Kinase Phosphatase Ligand Transcription Factor Other Receptor Phospho Activation
Membrane Cell Function Binding/Association
Activation Inhibition Indirect Effect Dissociation
P
www.biossusa.com800.501.7654 | [email protected]
Beta catenin FZD3 / Frizzled 3 DKK3 SFRP1 PLCZ1
IF | Rat brain WB | Mouse pancreas IHC-P | Rat mucosa cancer WB | Rat brain IF | Rat testis
B I O S S P AT H W AY S
TCFWNT target genese:
MYC, TCF-1, Cyclin-D1, MMP-7, Axin-2, CD44, etc.
PP2A
Ca2+
GSK3 DVLDVL
APC Axin
B-cateninWTX
B-catenin
B-Tvcp
UbUb
Ub
TCFHDAC
Groucho
CREB
Cdk8
CBP β-catenin
BCL-9 Pygo
RA Chibby
DVL
CK-1 Ca2+
β-catenin
β-cateninβ-catenin
RAC
DVL
Daam1
Rho
ROCK
RAC
JNK
Proflin
G-protein
PLC
Ca2+
Ca2+
Ca2+
Ca2+
Wnt
WntLRP5/6
Axin
Wnt
LRP516
26S proteosome
degradation
WNT target genes
Frizzled
NFATpathway
Wnt target genes
cytoskeletal rearrangement
Proliferation, differentiation, adhesion and survival
SFRPDKK
GBP
CK-1
GSK3
SFRP
WIF
P
P Ca2+Naked
PAR-1
β-catenin
RAR
ICAT
Calcineurin
NFAT
NLK
TAK1
NLK
CamKII
PKC pathway
PKC
Cell survival, gene expression,
cytoskeleton arrangement
ONOFF
TCFWNT target genese:
MYC, TCF-1, Cyclin-D1, MMP-7, Axin-2, CD44, etc.
PP2A
Ca2+
GSK3 DVLDVL
APC Axin
β-cateninWTX
β-catenin
β-Trcp
UbUb
Ub
TCFHDAC
Groucho
CREB
Cdk8
CBP B-catenin
BCL-9 Pygo
RA Chibby
DVL
CK-1 Ca2+
B-catenin
B-cateninB-catenin
RAC
DVL
Daam1
Rho
ROCK
RAC
JNK
Proflin
G-protein
PLC
Ca2+
Ca2+
Ca2+
Ca2+
Wnt
WntLRP5/6
Axin
Wnt
26S proteosome
degradation
WNT target genes
Frizzled
NFATpathway
Wnt target genes
cytoskeletal rear-rangement
Proliferation, differentiation, adhesion and survival
SFRP
DKK
GBP
CK-1
GSK3
SFRPWIF
P
P Ca2+Naked
PAR-1
B-catenin
RAR
ICAT
Calcineurin
NFATNLK
TAK1
NLK
CamKII
PKC pathway
PKC
Cell survival, gene expression,
cytoskeleton arrangement
LRP5/6
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