Download - Dentifrices
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COMPOSITION & CHEMISTRY OF DENTIFRICES
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COMPOSITION & CHEMISTRY OF DENTIFRICES
DENTIFRICE:A dentifrice is a substance used with a toothbrush for the purpose of cleaning the accessible surfaces of the teeth (American Dental Association)
TOOTHPASTE:Toothpaste is a colloidal suspension of a mixture of ingredients that must be carefully balanced in order to provide an efficacious, safe, and consumer friendly product
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TOOTHPASTE INGREDIENTS
• Abrasive• Binder• Humectant• Sweetener• Flavor• Surfactant
• Active Ingredients
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ABRASIVE
• Function:– Cleaning and polishing
• Characteristics:– Solid, insoluble particles– Abrasive– Potential for fluoride interaction
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ABRASIVE
• Types :
– Silica– Phosphate Salts – ie “Dical”– Carbonates – ie Calcium Carbonate or Chalk– Others
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Radioactive Dentin Abrasion Method
This procedure involves the use of accelerated toothbrushing apparatus and dentin section that contain radioactive phosphorous. The ADA standard was set at 100, which corresponds to RDA value of 475.
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Figure 7: In-vitro Abrasion Studies, RDA
• This photograph shows a two-brush model abrasion machine, which is used in in vitro dentifrice abrasion studies.
Source: Stallard, Richard E. A Textbook of Preventive Dentistry (Second Edition).
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Comparative Abrasiveness of some Commercially Available Dentifrices as Determined by a Radioactive Dentin Procedure
Source: Stallard, Richard E. A Textbook of Preventive Dentistry (Second Edition).
DENTIFRICE MANUFACTURER PRINCIPAL ABRASIVE
ABRASIVITY INDEX
Sensodyne Block Drug Co. Silica 157Vote Bristol-Myers Co. Silica 134Plus White Plus Bishop Industries, Inc. Dicalcium Phosphate (anhydrous) 132Plus White Bishop Industries, Inc. Dicalcium Phosphate (anhydrous) 110Gleem II Procter and Gamble Co. Calcium Pyrophosphate 106Macleans (old formulation) Beecham Products, Inc. Calcium Carbonate 93Crest (Mint and Regular) Procter and Gamble Co. Calcium Pyrophosphate 88Close-Up Lever Brothers Co. Silica 87
Pearl Drops Carter-Wallace, Inc.Alumina and Dicalcium Phosphate (dihydrate) 72
Macleans (new formulation) Beecham Products, Inc. Dicalcium Phosphate (dihydrate) 68Ultra Brite Colgate-Palmolive Co. Dicalcium Phosphate (dihydrate) 64Colgate with MFP Colgate-Palmolive Co. Insoluble Sodium Metaphosphate 51Pepsodent Lever Brothers Co. Dicalcium Phosphate (dihydrate) 26
Thermodent Chas. Pfizer and Co.Magnesium Carbonate (basic) and Calcium Carbonate 24
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BINDER
• Function:Used to stabilize toothpaste formulations to prevent separation of the liquid and solid phases
• Characteristics:Can be natural or synthetic
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BINDER
• Types:
– Natural Polymers• Carboxymethyl Cellulose (CMC)• Carrageenans• Xanthan Gum
– Synthetic Polymers– Others
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HUMECTANT
• Function: Used in toothpaste to prevent loss of water and
subsequent hardening of the product upon exposure to air
• Characteristics: Affect taste perception Proper usage level produce a clear translucent toothpaste
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HUMECTANT
• Types:
– Glycerine– Sorbitol– Polyethylene Glycol– Xylitol– Propylene Glycol
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SWEETENER
• Types:
– Sodium Saccharin – Sodium Cyclamate– Acesulfame K
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SWEETENER
• Function: An important part of toothpaste flavoring system
• Characteristics: Government regulations Non-cariogenic
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FLAVOR
• Function: Improve taste of toothpaste
• Characteristics: One of the most important factors for consumer
A mixture of flavoring agents
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FLAVOR
• Types:
– Minty– Fruity– Medicinal– Cinnamon
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Oral products have a unique and specialized flavor requirements. To be successful in oral products, a flavor must:
• Have a pleasant taste while brushing• Leave a pleasant taste in your mouth after
brushing• Be compatible with the base
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All factors being roughly equal – “mouthfeel” appearance, perceived therapeutic attributes, etc. – the consumer will look to flavor as the determinant in selecting a product for use day after day and year after year.
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SURFACTANT
• Function: Produce foam and aid in the removal of debris Emulsifies flavoring agents
• Characteristics: May react with other toothpaste components High level may cause mucosal irritation
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SURFACTANT
• Types:
– Sodium Lauryl Sulfate– Sodium N-Lauroyl Sarcosinate– Sodium Dodecyl Benzene Sulfonate– PEG Oil
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FLUORIDE ACTIVES
• Function: Increase resistance to enamel solubility
• Characteristics: Regulated by Government
Restricted usage level Soluble fluoride ion is essential for activity
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FLUORIDE ACTIVES
• Types:
– Sodium Fluoride NaF
– Sodium Monofluorophosphate MFP
– Stannous Fluoride SnF2
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Anticaries Dentifrices: FDA Tentative Final Monograph
Package size limitation
Identity (labeling)
Indications
WarningsDirections
Aids in the prevention of dental caries or cavities or decay (as deemed appropriate by the manufacturer); misleading statements not permitted
"Adults and children 2 years of age and older; brush teeth thoroughly at least once daily or as directed by a dentist. Children under 6 years of age should be supervised in the use of this product." Also for stannous fluoride dentifrices, "This product may produce surface staining of the teeth. Adequate toothbrushing may prevent these stains which are not harmful or permanent and may be removed by your dentist."
None required for dentifrices
Anticaries active agents (category I)
Package shall not contain more than 260 mg total fluorine per package
Contains established name of drug; identifies product as "anticavity", "fluoride", "dentifrice", or "toothpaste", as appropriate
Sodium fluoride, 0.22%Sodium monofluorophosphate, 0.76%Stannous fluoride, 0.4%
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OTHER ACTIVES• Tartar Polyphosphates
Zinc Citrate
• Plaque / Gingivitis TriclosanSnF2Chlorhexidine
Zinc Citrate
• Desensitizer Potassium Nitrate
• Whitening Calcium PeroxideHydrogen Peroxide
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TYPICAL COMPOSITION
Ingredients Weight %Humectants 60 – 20Water 0 – 50Binders 0 – 12Abrasive 18 – 50Flavor 0.5 – 2.0Sweetener 0.2 – 1.0Surfactant 0.5 – 2.0Fluoride 0.2 – 1.2
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U.S. FORMULA COMPARISONIngredients Colgate P&G Unilever SKB
Humectants Glycerin Glycerin Glycerin GlycerinSorbitol Sorbitol Sorbitol SorbitolPEG PEG PEG PEG
Binders CMC Xanthan CMC CMCCarrageenan Carbopol CarrageenanXanthan
Abrasive Silica Silica Silica PCCDical SilicaPCC
Flavor Mint Mint Mint MintSweetener Saccharin Saccharin Saccharin SaccharinSurfactant SLS SLS SLS SLSFluoride NaF NaF NaF MFP
MFP SnF2 MFPSnF2
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TOOTHPASTE CONSIDERATIONS
• Safety• Efficacy• Consumer Friendly
– Pleasing taste– Ease of use– Pleasing appearance
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PRODUCT CRITERIA
• Minimum one year shelf life• Easily dispensable• Compatible with the package• Efficacious• Safe
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History of Toothpastes• Dentifrices date back over 2000 years• Colonial America
– mixed own powders and pastes• became popular with re-invention of toothbrush by
William Addis about 1770.
• Dentifrices usually a “family pot”• Invention of the toothpaste tube
– 1892 by Dr. Washington Wentworth Sheffield
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History of Toothpastes (cont.)
• Development of fluoride toothpastes– Bibby (1942): first clinical trial of fluoride
toothpaste.– Conventional toothpaste contained dicalcium
phosphate and NaF added.– Fluoride bound to the dicalcium phosphate
causing the NaF to dissociate= inactive fluoride.– No caries preventive effect found.
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History of Toothpastes (cont.)
• Development of fluoride toothpastes– Muhler er al (1954)
• used newly developed Ca-pyrophosphate abrasive system
– Caries preventive effect found. (10% caries reduction)
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History of Toothpastes (cont.)
• Discovery of Monofluorophosphate– 1940s at Ozark Mahoning Company in Tulsa,
Oklahoma.– By Dr. Harold Hodge, Dr. John Hein, Dr. Wayne
White and Dr. Kanwar Shourie– First described the caries preventive properties of
sodium monofluorophosphate.– Acute toxicity half that of sodium fluoride.
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History of Toothpastes (cont.)
• Discovery of Monofluorophosphate– 1940s at Ozark Mahoning Company in Tulsa,
Oklahoma.
– By Dr. Harold Hodge, Dr. John Hein, Dr. Wayne White and Dr. Kanwar Shourie
– First described the caries preventive properties of sodium monofluorophosphate.
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History of Toothpastes (cont.)
• Colgate Palmolive Company marketed sodium N lauroyl sarcosinate dentifrice.
• November 1955: Proctor and Gamble marketed Crest, its stannous fluoride dentifrice.
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Current Toothpastes• Oriented towards a certain goal: i.e.
– cleaning– anticaries– antimicrobial– tartar inhibition
• Contain many different substances which are necessary to obtain the desired effects i.e. abrasives, active components, motivators.
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Fluoride in Toothpastes• The first therapeutic addition to the basic
dentifrice.
• Stannous fluoride (SnF2)
• Sodium monofluorophosphate (Na MFP)• Sodium fluoride (NaF)• Sodium fluoride and Calcium Phosphate
(NaF/CaPO4)
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How Much Toothpaste Should I Use ?
• For children: A pea-sized amount of toothpaste to avoid fluorosis.
• For adults: Enough toothpaste to cover the whole length of the toothbrush bristles.
• *Dr. Barry Kaufman for the ADA’s Dental Newsline.
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Common Ingredients in Toothpastes
Constituent Concentration (%)
Abrasive 20 - 50
Water 20 - 40
Humectants 20 - 35
Detergent 1 - 3
Thickening agent 1 - 2
Flavoring agent 0 - 2
Sweetening agent 0 - 2
Therapeutic agent 0 - 2
Coloring or preservative 0.05 - 0.5
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Common Ingredients in Toothpastes. What Do They Do?
Constituent1. Abrasive2. Water3. Humectants4. Detergent5. Thickening agent6. Flavoring agent7. Sweetening agent8. Therapeutic agent(s)9. Color or preservative10.Binder
Purpose1. Cleaning/stain removal2. Solvent for ingredients3. Provide creamy texture4. Surfactant/foam builder5. Controls viscosity6. Improves taste7. Enhances flavor8. Active ingredient(s)9. Color or preservative10.Holds ingred. together
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Common Ingredients in Toothpastes. What Do They Do?
Constituent• Abrasive
Examples• Silica / hydrated silica• Brushite• Gibbsite• Calcite + argonite
Purpose• Cleaning / stain removal• Cleaning effect of one is combined with polishing effect
of another to give the best result.• Cleaning power of abrasive depends on:
– type and amount of abrasive particles– surface it contacts– dilution by saliva– brushing pressure / individual
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Common Ingredients in Toothpastes. What Do They Do?
Constituent• Water
Purpose
• Dissolves ingredients allowing them to be mixed.
• Solvent
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Common Ingredients in Toothpastes. What Do They Do?
Constituent• Humectant
Examples• Glycerin• Sorbital• Polyethylene Glycol• Paraffin oil
Purpose• Moisturizing agent• Protect toothpaste from drying up during storage• Provides smooth creamy texture• Glycerin and sorbitol are sweet = flavoring agents too.
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Common Ingredients in Toothpastes. What Do They Do?
Constituent• Detergent / Surfactant
Examples• Na-laurylsulfate• Sodium laurylsarcoside• Sodium monoglyceride sulfate• ethionates of fatty acid
Purpose• Surface-active substances• Decrease surface tension• Penetrate and loosen debris• Emulsify and remove debris along with the foaming
toothpaste
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Common Ingredients in Toothpastes. What Do They Do?
Constituent• Thickening agent /
binding agent
Examples• Xanthum gum• Carboxymethylcellulose• Carrageenan• Carbomer-940 A or
Carbomer-956
Purpose
• Control viscosity
• Hold the toothpaste ingredients together
• Keep the creamy consistency during storage
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Common Ingredients in Toothpastes. What Do They Do?
Constituent• Flavoring agent
Examples (Crest)• Regular flavor =
wintergreen• Mint flavor = spearmint
taste• Gel flavor = sweet spice
taste.
Purpose• Provide flavor
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Common Ingredients in Toothpastes. What Do They Do?
Constituent• Sweetening agent
Examples (Crest)• Sodium saccharine• Sodium cyclamate
Purpose• Enhances the flavor
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Common Ingredients in Toothpastes. What Do They Do?
Constituent• Therapeutic agents
– (Active components)
Examples (Crest)• Fluoride• Triclosan• Metal ions• Sanguinarine• Surface-active subst. • Chlorhexidine
Purpose• In general:
– reduce caries– antimicrobial– inhibit tartar formation– desensitization– anti-inflammatory
Active substances must not be deactivated by the other ingredients.
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Common Ingredients in Toothpastes. What Do They Do?
Constituent• Coloring / Preservative
Examples
• Titanium Dioxide
• FD&C Blue No. 1
• FD&C Yellow No. 5
Purpose
• Colorants
• Titanium Dioxide = makes toothpaste opaque. Not in gels.
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ADA’s Four Classifications of Toothpastes
1. Anticavity
2. Anticavity / Tartar Control
3. Anticavity / Desensitizing
4. Anticavity / Antiplaque / Antigingivitis / Tartar Control
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Anticaries Toothpastes
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Tartar Control Toothpastes
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Common Tartar Control Ingredients
Examples
• Phosphonates– Tetrasodium pyrophosphate
– Tetrapotassium pyrophosphate
– Disodium pyrophosphate
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Tartar Control using Pyrophosphates
• Stabilize the amount of calcium in saliva.• Interferes with calculus’ crystalline structure.
_________________________• Absorbed into the enamel surface as a calcium
complex.• Phosphate is freed from the crystal lattice but
calcium is not.• The calcium rich crystal lattice inhibits the growth
of crystals on the enamel surface and thus the formation of tartar.
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Anticavity / Desensitizing
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Desensitizing Toothpastes• Basic desensitizing ingredients:
– strontium chloride– potassium nitrate – sodium citrate
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Anticavity / Antiplaque / Antigingivitis / Tartar
Control
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Baking Soda Toothpastes
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Baking Soda• White crystalline powder:
– sodium bicarbonate, bicarbonate of soda, sodium hydrogen carbonate, or sodium acid carbonate.
• Reacts with acids causing effervescence and releasing CO2.
• Neutralizes acid • Cleans with low abrasion• Removes extrinsic stain • Inhibits plaque attachment to tooth
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Whitening Toothpastes
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Natural Toothpastes
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Natural Toothpastes• No dyes or artificial preservatives.• No sweeteners”Tom’s of Main.”• Their nonfluoridated toothpaste has:
– propolis = anitbacterial resin– myrrh = gingival stimulation
• Their fluoridated toothpaste has:– essential oils for flavor– finely ground calcium as abrasive
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Xylitol Toothpastes
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Calcium Phosphate Toothpastes
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Enamelon• Theory is by Dr. Fred Eichmiller at NIST.
• NaF and CaPO4
• Provides fluoride as well as calcium and phosphate which act to strengthen the enamel.
• The soluble calcium and phosphate enhance
remineralization process by converting these
to naturally hydroxyapatite.
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ThemeGallery is a Design Digital Content & Contents mall developed by Guild Design Inc.
Click to add Title
ThemeGallery is a Design Digital Content & Contents mall developed by Guild Design Inc.
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Title
Title
Title
ThemeGallery is a Design Digital Content & Contents mall developed by Guild Design Inc.
ThemeGallery is a Design Digital Content & Contents mall developed by Guild Design Inc.
ThemeGallery is a Design Digital Content & Contents mall developed by Guild Design Inc.
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TitleAdd your text
TitleAdd your text
TitleAdd your text
TitleAdd your text
TitleAdd your text
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Add Your Title hereThemeGallery is a Design Digital Content & Contents mall developed by Guild Design Inc.
Add Your Title hereThemeGallery is a Design Digital Content & Contents mall developed by Guild Design Inc.
Add Your Title hereThemeGallery is a Design Digital Content & Contents mall developed by Guild Design Inc.
Add Your Title hereThemeGallery is a Design Digital Content & Contents mall developed by Guild Design Inc.
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ThemeGallery is a Design Digital Content & Contents mall developed by Guild Design Inc.
Add Your Title here
ThemeGallery is a Design Digital Content & Contents mall developed by Guild Design Inc.
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ThemeGallery is a Design Digital Content & Contents mall developed by Guild Design Inc.
ThemeGallery is a Design Digital Content & Contents mall developed by Guild Design Inc.
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ThemeGallery is a Design Digital Content & Contents mall developed by Guild Design Inc.
ThemeGallery is a Design Digital Content & Contents mall developed by Guild Design Inc.
ThemeGallery is a Design Digital Content & Contents mall developed by Guild Design Inc.
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