Stargazin interacts with AMPA receptors in an intracellular compartment in the cell and promotes their delivery to the cell surface. The carboxyl terminus of stargazin binds specifically to the anchor protein PSD-95 and mediates recruitment of the stargazin-AMPA receptor complex to postsynaptic sites.
Loss of AMPA current in stargazer mutant mice
(recordings from cerebellar granule neurons)
Stargazin enhances glutamate response
Stargazin restores AMPA currents in mutants
(Stargazin-deltaC restores surface expression, but not synaptic targeting)
PSD95 and Stargazin have distinct effects on synaptic responses and surface AMPA receptors
Stargazin-deltaC inhibits AMPA responses
Stargazin increases AMPA channel openings
Stargazin increases surface GluR1 expression
GluR1-C tail expression inhibits LTP
Effect of GluR1 S887A (C tail) on LTP
Role of GluR1 trafficking in fear conditioning: Physiology of GluR1 transfected neurons in Amygdala
Expression of GluR1-C inhibits plasticityin Amygdala