![Page 1: Antidepressant activity of moringa oleifera flower extract in](https://reader035.vdocument.in/reader035/viewer/2022062319/557d19c3d8b42a4a498b4c29/html5/thumbnails/1.jpg)
ANTIDEPRESSANT ACTIVITY OF MORINGA OLEIFERA
FLOWER EXTRACT
BY SREEREMYA.SM.phil
![Page 2: Antidepressant activity of moringa oleifera flower extract in](https://reader035.vdocument.in/reader035/viewer/2022062319/557d19c3d8b42a4a498b4c29/html5/thumbnails/2.jpg)
INTRODUCTION Depression is a widespread psychiatric disorder that effect several millions of the world population.
Recognized to be symptomatically, psychologically & biologically heterogeneous .
The disorder is characterized by change in mood, lack of interest in the surroundings, lack of motivation, feelings of gloominess,retardation of thinking and activity , sense of hopelessness , lack of physical energy and despair and suicidal ideation etc……..
Major depressive disorder is a disability condition that adversely affects a person’s family , work or school life , sleeping & eating habit& general health.
![Page 3: Antidepressant activity of moringa oleifera flower extract in](https://reader035.vdocument.in/reader035/viewer/2022062319/557d19c3d8b42a4a498b4c29/html5/thumbnails/3.jpg)
CONTI…………The major causes are decrease in the neurotransmitter level
in the brain , oxidative stress and biochemical imbalance etc…….
Depression may treated with antidepressent medication , psychotherapy , self neglect ,etc………
Both synthetic drugs (imipramine & diazepam) and herbal drugs are used for antidepression treatments. in them herbal drugs are more preferable because of less side effects & wider safety margin .
Works have been done on several medicinal plants like citrus maxima
leaves , Artemisia absinthium , Passiflora foetida leaves etc……..
![Page 4: Antidepressant activity of moringa oleifera flower extract in](https://reader035.vdocument.in/reader035/viewer/2022062319/557d19c3d8b42a4a498b4c29/html5/thumbnails/4.jpg)
Moringa oleifera
![Page 5: Antidepressant activity of moringa oleifera flower extract in](https://reader035.vdocument.in/reader035/viewer/2022062319/557d19c3d8b42a4a498b4c29/html5/thumbnails/5.jpg)
Conti……… Moringa Oleifera is a highly valued medicinal
plant which is also known as “miracle tree”.
It is most widely cultivated species & it’s grown mainly in semi arid ,tropical & sub tropical areas.
Flower , root , leaves , gum , bark , fruits , seeds are also have medicinal values.
![Page 6: Antidepressant activity of moringa oleifera flower extract in](https://reader035.vdocument.in/reader035/viewer/2022062319/557d19c3d8b42a4a498b4c29/html5/thumbnails/6.jpg)
Conti……….
several researches have already done in moringa which are anti tumer , anti ulser , anti inflamatory , antiepileptic , anti bacterial , antifungal , anti hepatoprotective , cholestrol lowering , anti alzheimer’s etc……
Different part of this plant contain important minerals , vitamins ,mode of sleeping power, beta-carotene in addition to it’s compelling water purifying power & high nutritional values.
![Page 7: Antidepressant activity of moringa oleifera flower extract in](https://reader035.vdocument.in/reader035/viewer/2022062319/557d19c3d8b42a4a498b4c29/html5/thumbnails/7.jpg)
Conti…..Phytochemical assays
1 Test for total phenolic content2 Test for flavonoid content3 Alkaloids4 Tannins5 Resin6 Carbohydrate 7 Steroids & steroid8 Saponin9 Terpanoid10 Glycoside .
![Page 8: Antidepressant activity of moringa oleifera flower extract in](https://reader035.vdocument.in/reader035/viewer/2022062319/557d19c3d8b42a4a498b4c29/html5/thumbnails/8.jpg)
Conti…..
Anti oxidant studies
1, DPPH radical –scavinging activity
2, FRAP(Ferric radical scavenging activity)
3, SO2 (Super oxide scavinging activity)
4, nitric oxide scavinging activity
![Page 9: Antidepressant activity of moringa oleifera flower extract in](https://reader035.vdocument.in/reader035/viewer/2022062319/557d19c3d8b42a4a498b4c29/html5/thumbnails/9.jpg)
Conti…….
Behavioral test
Tail suspention test
Forced swimming test
Open field test
![Page 10: Antidepressant activity of moringa oleifera flower extract in](https://reader035.vdocument.in/reader035/viewer/2022062319/557d19c3d8b42a4a498b4c29/html5/thumbnails/10.jpg)
Conti…..Evaluate the neurotransmitter level
in mice brain
Noradrenaline level
Serotonin level
![Page 11: Antidepressant activity of moringa oleifera flower extract in](https://reader035.vdocument.in/reader035/viewer/2022062319/557d19c3d8b42a4a498b4c29/html5/thumbnails/11.jpg)
WORKDONEPrepared extractThe powderd sample was extracted using soxhlet method in ethanol .
![Page 12: Antidepressant activity of moringa oleifera flower extract in](https://reader035.vdocument.in/reader035/viewer/2022062319/557d19c3d8b42a4a498b4c29/html5/thumbnails/12.jpg)
THANK YOU