Your first mentored grant proposal:

The National Institutes of Health

F and K proposals, and Foundations

Alison K. Hall, Ph.D.

Case School of Medicine

Office of Graduate Education

You are at a critical juncture in training

productive

self-reliant

about to embark on independent careers

becoming physician-scientists

Often write a grant to seek financial support and recognition for research

Why do you want a mentored grant?

1. Makes the relationship with the PI explicit

2. Benefits associated with grant

3. Looks good on your resume

4. Great learning experience

5. The future inclues an R01…

The Number of Pre-Doctoral and Post-Doctoral Research Training Positions on NIH Training Grants and Fellowships

(NRSA)Fiscal Year 2005

8,367

1,267

5,621

1,635

0

1,000

2,000

3,000

4,000

5,000

6,000

7,000

8,000

9,000

10,000

Fellowships

Training Grants

Pre-Doctoral PositionsPost-Doctoral Positions

(86.8%)

(13.2%)

(22.5%)

(77.5%)

Where do you start?

Communicateyour PI, potential mentorsyour chairpersonthe Office of Research/ Univ Review, compliance

Are you ready?pilot datatime to focusdeadlines

Do you qualify?

appointment statusUS citizens, permanent residents

The Number of Research Training Positions on NIH Training Grants and Fellowships

(NRSA) Fiscal Years 1996 - 2005

0

2

4

6

8

10

12

14

16

18Thousands

1996 1997 1998 1999 2000 2001 2002 2003 2004 2005

Fellowships

TrainingGrants

Number of Fellowship (F31) Applications Reviewed and AwardedFiscal Years 1990 – 2005

0

300

600

900

1200

1500

1990199119921993199419951996199719981999200020012002200320042005

Received

Awarded

The F30 National ResearchService Award (NRSA) for individual

Predoctoral MD/PhD fellows

http://grants.nih.gov/grants/guide/pa-files/PA-05-151.html

set stipend scale and supplement

The F32 NRSA Jan. 9, 2006 Stipends for Kirschstein-NRSA awards 2006Postdoctoral

Years of Experience:0 $36,996 1 $38,976 2 $41,796 3 $43,428 4 $45,048 5 $46,992 6 $48,852 7 or more $51,036

Institutional Allowance $5,500 Research supplies, health insurance, travel to mtgs Program announcements http://grants.nih.gov/training/nrsa.htm

Components of Participating Organizations National Institute on Aging (NIA/NIH), (http://www.nia.nih.gov/) National Institute on Alcohol Abuse and Alcoholism (NIAAA/NIH), (http://www.niaaa.nih.gov) National Institute on Deafness and Other Communication Disorders (NIDCD/NIH), (http://www.nidcd.nih.gov) National Institute on Drug Abuse (NIDA/NIH), (http://www.nida.nih.gov) National Institute of Environmental Health Sciences (NIEHS/NIH), (http://www.niehs.nih.gov) National Institute of Mental Health (NIMH/NIH), (http://www.nimh.nih.gov) National Institute of Neurological Disorders and Stroke (NINDS/NIH), (http://www.ninds.nih.gov) Office of Dietary Supplements (ODS/NIH), (http://ods.od.nih.gov)

April 5August 5December 5

Individual fellowships (F31) for minority students or students with disabilities have special receipt dates

The F31 NRSA There are some 25 Institutes at NIH that each have mission

Look at CRISP databasehttp://crisp.cit.nih.gov/crisp/crisp_query.generate_screen

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As director of the National Institute of General Medical Sciences from 1974 to 1993, Ruth Kirschstein MD was the first woman institute director at the National Institutes of Health (NIH). Throughout her career, she has worked as an administrator, fundraiser, and scientific researcher, investigating possible public health responses in the midst of crisis and conservatism.

Stipends 20,772 (suppplement)

Tuition and fees (formula)

Health insurance

Institutional Allowance 30 fellows receive an institutional allowance of $2,750 per 12-month period to non-federal, or nonprofit sponsoring institutions to help defray such awardee expenses as research supplies, equipment, books, and travel to scientific meetings.

2002 Number number total cost success reviewed awarded awarded 1000s rate*

MD 202 91 4,602 45 PHD 1,336 516 20,813 38.6 all 1,538 607 25,415 39.5

http://grants.nih.gov/grants/award/training/F32MDPHD9502.HTM

The F32 NRSA is a reasonable goal:

Grant NumberPI NameProject Title

5F32GM074554-02ARMBRUSTER, BLAINECreation of designer biogenic amine receptors5F30DC007274-02 BALU, RAMANIIntrinsic properties of olfactory bulb mitral cells5F30NS050913-02 COWAN, THOMASAssistive Device Control With Brain Surface Signals1F31NR008984-01A 2DIMARCO, MARGUERITEUtilization Dental Care by Homeless Children5F30ES011931-04 ETLING, MICHELEInitiation of Experimental Colitis by Commensal Flora5F31HD049326-02 JAGODNIK, KATHLEENUpper Extrem. Control Using Reinforcement Learning5F31MH073296-02 LERCH, JESSICAMolecular Genetics of the Serotonin System5F31NR009344-02 MURROCK, CAROLYNDance and Physical Activity in Afr. American Women1F32AA015833-01 PRITCHARD, MICHELEEgr-1 and EtOH-induced hepatic leukocyte recruitment5F31HD041926-04 ROHDE, TREENAPREDOC FELLOWSH FOR STUDENTS WITH DISABILITIES5F31MH074241-02 SAMUELS, IVYERK2 Specific Function of the CNS1F32CA115150-01A1 SWEENEY, COLINRetroviral Insertional Mutagenesis in LMO1 Stem Cells5F32AG024031-02 WILKINSON, BRANDYMechanisms of Abeta-Stimulated ROS in Microglia

Prepare the Application: read the instructions!!start early, seek internal reviewers

a. Candidate US citizen or permanent residentDoctoral degree (many ok)

b. Sponsor and Training Environment c. Research Proposal

Up to 3 yrsc. Training Potential-impt!d. Vertebrate Animals, Human Subjects etc.e. Three letters of referencef. 3 times per year, usu Apr 5, Aug 5, Dec 5

The A1 or A2. You may have to resubmit…http://grants.nih.gov/training/nrsa.htm

NRSA Review Criteria•Candidate:

•previous academic and research performance•potential to become an important contributor

•Sponsor and Training Environment: •quality of the training environment •qualifications of the sponsor as a mentor

for the proposed research training experience.

•Research Proposal: •merit of the scientific proposal•relationship to the candidate's career plans.

•Training Potential: •value of the proposed fellowship experience as it relates to the candidate's needs in preparation for a career as an independent researcher.

The K08 Mentored Clinical Scientist Development Award

For clinically trained persons to pursue research careers in basic or clinical sciences.

Must apply within 3 years of clinical Training (residency +1 year of clinical fellowship)

K08->K02-> R01up to $85,000 salary up to $50,000 costs/ yearup to five years, non-renewable

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The K08

Prepare the Application: read the instructions!!

a. Candidateb. Research Planc. Career Development Plan/ Training Pland. Environment/ Institutional supporte. Mentor*f. Vertebrate Animals, Human Subjects etc.g. The A1 or A2. You may have to resubmit…h. (The summary statement)

The K08

Candidate****some Institutes require faculty app’t (eg Instructor)

Basic Science Mentor/co Mentor:

1. Good working relationship

2. Often funded by NIH

3. Expert in this area

4. Experienced trainer

The K08

Career Development Plan (very important)

• Focused and relevant

• New techniques, new area, could be funded

• Present at meetings, review grants, external courses

• Update didactics

• Create an oversight committee familiar with research, career goals, meet six mos for feedback

Research Plan

•Provide preliminary data to support rationale,

approach. Focus!

•Include study of Research Ethics, animals etc.

The K08

http://grants.nih.gov/grants/guide/pa-files

See supplementary info at each institute

Insure protected time-Do not assume that 75% means anythingexcept 75% of your total working hours

-These estimates are carefully reviewedessential that your chair state thisnot contingent on receipt of the grant

-50% Neurosurgery

What happens to your application after it leaves the mailbox?

Center for Scientific Review receives the application assigned to the Initial review group or “Study section”

Review for SCIENTIFIC MERIT and TRAINING POTENTIAL.

Summary statement, see NIH Commons

Scores and percentiles. NRSAs are not streamlinedPriority score 100-500, with 100 is best.

Rewrite? Respond to critique

Funded?Progress report each year

Inside the NIH Grant Review Process

39 min video NIH Center for Scientific Review

Includes R01/K08/ R03

Download proposals

http://www.drg.nih.gov/Video/video.asp#docs

View the video on the web

http://www.drg.nih.gov/Video/Video.asp

Helpful Hints for an NLHBI K08 Application http://www.nhlbi.nih.gov/funding/training/redbook/hints.htm

Grantwriting Resources

Grantpersonship: An Instruction Manualhttp://www.pitt.edu/~survival

NIMH Grant Application Processhttp://www.nimh.nih.gov/researchFunding/grantprocess.cfmhttp://www.nimh.nih.gov/researchFunding/training.cfm

FASEB Grantsmanship Training Programhttps://ns2.faseb.org/careerutilities/grantprg.htm

Grant Application Writer’s Handbook, Reif-Lehrer

What about foundations and organization fellowships?

Public charitable organizations-MDA, AHA, ACSDerives support from members of the public

Foundations-Private, Corporatederives support from a family, individual or corporation

see The Foundation Centerwww.fdncenter.org/cleveland

(Richard Sohn, Research Admin has subscr.)

often have a disease focusmay support non US citizensOften have one deadline per year

Where to find these other grants?

Grantsnet http://sciencecareers.sciencemag.org/funding?CFID=380054&CFTOKEN=35995422

“Initial MD postdoc, dermatology, skin” examples:

18. LRF Postdoctoral Fellowship Awards ProgramSponsor: Medical FoundationProgram Type: Anatomy, Biochemistry, Bioengineering, Bioinformatics, Biology, Biophysics, Cell Biology, Chemistry, Developmental Biology, Immunology, Microbiology, Molecular Biology, Physiology, Structural BiologyDeadline(s): 11/15/2005

23. Research GrantsSponsor: American Skin Association, Inc.Program Type: Biology, Cancer, Cell Biology, Clinical Research, Developmental Biology, Disease-Specific Research Skin Cancer/Melanoma, Psoriasis, Epidemiology, Immunology, Molecular Biology, Structural Biology, Other (specify): Vitiligo, Childhood Skin Diseases/Disfigurement, Pigment Cell Biology and Auto-immune Inflammatory Skin DiseasesDeadline(s): 10/03/2005