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Caenorhabditis elegans as a model
§ Aprox 40% genes are homologues to human § Different cell types, tissues and organs (intestine, nervous system, epithelial cells) § Easy to growth and manipulate § Short life cycle § Many genetic pathways are conserved
Manuel Muñoz
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0
20
40
60
80
100
0 10 20 30 40
fer-15dyf-2(m881)/liv-1
% s
urvi
val
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40
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100
0 5 10 15 20 25 30 35
fer-15dyf-2(m886)/liv-1
% s
urvi
val
days
0
20
40
60
80
100
0 5 10 15 20 25 30 35
fer-15liv-2(m882)
% s
urvi
val
days
0
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40
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80
100
0 5 10 15 20 25 30 35
fer-15unc-13(m873)/liv-3
% s
urvi
val
days
0
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40
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80
100
0 5 10 15 20 25 30 35
fer-15liv-4(m872)
% s
urvi
val
days
0
20
40
60
80
100
0 10 20 30 40 50
liv-6(m889)
fer-15(b26)
% s
urvi
val
days
Genética de la longevidad
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Wild type Old animal (20 days)
sul-‐2(pv17) Old animal (20 days)
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0 5 10 15 20 25 30 350
20
40
60
80
100 silvestresul-2
Días a 25 ºC
Porc
enta
je d
e su
perv
ivie
ntes
(gk187)
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Wild type Parkinson
1. Parkinson Model
Mobility assays
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Parkinson
Parkinson; STX64
Adult 3º día
Mobility assays
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Modelos que usamos de forma habitual
1. Envejecimiento 2. Modelo de Diabetes 3. Modelo de Ovario poliquístico 4. Modelo de Alzheimer 5. Modelo de Parkinson 6. Modelo de Corea de Huntington 7. Modelo de obesidad 8. Modelo para ensayos de compuestos
antiproliferativo o proapoptótico 9. Modelo de galactosemia tipo III 10. Modelo de ictiosis ligada al cromosoma X
11. Podemos estudiar otros modelos a solicitud del interesado.
Empresas que nos han contratado Biosearch Life LandsteinerGenmed Bionaturis Hojiblanca ResBioagro Puleva Biotech
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[email protected] Manuel Muñoz