Day 1: Monday ,18 November 2019
Chairs: Dr. Qamar Al Mutawa & Ms. Rawasi M Al Saadi
07:30 - 08:00 Registration
08:00 - 08:30 Opening Ceremony
08:30 - 09:00Objective of the workshop & Current status of the cyclotron in Kuwait
Dr. Shorouk Dannoon
09:00 - 10:00Introduction of Cyclotrons: Practical Information
Prof. Ibrahim Aljammaz
10:00 - 10:30 Break
10:30 - 11:30Production of PET Radioisotopes & 18F-FDG
Prof. Ibrahim Aljammaz
11:30 - 12:00 Break & Praying
12:00 - 01:00Production of Beyond FDG PET Radiopharmaceuticals
Prof. Vijay Kumar
01:00 - 02:00Facility, Design & Layout for Cyclotron According to GMP
Prof. Roberto La Forgia
Day 2: Tuesday, 19 November 2019
Chairs: Mrs. Lolwah Al Mutari & Ms. Zainab Al-Qallaf
08:30 - 09:30Automated Quality Control of PET Radiopharmaceuticals
Prof. Vijay Kumar
09:30 - 10:30Qualification & Validation according to GMP
Prof. Roberto La Forgia
10:30 - 11:30Radiopharmaceuticals Regulations: Pharmaceuticals Aspects & Radiation Protection
Prof. Ibrahim Aljammaz
11:30 - 12:00 Break & Praying
12:00 - 01:00Staff Requirements for PET Radiopharmaceuticals Production Facility
Prof. Vijay Kumar
01:00 - 01:30New PET radiopharmaceuticals: Research & Development
Prof. Ibrahim Aljammaz
01:30 - 02:00 Conclusions & Recommendations
RADIOPHARMACEUTICALS current status and future prospects
CYCLOTRON &
PET
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F18
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The Nuclear Medicine CouncilNuclear MedicineWorkshop
2019
18-19 November 2019
Jaber Al Ahmed Al-Sabah Hospital,Conference Hall
For more Information :
pointsCME9
Under The Patronage of H.E. The Minister of Health
Dr. Basel H. Al Sabah
What is a Cyclotron?- It is a device that accelerates charged particles such as protons, deutrons,
particles to very high energies.
- Types of cyclotron:
- How does it work:- A charged particle can be accelerated to very high energies by making it
pass through a moderate electric field multiple times.
- Main internal components of cyclotron:
- Ion source, • Produces particles to be accelerated,- Magnet, • Keeps particles on a circular motion,- Radiofrequency system, • Accelerated beam,- Extraction system, • Guides particles out of the cyclotron,- Vacuum system,- Cooling system,- Diagnostics (beam probe)
- Main external components of cyclotron:• Quadrupoles, • Steering magnet,• Beam stop, • Beam viewers,
• Signals pickup elements, • Collimator,
- What is a hot cell?- It is a compartment made of lead that is thick enough to shield 511 kev pho-
tons. It is also used to house PET radiotracer synthesizers. In addition, there are class A dispensing unit in a hot cell.
1. Linear accelerators:Accelerate particles in a straight line.
2. Cyclotrons:Accelerate particles along an outward spi-ral path.
3. Synchrotrons:Cyclic accelerators that send the particles into a closed-loop path. PET
RadiopharmaceuticalsSynthesis
Ga-68 Dota Noc or PSMA synthesis
It is used to diagnose neuroblastoma or prostate.
Ga-68 generator elution
Labelling
Pure HCL
Purification
Peptide
Peptide recovery
Ethanol evaporation
Ethanol
Formulation NACL 0.9%
Ga-68 [Dota Noc] or
Ga-68 [PSMA]
Impurities waste
Waste
Quality control HPLC
ITLC
F-18 FDG synthesis
F-18 FDG (F-18 2-fluoro-2-deoxy-D-glucose) or fluorodeoxyglucose (glucose analogue).
It is used to diagnose cancer and infection in the tissues.
Cyclotron
F-18 Trapping
O-18 enriched water
Synthesis of F-18
Purification Impurities waste
Formulation
F-18 FDG
Quality control
Endotoxin
LAL test
HPLC
ITLC
PH
Dispensing
Release
Recovery O-18 K222
Evaporation