intellectual property plan 10%

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MTTC FUND RFPMTTC FUND RFP

Commercialization Services Program Review Criteria and Weighting

Commercialization Services Program Review Criteria and Weighting

Criterion Weighting

Quality, uniqueness, and importance of commercialization service

30%

Organizational expertise and available resources

20%

Implementation and administrative plan

20%

Leveraging/matching funds 15%

Identification of future uses/users/fee structure and intellectual property plans (where applicable)

15%

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MTTC FUND RFPMTTC FUND RFP

Commercialization Investment Proposal Review Criteria and Weighting

Commercialization Investment Proposal Review Criteria and Weighting

Criterion WeightingQuality and importance of commercialization opportunity

20%

Commercialization feasibility with available time/funds/facilities/resources

15%

Market analysis/competitiveness of proposed commercialization opportunity

15%

Economic impact on Michigan 15%

Management team experience and expertise

20%

Leverage/matching funds 10%

Quality of intellectual property plan 5%

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Things to Remember When Submitting Pre-

Proposals:

Things to Remember When Submitting Pre-

Proposals: Online submissions only No PAF required but send copy

of submission to Anna Schork or Elaine Brock at DRDA

No change in subject matter is allowed from pre-proposal to full proposal

Science limited to 250 word Executive Summary

Criteria by category apply to pre-proposals and full proposals

Online submissions only No PAF required but send copy

of submission to Anna Schork or Elaine Brock at DRDA

No change in subject matter is allowed from pre-proposal to full proposal

Science limited to 250 word Executive Summary

Criteria by category apply to pre-proposals and full proposals

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Things to Remember About Pre-Proposals

(cont’d):

Things to Remember About Pre-Proposals

(cont’d): 2 page Biosketches required on Form MTTC-01 (include patents and licenses)

Budget required Applicant Organization is “The

Regents of the University of Michigan”

Authorized Rep is “ Elaine L. Brock”

DUNS # 0731331571 Cash Match required for all

proposals

2 page Biosketches required on Form MTTC-01 (include patents and licenses)

Budget required Applicant Organization is “The

Regents of the University of Michigan”

Authorized Rep is “ Elaine L. Brock”

DUNS # 0731331571 Cash Match required for all

proposals

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Things to Remember About Full Proposals

Generally:

Things to Remember About Full Proposals

Generally: On-line submission only. The system slows as more submitters are on it. Don’t wait till 4:55 on March 9th.

Follow the outline exactly. Project Plan limited to 20 pages. No

appendix material accepted. Request letters of

commitment/support via online system, i.e., you submit name to MEDC system. MEDC requests letter. Letter is submitted to MEDC online by proposal deadline.

On-line submission only. The system slows as more submitters are on it. Don’t wait till 4:55 on March 9th.

Follow the outline exactly. Project Plan limited to 20 pages. No

appendix material accepted. Request letters of

commitment/support via online system, i.e., you submit name to MEDC system. MEDC requests letter. Letter is submitted to MEDC online by proposal deadline.

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Things to Remember About

Full Proposals (cont’d):

Things to Remember About

Full Proposals (cont’d):• Separate forms for Total (01),

MTTC funds requested (02), and Matching funds (03)

• Budget forms are self-calculating. Matching funds are subtracted from total costs so apparently you should not try to quantify in-kind contributions.

• Budget justifications have no page limits so could include in-kind contributions there and/or under personnel and facilities sections.

• Separate forms for Total (01), MTTC funds requested (02), and Matching funds (03)

• Budget forms are self-calculating. Matching funds are subtracted from total costs so apparently you should not try to quantify in-kind contributions.

• Budget justifications have no page limits so could include in-kind contributions there and/or under personnel and facilities sections.

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Things to Remember About

Full Proposals (cont’d):

Things to Remember About

Full Proposals (cont’d): Collaborators must fill out 04 budget form if they are getting MTTC $$ and 05 form if they are not.

For-profit companies must secure a cash match from a qualified investor.

Need separate forms for each year of the project for each collaborator

These forms have had some weird glitches in the past so start working on them well in advance of deadline

Collaborators must fill out 04 budget form if they are getting MTTC $$ and 05 form if they are not.

For-profit companies must secure a cash match from a qualified investor.

Need separate forms for each year of the project for each collaborator

These forms have had some weird glitches in the past so start working on them well in advance of deadline

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Things to Remember About Full Proposals

(cont’d):

Things to Remember About Full Proposals

(cont’d): All proposals require an Intellectual Property Plan or and explanation of why there are no IP issues involved in the project.

The IP Plan must be specifically developed for the project, i.e., can’t use the templates from previous years.

Contact your DRDA PR or OTT Licensing Rep for help. Start this part early!

All proposals require an Intellectual Property Plan or and explanation of why there are no IP issues involved in the project.

The IP Plan must be specifically developed for the project, i.e., can’t use the templates from previous years.

Contact your DRDA PR or OTT Licensing Rep for help. Start this part early!

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Things to Remember About Full Proposals

(cont’d):

Things to Remember About Full Proposals

(cont’d): All proposals require

disclosure of significant financial interests by applicant organization and each collaborating organization: Salary and other payment for

services Equity interests Intellectual property rights,

royalties Other contractual arrangements

All proposals require disclosure of significant financial interests by applicant organization and each collaborating organization: Salary and other payment for

services Equity interests Intellectual property rights,

royalties Other contractual arrangements

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Things to Remember About Full Proposals

Category I:

Things to Remember About Full Proposals

Category I: Science gets only 20% of the

consideration. Quality of the team also is

20%. Commercial partners preferred.

Showing ability to match or leverage other funding is essential. Each participant must show contribution of specific new resources.

Science gets only 20% of the consideration.

Quality of the team also is 20%. Commercial partners preferred.

Showing ability to match or leverage other funding is essential. Each participant must show contribution of specific new resources.

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Things to Remember About Full Proposals

Category II:

Things to Remember About Full Proposals

Category II: Focus on translating research findings to commercial applications.

Collaboration is required - at least 2 institutions or organizations. Commercial partners preferred.

Each participant must show contribution of specific new resources.

Focus on translating research findings to commercial applications.

Collaboration is required - at least 2 institutions or organizations. Commercial partners preferred.

Each participant must show contribution of specific new resources.

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Things to Remember About Full Proposals

Category III A:

Things to Remember About Full Proposals

Category III A: Focus on building a commercialization support system. Preference for proposals that offer unique, specialized services to the MTTC business community.

Match or fee for service structure required.

Describe how service will be self-supporting after MTTC funding.

Focus on building a commercialization support system. Preference for proposals that offer unique, specialized services to the MTTC business community.

Match or fee for service structure required.

Describe how service will be self-supporting after MTTC funding.

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Things to Remember About Full Proposals

Category III B:

Things to Remember About Full Proposals

Category III B: UM is not eligible to apply

directly but can participate on companies’ proposals.

Focus on commercialization of a product.

Awards in the form of loans or equity investments.

10 page proposal plus 20 page business plan required.

UM is not eligible to apply directly but can participate on companies’ proposals.

Focus on commercialization of a product.

Awards in the form of loans or equity investments.

10 page proposal plus 20 page business plan required.

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To Get Help With:To Get Help With:

RFP Details: DRDA will establish an email list and

provide updates, tips, advice. Email to [email protected] to get on or off list. We’ll start with MLSCF Awardees list. Please check UM Directory to see if you’re on it before messaging Pat.

MTTC will have a FAQ site and help desk. DRDA -

Anna Schork, [email protected], 935-1356Elaine Brock, [email protected], 763-7188Pat Roe, [email protected], 936-1289

RFP Details: DRDA will establish an email list and

provide updates, tips, advice. Email to [email protected] to get on or off list. We’ll start with MLSCF Awardees list. Please check UM Directory to see if you’re on it before messaging Pat.

MTTC will have a FAQ site and help desk. DRDA -

Anna Schork, [email protected], 935-1356Elaine Brock, [email protected], 763-7188Pat Roe, [email protected], 936-1289

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To Get Help With:To Get Help With: COI Disclosures:

DRDA - Anna Schork, me[email protected], 935-1356Elaine Brock, [email protected], 763-7188

Med School - Valerie Rup, [email protected], 936-1971

Outside the Med School - Judy Nowack, jno[email protected], 763-1289 Lynn Cook, [email protected], 647-7768

COI Disclosures: DRDA -

Anna Schork, me[email protected], 935-1356Elaine Brock, [email protected], 763-7188

Med School - Valerie Rup, [email protected], 936-1971

Outside the Med School - Judy Nowack, jno[email protected], 763-1289 Lynn Cook, [email protected], 647-7768

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To Get Help With:To Get Help With:

IP Plans: DRDA -

Anna Schork, [email protected], 936-1356,

Elaine Brock, [email protected], 763-7188,

Tom Zdeba, [email protected] , 936-1292

OTT - Robin Rasor, [email protected], 615-8433

IP Plans: DRDA -

Anna Schork, [email protected], 936-1356,

Elaine Brock, [email protected], 763-7188,

Tom Zdeba, [email protected] , 936-1292

OTT - Robin Rasor, [email protected], 615-8433