Biotechnology R&D in India Biotechnology R&D in India
Dr. Renu Swarup, AdviserDepartment of Biotechnology
Ministry of Science & TechnologyGovernment of India
28 February, 201328 February, 2013
What is Biotechnology?What is Biotechnology?
Biotechnology is ….
“Any technique that uses living organisms, or substances from those organisms, to make or modify a product to improve plants or animals, or to develop microorganisms for specific uses”.
India’s Research Scenario India’s Research Scenario
• Population 1.2 billion
• No. of researchers - 0.15 million ( 140 per million)
• No. of universities - 457
• No. of publications – 65,000 per year ( 3.1% share)
• About 1% of GDP is spent on R&D
• World share of output over 2006-2010 – 3.3%
• Citation impact 2006-2010 – 0.68
• Narrowing gap between India and established economics
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India – Major S&T AgenciesIndia – Major S&T Agencies Ministry of Science and Technology
Department of Biotechnology (DBT) Department of Science and Technology (DST) Council of Scientific and Industrial Research (CSIR)
Ministry of Earth Sciences Department of Atomic Energy (DAE) Department of Space (DoS) Ministry of New & Renewable Energy Ministry of Health & Family Welfare
Department of Health & Family Welfare Indian Council of Medical Research (ICMR)
Ministry of Agriculture Indian Council of Agricultural Research (ICAR)
Ministry of Environment and Forests
Department of BiotechnologyDepartment of Biotechnology
1982 : National Biotechnology Board (NBTB)
1986 : Department of Biotechnology (DBT)
2012 : Biotechnology Industry Research Assistance Council (BIRAC)
“Attaining new heights in biotechnology research, shaping biotechnology into a premier precision tool of the future for creation of wealth and ensuring social justice – specially for the welfare of the poor”.
VISION
Budget allocation for S&T agenciesBudget allocation for S&T agencies
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Directions of Growth
BIOTECHNOLOGY FOR THE BIOTECHNOLOGY FOR THE NEW MILLENIUM A FEW NEW MILLENIUM A FEW
GLIMPSESGLIMPSES
BIOTECHNOLOGY FOR THE BIOTECHNOLOGY FOR THE NEW MILLENIUM A FEW NEW MILLENIUM A FEW
GLIMPSESGLIMPSES
Micropropagation
Micropropagation
Plant Genome Research
Plant Genome Research
Crop Biotechnology
and Transgenics
Crop Biotechnology
and Transgenics NeurosciencesNeurosciences Immunology Immunology Cell ScienceCell Science
Diagnostics Molecular probes
Diagnostics Molecular probes
Gene therapy and functional genomics
Gene therapy and functional genomics
Special Societal
Programmes
Special Societal
Programmes
Human Resource
Development
Human Resource
DevelopmentBioinformaticsBioinformaticsAquaculture and Marine ResourceAquaculture and Marine Resource
Biodiversity Inventorisation,
Characterisation, Conservation
Biodiversity Inventorisation,
Characterisation, Conservation
Patenting in Biotechnology and
Biosafety
Patenting in Biotechnology and
Biosafety
Prospecting of Genes and Molecules
Prospecting of Genes and Molecules
Environmental Pollution
abatemant
Environmental Pollution
abatemant
Animal Biotechnology
Animal Biotechnology
New Generation Vaccines
New Generation Vaccines
Bioproduct Development Down Stream Processing
Bioproduct Development Down Stream Processing
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Biotechnology pervades multiple facets of lifeAgriculture
Transgenics crops, designer breeding, plants as biofactories, biopesticides, biofertilizers, diagnostics
Human health Biodrugs, vaccines, diagnostics, biomarkers, cell & tissue
engineering products, artificial organs, nano based drug delivery systems, biobased implants and devices
Animal Transgenics, vaccines, diagnostics, feed, biofactoriesBioresources
Bioactives and drugs, biological processes, microbial prospecting Environment
Bioremediation, pollution abatement, biofuelsIndustrial /Manufacturing Enzymes, biomass based bioproducts, disposable GMP biofactories,
plant based bioactives bionutraceuticals, biosensors, bioequipment and enabling technology platforms
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Biotechnology is a multidisciplinary field Integrated development is essential
• Biological and material science• Physical Science• Chemical Science• Engineering – bioengineering,
electronics• Medicine• Agronomics• Aquaculture• Animal Science• Energy Bioscience• Environment Science• Bioresource• Nano Science• Forestry
Investment and Finance
Management
Law
DBT Technology Focus
Vaccines and Diagnostics -Human , Animal Stem Cells Implants and devices Transgenics and marker assisted breeding Animal vaccines, feed and breeding Bioresources utilization (drugs, antivirals others) Food and nutrition technology Bio-pesticides and bio-fertilizers Novel and green manufacturing /technologies
Genomics based strategy is now required for drought, salinity, heat ….
Strategic basic research Discover genes, genomic regions and their function
Designer breeding Transgenics Molecular assisted breeding
New Models of R&D Major capacity building in genomics and designer
breeding
Rice Tomato
Genome Initiative: India Moves Ahead !
Sugarcane
Chickpea
Wheat
Coffee
Chromosome 11 Chromosome 5
Complete Bacterial Genome
Silk worm
National Programme on Energy BiosciencesNational Programme on Energy Biosciences
More than 53 research institutes, universities and industries involved
Bioethanol
Algal Biofuel
Biodiesel
Energy Energy Bioscience Bioscience
CentreCentre
Capacity Building
• Re-engineered feed stock
• Re-engineered microorganisms
• Process optimization • Collection and characterization
• Establishment of repositories
• Development of production system
• Quality planting material
• Improved feed stock
• Process optimization • Biohydrogen
• Biobutanol
• Synthetic biology
• Energy Bioscience Chairs
• Energy Bioscience Overseas Fellowships
Next generation Biofuels
Screening for Bio-Molecules from Microbial Diversity from Different Ecological Niches
NIOMarine isolates
NIOMarine isolates
IGIBRiver
Sediments
IGIBRiver
Sediments
ILSExtremophi
les from Orissa,
Bihar and West
Bengal
ILSExtremophi
les from Orissa,
Bihar and West
Bengal
NCCSWestern
Ghats, Insect guts
NCCSWestern
Ghats, Insect guts
NEERINEERIEffluent Treatment Effluent Treatment
plants /contaminated plants /contaminated sitessites
NEERINEERIEffluent Treatment Effluent Treatment
plants /contaminated plants /contaminated sitessites GNDUGNDU
Wet land Wet land ecosystems of ecosystems of
North West IndiaNorth West India
GNDUGNDUWet land Wet land
ecosystems of ecosystems of North West IndiaNorth West India
MSSRFMSSRFEastern Ghats, Eastern Ghats, and Mangroves and Mangroves
AreaArea
MSSRFMSSRFEastern Ghats, Eastern Ghats, and Mangroves and Mangroves
AreaArea
IBSDIBSDNorth East North East
areaarea
IBSDIBSDNorth East North East
areaarea
7000 isolates7000 isolates/month/month
Univ DelhiHot Springs of Himachal
Pradesh
Univ DelhiHot Springs of Himachal
Pradesh
Country’s largest Microbial Culture Collection Country’s largest Microbial Culture Collection Centre Set Up at NCCS, PuneCentre Set Up at NCCS, Pune
Recognized as International Depositary Authority (IDA) w.e.f. 9th April 2011
• Has a capacity to hold more than 2,00,000 bacteria and fungi
• Presently holding 100,000 culture
Oil Zapper
• Bacterial consortium (5 strains) - ‘Oilzapper’ for remediation of oily sludge and crude oil spills developed by TERI, New Delhi and demonstrated at a number of refineries
• Technology transferred to Bharat Petroleum Corporation Ltd, Mumbai and Sriram Biotech Ltd.; used in Kuwait and Oman on contract basis
Environmental Biotechnology
Stem Cell Research - StrategyStem Cell Research - Strategy
Basic Stem Cell
Research
Stem Cell
Bank
Stem Cell Therapy Productio
n Unit
Stem Cell
Clinical Trials
Licensed Product
Manufacture
Vaccine Grand ChallengeVaccine Grand ChallengeVaccines in Trials or Transferred to IndustryVaccines in Trials or Transferred to Industry
Rotaviral Diarrhoea Japanese Encephalitis Rabies Dengue Typhoid Malaria Leprosy Anthrax Cholera Infectious Bovine Rhinotracheitis
India A Vaccine Manufacturing Hub
National Biodesign Alliance: partnering institutions
An effective and consistent way to deliver chest compressions to sudden cardiac arrest victims
A better way to gain intra-osseous access in emergency patients.
Non-invasive, rapid and definitive way of airway management.
Esophagus Entry
Trachea Entry
Stanford-India Biodesign ProgrammeCreating Entrepreneurs
New InstitutionsNew Institutions National Institute of Biomedical Genomics, Kalyani
Regional Centre for Biotechnology, Faridabad, Haryana
National Institute of Animal Biotechnology, Hyderabd
Translational Health Sciences and Technology Institute, Faridabad
National Agri-Food Biotechnology Institute and Bioprocessing Unit, Mohali, Punjab
Institute of Stem Cell Biology and Regenerated Medicine, Bangalore
Institute of Bioinformatics & Computational Biology
Institute of Marine & Microbial Biotechnology
Biotechnology Regulatory Authority of India (BRAI)
Institute of Biodesign, Bioscience & Bioengineering (includes Medical Centre)
Institute of Chronic Disease Science & Biotechnology
Infectious Science & Biotechnology Institute in North East (linking to THSTI as partner for training & Education)
Automated high-throughput DNA sequencing facilities
Phytotron Facility
National Containment - cum - Quarantine Facility for transgenic
planting material
National Plant Gene Repository
Technology Platform for Translational Research on Transgenic Crops
International Depository authority for patent deposits of
microorganisms
Access to European Synchtron Research Facility, Grenoble
Primate Research Platform
Microbial Respository
National Certification system for Tissue culture raised Plants
Core Immunological Laboratory for vaccine immune responses
Biomolecular characterisation centre
Research Facilities ,Resources,and Services
Bioinformatics Network
Total number of Centres - 168 Centre of Excellences (CoEs) - 5 Distributed Information Centres (DICs)- 11 Distributed Information Sub Centres- 50 Bioinformatics Infra. Facility - 101 Apex BTIC - 1 Graphics Facility - 6 MSc/M.Tech/Diploma - 5 R&D Projects - 97
Developing the Human ResourceDeveloping the Human Resource
The Department of Biotechnology is implementing an integrated programme of human resource development in biotechnology comprising of postgraduate teaching programmes in biotechnology to create a pool of talented students and upgrading skills of mid career scientists and faculty by specialized training in leading national laboratories and overseas laboratories .
• Postgraduate M.Sc./ M. Tech teaching programme
• Details of ongoing teaching programmes
• PG diplomas (Post M.Sc. /M.D./MS/ M.Tech)
• Biotech industrial training programme
• Training programmes
• Star college scheme for strengthening of life science and biotechnology education and training at undergraduate level
Career Development Opportunities Career Development Opportunities
• Rapid Grant for Young Investigators (RGYI)
• FAST TRACK Scheme for Young Scientists
• National Bioscience Awards for Career Development
• Innovative Young Biotechnologist Award (IYBA)
• Biotechnology Career Advancement and Re-orientation (Bio-care) Programme / Awards for Women Scientists
• Women Scientists Scheme (WOS-A)
• Tata Innovation Fellowship
• Innovation in Science Pursuit for Inspired Research (INSPIRE)
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Re-entry Fellowship / Grant SchemesRe-entry Fellowship / Grant Schemes
• Ramanujan Fellowship
• Ramalingaswamy Fellowship
• Energy Bioscience Fellowship
• Wellcome Trust Fellowship
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Indo-Swiss
Stanford Biodesign
Indo-UK
Indo-US
Collaboration with IAVI, GATES
Foundation, MVI, PATH,
WellcomeTrust
International partnerships HST,31
Indo-Australia
Indo-Canada
Indo-Denmark
Indo-EU
Indo-Finland
Indo-German
Indo-Japan
Indo-Norway
New Global Partnerships
InnovationInnovation
DiscoveryDiscovery
EnterpriseEnterprise
Department of Biotechnology How it has evolved
30% budget to be spent on PPP30% budget to be spent on PPP
BIRAC to Nurture Industry R&DBIRAC to Nurture Industry R&D
Drivers of Innovation
• Real Public R&D expenditure
• R&D personnel per million persons
• Education share of GDP
• IP protection
• Cluster specific environment
• R&D funded by industry
• R&D performed by universities
• Global / National Model
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India is in 12th rank in the world in biotechnology and 3rd largest in Asia-Pacific after Japan and Korea.
The Sector employees approximately 20,000 scientists and over 352 companies drive it towards further growth.
Science ClustersStrength of Synergy
Teaching, discovery, creativity, innovation as a federation
Faridabad
Mohali
Bangalore
Institutional RedesignMechanisms to make industry –academia interaction happen
Concept and design centers
Technologies licensing and management
Incubation
Ignition, pre competitive grants
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About BIRACAbout BIRAC
A ‘Not for Profit Company’ set up by Department of Biotechnology (DBT), Government of India as an
Interface Agency to strengthen and empower the emerging Biotech enterprise to undertake strategic
research and innovation, addressing nationally relevant product development needs.
BIRAC StrategiesBIRAC Strategies
How does BIRAC accomplish its Mission How does BIRAC accomplish its Mission
Public-Private
Partnership
Funding Options
Biotechnology Industry Partnership
Programme (BIPP)
Technopreneur Promotion
Program (TePP)
Biotechnology Ignition Grant
(BIG)
Pharmaceutical Research &
Development Support Fund
(PRDSF)
Small Business Innovation Research
Initiative (SBIRI)
To promote innovation, high risk research To promote innovation, high risk research product development and commercializationproduct development and commercialization
Contract Research/Service Scheme (CRS)
The Vision and Opportunity for Indian Biotechnology :
An $100 billion dollar industry by 2025.
Science, Technology and Innovation Science, Technology and Innovation Policy 2013Policy 2013
The guiding vision of aspiring Indian STI enterprise is to accelerate the pace of
discovery and delivery of science-led solutions for faster, sustainable and inclusive growth.
BRAI
Regulation
DBT
Science
People
Infrastructure
Legislations
BIRAC
Innovation
Entrepreneurship
Public -Private -Partnership
A Biotechnology Enterprise of future A Biotechnology Enterprise of future