2004 Oxazole derivatives

Oxazole derivativesR 0220 4,5-Disubstituted-1,3-oxazolidin-2-imine Derivatives: A New Class of Orally Bio-

available Nitric Oxide Synthase Inhibitor. — Synthesis, SAR, in vitro and in vivo inhibitory activities and selectivities are reported for 19 members of the title series. — (UEDA*, S.; TERAUCHI, H.; YANO, A.; IDO, M.; MATSUMOTO, M.; KAWASAKI, M.; Bioorg. Med. Chem. Lett. 14 (2004) 2, 313-316; Chem. Res. Lab., Dainippon Pharm. Co., Ltd., Suita, Osaka 564, Japan; Eng.) — D. Singer

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