Download - Asthma
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- 1. WHAT YOU SHOULD HAVE READ BUT.2010
- asthma
- 2. Asthma phenotypes
- 3. Elucidation of asthma phenotypes in atopic teenagers through
parallel immunophenotypic and clinical profiling HollamsJACI
2009;124:463
- 1380 unselected14-year-olds.
- Clinical history, allergic sensitization, and respiratory function.
- 4. Elucidation of asthma phenotypes in atopic teenagers through
parallel immunophenotypic and clinical profiling HollamsJACI
2009;124:463
- 1380 unselected14-year-olds.
- Clinical history, allergic sensitization, and respiratory function.
- 5. Elucidation of asthma phenotypes in atopic teenagers through
parallel immunophenotypic and clinical profiling HollamsJACI
2009;124:463
- 1380 unselected14-year-olds.
- Clinical history, allergic sensitization, and respiratory and immunoinflammatory function.
- 6. Identification of Asthma Phenotypes Using Cluster Analysis
in the Severe Asthma Research Program MooreAJRCCM2010;181:315
- Severe Asthma Research Program cohort.
- Cluster analysiswas performedon 726 subjects.
- 7. Identification of Asthma Phenotypes Using Cluster Analysis
in the Severe Asthma Research Program MooreAJRCCM2010;181:315
- Severe Asthma Research Program cohort.
- Cluster analysiswas performedon 726 subjects.
- 8. Identification of Asthma Phenotypes Using Cluster Analysis in the Severe Asthma Research Program MooreAJRCCM2010;181:315Using three variables (baseline FEV 1[with a bronchodilator withhold], maximal "Max" FEV 1after six to eight puffs of albuterol, and age of onset of asthma), subjects can be assigned to the five clusters that range from milder asthma(Cluster 1) to more severe disease (Clusters 4 and 5).
- 9. Identification of Asthma Phenotypes Using Cluster Analysis in the Severe Asthma Research Program MooreAJRCCM2010;181:31550 40 30 20 10 0 5 0 % Sputum:Eosinophils ,Neutrophils 12345 23.3% 33.3% 37.6% 34.7% 48.3% 0.7% 0.7% 1.9% 1.5% 1.2% Cluster
- 10.
- asthma natural history
- 11. Background:Clinicians have difficulty indiagnosing asthma in preschool children withsuggestive symptoms. Objective:We sought to develop a clinical asthmaprediction score for preschool children who haveasthma-like symptoms for the first time. Predicting the long-term prognosis of children with symptoms suggestive of asthma at preschool age CaudriJACI 2009;124:903
- 12. Predicting the long-term prognosis of children with
symptoms suggestive of asthma at preschool age CaudriJACI
2009;124:903
- Birth cohort followed3,963 children for 8 years .
- Between 0 and 4 years of age, 2,171 (55%) children reported wheezing, coughing at night withouta cold, or both.
- Asthma was defined as wheezing, inhaled steroid prescription, or a doctor's diagnosis of asthma at both age 7 and 8 years of age.
- 13. Predicting the long-term prognosis of children with
symptoms suggestive of asthma at preschool age CaudriJACI
2009;124:903
- Male sex,
- Post-term delivery,
- Parental education
- Inhaled medication,
- Wheezing frequency,
- Wheeze/dyspnea apart from colds,
- Respiratory infections,
- Eczema
- 14. Predicting the long-term prognosis of children with symptoms suggestive of asthma at preschool age CaudriJACI 2009;124:903 MALE SEX 2.5 2.0 1.5 1.0 0.5 01.7 POST-TERM DELIVERY MEDIUM/LOW PARENTAL EDUCATION ECZEMA 3 4 2.5 1.5 2.1 1.5 2.3 ORFOR ASTHMA AT AGE 7-8 YEARS WHEEZINGFREQUENCY TIMES/Y
- 15. Increased Fraction of Exhaled Nitric Oxide Predicts
New-Onset Wheeze in a General Population Olin AJRCCM2010;181:32449
subjects reported new-onset wheeze
- 2,200 men and women from a general populationbased study.
- Questionnaires, blood samples, pulmonary function tests, and F E NO.
- Follow-up 4 years later.
- 16. 18.8 New-onset No onset 20 15 10 0 5 015.8 Increased
Fraction of Exhaled Nitric Oxide Predicts New-Onset Wheeze in a
General Population Olin AJRCCM2010;181:324Median Concentrationof
FeNO at Baseline ppb p=0.03
- 2,200 men and women from a general populationbased study.
- Questionnaires, blood samples, pulmonary function tests, and F E NO.
- Follow-up 4 years later.
- 17. 2.8 90 percentile 4.0 3.5 3.0 2.5 2.0 1.5 1.0 0.5 03.2
- 2,200 men and women from a general populationbased study.
- Questionnaires, blood samples, pulmonary function tests, and F E NO.
- Follow-up 4 years later.
- 18. Adulthood asthma after wheezing in infancy:a questionnaire
study at 27 years of age M. Ruotsalainen, Allergy 2010;65;503
- At the median age of 27.3 years
- questionnaire to 59 study subjects hospitalized for wheezing at