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1
Kumar et al, Chest 2009; 136:1237–1248
survival (%)0 20 40 60
non-albicans yeast
C. albicans
Ps. aeruginosa
Enterobacter sp
Klebsiella sp
E. coli
other Strep sp
Enterococcus sp
S. pneumoniae
S. aureus
inappropriateappropriate
153
290
295
148
869
312
n p value
odds ratio0.1 1 10 100
268
181
284
597
.0002
<.0001
<.0001
.0002
<.0001
<.0001
.0005
<.0001
.0101
<.0001
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2
Impact of Appropriateness of Initial Antimicrobial Therapy on Survival from Septic Shock
percent (%)
0 20 40 60 80 100
lcbi
cri
uti
sst
IAI
pneu
nosocomial
community
bacteremia -
bacteremia +
culture -
culture +
all
%survival% appropriate
survival (%)
0 10 20 30 40 50 60 70 80
lcbi
cri
uti
sst
IAI
pneu
nosocomial
community
bacteremia -
bacteremia +
culture -
culture +
all
inappropriateappropriate
Kumar et al, Chest 2009; 136:1237–1248
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5
Impact of Appropriateness of Initial Antimicrobial Therapy on Survival from Septic Shock
survival (%)
0 10 20 30 40 50 60 70 80
lcbi
cri
uti
sst
IAI
pneu
nosocomial
community
bacteremia -
bacteremia +
culture -
culture +
all
inappropriateappropriate
Kumar et al, Chest 2009; 136:1237–1248Odds Ratio
1 10 100 1000
236
205
499
344
1041
1381
1912
2144
2044
2013
1659
4056
5715
<.0001
<.0001
<.0001
<.0001
<.0001
<.0001
<.0001
<.0001
<.0001
<.0001
<.0001
<.0001
<.0001
n p value
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6
Kumar et al, Chest 2009; 136:1237–1248
survival (%)0 20 40 60
nosocomial
community
bacteremia -
bacteremia +
culture -
culture +
all
inappropriateappropriate
2144
2044
2013
1659
1912
5715
4056
n
<.0001
<.0001
<.0001
<.0001
<.0001
<.0001
<.0001
p value
odds ratio1 10 100
![Page 5: 1 Kumar et al, Chest 2009; 136:1237–1248. 2 Impact of Appropriateness of Initial Antimicrobial Therapy on Survival from Septic Shock Kumar et al, Chest](https://reader036.vdocument.in/reader036/viewer/2022082816/56649cfd5503460f949cdf6c/html5/thumbnails/5.jpg)
7
Kumar et al, Chest 2009; 136:1237–1248
survival (%)0 20 40 60 80
pbi
cri
uti
sst
IAI
pneu
inappropriateappropriate
236
205
499
344
1381
1041
n
<.0001
<.0001
<.0001
<.0001
<.0001
<.0001
p value
odds ratio1 10 100
![Page 6: 1 Kumar et al, Chest 2009; 136:1237–1248. 2 Impact of Appropriateness of Initial Antimicrobial Therapy on Survival from Septic Shock Kumar et al, Chest](https://reader036.vdocument.in/reader036/viewer/2022082816/56649cfd5503460f949cdf6c/html5/thumbnails/6.jpg)
8
Kumar et al, Chest 2009; 136:1237–1248
survival (%)0 20 40 60
non-albicans yeast
C. albicans
Ps. aeruginosa
Enterobacter sp
Klebsiella sp
E. coli
other Strep sp
Enterococcus sp
S. pneumoniae
S. aureus
inappropriateappropriate
153
290
295
148
869
312
n p value
odds ratio0.1 1 10 100
268
181
284
597
.0002
<.0001
<.0001
.0002
<.0001
<.0001
.0005
<.0001
.0101
<.0001
![Page 7: 1 Kumar et al, Chest 2009; 136:1237–1248. 2 Impact of Appropriateness of Initial Antimicrobial Therapy on Survival from Septic Shock Kumar et al, Chest](https://reader036.vdocument.in/reader036/viewer/2022082816/56649cfd5503460f949cdf6c/html5/thumbnails/7.jpg)
9
Kumar et al, Chest 2009; 136:1237–1248
survival (%)0 20 40 60
yeast
anaerobes
g-b
g+c
inappropriateappropriate
443
156
2002
1355
n p value
odds ratio1 10 100
<.0001
.0048
<.0001
<.0001
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10
Kumar et al, Chest 2009; 136:1237–1248
survival (%)
0 10 20 30 40 50 60 70 80
lcbi
cri
uti
sst
IAI
pneu
nosocomial
community
bacteremia -
bacteremia +
culture -
culture +
all
inappropriateappropriate
survival (%)
0 10 20 30 40 50 60 70
non-albicans
C. albicans
Ps. aeruginosa
Enterobacter sp
Klebsiella sp
E. coli
other Strep sp
Enterococcus sp
S. pneumoniae
S. aureus
yeast
anaerobes
g-b
g+c
inappropriateappropriate
![Page 9: 1 Kumar et al, Chest 2009; 136:1237–1248. 2 Impact of Appropriateness of Initial Antimicrobial Therapy on Survival from Septic Shock Kumar et al, Chest](https://reader036.vdocument.in/reader036/viewer/2022082816/56649cfd5503460f949cdf6c/html5/thumbnails/9.jpg)
11
Kumar et al, Chest 2009; 136:1237–1248
percent (%)
0 20 40 60 80 100
lcbi
cri
uti
sst
IAI
pneu
nosocomial
community
bacteremia -
bacteremia +
culture -
culture +
all
%survival% appropriate
percent (%)
0 20 40 60 80 100
non-albicans
C. albicans
Ps. aeruginosa
Enterobacter sp
Klebsiella sp
E. coli
other Strep sp
Enterococcus sp
S. pneumoniae
S. aureus
yeast
anaerobes
g-b
g+c
% survival% appropriate