CORTICO-CEREBELLAR PATHWAYS FOR UNDERSTANDING LANGUAGE COORDINATION

MagdaL.Dumitru,LaurensVanCalster,MarionBouffier,SteveMajerusUniversityofLiège

magda.dumitru@gmail.com

Cognitiveprocessingactivatestheposteriorlobesofthecerebellum,correspondingtocontralateralareasofthecerebrum.

BACKGROUND

CONCLUSIONSRATIONALE&MATERIALS

Buckner,R.L.,Krienen,F.M.,Castellanos,A.,Diaz,J.C.,&Yeo,B.T.T.(2011).Theorganizationofthehumancerebellumestimatedbyintrinsicfunctionalconnectivity.J.Neurophysiol106,2322-2345;Diedrichsen,J.(2015).Cerebellartoolbox(SUIT).Availablefrom:http://www.icn.ucl.ac.uk/motorcontrol/imaging/suit.htm;Dumitru,M.L.,&Joergensen,G.H.(2016).Gestaltreasoningwithconjunctionsanddisjunctions.PLoSONE11(3):e0151774; Eickhoffetal.(2005).AnewSPMToolboxforcombiningprobabilisticcytoarchitectonicmapsandfunctionalimagingdata.Neuroimage25,(4):1325-1335;Penny,W.,Friston,K.,Ashburner,J.,Kiebel,S.,&Nichols,T.(2006).StatisticalParametricMapping:TheAnalysisofFunctionalBrain.1st Edition,AcademicPress;Stoodley,C.J.,&Schmahmann,J.D.(2010).Functionaltopographyinthehumancerebellum:ameta—analysisofneuroimagingstudies.Neuroimage,44,489-501;Schrouff,J.,Rosa,M.J.,Rondina,J.M.,Marquand,M.F.,Chu,C.,Ashburner,J.,etal.(2013).PRoNTo:PatternRecognitionforNeuroimagingToolbox.Neuroinformatics,11,319–337- https://github.com/CyclotronResearchCentre/PRoNTo_SearchLight;Turner,B.O.,Marinsek,N.,Ryhal,E.,&Miller,M.B.(2012).Hemisphericlateralisationinreasoning.Ann.N.Y.Acad.Sci,1359,47-64 25th MeetingoftheCognitiveNeuroscienceSociety,24-27March2018,BostonMA

Volunteers:22right-handedadultsScanner:3TSiemensMagnetomPrisma

Whole-BrainSearchlight

Wepredictedcomplementarycerebrallateralisationandcontralateralcerebellaractivation.

UnivariateAnalysis

AND>ORL.I.- 0.493

OR>ANDL.I.+0.362

Therightcerebellumismorerelevanttolinguisticprocessing;theleftcerebellumismoreconcernedwithspatialinformation.

Therightcerebralhemispheremanagesconflictsbyassessing,rejecting,orrefiningexplanationswhenfacedwithnewevidence.Theleftcerebralhemispherebuildscoherencebydrawinginferencesorcreatingexplanationsatthecostofignoringevidenceorclashingexplanations.

RestingStateNetw

orksWeinvestigatedtheroleofcortico-cerebellarpathwaysinunderstandingthediscourseconnectivesAND &OR.

ANDactivatestherightcerebralandtheleftcerebellarhemispheres.

MVP

Amod

elANDvs.O

R

Seed

-based

ana

lysis

ORactivatestheleftcerebralandtherightcerebellarhemispheres.

Neuralpatternsrevealedbywhole-brainsearchlightanalysissuggestrapidrecruitmentofspatialreasoningcorticalareasuponhearingthetwoconnectives.

TheconnectiveANDevokesasingleGestaltbyaccumulatingandmerginginformation.TheconnectiveORevokestwoGestalts.