5’-terminal sequences

3’-terminal sequencesdsRNA1 UAA..(48 nt)..dsRNA2 UAA..(120 nt).dsRNA3 UGA..(59 nt)..dsRNA4 UAA..(166 nt).

ACGGGAAACAAA-CAAUACAUAU---UAGCGGAAACGCAAUUCAAUAGAUAUACGUGCUAUUGAUCUUGAGAAUAUUC(G/A)-3’ 4,971-UGCAAACCAAA-ACAUACAUAU---UAGCGGAAACGCAAUUCAAUAGAUAUACGUGCUAUUGAUCUUGAGAAUAUUC(A/G)-3’ 4,307GUGUAUAACAAGUCAAUACAUAUUAUCAGCGGAAACGCAAUUCA-UAAGUGCGCGUGACGUUGACUUUGAGAAUAUUC(G/A)-3’ 4,093-GCUAAACCAAA-ACACACAUAUAAUCAGCGGAAACGCAAUUCAAUAGGUAUACGUGCUAUUGACCAUGAGAAUAUUC(G/A)-3’ 3,468

dsRNA1 5’-(C/U)ACGAUUCAACCCACUACUAACUUAAAGUAUC---GUUGAACAUGCAAUCCACUCGUAAG...dsRNA2 5’-(U/C)ACGAUUCAACCCACACAUUGAUCCAUCAAUUCGAAUCACUAUGGCGACCCAAAUGCAAC...dsRNA3 5’-(C/U)ACGAUUCAGCCCCACACUAACCAUGGAUAACCACACCGAUAUUGAGACUGAUACCUACC...dsRNA4 5’-(C/U)ACGAUUCAACCCAACUUUUAGUUCUGCUAUUCGAAUCAACAACAAUGUCCGCACCAAGU...

Supplementary Fig. 3

(a)

(b)

(c)

5’-(U/C)CACGAUUCAgCC 3’-(A/G)CUUAUAAGAGUU