Download - 2008 IR-4 Food Use Workshop Sacramento, CA
![Page 1: 2008 IR-4 Food Use Workshop Sacramento, CA](https://reader036.vdocument.in/reader036/viewer/2022062315/56815d2e550346895dcb2798/html5/thumbnails/1.jpg)
Nichino America Inc.Jim Adams, Manager, Product Development
Marie Maks-Regulatory Affairs ManagerPhone: (302) 636-9001
Web site: www.nichino.net
2008 IR-4 Food Use WorkshopSacramento, CA
![Page 2: 2008 IR-4 Food Use Workshop Sacramento, CA](https://reader036.vdocument.in/reader036/viewer/2022062315/56815d2e550346895dcb2798/html5/thumbnails/2.jpg)
NAI-2302 15ECNAI-2303 15SC
Tolfenpyrad
![Page 3: 2008 IR-4 Food Use Workshop Sacramento, CA](https://reader036.vdocument.in/reader036/viewer/2022062315/56815d2e550346895dcb2798/html5/thumbnails/3.jpg)
Chemical Details on TolfenpyradChemical Name: 4-chloro-3-ethyl-1-
methyl-N-[4-p-tolyloxy)benzyl] pyrazole -5-carboxamide
Empirical Formula: C21H22Cl N3O2Molecular Weight: 283.9Code Number: NAI-2302
![Page 4: 2008 IR-4 Food Use Workshop Sacramento, CA](https://reader036.vdocument.in/reader036/viewer/2022062315/56815d2e550346895dcb2798/html5/thumbnails/4.jpg)
Insects ControlledHemiptera, Coleoptera, Diptera,
Lepidoptera, Thysanoptera, and AcarinaPoisoning by ingestion; contact activity;
anti-feeding activity against lepsTarget Crops:
Vegetables, Cucurbits, Cole CropsFruits & NutsSelected row cropsOrnamentals
![Page 5: 2008 IR-4 Food Use Workshop Sacramento, CA](https://reader036.vdocument.in/reader036/viewer/2022062315/56815d2e550346895dcb2798/html5/thumbnails/5.jpg)
Efficacy Trials
Use rate 0.137 to 0.274 lb. a.i/acre (153-307 grams ai / hectare)
14 – 27 oz/a (15% EC and 15% SC formulations)
Alternative mode of action useful against numerous vegetable and fruit/nut pests
![Page 6: 2008 IR-4 Food Use Workshop Sacramento, CA](https://reader036.vdocument.in/reader036/viewer/2022062315/56815d2e550346895dcb2798/html5/thumbnails/6.jpg)
U.S. Registration Timeline
Submit non-crop indoor greenhouse use mid 2008 as reduced risk candidate
Submit crop uses with residue chemistry data by 2010 as reduced risk candidate
![Page 7: 2008 IR-4 Food Use Workshop Sacramento, CA](https://reader036.vdocument.in/reader036/viewer/2022062315/56815d2e550346895dcb2798/html5/thumbnails/7.jpg)
NNI-0771NNI-0772NNI-0776
Flubendiamide-Based Insecticides
![Page 8: 2008 IR-4 Food Use Workshop Sacramento, CA](https://reader036.vdocument.in/reader036/viewer/2022062315/56815d2e550346895dcb2798/html5/thumbnails/8.jpg)
CF3
CF3F
I
ONH
OCH3
HN
CH3CH3SCH3
OO
NAI-2310 (FLUBENDIAMIDE)
New generation of chemistry active against Lepidoptera at low rates
Discovered by NNC and marketed by NNC and Bayer
Registered in Japan as Phoenix
![Page 9: 2008 IR-4 Food Use Workshop Sacramento, CA](https://reader036.vdocument.in/reader036/viewer/2022062315/56815d2e550346895dcb2798/html5/thumbnails/9.jpg)
FLUBENDIAMIDEProduct Characteristics
Flubendiamide (NAI-2310) Target Mkts: TNV, Vegetables, Cotton Chemistry: Substituted phtallic acid diamide MOA: Ryanodine receptor modulator Ingestion by insect results in immediate cessation
of feeding Contact (not systemic in plants and has only
limited translaminar movement) Rates: 15-140 gms ai/hectare
![Page 10: 2008 IR-4 Food Use Workshop Sacramento, CA](https://reader036.vdocument.in/reader036/viewer/2022062315/56815d2e550346895dcb2798/html5/thumbnails/10.jpg)
2009 IntroductionsNNI-0772 (Tourismo™)
Tree Nuts, Pome, Stone, Vines, CottonNNI-0871 (Vetica™)
Vegetables, Cucurbits, Cole Crops
![Page 11: 2008 IR-4 Food Use Workshop Sacramento, CA](https://reader036.vdocument.in/reader036/viewer/2022062315/56815d2e550346895dcb2798/html5/thumbnails/11.jpg)
US Registration TimelineSubmission to EPA 2008Commercial Launch 2009
![Page 12: 2008 IR-4 Food Use Workshop Sacramento, CA](https://reader036.vdocument.in/reader036/viewer/2022062315/56815d2e550346895dcb2798/html5/thumbnails/12.jpg)
NNI-0101
Pyrifluquinazon
![Page 13: 2008 IR-4 Food Use Workshop Sacramento, CA](https://reader036.vdocument.in/reader036/viewer/2022062315/56815d2e550346895dcb2798/html5/thumbnails/13.jpg)
NNI-0101(Pyrifluquinazon)
Chemistry: Quinazolinone Chemistry MOA: Insect Behavior Modifier
Rapid cessation of feeding Insects remain but starve to death
Target Mkts: TNV, Vegetables, Cotton, Cucurbits
![Page 14: 2008 IR-4 Food Use Workshop Sacramento, CA](https://reader036.vdocument.in/reader036/viewer/2022062315/56815d2e550346895dcb2798/html5/thumbnails/14.jpg)
Pyrifluquinazon (NNI-0101)Hemiptera / Homptera
Rates: 12.5-50 grams ai/hectareWhitefly, Aphids
Rates: 50-125 grams ai/hectareMealybug, thrips, leafhopper
Higher Rates:ScaleTrue bugs
![Page 15: 2008 IR-4 Food Use Workshop Sacramento, CA](https://reader036.vdocument.in/reader036/viewer/2022062315/56815d2e550346895dcb2798/html5/thumbnails/15.jpg)
Biological mode of action on aphids
0
20
40
60
80
100
0 20 40 60 80 100
Mortality
% of dispersion
Mortality of starvedinsects
Hours after treatment
Percent of dispersal
insects (stop feeding) &
mortality
Abnormal behavior Death by starvation
Appearance of activity/Green peach aphid
Figure 1. Mortality and percent of insect dispersal from treated plants of green peach aphid, Myzus persicae, after treatment with NNI-0101 at a dose rate of 50ppm.
(insects may appear normal)
of NNI-0101 treated insects
of NNI-0101 treated insects
NNI-0101 shows two distinct effects on aphids; 1. Rapid response of abnormal behavior (insect dispersion, feeding cessation)2. Slow lethal action
![Page 16: 2008 IR-4 Food Use Workshop Sacramento, CA](https://reader036.vdocument.in/reader036/viewer/2022062315/56815d2e550346895dcb2798/html5/thumbnails/16.jpg)
Possible IR-4 InterestsOnion thrips (PCR submitted)Aphid, Thrip, Whitefly, Mealybug and Scale control on ornamentals
Rapid cessation of whitefly and aphid feeding reduces transmission of viruses vectored by these pests on important fruit and vegetable crops
![Page 17: 2008 IR-4 Food Use Workshop Sacramento, CA](https://reader036.vdocument.in/reader036/viewer/2022062315/56815d2e550346895dcb2798/html5/thumbnails/17.jpg)
US Registration Timeline
Submit for food crop uses early 2010
![Page 18: 2008 IR-4 Food Use Workshop Sacramento, CA](https://reader036.vdocument.in/reader036/viewer/2022062315/56815d2e550346895dcb2798/html5/thumbnails/18.jpg)