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Chronic Venous Insufficiency Recognition, Prevention and
Management
Carl M. Black, MD
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Disclosures
Will discuss off-label UseCook VIVO Stent Trial Site PITXTONOMY Co-founder
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Objectives - Chronic Venous Insufficiency
• Pathophysiology of chronic venous insuffciency (CVI)
• Recognize the clinical findings• Summarize major clinical trials in CVI management and prevention
• Understand the role of imaging• Describe endovascular options for veno-occlusion/reflux
• Discuss the importance of a multidisciplinary approach to CVI care
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Evolution in Evaluation and Management• Recognition• Imaging• Endovascular options
– Pharmaco-mechanical Thrombolysis (PMT)– Endovenous Ablation– Embolization– Revascularization
Acropolis in Athens circa 4 BC
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Chronic Venous Insufficiency • Superficial
• Obstruction• Reflux
• Deep• Obstruction• Reflux
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Age Female Male
20-29 8% 1%
40-49 41% 24%
60-69 72% 43%
Demographics of Venous Insufficiency
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CVI Insufficiency Risk Factors• Female > Male• Childbearing• Family history• History of venous thrombosis • Occupation• Pelvic venous congestion
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CEAP Classification CEAP
– Clinical severity– Etiology (primary, secondary)– Anatomy– Pathophysiology
Clinical severity– C0 Normal– C1 Spider/reticular Veins– C2 Simple varicose veins– C3 Ankle edema– C4 Hyperpigmentation (lipodermatosclerosis)– C5 Healed stasis ulcer– C6 Open stasis ulcer
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Venous Stasis Ulcerations
• Poor healing• Often mistreated• $$$
Not an infection. This is a plumbing problem.
Abbade LP, Lastória S. Int J Dermatol. 2005;44(6):449–456.
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Which is better ?
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Can we prevent PTS?
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Iliac Vein Obstruction
• Compression by adjacent artery• Thrombosis and subsequent scarring• Cancer• Aneurysm• Fibroids• Abscess• Osteophyte• Retroperitoneal Fibrosis• Pregnancy
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• Endothelial injury• Trauma• Surgery
• Stasis of blood flow• Immobility• CHF• Obesity• Travel
• Hypercoagulability• OCP’s• Cancer
Virchow Triad
Virchow R. Uber die Erweiterung kleiner Gefasse. Arch Path Anat 1851;3:427.
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What do we know about iliofemoral DVT?•Despite anticoagulation . . .
– May be a lower incidence of recanalization.
– Associated with venous hypertension and post-thrombotic syndrome.
•Amenable to thrombolysis
Strandess et al. JAMA. 1983;250:1289-1292.Akesson H, Brudin L, et al. Eur J Vasc Surg. 1990;4(1):43-48.Prandoni P et al. Ann Intern Med 1996;125:1-7.Mewiseen MW et al. Radiology. 1999 Apr;211(1):39-49.
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What do we know about anticoagulation?•Prevents
– Clot recurrence and propagation
– PE and pulmonary hypertension
– Reduces, but does not eliminate risk of PTS
•Not a thrombolytic
Johnson BF, Manzo RA, et al. J Vascular. Surgery 1995; 21:307-313Prandoni P, Lensing AWA, et al. Ann Intern Med 2002; 137:955–960.Akesson H, Brudin L, et al. Eur J Vasc Surg 1990;4(1):43-48. Van Dongen CJJ. J Thromb Haemost 2005;3:939-942
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Iliofemoral DVTWhat do I need to know?
• Most central extent
• Outflow obstruction
• Status of the IVC
• Extrinsic pathology
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PhelgmasiaAlba Dolens
Phelgmasia CeruleaDolens
Definition Massive DVT without gangrene
Massive DVT with ischemia
Extent Spares superficialcollaterals
Involves superficial collaterals
Signs & Symptoms Edema, pain, blanching, w/o cyanosis Edema, pain, cyanosis
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My Experience
• Consider CT pre-procedure• Game-changer: 8F Angiojet
• Power Pulse (10 mg tPA in 100 ml NS)• Wait 30-45 min, f/u PMT
• 10F Pronto Aspiration• Fully anticoagulated patients lyse faster• Popliteal inflow highly predictive of success• Early, aggressive measures• Lovenox transition• Close follow up
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Meissner MH et al, J Vasc Surg 2010
Grade of Recommendation
1 – Strong2 – Weak
Evidence QualityA – High
B – ModerateC - Low
1We recommend precise characterization of the most proximal extent of DVT as involving the iliofemoral, femoral-popliteal, or calf veins
1 A
2.1 We suggest a strategy of early thrombus removal in patients with a) a first episode of IF thrombosis, b) symptoms ≤ 14 days, c) low bleeding risk, d) good life expectancy
2 C
2.2We recommend early thrombus removal as the treatment of choice in patients with limb threatening ischemia due to IF thrombosis
1 A
3.1 We suggest catheter-directed lysis (CDT) as first line therapy for early thrombus removal
2 C
3.2We suggest a strategy of pharmacomechanicalthrombolysis be considered over CDT alone if resources are available
2 C
AVF Practice GuidelinesMeissner MH, et al, J Vasc Surg 2010.
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ATTRACT• Control Arm Treatment: Initial anticoagulant therapy with
unfractionated heparin or enoxaparin for at least 5 days overlapped with long-term oral warfarin (target INR 2.0-3.0).
• Experimental Arm Treatment: Initial anticoagulant therapy (same as Control Arm) overlapped with long-term oral warfarin (target INR 2.0-3.0) and PCDT with intra-thrombus delivery of t-PA into the DVT over a period of up to 24 hours.
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ATTRACTModerate-to-severe post-thrombotic syndrome was less likely with PCDT (17.9% versus 23.7%, P=0.035)
Vedantham S, et al. 2017 NEJM
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Intermountain VTE Best Practice
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IFDVT Summary• Pathophysiology of iliofemoral DVT
• Advances in endovascular DVT management
• PMT helps achieve early thrombus removal with lower doses of thrombolytic with shorter treatment time and reduced complications
• Ensure adequate outflow by stenting iliac pathology
• Goal is to Prevent PTS
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Endovascular Options in Chronic Venous Obstruction and Insufficiency
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Superficial Venous Disease
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Goal of TreatmentComprehensively address the underlying
pathophysiology with minimal or no disfigurement.
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Comprehensive Approach• Accurate diagnosis
• Absolutely crucial• Often neglected
• All sources of reflux must be identified and addressed if possible
• Expect the Unexpected!
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Extremity Treatment Options• Endovenous Thermal Ablation
• Endovenous Laser• Radiofrequency Ablation• Mechanico-chemical• Cyanoacrylate
• Ambulatory phlebectomy• US-guided Foamed sclerotherapy
Endovenous Ablation
SclerotherapyAmbulatory Phlebectomy
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What you see is often only the tip of the iceberg
Adapted from Olivier Pichot
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Pelvic Venous Congestion Syndrome
• Pain exacerbated by• Intercourse• Menstruation• Prolonged Standing• Multiple pregnancies
• Atypical patterns of painful varicosities• Vulvar/Labial• Thigh (lateral complex)• Gluteal
Hobbs JT. Br J Hosp Med 1990;43:200-6
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Prevalence of PVI
10 to 15% incidence of pelvic varicosities
Most are asymptomatic
Approximately one-third of patients with chronic pelvic pain may have PVC
Beard RW, et al. Lancet 1984;2:946-949
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Differential Diagnosis in PVI
• Endometriosis• Pelvic adhesions• Pelvic inflammatory disease• Fibroids• Irritable bowel
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Baseline VAS
Black CM, et al. J Vasc Interv Radiol 2010; 21:796–803
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Role of Imaging in PVI
• Exclude Concurrent Pathology• Confirm the Diagnosis• Define Anatomy
• Vascular Anomalies• Technical Challenges
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83% of the patients exhibited clinical improvement
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Comparison of treatments for pelvic venous congestion syndrome
Tohoku J Exp Med 2003 Nov;201(3):131-138 n=106Diagnosis of pelvic venous congestion syndromeClinical diagnosis confirmed through laparoscopy and venographyNo response to medication after 4-6 months medication
Three arms: Embolotherapy (n=52);hysterectomy/bilateral oophorectomy and hormone replacement (n=27);hysterectomy with unilateral oophorectomy (n=27).
The visual analog scale implemented to track clinical response.
CONCLUSIONS:1. Embolotherapy more effective at reducing pelvic pain (p < 0.05)2. Embolization appears to be a safe, well-tolerated, effective
treatment for pelvic congestion syndrome.
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Modality Key Findings Advantages Disadvantages
US • Ovarian/pelvic varices• Possible visualization of
ovarian vein ectasia
• Non-invasive• Availability• Other pathology• Real-time Valsalva
• Patient factors• Technical Variability
CT/CTA • Ovarian/pelvic varices• Ovarian vein ectasia• Obstructive lesions
• Non-operator dependent• Anatomic definition• Multiplanar• Rapid acquisition
• Radiation• Supine• Limited definition of
adnexa and uterus• Expense
MRI/MRV • Ovarian/pelvic varices• Ovarian vein ectasia• Obstructive lesions
• No ionizing radiation• Multiplanar• Pelvic organ definition• Other pathology
• Supine • Metallic artifacts• Motion artifacts• Expense
CatheterVenography
• Ovarian/pelvic varices• Real-time Reflux• Collateral pathways• Obstructive lesions
• Intent-to-treat efficiency• Real-time Valsalva• ‘Gold Standard’
• Does not exclude concurrent pathology
• Radiation• Expense
The Imaging Menu for PVC
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PVI Summary• PVI is a well described entity, associated with
chronic disabling pain
• Traditional medical therapy is temporary at best with no published data on long-term effectiveness
• Visible varicosities may be the “Tip of the Iceberg”
• The H&P with US have high predictive value
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PVI Summary• Venography remains the gold standard for diagnosis
• Cross-sectional Imaging helpful in select cases
• Endovascular minimally invasive embolization techniques represent the best practice state-of-the art
• Embolization for PVI is safe and effective
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Central Venous Hypertension• Review Differential Considerations • Describe Approach
• Diagnostic Work-up• Endovascular Technique
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Indications for Stenting• C4 to C6 disease• Pain• Edema• Failed “conservative therapy”
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The Imaging Checklist
Anatomic Variants NutcrackerMass May-Thurner Gonadal Veins
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Modality Key Findings Advantages Disadvantages
US • Ovarian/pelvic varices• Possible visualization of ovarian vein
ectasia• Waveform analysis
• Non-invasive• Availability• Other pathology• Real-time Valsalva
• Body habitus• Technical Variability• Limited field of view
CT/CTA • Ovarian/pelvic varices• Ovarian vein ectasia• Obstructive pathology• Anatomic variants
• Operator independent• Anatomic definition• Multiplanar• Rapid acquisition• Full field of view
• Radiation• Supine• Limited definition of adnexa and
uterus• Expense
MRI/MRV • Ovarian/pelvic varices• Ovarian vein ectasia• Obstructive pathology• Anatomic variants
• Operator independent• No ionizing radiation• Multiplanar• Pelvic organ definition• Other pathology• Full field of View
• Supine • Metallic artifacts• Motion artifacts• Expense
Catheter Venography • Ovarian/pelvic varices• Real-time Reflux• Collateral pathways
• Intent-to-treat• Real-time Valsalva
• Does not exclude concurrent pathology
• Endoluminal view• Radiation• Expense
The Imaging Menu for CVO
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Summary• Endovenous thermal ablation is safe and effective.• Venous stasis ulceration reflects hemodynamic compromise (elevated
hydrostatic pressure).• PVI is a well described entity associated with chronic, often disabling
pelvic and LE pain.• Acute iliofemoral DVT warrants aggressive work-up and possible
catheter-directed thrombolytic treatment.
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Summary• Venous anatomy is highly variable. There is no one size fits all.• Often what is visible is “the tip of the iceberg.” Treating what is
visible is often the last step.• All sources of reflux should be identified and addressed.• Meticulous sonographic, and in some cases, venography is critical.