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Daily Temozolomide Following Failure of Prior RT + TMZ for GBM:
Update on the RESCUE Study
J. Perry, W. Mason, K. Belanger, P. Kavan, D. Fulton, J. Easaw, S. Kirby, D. MacDonald,
C. Shields and J.-F. Pouliot
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42-year-old woman with GBM treated with daily temozolomide at first relapse on the NCIC-CTG/EORTC Trial
PD: 9 mo after RT/TMZ,6 cycles adjuvant TMZ
CR after 4 cycles continuous TMZ 50 mg/m2
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Temozolomide Dose-intense Rescue
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RESCUE Study Design
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Study Objectives
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Main Inclusion Criteria
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Main Exclusion Criteria
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Demographics
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Six-month Progression-free Survival
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Progression-free Survival (by subgroup)
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Non hematological Toxicity (worst grade)
*All AEs irrespective of causality incidence >2%
No Grade 4 toxicity reported at this point in time
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Hematological Toxicity(worsened grade since baseline)
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Baseline Hematological Abnormalities(all patients)
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Conclusions