Download - Current Research on Falls Prevention
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Current Research on Falls Prevention
Jane Mahoney, MD
University of Wisconsin Medical School
Dec 15, 2004
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Scope of the Problem
• In 1999, accidents were the 8th leading cause of death for adults age 65 and older in the US, and the leading cause of accidental deaths was falls.
• Fractures accounted for 531,000 hospitalizations in the over-65 age group.
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Falls in Wisconsin
• In 2002, there were 22,500 hospitalizations in Wisconsin for fall-related injuries.
• The state’s death rate due to falls has increased 20% from 1992 to 2002
• The state’s death rate due to falls is almost twice the national average.
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Fall-Injury Rates Are Increasing Over Time
• Kannus et al, Lancet 1997
• Finnish data – national hospital discharge register
• Age-adjusted incidence of fall-related injury for ages 60 and over
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Purpose
• Overview of current guidelines for fall prevention• Intervention research: multifactorial trials,
exercise, group cognitive-behavioral classes• Prevention after hospital discharge• Preliminary data, Kenosha County Falls
Prevention Study• Dane County SAFE Study: evaluating research
findings in a community setting
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Definition of Accidental Fall
An accidental fall is an event which results in a person coming to rest inadvertently on the ground or other lower level not due to obvious loss of consciousness, stroke, seizure or sustaining a violent blow.
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Components of Postural Control
CognitionCNS pathways
Medications
Environ-ment
SensoryInput
CentralProcessing
Musculoskeletal
Strength
Biomechanical
EffectorOutput
Visual
Vestibular
Proprioceptive
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Risk Factors For Falls from Epidemiologic Studies
• Previous hx of falls• Balance or gait
impairment• Dementia• Visual deficit
• Neuropathy• Muscle weakness• Psychotropic
medications• Depression• Arthritis, Parkinson’s,
stroke
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Risk Factors are Additive Tinetti, NEJM, 1988
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% falling
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2001 GuidelinesAmerican Geriatrics Society, British Geriatric
Society, American Academy of Orthopedic Surgeons
• All older adults should be asked at least once a year about falls.
• All older adults who report a single fall should be observed rising from a chair and walking.
• Older adults with 2 or more falls in the past year, 1 fall with injury, or 1 fall with gait and balance problems should receive a fall evaluation followed by multifactorial intervention.
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2001 Guidelines Multifactorial Intervention
• Gait training including advice on assistive devices• Review/modify medications, especially
psychotropics• Individualized, progressive exercise programs
with balance training• Treat postural hypotension• Modify environmental hazards• Treat cardiovascular disorders including
arrythmias
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Randomized Trials of Multifactorial Interventions
Study
• Tinetti, NEJM 1994
• Wagner, AJPH, 1994
• Close, Lancet, 1999
• Day, BMJ, 2002
Outcome
Rate 31%
Risk 9%
Risk 61%
Rate 33%
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Benefit of Exercise in Reducing Falls
• Previous studies have shown that patients with a history of multiple previous falls will benefit from individualized physical therapy
• Physical therapy should be progressive, last several months, and should include balance exercises
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Randomized Trials of Group Exercise
Study
Wolf, JAGS, 1996 Tai Chi
Lord, JAGS, 2003 standing
Barnett, Age Ageing, 2003 standing
Day, BMJ, 2002 standing
Wolf, JAGS, 2003 Tai Chi
Outcome
Risk 47%
Rate 22%
Rate 40%
Rate 18%
Risk 25% NS
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Group Exercise for Falls Prevention
• Include standing exercises that challenge balance– Stepping, Tai Chi, change of direction, dance
steps
• Complexity and speed of exercises increase• Classes held 1-2 times per week, typically
also with home exercises• Exercises are individualized as needed
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Group classes: cognitive-behavioral learning
• 7-week classes plus 1 home OT visit to improve self-efficacy, encourage behavioral change, reduce falls
• Focus on improving balance and strength, improving home and community environamental and behavioral safety, encouraging vision screen and med review
• Results = 31% reduction in falls
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Post-hospital falls prevention - rationale
CNS Delirium
Environ-ment
MusculoskeletalOutputSensory
Systemic Effects of Illness
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Acute Changes in Postural Control
CNS changes
MusculoskeletalOutputSensory
Bedrest, Deconditioning
New Medications
Environ-ment
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Effects of Bedrest
• Loss of muscle mass and strength
• Orthostasis, volume contraction
• Increased body sway
• Slower gait speed
• Visual-spatial abnormalities
• Impaired coordination
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Risk of Falls after Hospitalization Mahoney, JAGS, 1994
• Older adults discharged from St. Mary’s Hospital after acute illness - 14% fell in the month after hospital discharge.
• Risk was higher among those receiving home nursing compared to those not (20% vs 8% fell, p=.01)
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Risk factors by home nursing use
Not receiving home nursing
Vision impairment
Self-report of confusion
Receiving home nursing
Mobility imp pre-hosp
Decline in mobility by discharge
Use of anticholinergics or antihistamines
Self-report of confusion
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Falls After Hospital Discharge Mahoney, Arch Int Med, 2000
- 311 older adults receiving home nursing after discharge
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Rehospitalizations Due to Fall Injuries
• 15% of all re-hospitalizations in the first month were due to fall injuries.
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Risk Factors for Falling: Pre-Hospital
Pre-Hospital:• Prior dependence in
ADLs• Used standard walker• > 2 falls in yr prior• # hospitalizations
in year prior
Odds Ratio
2.3
3.2
1.7
1.1
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Risk Factors Potentially Related to Hospitalization and Acute Illness
Post-Hospital:
Admit for GI dx
First generation tricyclic
Uses cane indoors
Middle tertile balance
Lowest tertile balance
Probable delirium
Odds Ratio
2.5
3.2 0.3
2.2
3.3
6.7
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Post-Hospital Falls Prevention : Nikolaus, Bach: JAGS, 2003
• Home visit during hospitalization followed by 1+ visits after discharge
• Typically OT and other member of interdisc team (RN, PT or SW)
• Evaluate and modify home hazards, teach safe behaviors including use of mobility and functional aids
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Results
• 30% decrease in falls in 1-year follow-up compared to no home visits
• Most effective in those with 2+ falls in year prior: IRR = 0.63
• Both groups got comprehensive geriatric assessment prior to discharge
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Post-Hospital Fall Prevention: Cumming et al, JAGS 1999
• 1+ home OT visits, and 1 phone call 2 weeks post-first visit
• Assess and modify home hazards, teach safe behaviors, evaluate and recommend safe footwear
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Results
• 19% reduction in fallers (p=.050)
• 36% reduction in fallers among those with prior hx of falls (p=.001)
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Approach to post-hospital falls prevention
• Minimize bedrest during hospitalization• Observe patient doing functional tasks
– walking, transferring, reaching, dressing
• Educate older patients about post-hospital risk– Use mobility aid, caution with maneuvers– Eyeglasses, sturdy footwear, home safety check
• Stratify post-hospital falls risk: – 2+ falls in year prior– significant decline in mobility with hosp
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For high risk patients
• Reduce psychotropics• Refer to home health for home OT (if qualifies)
– Evaluate transfers and ADL– Assess need for home functional aids– Assess and modify home hazards– Teach safe behaviors
• Obtain PT in-hospital– Evaluate for home assistive device– Evaluate need for home PT– Provide balance, strengthening exercises for home
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Applying Multifactorial Interventions in the Community
• Multifactorial falls prevention strategies have been successful in research studies – utilized specific exercise programs or physical
therapists– utilized multiple specialists
• It is unknown if a multifactorial intervention utilizing existing medical systems will decrease falls.
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Randomized Trial of Community-Based Multifactorial Intervention
• Kenosha County Falls Prevention Study– Funded by Wisc Resource Center Prevention
Grant– Algorithm for falls assessment,
recommendations, and monthly follow-up.– Recommendations to physician, referral to PT
followed by exercise, other referrals as needed.
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Methods• Inclusion Criteria:
- Residing in Kenosha County, WI, age >65. - Two or more falls in past year, or one fall in past 1 to
2 years with injury or gait and balance problems• Exclusion Criteria:
- Residence in Nursing home or CBRF - Diagnosis of dementia, no related caregiver in home.• Baseline information collected regarding: demographics,
health status, mobility, function, cognition, depression, medications, vision, and health behaviors.
• Followed monthly for falls for 1 year
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Enrollment Characteristics
616 Referred
418 Eligible (68%)
349 Enrolled (83% of eligible)
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Baseline Characteristics (n=349)DOMAIN MEASUREMENT BASELINE
Demographics Age 80.0 ±7.5
Female 78.5%
Falls No. falls in past year 2.4 ± 2.5
Health status Emergency Room visit(s) past 4 months 30.7%
Mobility Assistive device use indoors 35.9%
Function
Barthel Index 88.1 ±16.6
No. of independent Instrumental Activities of Daily Living out of 7, (IADLs)
4.8 ± 2.2
Cognition Mini-Mental State Exam (max 30) 27.1 ± 4.4
Meds No. of prescription medications 5.7 ± 3.3
Health Behaviors
Any alcohol intake 37.3%
Frequency of exercise (days per week) , (%)
<1 34.7%
1-3 21.2%
4-7 44.1%
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Differences in 2+ fallers versus single fallers
Kenosha County Falls Prevention Study
funded by the Wisconsin Department of Health and Human Services
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Differences in recurrent fallers versus single fallers
• The AGS recommends that older adults who have had 2+ falls in the past year, 1 fall with injury, or 1 fall with gait or balance problems receive a multifactorial falls evaluation.
• Purpose: to examine baseline characteristics of those who have had 2+ falls in the past 12 months, compared to those with 1 fall in past 1-2 years. If there are differences, this could have implications for treatment.
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Enrollment by Falls History
020406080
100120140160180200
2+falls past 12 mos,n=189
1 fall past 12 mos. Withinjury, n=64
1 fall past 12 mos. withgait/balance problems,n=51fall past 12-24 mos. Withinjury, n=30
fall past 12-24 mos. Withgait/balance problems,n=15
•Comparison: 2+ falls past 12 mos. (n=189) vs. 1 fall in past 24 mos. (n=160)
•Two-sample t-tests for continuous variables and Pearson’s chi-square tests for categorical variables.
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Comparison of Baseline CharacteristicsDOMAIN MEASUREMENT 2+ FALLS
PAST YEAR
N=189
1 FALL PAST 1-2 YEARS
N=160
P-VALUE
DemographicsAge 79.9 80.0 0.94
Female 73.5% 84.4% 0.014
Falls No. falls in past yr 3.7 0.8 <0.0001
Health status
Hx of hip fx , % 11.2% 7.6% 0.25
Hx of CVA , % 31.2% 18.8% 0.008
Health rated fair/poor , %
38.1% 21.3% 0.007
ER visits in past 4 mos, %
38.1% 21.9% 0.001
Mobility
Assistive device use indoors , %
42.3% 28.1% 0.006
Walk outside, %
Without help
60.9% 83.8%
<0.0001Some help
26.5% 11.9%
Unable 12.7% 4.4%
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Comparison of Baseline CharacteristicsDOMAIN MEASUREMENT 2+ FALLS
PAST 12 MOS
N=189
1 FALL PAST 24 MOS. WITH INJURY OR GAIT/BALANCE
PROBLEMS
N=160
P-VALUE
FunctionNo. IADLs 4.3 5.4 <0.0001
Barthel Index score 85.1 91.6 0.0002
Cognition MMSE score 26.6 27.6 0.028
Depression GDS scpre 3.4 2.5 0.004
Medication
No. prescription medications
6.2 5. 0.0007
No. Psychotropics 0.3 0.1 0.018
Vison Able to watch TV, % 91.5% 96.9% 0.037
Health Behaviors
Any intake alcohol , % 34.4% 40.6% 0.29
Exercise program , % 18% 18.1% 0.97
Frequency of exercise, times per week , %
<1 36% 33.1%
0.701-3 19.5% 23.1%
4-7 44.4% 43.8$
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Barthel ComparisonSELECTED BARTHEL ACTIVITY
lower score indicating more
impairment
MEAN BARTHEL SCORE
P-VALUE2+ FALLS PAST YEAR
1 FALL PAST 1-2 YEARS
Bathing Self 3.6 4.4 0.0002
Dressing 8.8 9.3 0.036
Toileting 9.6 9.9 0.019
Transferrring 14.1 14.7 0.014
Walking on level surface
11.7 13.3 0.001
Climbing stairs 7.1 8.5 0.0002
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Conclusion
• There are multiple significant differences in domains of: health status, mobility, function, cognition, depression, medications, and vision, comparing recurrent fallers and single fallers. Recurrent fallers are more likely to have risk factors in multiple domains.
• The propensity for positive exercise behavior was similar in both groups.
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Implications
• Given the greater number of risk factors and impairments in the recurrent faller group, we may need to consider focusing a multifactorial approach toward this group.
• Our data on exercise behavior suggests recurrent fallers may be equally likely to adhere to an exercise intervention as single fallers
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Limitations
• The sample was self selected by those interested in a falls prevention trial and may not be representative of all fallers.
• This was primarily a white, middle-class population and may not be generalizable to other populations.
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Dane County SAFE Study
• Three-year RCT funded by CDC• Will randomize 420 older adults at high risk for
falls to multifactorial intervention and follow-up or health information booklets.
• Intervention similar to Kenosha County study.• But, supplemented by educational initiatives to
increase physician and physical therapy utilization of recommendations.
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Grant Overview
Two components Goal 1: In-home multifactorial assessment randomized
trial for high-risk older adults Goal 2: Education of primary health care providers in
Dane County.
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Goal 1: Multifactorial intervention trial
• Target group:– Community-residing adults age 65 and older at high
risk for falls – AGS criteria• 2+ falls in the past year
• 1 fall with injury
• 1 fall with abnormal gait or balance
– Exclusion criteria: • residence in NH or CBRF
• Unable to give informed consent and no related caregiver in home.
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Randomization
In -ho m e m u lti fac to r ia l in te rve n tion(n = 2 10)
E d uca tion a l b oo kle ts(n = 2 10)
H igh ris k o lde r a du lts(n = 4 20)
in fo rm ed co n se n tb a se line assessm e nt
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Outcomes
• Primary outcome = falls– Hypothesized 40% reduction in rate of falls over 1 year
compared to control group– Falls obtained via monthly calendar
• Secondary outcomes– # hospitalizations and hospital days– # nursing home admissions and NH days– Change in function, mood, vision, medications, fear of
falling, and physical performance at 12 months compared to baseline.
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Multifactorial assessment
• Follows principles of AGS guidelines
• Can be performed by PT or RN with cross-training
• Requires about 2 hours to perform
• Is performed in-home preferably with caregiver present
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Algorithm assesses:
– History of falls, comorbidities, risk related to IADLs and ADLs, fear of falling, risky behaviors, footwear
– depression, cognition
– medications, alcohol intake
– Exam: Orthostatics, vision, visual fields, vibration, Romberg
– Gait and balance: Sensory integration, reactive balance, Berg balance, Tinetti Gait, Attention, Foot/ankle alignment
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Outcome of assessment
• Algorithm generates recommendations to patient and physician, and referrals to PT, opthalmology, podiatry, OT, and other health provider and community resources
• Assessor returns to the home within 2 weeks to provide recommendations and referrals
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Intervention continues for 1 year
• Monthly phone call from assessor to encourage and assess compliance, help with problem-solving, etc.
• For most participants, the algorithm generates a referral to physical therapy. Physical therapy is followed by an ongoing, individualized exercise plan for community or home exercise, with an exercise “buddy” if needed.
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Goal 2: Provider Education
• Target Groups– Primary care physicians– Physician Assistants and NPs– Physical Therapists, Paramedics
• Purpose: Educate for falls prevention• Outcomes: Compare change in rate of
hospitalizations for fall-related injuries in Dane County to other counties
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Strategies for Recruitment
• Direct to seniors
• Community groups
• Professional providers
• Enrolled to date: 337
• Enrollment will continue through April 05
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Referrals by Referral Type (N=729)7% 2%
1%
13%
3%
7%
67%
DCAAA
Post Hosp/ER
Home Care
Primary MD/clinic
Therapy OT/PT
Other Indirect
Self Referred
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Participants by Referral Type (N=290)
14%
2%
10%
66%
1%1%6%
DCAAA
Post-Hosp/ERhome care
Primary MD/clinicsTherapy (PT/OT)
Other IndirectSelf Referred
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Thank-you
Wisconsin Dept. of Health and Family Services Terry Shea, PT, Co-Principal Investigator Bob Przybelski, MD, Co-Investigator Ron Gangnon, Mari Palta, Biostatistics Nurses and physical therapists with the Dane
County SAFE Study Sheila Guilfoyle, Coordinator Community agencies, health care providers