Download - ALZHEYMER'S DISEASE, ZIKA VIRUS AND PROTEINS
PROTEINSCARLOS A. LOPEZ DIAZ
MEDICINE STUDENT
BLIBLIOGRAPHY
• Michele Vendruscolo, T. (Thursday 11 August 2016). Poor protein control key to Alzheimer's / Dementia. medicalnews.
• Preidt, R. (THURSDAY, Aug. 11, 2016). 2 Zika Virus Proteins Linked to Microcephaly ID'd. HealthDay.
• http://www.merriam-webster.com/dictionary/protein
PROTEINSMEDICAL UTILITY
The proteins are so much important, are versatile molecules because can realize diverses functions and we can use it like: enzymes: can catalysis chemical reactions Hormones: the proteins can work with the plataletes to help to the blood coagulation Transport of substances Immunological factor: the antibodies produced with leukocyte
And the most important characteristic, they are molecular target so, we can use it to medical treatment, therapies to the cancer and another diseases . Also we can use the proteins presence and characteristic behavior for diagnosis of many sicknesses
By: CARLOS ALBERTO LOPEZ DIAZMOLECULAR BIOLOGY
Teacher: LINA MARIA MARTINEZ SANCHEZ
INTRODUCTION THE PROTEINS
are any of various naturally occurring extremely complex substances that consist of amino-acid residues joined by peptide bonds, contain the elements carbon, hydrogen, nitrogen, oxygen, usually sulfur, and occasionally other elements (as phosphorus or iron), and include many essential biological compounds (as enzymes, hormones, or antibodies)
Poor protein control key to Alzheimer's progression
New research investigating the pattern of protein build-up in Alzheimer's brains may open the door to
a deeper understanding.Previous research has identified that certain areas of the brain are more sensitive to the aggregation
of proteins. The disease often begins in the entorhinal region (at the base of the brain) and
spreads out to all of the neocortex (the largest part of the cerebral cortex)
How did it? They analyzed approximately 500 samples of
healthy brain taken from the Allen Brain Atlas In the healthy tissue, they observed a distinctive joint of
genes important in the control of beta amyloid and tau protein. They contrasted with Alzheimer`s brains and discovered a identical pattern in advance of the
sickness throughout the brain.
Student’s observations I think that it’s very interesting and useful for the study of specifics cerebral regions and resolve the
likelihood of suffer this sickness and accordingly it’s importanto to find preventive actions
2 Zika Virus Proteins Linked to Microcephaly ID'd
First study to examine Zika infection in human neural stem cells from second-trimester fetuses, researchers say.USC researchers have tracked down two Zika proteins potentially responsible for thousands of microcephaly cases; taking one small step toward preventing Zika-infected mothers from birthing babies with abnormally small heads. Babies with microcephaly have abnormally small heads and brains. The Zika virus include 10 proteins, however only NS4B and NS4A are the responsible, in accordance with the study published in the journal Cell Stem Cell. These malicious proteins, researchers discovered, have two shared life goals: to handicap fetal brain formation and to mobilize their malevolent forces.
Student’s observations I think this discovery is so much useful for
implement measurement prevents to this disease and have power over about it.
INTRODUCCIÓN
Proteins are vital to basic cellular and body functions, including cellular regeneration and repair, tissue
maintenance and regulation, hormone and enzyme production, fluid balance, and the provision of
energy.
Poor protein control key to Alzheimer's progression
New research investigating the pattern of protein build-up in Alzheimer's brains may open the door to
a deeper understanding.Previous research has identified that certain areas of the brain are more sensitive to the aggregation
of proteins. The disease often begins in the entorhinal region (at the base of the brain) and
spreads out to all of the neocortex (the largest part of the cerebral cortex)
How did it? They analyzed approximately 500 samples of
healthy brain taken from the Allen Brain Atlas In the healthy tissue, they observed a distinctive joint of
genes important in the control of beta amyloid and tau protein. They contrasted with Alzheimer`s brains and discovered a identical pattern in advance of the
sickness throughout the brain.
Student’s observations I think that it’s very interesting and useful for the study of specifics cerebral regions and resolve the
likelihood of suffer this sickness and accordingly it’s importanto to find preventive actions
POOR PROTEIN CONTROL KEY TO ALZHEIMER’S PROGRESSION
By. Prof. Michele Vendruscolo, of the Centre for Misfolding Diseases at Cambridge's Department of
Chemistry in the United Kingdom.THURSDAY, Aug. 11, 2016.
Alzheimer's disease, is a chronic neurodegenerative disease that usually
starts slowly and gets worse over time. Normally appearing around the age of 60.
Although a great deal has been learned about the disease, there is no cure, and many
questions remain unanswered
POOR PROTEIN CONTROL KEY TO ALZHEIMER’S PROGRESSION
Mapeo de la forma en que se gestiona la proteína en el cerebro da una nueva perspectiva sobre la enfermedad de Alzheimer.
Crédito de la imagen: J Freer
Amyloid - beta genes and tau protein, involved in the control
and important factor in this study to evaluate the pattern in
the Alzheimer brains compared with healthy brains
Previous research has identified that certain areas of the brain are more
sensitive to the aggregation of proteins. The disease often begins in the
entorhinal region (at the base of the brain) and spreads out to all of the neocortex (the largest part of the
cerebral cortex).
Prof. Vendruscolo explains the findings:"Vulnerability to Alzheimer's disease isn't dictated by
abnormal levels of the aggregation-prone proteins that form the characteristic deposits in disease, but rather by the weaker control of these proteins in the
specific brain tissues that first succumb to the disease."
Co-author Prof. Christopher Dobson says: "Linking the properties of specific protein molecules to the onset
and spread of neuronal damage is a crucial step in the quest to find effective drugs to combat this dreadful
neurodegenerative condition."
In my opinion the advance in the knowning about the Alzheimers disease is so much important to the
medicine because actually exist much ignorance about it and researching, the medicine can to be
near more every day to find any possibility of resolve this problem with any cure or otherwise
every time improvement in the treatment. I think that investigations type’s like the previous
are too contributors to the medicine. If it continue we can reach big steps in medicine.
2 Zika Virus Proteins Linked to Microcephaly ID'd
Researchers from a team led by University of Southern California scientists say they've identified two
proteins in the ZIKA VIRUS linked to the severe birth defect MICROCEPHALY.
THURSDAY, Aug. 11, 2016 (HealthDay News).
Zika virus is a mosquito-borne illness that is spread by the Aedes species of mosquito.
The two known species responsible for Zika transmission are the Aedes albopictus, known
as the Asian Tiger mosquito, and the Aedes aegypti species.
• Fever• Eruption• Arthralgia• Conjunctivitis• Myalgia• Headache• Vomit• Ocular pain
Symtomps
• Microcephaly is a medical condition in which the brain does not develop properly resulting in a smaller than normal head. Microcephaly may be present at birth or it may develop in the first few years of life.Microcephal
y
The Zika virus contains 10 proteins, but only two -- called NS4A and NS4B -- are linked to
microcephaly, according to the researchers.El descubrimiento podría algún día conducir a una
manera de evitar que el defecto de nacimiento, según los científicos
"We now know the molecular pathway, so we made the first big step toward target therapy for Zika-induced microcephaly,".
"Dentro de unos años, un disparo o una serie de disparos podrían dirigirse a las proteínas NS4A y NS4B o sus colaboradores,“ Zhen Zhao author of this study.
"It is important to remember that not every pregnant woman infected with Zika virus gives birth to a baby with microcephaly. Nevertheless, we are trying to develop a cure for that percentage that does get Zika-related microcephaly," said study corresponding co-author Zhen Zhao.
My opinion: The zika virus is a disease very common actually and affect so much person in
the world thanks to discoveries like theses researches we can advance and go a step
forward and save many person of suffer theses mishaps
MEDICAL UTILITY
The proteins are so much important, are versatile molecules because can realize diverses functions and we can use it like: enzymes: can catalysis chemical reactions Hormones: the proteins can work with the plataletes to help to the blood coagulation Transport of substances Immunological factor: the antibodies produced with leukocyte
And the most important characteristic, they are molecular target so, we can use it to medical treatment, therapies to the cancer and another diseases
MEDICAL UTILITY
Both researches about caracteristic proteins in the human body have a
relation with some disease and it help to study the
previous diseases
Both researches help to the medicine to reach goals like create any
treatment in order to anticipate theses diseases
and reduce their frequency
BIBLIOGRAPHY• Michele Vendruscolo, T. (Thursday 11 August 2016). Poor protein control key
to Alzheimer's / Dementia. medicalnews. http://www.medicalnewstoday.com/articles/312243.php
• Preidt, R. (THURSDAY, Aug. 11, 2016). 2 Zika Virus Proteins Linked to Microcephaly ID'd. HealthDay. http://www.webmd.com/news/20160811/study-ids-2-zika-virus-proteins-linked-to-microcephaly
• MARTÍNEZ SÁNCHEZ, Lina María. Biología molecular. Libro de clase. 8 edición. Medellín: UPB. Fac. de Medicina. Pag. 147 .
• Protein. (07 de 09 de 2016). Obtenido de MERRIAM-WEBSTER: http://www.merriam-webster.com/dictionary/protein
• SMITH, L. (15 de JULIO de 2016). Virus Zika: Síntomas, Datos, Diagnóstico. Obtenido de http://www.medicalnewstoday.com/articles/305163.php