![Page 1: Comorbid Conditions in Autism Spectrum Illness · 2014. 6. 9. · Sources RUPP Autism Network (2002) Risperidone in children with autism and serious behavior problems, New England](https://reader034.vdocument.in/reader034/viewer/2022051805/5ff711a95385c801b3161e73/html5/thumbnails/1.jpg)
Comorbid Conditions
in Autism Spectrum
Illness
David Ermer MD
June 13, 2014
![Page 2: Comorbid Conditions in Autism Spectrum Illness · 2014. 6. 9. · Sources RUPP Autism Network (2002) Risperidone in children with autism and serious behavior problems, New England](https://reader034.vdocument.in/reader034/viewer/2022051805/5ff711a95385c801b3161e73/html5/thumbnails/2.jpg)
Overview
Diagnosing comorbidities in autism
spectrum illnesses
Treatment issues specific to autism
spectrum illnesses
Treatment options with emphasis on
pharmacology
![Page 3: Comorbid Conditions in Autism Spectrum Illness · 2014. 6. 9. · Sources RUPP Autism Network (2002) Risperidone in children with autism and serious behavior problems, New England](https://reader034.vdocument.in/reader034/viewer/2022051805/5ff711a95385c801b3161e73/html5/thumbnails/3.jpg)
Autism and Comorbidity
64 % poor attention and concentration
36-48% hyperactive
43-88% morbid or unusual preoccupation
37% obsessions
16-18% compulsions or rituals
50-89% had stereotyped utterance
68-74% stereotyped movements
![Page 4: Comorbid Conditions in Autism Spectrum Illness · 2014. 6. 9. · Sources RUPP Autism Network (2002) Risperidone in children with autism and serious behavior problems, New England](https://reader034.vdocument.in/reader034/viewer/2022051805/5ff711a95385c801b3161e73/html5/thumbnails/4.jpg)
Autism and Comorbidity (cont)
17-74% had anxiety or fears
9-44% irritability, agitation
24-43% self injury
8% motor or vocal tics
5 % seizures
![Page 5: Comorbid Conditions in Autism Spectrum Illness · 2014. 6. 9. · Sources RUPP Autism Network (2002) Risperidone in children with autism and serious behavior problems, New England](https://reader034.vdocument.in/reader034/viewer/2022051805/5ff711a95385c801b3161e73/html5/thumbnails/5.jpg)
Comorbidity vs “Associated
Features”
Research on the specific relationship
between these associated features and
autism is sparse.
Is it truly a comorbid illness or part of
autism?
Preoccupations, anxiety, lack of concern
regarding activity, stereotypies can all
appear as ADHD
![Page 6: Comorbid Conditions in Autism Spectrum Illness · 2014. 6. 9. · Sources RUPP Autism Network (2002) Risperidone in children with autism and serious behavior problems, New England](https://reader034.vdocument.in/reader034/viewer/2022051805/5ff711a95385c801b3161e73/html5/thumbnails/6.jpg)
Assessing Children With Autism
Spectrum Disorder and
Comorbidity Careful history gathering
Observations from multiple settings
Multidisciplinary evaluation is essential
Information on prior interventions
![Page 7: Comorbid Conditions in Autism Spectrum Illness · 2014. 6. 9. · Sources RUPP Autism Network (2002) Risperidone in children with autism and serious behavior problems, New England](https://reader034.vdocument.in/reader034/viewer/2022051805/5ff711a95385c801b3161e73/html5/thumbnails/7.jpg)
Diagnostic Dilemma
Even after careful evaluation, it may be
impossible to determine if the symptoms
constitute a comorbid Ilness
Must establish treatment priorities
![Page 8: Comorbid Conditions in Autism Spectrum Illness · 2014. 6. 9. · Sources RUPP Autism Network (2002) Risperidone in children with autism and serious behavior problems, New England](https://reader034.vdocument.in/reader034/viewer/2022051805/5ff711a95385c801b3161e73/html5/thumbnails/8.jpg)
Considerations for Treatment
Priorities
Symptoms that threaten the safety of
patient, family members or others
Symptoms that generate subjective
distress for the patient
Symptoms that are sources of adversity in
the family’s life
Symptoms that jeopardize sustained
education progress
![Page 9: Comorbid Conditions in Autism Spectrum Illness · 2014. 6. 9. · Sources RUPP Autism Network (2002) Risperidone in children with autism and serious behavior problems, New England](https://reader034.vdocument.in/reader034/viewer/2022051805/5ff711a95385c801b3161e73/html5/thumbnails/9.jpg)
Must Characterize Symptoms
Distribution
Intensity
Onset: Time and location
Duration
Ameliorating Factors
Aggravating Factors
![Page 10: Comorbid Conditions in Autism Spectrum Illness · 2014. 6. 9. · Sources RUPP Autism Network (2002) Risperidone in children with autism and serious behavior problems, New England](https://reader034.vdocument.in/reader034/viewer/2022051805/5ff711a95385c801b3161e73/html5/thumbnails/10.jpg)
Treatment Issues in Autism
Spectrum Illnesses
Building relationships and gaining trust
can be difficult
Many of the difficulties are more
distressing for the people around the
patients than the patient themselves
The patient may have trouble identifying
their own internal mood state
![Page 11: Comorbid Conditions in Autism Spectrum Illness · 2014. 6. 9. · Sources RUPP Autism Network (2002) Risperidone in children with autism and serious behavior problems, New England](https://reader034.vdocument.in/reader034/viewer/2022051805/5ff711a95385c801b3161e73/html5/thumbnails/11.jpg)
Treatment Issues (cont)
Patient difficulty in understanding people’s
intentions, wishes, and needs
Weaknesses in ability to observe
sequence of events and logical responses;
flawed sense of proportion, highly
concrete
Patients are often rigid and inflexible with
treatment interventions
![Page 12: Comorbid Conditions in Autism Spectrum Illness · 2014. 6. 9. · Sources RUPP Autism Network (2002) Risperidone in children with autism and serious behavior problems, New England](https://reader034.vdocument.in/reader034/viewer/2022051805/5ff711a95385c801b3161e73/html5/thumbnails/12.jpg)
Treatment Strategies for
Pharmacologic Intervention
Educational and behavioral supports are
the mainstays of treatment
Pharmacologic treatments are available
and significantly beneficial
It is essential to integrate behavioral and
pharmacologic treatments
Focus on Target Syptoms vs Diagnosis
![Page 13: Comorbid Conditions in Autism Spectrum Illness · 2014. 6. 9. · Sources RUPP Autism Network (2002) Risperidone in children with autism and serious behavior problems, New England](https://reader034.vdocument.in/reader034/viewer/2022051805/5ff711a95385c801b3161e73/html5/thumbnails/13.jpg)
Realistic Expectations Must be Set
Expectation that symptoms remit more
quickly with pharmacologic treatment over
behavioral treatments
Expectation that response will be more
complete with pharmacologic treatments
“magic bullets”
![Page 14: Comorbid Conditions in Autism Spectrum Illness · 2014. 6. 9. · Sources RUPP Autism Network (2002) Risperidone in children with autism and serious behavior problems, New England](https://reader034.vdocument.in/reader034/viewer/2022051805/5ff711a95385c801b3161e73/html5/thumbnails/14.jpg)
Must Optimize Environment
Evaluate school setting
Work with caregivers on home
environment
Pharmacologic strategies ineffective in
unsupportive and inadequate
environments
![Page 15: Comorbid Conditions in Autism Spectrum Illness · 2014. 6. 9. · Sources RUPP Autism Network (2002) Risperidone in children with autism and serious behavior problems, New England](https://reader034.vdocument.in/reader034/viewer/2022051805/5ff711a95385c801b3161e73/html5/thumbnails/15.jpg)
Parental Collaboration is Essential
Monitor patient and provide information to
provider
Administer medication
Observe side effects
Note emotional and behavioral effects
Collaborate their information with school
![Page 16: Comorbid Conditions in Autism Spectrum Illness · 2014. 6. 9. · Sources RUPP Autism Network (2002) Risperidone in children with autism and serious behavior problems, New England](https://reader034.vdocument.in/reader034/viewer/2022051805/5ff711a95385c801b3161e73/html5/thumbnails/16.jpg)
Focus on Symptom Clusters
Most of the core symptoms are likely to remain
Must focus on specific measurable symptoms
The clinician’s goal is a reduction in the specific symptoms that interfere with functioning
Unlikely that medications will improve skills
![Page 17: Comorbid Conditions in Autism Spectrum Illness · 2014. 6. 9. · Sources RUPP Autism Network (2002) Risperidone in children with autism and serious behavior problems, New England](https://reader034.vdocument.in/reader034/viewer/2022051805/5ff711a95385c801b3161e73/html5/thumbnails/17.jpg)
Side Effects
Side effects are more likely for all medicines
used in autism spectrum disorders; greater
variety and rate due to atypical sensory world
May find even minor side effects impossible to
tolerate
They may be less likely to report side effects
Highly concrete patients may need to be asked
about specific side effects
![Page 18: Comorbid Conditions in Autism Spectrum Illness · 2014. 6. 9. · Sources RUPP Autism Network (2002) Risperidone in children with autism and serious behavior problems, New England](https://reader034.vdocument.in/reader034/viewer/2022051805/5ff711a95385c801b3161e73/html5/thumbnails/18.jpg)
Medication Indications in Autism
Spectrum Illnesses
No medication influences core pragmatic
social skill
Absence of high quality valid studies
Absence of studies in autism with
comorbid conditions (Almost all treatment
studies with medication in childhood
disorders exclude autism spectrum
illnesses)
![Page 19: Comorbid Conditions in Autism Spectrum Illness · 2014. 6. 9. · Sources RUPP Autism Network (2002) Risperidone in children with autism and serious behavior problems, New England](https://reader034.vdocument.in/reader034/viewer/2022051805/5ff711a95385c801b3161e73/html5/thumbnails/19.jpg)
Target Symptoms for Medications
Hyperactivity and Attention Problems
Impulsivity
Anxiety including Social Anxiety
Obsessive-compulsive symptoms
Tics
Depression
![Page 20: Comorbid Conditions in Autism Spectrum Illness · 2014. 6. 9. · Sources RUPP Autism Network (2002) Risperidone in children with autism and serious behavior problems, New England](https://reader034.vdocument.in/reader034/viewer/2022051805/5ff711a95385c801b3161e73/html5/thumbnails/20.jpg)
Medication Target Symptoms
(Cont.)
Stereotypies
Mood Swings
Agitation
Aggression
Self Injury
Insomnia
![Page 21: Comorbid Conditions in Autism Spectrum Illness · 2014. 6. 9. · Sources RUPP Autism Network (2002) Risperidone in children with autism and serious behavior problems, New England](https://reader034.vdocument.in/reader034/viewer/2022051805/5ff711a95385c801b3161e73/html5/thumbnails/21.jpg)
Trends in Medication Use
In one study 55% of Autistic individuals were taking a psychotropic medication
29.3% were on two or more medications
Antidepressants were most common 32.1%
Stimulants next most common 20.2%
Followed by neuroleptics 16.5%
![Page 22: Comorbid Conditions in Autism Spectrum Illness · 2014. 6. 9. · Sources RUPP Autism Network (2002) Risperidone in children with autism and serious behavior problems, New England](https://reader034.vdocument.in/reader034/viewer/2022051805/5ff711a95385c801b3161e73/html5/thumbnails/22.jpg)
Stimulant Medications
Useful for hyperactivity, attention, and impulsivity
49% response rate (lower than children without
autism 60%)
18% had intolerable side effects (much higher
than children without autism)
Side effects more common in autism include
irritability, stereotypy, and self injury
![Page 23: Comorbid Conditions in Autism Spectrum Illness · 2014. 6. 9. · Sources RUPP Autism Network (2002) Risperidone in children with autism and serious behavior problems, New England](https://reader034.vdocument.in/reader034/viewer/2022051805/5ff711a95385c801b3161e73/html5/thumbnails/23.jpg)
Atomoxetine
43% response rate for ADHD symptoms
Heterogeneous response with some doing
quite well
Less serious adverse side effects such as
irritability
Stomach upset was most common side
effect
![Page 24: Comorbid Conditions in Autism Spectrum Illness · 2014. 6. 9. · Sources RUPP Autism Network (2002) Risperidone in children with autism and serious behavior problems, New England](https://reader034.vdocument.in/reader034/viewer/2022051805/5ff711a95385c801b3161e73/html5/thumbnails/24.jpg)
Alpha II Agonists
(Clonidine, Tenex, Intuniv)
Several small studies showed significant
improvement over placebo in hyperactivity
Sedation is major side effect with clonidine
Less irritability than stimulants
Clonidine can be helpful at night for sleep
![Page 25: Comorbid Conditions in Autism Spectrum Illness · 2014. 6. 9. · Sources RUPP Autism Network (2002) Risperidone in children with autism and serious behavior problems, New England](https://reader034.vdocument.in/reader034/viewer/2022051805/5ff711a95385c801b3161e73/html5/thumbnails/25.jpg)
Neuroleptics
Risperidone (Risperdal), quetiapine
(Seroquel), olanzapine (Zyprexa),
aripiprazole (Abilify)
Used for tics, mood swings, stereotypies,
aggression, self injury, obsessions
All have potential for movement disorders
as long term side effects
![Page 26: Comorbid Conditions in Autism Spectrum Illness · 2014. 6. 9. · Sources RUPP Autism Network (2002) Risperidone in children with autism and serious behavior problems, New England](https://reader034.vdocument.in/reader034/viewer/2022051805/5ff711a95385c801b3161e73/html5/thumbnails/26.jpg)
Risperidone
FDA approved for “treatment of irritability
associated with autistic disorder in children and
adolescents, including symptoms of aggression
toward others, deliberate self-injuriousness,
temper tantrums and quickly changing moods.”
Studies also showed improvement in stereotypic
behaviors and hyperactivity
Lack of clear benefit of core symptoms
![Page 27: Comorbid Conditions in Autism Spectrum Illness · 2014. 6. 9. · Sources RUPP Autism Network (2002) Risperidone in children with autism and serious behavior problems, New England](https://reader034.vdocument.in/reader034/viewer/2022051805/5ff711a95385c801b3161e73/html5/thumbnails/27.jpg)
Risperidone
Side effects include weight gain, increased
appetite, fatigue, drooling, tremor,
constipation, increased prolactin
Authors of RUPP study concluded that
“risperidone should be reserved for
treatment of moderate-to-severe
behavioral problems associated with
autism
![Page 28: Comorbid Conditions in Autism Spectrum Illness · 2014. 6. 9. · Sources RUPP Autism Network (2002) Risperidone in children with autism and serious behavior problems, New England](https://reader034.vdocument.in/reader034/viewer/2022051805/5ff711a95385c801b3161e73/html5/thumbnails/28.jpg)
Aripiprazole (Abilify)
FDA approved for irritability associated
with autism
Weight gain, fatigue, restlessness can be
side effects
![Page 29: Comorbid Conditions in Autism Spectrum Illness · 2014. 6. 9. · Sources RUPP Autism Network (2002) Risperidone in children with autism and serious behavior problems, New England](https://reader034.vdocument.in/reader034/viewer/2022051805/5ff711a95385c801b3161e73/html5/thumbnails/29.jpg)
Serotonin Reuptake Inhibitors
Sertraline, fluoxetine, citalopram, etc
Helpful in depression, anxieties,
obsessive-compulsive behavior, anger
Can be activating and disinhibiting
![Page 30: Comorbid Conditions in Autism Spectrum Illness · 2014. 6. 9. · Sources RUPP Autism Network (2002) Risperidone in children with autism and serious behavior problems, New England](https://reader034.vdocument.in/reader034/viewer/2022051805/5ff711a95385c801b3161e73/html5/thumbnails/30.jpg)
Mood Stabilizers
Valproic acid (Depakote), carbamazepine
(Tegretol), Lithium etc
Used for mood swings, self injury,
aggression
![Page 31: Comorbid Conditions in Autism Spectrum Illness · 2014. 6. 9. · Sources RUPP Autism Network (2002) Risperidone in children with autism and serious behavior problems, New England](https://reader034.vdocument.in/reader034/viewer/2022051805/5ff711a95385c801b3161e73/html5/thumbnails/31.jpg)
Melatonin
Supplement used for sleep
![Page 32: Comorbid Conditions in Autism Spectrum Illness · 2014. 6. 9. · Sources RUPP Autism Network (2002) Risperidone in children with autism and serious behavior problems, New England](https://reader034.vdocument.in/reader034/viewer/2022051805/5ff711a95385c801b3161e73/html5/thumbnails/32.jpg)
Conclusions
Paucity of studies in autism spectrum disorders
and comorbidity making diagnoses quite difficult
Behavioral interventions are first line
Must have clear, realistic, measurable target
symptoms
Lower response rate and more side effects with
medication management in autism spectrum
disorders
![Page 33: Comorbid Conditions in Autism Spectrum Illness · 2014. 6. 9. · Sources RUPP Autism Network (2002) Risperidone in children with autism and serious behavior problems, New England](https://reader034.vdocument.in/reader034/viewer/2022051805/5ff711a95385c801b3161e73/html5/thumbnails/33.jpg)
Sources
RUPP Autism Network (2002) Risperidone in children with autism and serious behavior problems, New England Journal of Medicine 347:314-321
Arnold et al (2006) Atomoxetine for hyperactivity in autism spectrum disorders: Placebo-Controlled Crossover Pilot Trial, J Am Acad Child Adol Psychiatry 45:1196-1205
Towbin K, Strategies for pharmacologic treatment of high functioning autism and Asperger syndrome (2003) Child and Adolescent Clinics of North America 12:23-45