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Page 1: A Practical Synthesis of Enantiopure (S)-4-(4-Hydroxybenzyl)-oxazolidin-2-one

2003 Oxazole derivatives

200352.fm Page 138 Thursday, November 27, 2003 1:51 PM

Oxazole derivativesR 0220 A Practical Synthesis of Enantiopure (S)-4-(4-Hydroxybenzyl)-oxazolidin-2-one.

— The title compound is a key intermediate for the synthesis of a number of poly-mer-supported Evans' oxazolidin-2-ones that have been used previously for solid-sup-ported asymmetric transformations. — (GREEN, R.; TAYLOR, P. J. M.; BULL*, S. D.; JAMES*, T. D.; MAHON, M. F.; MERRITT, A. T.; Tetrahedron: Asymmetry 14 (2003) 17, 2619-2623; Dep. Chem., Univ. Bath, Claverton Down, Bath BA2 7AY, UK; Eng.) — Jannicke

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