Download - 355 Metastasis
4/7/2015
1
Photo citations: 1. x
Metastasis Part 1
1.Cell Migration
2.PAR 1, an Outside-
in-Signal
3.Signal Transduction
intermediates
4.PAR 1 Localization
via antibody-QD
Objectives
Learn about cell signaling from the perspective of a
G-protein coupled receptor (GPCR).
Understand the signals that stimulate these GPCRs
and the downstream effects of GPCR stimulation.
Develop a deep understanding of what an abstract is.
Understand antibody-based techniqueS (numerous)
for localizing proteins of interest and recognizing
which is important for a given purpose.
Photo citations: 1. Karp, figure 9.70 2. Karp, figure 9.69.
Metastasis Part 1
1.Cell Migration
2.PAR 1, an Outside-
in-Signal
3.Signal Transduction
intermediates
4.PAR 1 Localization
via antibody-QD
Photo citations: 1. Karp, figure 9.1
Metastasis Part 1
1.Cell Migration
2.PAR 1, an Outside-
in-Signal
3.Signal Transduction
intermediates
4.PAR 1 Localization
via antibody-QD
4/7/2015
2
Photo citations: 1. Karp, figure 9.64
Metastasis Part 1
1.Cell Migration
2.PAR 1, an Outside-
in-Signal
3.Signal Transduction
intermediates
4.PAR 1 Localization
via antibody-QD
Photo citations: 1. Karp, figure 9.70
Metastasis Part 1
1.Cell Migration
2.PAR 1, an Outside-
in-Signal
3.Signal Transduction
intermediates
4.PAR 1 Localization
via antibody-QD
Photo citations: 1. Creative commons
File:A2A_receptor_bilayer.png
Metastasis Part 1
1.Cell Migration
2.PAR 1, an Outside-
in-Signal
3.Signal Transduction
intermediates
4.PAR 1 Localization
via antibody-QD
PAR1 = protease activated receptor
G-protein coupled receptor
4/7/2015
3
Photo citations: van der Poll Critical Care 2008 12(Suppl 6):S3 doi:10.1186/cc7026
Metastasis Part 1
1.Cell Migration
2.PAR 1, an Outside-
in-Signal
3.Signal Transduction
intermediates
4.PAR 1 Localization
via antibody-QD
Photo citations: 1. Karp, Figure 15.4
Metastasis Part 1
1.Cell Migration
2.PAR 1, an Outside-
in-Signal
3.Signal Transduction
intermediates
4.PAR 1 Localization
via antibody-QD
Photo citations: 1. x
Metastasis Part 1
1.Cell Migration
2.PAR 1, an Outside-
in-Signal
3.Signal Transduction
intermediates
4.PAR 1 Localization
via antibody-QD
http://www.youtube.com/w
atch?v=xT0mAQ4726s
4/7/2015
4
Photo citations: 1. Karp, figure 15.2
Metastasis Part 1
1.Cell Migration
2.PAR 1, an Outside-
in-Signal
3.Signal Transduction
intermediates
4.PAR 1 Localization
via antibody-QD
Photo citations: 1. Karp, figure 15.7
Metastasis Part 1
1.Cell Migration
2.PAR 1, an Outside-
in-Signal
3.Signal Transduction
intermediates
4.PAR 1 Localization
via antibody-QD
Photo citations: 1. Karp, Figure 9.69
Metastasis Part 1
1.Cell Migration
2.PAR 1, an Outside-
in-Signal
3.Signal Transduction
intermediates
4.PAR 1 Localization
via antibody-QD
4/7/2015
5
Photo citations: 1. imgarcade.com 2. http://commons.wikimedia.org/wiki/File:C
dSeqdots.jpg 3. http://commons.wikimedia.org/wiki/File:Bi
ological_and_technological_scales_compared-en.svg
Metastasis Part 1
1.Cell Migration
2.PAR 1, an Outside-
in-Signal
3.Signal Transduction
intermediates
4.PAR 1 Localization
via antibody-QD
Photo citations: Image Credit: Quantum Dot Corporation ://nanotechweb.org/cws/article/tech/16533
Metastasis Part 1
1.Cell Migration
2.PAR 1, an Outside-
in-Signal
3.Signal Transduction
intermediates
4.PAR 1 Localization
via antibody-QD