JUVIC
Application of Microneedles in Cosmetic and Medicine
Hyungil Jung, Professor, Department of Biotechnology, Yonsei UniversityFounder and CEO, Juvic [email protected]
JUVICJUVIC
Microneedle is referred to micro dimensioned needlesIt is a novel delivery method to deliver drugs across the skin in a minimally invasive manner
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Microneedle patch
Skin
Application Delivery
JUVICJUVIC
Microneedle can be utilized in various fields of beauty, medical, cell therapy and beauty clinics.
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Beauty
Beauty Clinic
Medical
Cell Therapy
Anti wrinkleWhiteningAlopecia treatment
Insulin patchPTHEPOMicrolancet
AcneAlopecia treatmentBotox
Influenza VaccineArthritis treatment
JUVIC
According to analysis of Frost & Sullivan, Microneedle was selected as top 10 technologies of Healthcare & Wellness in 2016
Frost & Sullivan, 2014
Microneedle market
Billion dollar"Drug delivery technology market has continued to grow rapidly due to impressive sales growth and trends."(BBC Research)
"Micro-needles are likely to replace existing syringes, which will increase demand for micro-needles in the future."(Frost & Suliivan)
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JUVIC
Currently, microneedle fabrication technologies are focused on cosmetics field.
You want to deliver1. Your valuable drugs2. Maintains its activity3. With high efficacy
Main elements of dissolving microneedle delivery systems
Drug Loading
Fabrication
Application
JUVIC
Centrifugal Lithography
Activity of EGF
Activity of Ascorbic acid
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JUVIC
Drug‐Polymer solution MN MN
Delivery
Centrifugal Lithography
Deliveryefficacy
Fabrication
PreparationStorage
Drug Activity
Process time
Drug
Solvent
JUVIC
All technologies are combinedInto innovative products
through JUVIC
JUVIC provides Total solution for Healthcare with Microneedle
Innovative polymer system(Any drugs)
Can load all type of drugs by amphipathic polymer system
Formulation Technology
Centrifugal lithography(Various conditions)
Can control easily the conditions to conserve the activity of drug
Fabrication Technology
Micro injector(Perfect delivery)
Can deliver DMN in high efficacyby shooting DMN into skin
Delivery Technology
JUVIC
Juvic is a technology based start-up.
Publications and patents Various patents on microneedle fabrication and
delivery methods (5 registered, 40 applied) Advanced Materials (2010, 2012), Scientific
Reports (2015) etc. about 30 publications
Achievements Yonsei University Industry-University Cooperation
Excellence Award (2009) Yonsei University Award of Excellent Achievement The 1st Yonsei University startup Award (2016) Awarded from Ministry of the Future Creation
Science Prize for Excellent Technology Commercialization (2015)
Technology transfer 7 transfers, 2 successful production
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RepresentativeHyungil Jung, Junbae Kim
Founded on 2015.10.
LocationYonsei University, Engineering Park
Main ownersHyungil JungYonsei University, etc.
JUVIC
We are carrying out various national R&D projects in both cosmetics and medical fields.
Project Title Department Our role Assignment amount Duration
New Industry Creation ProjectFuture Creation Science Division
Beauty patch development
$ 1.5 Million 2015.07~2017.06
Social problem solving technology development
Future Creation Science DivisionKorea Research
Foundation
Insulin needle development
$ 0.2 Million 2015.11~2017.11
Private investment-led technology start-up support
Small and Medium Business
Administration
Micro type patch development
$ 0.5 Million 2016.12~2018.12
Projects
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JUVIC
Ready for beauty patch for production
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JUVIC
Insulin microneedles
Hollow microneedles
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Smart tdiagnosis patchPainless anesthesia patch
Pharmaceutical Patch (Insulin and vaccine) Tuberculosis Patch
Dissolving microneedles
High efficiency and stability of biopharmaceuticals
Alopecia patech
JUVIC
Order from cosmetic partner
Beauty patch
production
Early business model: OEM/ODM for cosmetics
OEM/ODM Business
A
CollaborationMedicalpatch
production
Long term business: Medical
Our primary business target is to develop and commercialize dissolving microneedle beauty products and medical products in long term.
JUVIC
Lead in the Next GenerationMedical & Cosmetics Field
CosmeticsVaccination
PharmaceuticsNo.1 Bio & Pharma Technology World best drug delivery &
microneedle Technology
JUVIC
Thank You
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JUVIC
Various beauty / medical patches and smart touch patches for diagnosis based on our novel fabrication technique
Cosmetics patch
Alopecia treatment
마이크로구조체Micro‐structure
Micro-injector
Microfluidics chip
ImplantableMicro-capsule
Medical patch
Controlled release Bio
Patch
Painless needles
Diagnostic systems
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JUVIC
We are planning to enter biopharmaceutical industry in near future.
Polymer biopharmaceutical technology
High efficiency and stability of biopharmaceuticals
Potential of delivering lipophilic drugs (arthritis etc.
Maximization effect of anti-metabolism
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polymer
Drug
No activity loss during fabrication
Fabrication
Drug encapsulating microneedle
JUVIC
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Microneedle types
JUVIC
Based on the target site, Microneedles are fabricated in solid, hollow and dissolving types.
SOLID HOLLOW DISSOLVING
Drugs are coated over the outer layer of microneedle
Drugs are delivered by creating channels into skin
Delivers liquid drugs via hollow channels
Dissolves inside the skin upon penetration and releases the encapsulated drug
JUVIC
Currently, microneedle fabrication technologies are focused on cosmetics field. Our manufacturing technology can be extended to medical field.
From cosmetics to medical field
Competitors
Comparison Our technology Local competitorsInternational competitors
Technology Centrifugal lithography DAB Micromolding Micromolding
Company Juvic AEndo derma, Wellage,
other companiesGeorgia tech
Cos medi
Fabrication time Less than 10 min Less than 10 min Over 3 hours
Manufacturing
process
2 stepsDispensing > Fabrication
3 stepsDispensing > drawing > air
blow
More than 3 stepsMold fabrication > Substanse insertion >
centrifuge > drying > separation
Target drugUnstable protein drugscan be utilized
Mainly applicable to small molecule chemicals and is difficult to applybiopharmaceuticals due to fabrication temperature and air drying.
Microneedle fabrication pattern
Flexible Micro mold should be re-designed
Technologydevelopment time
2014 10 2010 4 2006 1 2002 1
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JUVIC
We have developed biodegradable micro-fabrication technology using Centrifugal Lithography and also developed an applicator technology that can deliver various drugs such as water-soluble / lipid-free with high efficiency.
Main elements of dissolving microneedle delivery systems
Drug Loading Fabrication Application
Capable of loading all sort of substances
Scalability of drugs No activity loss High efficiency
2 related patents applied
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2 related patents applied
2 related patents applied
Capability of fabrication in short
time and at low temperature
High delivery efficiency
JUVIC
Contents
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JUVIC
Through a variety of applicator technologies, we can effectively deliver encapsulated substances to the target site.
Pharmaceutical Patch (Insulin)
Painless anesthesia patch
Tuberculosis Patch22
Film
Microneedle
Sticky
Microneedle
JUVIC
Juvic has developed an innovative polymer system that can mix lipid soluble drugs (more than 50% of drugs) in microneedles.
Traditional microneedles were not capable of encapsulating lipid soluble drugs
Innovative polymer systemCapable of encapsulating lipid soluble drugs
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JUVIC
Dissolving microneedles fabricated via centrifugal lithography showed lower drug activity loss compared with other manufacturing processes (such as DAB)
Activity of EGF Activity of Ascorbic acid
Comparison of centrifugal lithography and DAB fabrication methods
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JUVIC
Microneedle applicator device
Microlancer shooting device
Alopecia treatment
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JUVIC
Juvic is a start up company founded in October 2015
2016.12Selected for Small and Medium Business Administration project
2016.05Transferred 45 patents related to microneedles from Yonsei University
2016.05.Awarded the 1st Prize of startup at Yonsei University
2015.11.Selected for social problem solving technology development project
2015.10.Founded Juvic
2015.07.Selected for new industrial project
Company Juvic, Inc.
Representative Hyungil Jung, Junbae Kim
Founded on 2015.10.
AddressSeoul, Yonsei University, Engineering Building
Investment 204 Million won (2017.02)
Main ownersHyungil JungYonsei University, etc.
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Government Project
JUVIC
Based on our innovative biodegradable micro-fabrication technology, we have developed a beauty patch using lab scale pilot equipment.
Centrifugal Lithography Lab-Scale Pilot
Our technology
Cosmetic patch fabrication
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JUVICII. 기술개발 준비현황(창업팀)
28
• 논문 게재 및 연구결과를 45 건의 특허로 권리화, 기술권리를 확보함.
• 마이크로니들 저온 제작 관련 핵심 특허를 자체 보유하고 있으며,
• 보유 특허를 통한 미세돌기 스킨케어 시스템을 이용한 셀프 필러 제품 구현 가능함.
• IP컨설팅 수행을 통해 기존 지식재산권과 침해여부 분석 완료했으며,
• 연세대학교 산학협력단을 통한 기술 유출 방지대책 마련 완료함.
<마이크로니들 관련 핵심특허 보유> <특허분석 수행>
JUVICII. 기술개발 준비현황(창업팀)
29
주빅 공동대표이사 정형일
1993 연세대학교 졸업
1995 연세대학교 식품공학 석사
2002 미 코넬대학교 생명공학 박사
2004~현재 연세대학교 생명공학과 교수
2015~현재 연세대학교 최초 교원창업기업 주식회사 주빅 설립
미용 및 의약품 경피전달체 기술관련 원천기술 및 특허 다수 보유
성공적 기술이전 (총 7건) 및 사업화 (총 2건) 이력 보유
미래창조과학부장관우수 기술사업화 성과
표창장 수상
미래융합의료기기개발(한국보건산업진흥원)GMP 인증 및 사업화
서울전략산업지원사업(서울산업통상진흥원)
화장품 패치 사업화 및 수출사업화 컨설팅 수행
JUVIC
국책과제 수행기관 (벤처기업) 경영 총괄 (3개사)
II. 기술개발 준비현황(창업팀)
30
주빅 공동대표이사 김준배
1996 연세대학교 졸업
2000 미 퍼듀대학교 경영학과 석사
2004 KTB 네트워크 투자심사역
2010 셀루메드 CFO
2012 코렌텍 CFO
2016~현재 연세대학교 최초 교원창업기업 주식회사 주빅 공동대표
국책과제 수행 벤처기업 경영, 내부통제 시스템 구축 및 운영 경험 보유
재무/회계/자금 등내부통제 시스템 구축 및 운영
JUVICII. 기술개발 준비현황(창업팀)
31
• 논문 게재 및 연구결과를 45 건의 특허로 권리화, 기술권리를 확보함.
• 마이크로니들 저온 제작 관련 핵심 특허를 자체 보유하고 있으며,
• 보유 특허를 통한 미세돌기 스킨케어 시스템을 이용한 셀프 필러 제품 구현 가능함.
• IP컨설팅 수행을 통해 기존 지식재산권과 침해여부 분석 완료했으며,
• 연세대학교 산학협력단을 통한 기술 유출 방지대책 마련 완료함.
<마이크로니들 관련 핵심특허 보유> <특허분석 수행>
JUVICII. 기술개발 준비현황(창업팀)
32
주빅 공동대표이사 정형일
1993 연세대학교 졸업
1995 연세대학교 식품공학 석사
2002 미 코넬대학교 생명공학 박사
2004~현재 연세대학교 생명공학과 교수
2015~현재 연세대학교 최초 교원창업기업 주식회사 주빅 설립
미용 및 의약품 경피전달체 기술관련 원천기술 및 특허 다수 보유
성공적 기술이전 (총 7건) 및 사업화 (총 2건) 이력 보유
미래창조과학부장관우수 기술사업화 성과
표창장 수상
미래융합의료기기개발(한국보건산업진흥원)GMP 인증 및 사업화
서울전략산업지원사업(서울산업통상진흥원)
화장품 패치 사업화 및 수출사업화 컨설팅 수행
JUVIC
국책과제 수행기관 (벤처기업) 경영 총괄 (3개사)
II. 기술개발 준비현황(창업팀)
33
주빅 공동대표이사 김준배
1996 연세대학교 졸업
2000 미 퍼듀대학교 경영학과 석사
2004 KTB 네트워크 투자심사역
2010 셀루메드 CFO
2012 코렌텍 CFO
2016~현재 연세대학교 최초 교원창업기업 주식회사 주빅 공동대표
국책과제 수행 벤처기업 경영, 내부통제 시스템 구축 및 운영 경험 보유
재무/회계/자금 등내부통제 시스템 구축 및 운영