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CPR: Role of adrenaline – Role of monitoring (etCO2) and mechanical
devices.
Tobias GrafUniversity Heart Center Luebeck, Germany
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CPR: Role of adrenaline? What do the ERC guidelines say?
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ERC Guidelines for Resuscitation
Soar et al. Resuscitation 2015
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CPR: Role of adrenaline?
ALS Section 3ERC Guidelines 2015
Soar et al. Resuscitation 2015
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CPR: Role of adrenaline?
Evidence?
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CPR: Role of adrenaline?
Jacobs et al. Resuscitation 2011
1:1 randomized, double blind,placebo controled trial of adrenalinadministration in OHCApatients in AUS
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CPR: Role of adrenaline?
Jacobs et al. Resuscitation 2011
- increased portion of patients with ROSC and admission to hospital afer OHCA
- adrenaline failed to demonstrate improved hospital survival and neurological outcome
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CPR: Role of adrenaline?
Lin et al. Resuscitation 2014
Dose related effects?i.e. 10fold higher doses
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CPR: Role of adrenaline?
Lin et al. Resuscitation 2014
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CPR: Role of adrenaline?
• Part of guideline recommended therapy in ALS
• Increases ROSC and hospital admission
• Fails to demonstrate improvement in survival at hospital discharge and neurological outcome
• Further RCT needed (PARAMEDIC-2 trial ongoing 8000 patients)
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CPR: Role of etCO2
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CPR: Role of etCO2
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CPR: Role of etCO2
ERC Guidelines 2015:
1. Ensuring tracheal tube placement Sheak et al. Resuscitation 2015
2. Monitoring ventilation rate
3. Monitoring quality of chest compression Hamrick JL et al J Am Heart Assoc 2014
4. Identifying ROSC under CPR
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CPR: Role of etCO2
ERC Guidelines 2015
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CPR: Role of etCO2
Resuscitation 2013
Ensuring tracheal tube placement
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CPR: Role of etCO2
Phelan et al. Resuscitation 2013
Ensuring tracheal tube placement:Get with the guidelines resuscitation Registry GWTG-R (176.504 patients)
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CPR: Role of mechanical devices
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CPR: Role of mechanical devices
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CPR: Role of mechanical devices
Acute compression decompressiondevice (ACD) LUCAS II
Load distribution band deviceAutoPulse
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CPR: Role of mechanical devices
Stehen et al., Resuscitation 2002
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CPR: Role of mechanical devicesLUCAS II in OHCA-CPR setting
Lancet 2015
Resuscitation 2014
Autopulse in OHCA-CPR setting
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CPR: Role of mechanical devices
Perkins et al. Lancet 2015
PARAMEDIC trial: No advantage ACD vs manual chest compresision in survival
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CPR: Role of mechanical devices
CIRC trial: No advantage load distribution band vs. manual chest compression in survival
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CPR: Role of mechanical devices
Why then thinking about mechanical devices?
Paramedic systems in rural regions withcomplex logistics/ bridge to advancedtherapies
Radiation dose reduction for CPRteams in cath lab settings
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Summary• Use of adrenalin strongly recommended
despite lack of outcome data
• Use of capnography strongly recommendedto monitor CPR and ROSC
• Use of mechanical devices might be considered
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