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AARHUSUNIVERSITYHEALTH
AU
August II: Symposium and workshop inSystematic Reviews and Meta-analyses
Aarhus University 6.4.2017
WelcomeOle Steen Nielsen, Vice Dean for Research, Faculty of Health
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6. APRIL2017VICE DEAN FOR RESEARCHOLE STEEN NIELSEN
HEALTH
AARHUS UNIVERSITETAU
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RESPONSIBLE CONDUCT OF RESEARCH
2
• Is of utmost importance for AU• Developed a policy • Set up a code of practice • Based on international guidelines
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6. APRIL2017VICE DEAN FOR RESEARCHOLE STEEN NIELSEN
HEALTH
AARHUS UNIVERSITETAU
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1. A university-wide policy on research integrity (RCR)2. Clear and precise discipline-specific standards for RCR3. Training in RCR at all levels4. A clear procedure for handling suspicion of breach of RCR5. Special advisers on research integrity at each faculty
RESPONSIBLE CONDUCT OF RESEARCH
3
It means that AU now has
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6. APRIL2017VICE DEAN FOR RESEARCHOLE STEEN NIELSEN
HEALTH
AARHUS UNIVERSITETAU
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Responsible behaviour must be a fundamental element in each phase of the research process including both
ØHumansØAnimals
THUS…
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6. APRIL2017VICE DEAN FOR RESEARCHOLE STEEN NIELSEN
HEALTH
AARHUS UNIVERSITETAU
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6. APRIL2017VICE DEAN FOR RESEARCHOLE STEEN NIELSEN
HEALTH
AARHUS UNIVERSITETAU
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1. From project initiation to project conclusion - ensuring RCR
1.1 Preparing a research project
1.2. Experimental studies1.3. Clinical studies
1.4. Clinical studies on medical devices1.5 Register-based research2. Data
3. Publication and authorship
4. Cooperation agreements with industry and other institutions
HEALTH: Standards + detailed descriptions of what to do:
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Ø Anyone conducting research in animals shall observe the provisions of the Danish Animal
Testing Act, and no such testing may be initiated without previous approval from the Danish
Animal Experiments Inspectorate.
Ø Anyone involved with studies in animals shall have completed an animal study training course.
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6. APRIL2017VICE DEAN FOR RESEARCHOLE STEEN NIELSEN
HEALTH
AARHUS UNIVERSITETAU
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Replacement
Reduction
Refinement
RCR AND 3R
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6. APRIL2017VICE DEAN FOR RESEARCHOLE STEEN NIELSEN
HEALTH
AARHUS UNIVERSITETAU
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Have all animals the same right for not being used
for experiments?
Are the animal at all the best model for human diseases?
Do you use enough time for developing the most
suitable model – or does that not fit with publish/perish?
WHAT DRIVES YOU IN CHOICE OF (ANIMAL) EXPERIMENTAL MODEL?
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6. APRIL2017VICE DEAN FOR RESEARCHOLE STEEN NIELSEN
HEALTH
AARHUS UNIVERSITETAU
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CAN SYSTEMATIC REVIEWS CONTRIBUTE TO IMPLEMENTATION OF THE 3R?
No. of animal studies online
SYSTEMATIC REVIEW:
• A more evidence based study design based on a single research question
META-ANALYSIS:
• Use of statistical methods to summarize the results from independent studies
• Refine our animal studies
• Eliminate unnecessary duplication => Reduce the number of animals used
YES
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6. APRIL2017VICE DEAN FOR RESEARCHOLE STEEN NIELSEN
HEALTH
AARHUS UNIVERSITETAU
For at få punktopstilling på teksten
(flere niveauer findes),
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Are the animal at all the best model for human diseases?
Do you use enough time for developing the most
suitable model – or does that not fit with publish/perish?
WHAT DRIVES YOU IN CHOICE OF (ANIMAL) EXPERIMENTAL MODEL?
Reflect, Reduce and
Replace
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TO CONSIDER RESEARCH INTEGRITY AND 3R SHOULD BE A
NATURAL PART OF YOUR RESEARCH PROCESS
THANK YOU!