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CJD and Kuru: Prion CJD and Kuru: Prion VirusesViruses
By: Danny NemethBy: Danny Nemeth
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PrionPrion
infectious agent composed of protein in a infectious agent composed of protein in a misfolded formmisfolded form
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CJDCJD
Creutzfeldt-Jakob DiseaseCreutzfeldt-Jakob Diseaseneurodegenerative disorderneurodegenerative disorderyear of onset of illness year of onset of illness
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StructureStructure
no Nucleic acidsno Nucleic acidsmass of 27,000 - 30,000 daltons mass of 27,000 - 30,000 daltons 145 amino acids145 amino acidsStructure unknownStructure unknown
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CauseCause
promotes refolding of native proteins promotes refolding of native proteins mass of misfolded proteins disrupts cell mass of misfolded proteins disrupts cell
functionfunction
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ALWAYS FATAL!ALWAYS FATAL!
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SymptomsSymptoms
Neurological Neurological DepressionDepressionConfusionConfusion loss of coordination and balanceloss of coordination and balance progressive blindness progressive blindness
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Transmission Transmission
GENETICS! GENETICS! Defective HGHDefective HGHCANNIBALISM! CANNIBALISM!
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KURUKURU
Misfolded ProteinsMisfolded Proteins
CannibalismCannibalismBrainsBrains
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SymptomsSymptoms
Coordination problemsCoordination problems Difficulty walking Difficulty walking Swallowing difficultySwallowing difficulty Tremors and muscle jerks Tremors and muscle jerks
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Treatment and PrognosisTreatment and Prognosis•NONE!
•Prognosis
•Death after 1 year of symptoms
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Stuff I UsedStuff I Used
http://www.cjdsurveillance.com/http://www.cjdsurveillance.com/abouthpd.htmlabouthpd.html
http://www.cdc.gov/ncidod/dvrd/cjd/http://www.cdc.gov/ncidod/dvrd/cjd/index.htmindex.htm
http://en.wikipedia.org/wiki/Kuru_(disease)http://en.wikipedia.org/wiki/Kuru_(disease)http://en.wikipedia.org/wiki/Creutzfeldthttp://en.wikipedia.org/wiki/Creutzfeldt
%E2%80%93Jakob_disease%E2%80%93Jakob_diseasehttp://www.ncbi.nlm.nih.gov/http://www.ncbi.nlm.nih.gov/
pubmedhealth/PMH0002355/pubmedhealth/PMH0002355/