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CELL MEMBRANESTRUCTURE AND FUNCTIONS
By. Dr Nazish
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Learning ObjectivesLearning Objectives
1.1. The bilayer structure of plasma membrane The bilayer structure of plasma membrane 2.2. Types of lipids in the membrane: physiological Types of lipids in the membrane: physiological
significance significance 3.3. Physiological importance of proteins in the Physiological importance of proteins in the
plasma membrane plasma membrane 4.4. Types of carbohydrates: physiological Types of carbohydrates: physiological
importance importance 5.5. Selective permeability characteristics of the Selective permeability characteristics of the
plasma membrane. plasma membrane.
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Lipid bilayer
Intracellularfluid
Extracellularfluid
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Choline
Phosphate
Glycerol
Fatty acid
Head(polar, hydrophilic)
Tails(nonpolar, hydrophobic)
-
= Negative charge on phosphate group-
Lipid bilayer is
phospholipids
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Lipid bilayer
ICF (water)
ECF (water)Polar heads(hydrophilic)
Nonpolar tails(hydrophobic)
Polar heads(hydrophilic)
Phospholipids form a bilayer That has a hydrophobic interior.
This interior is sandwiched between hydrophilic inner and outer surfaces.
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Functions of the lipid bilayer
Cholesterol : allows the membrane to be fluid.
- Forms the basic structure of the membrane.- Hydrophobic interior is a barrier to water- soluble substances- allows diffusion of fat soluble substances
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Extracellular fluid
Lipid bilayer
Intracellularfluid
Dark lineLight space
Appearance using an electron microscope
Dark line
Glycoprotein GlycolipidCarbohydratechain
Channel
Variousmembraneproteins
Cholesterolmolecule
Phospholipid molecule
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Functions of plasma membrane
Channel proteins
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Functions of membrane proteins
Carrier proteins
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Functions of plasma membrane
Receptor proteins
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Functions of plasma membrane
Docking marker acceptors
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Functions of plasma membrane
cell adhesion molecules
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Functions of cell membrane
Self identification markers
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Membrane-Membrane-bound bound enzymesenzymes
ReceptorReceptorCarrierCarrier moleculesmolecules
Functions of membrane proteins
ChannelsChannels
Docking-Docking-marker marker
acceptorsacceptors
Cell adhesion Cell adhesion moleculesmolecules Cell identity Cell identity
markersmarkers
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Channels: span the membrane as water-filled poresChannels: span the membrane as water-filled poresCarrier moleculesCarrier moleculesReceptor sites: proteins that bind with specific moleculesReceptor sites: proteins that bind with specific moleculesDocking-marker acceptors (on inner surface for Docking-marker acceptors (on inner surface for secretory vesicles)secretory vesicles)Filamentous meshwork (cytoskeleton)Filamentous meshwork (cytoskeleton)Membrane-bound enzymesMembrane-bound enzymesCell adhesion molecules : protrude from surfaceCell adhesion molecules : protrude from surfaceCell identity markers in conjunction with carbohydrates Cell identity markers in conjunction with carbohydrates
Functions of membrane proteins.
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CHO containing Surface markers involved in tissue CHO containing Surface markers involved in tissue growth.growth.Cell identity markers in conjunction with proteins Cell identity markers in conjunction with proteins
Functions of membrane carbohydrates.
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THANK YOUAND
HAVE A NICE DAY