Download - Development of urogenital system
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Development of urogenital system
1. Development of kidney and ureter
2. Development of urinary bladder and
urethra
3. Abnormality in urinary system
4. Development of gonad
5. Development of reproductive tracts
6. Abnormality in reproductive system
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Intermediate m
esoderm
Primordium of urogenital syste
m
Intermediate mesoderm ─────→
Nephrogenic cord
───→ Urogenital
ridge3rd week
───
Mesoneohric ridge
Gonadal ridge
Urinary system,
genital excurrent duts
Gonad
Intermediate mesoderm
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Urogenital ridge
Head (segmentation)→ Nephrotome →Pronephros
Other (migration, proliferation)→ Nephrogenic cord → Mesonephros and Metanephros
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Gonadal ridge
Mesonephric ridge
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Mesonephric ridge
Gonadal ridge
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Nephrotome (7-14th somite)
Pronephric tubule
Pronephric duct
Degeneration in 1 week
Mesonephric duct
Pronephric
tubule
Pronephric
duct
Development of kidney and ureter
1. Pronephros 4th week, no function
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2. Mesonephros
14-18th somite
Time : end of 4th week
Function:
transient urinary
Destiny:
Most degeneration,
Small part form male
excurrent duct
Mesonephric duct
Mesonephric tubule
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Mesonephric duct
Middle part of nephrogenic cord
Mesonephric tubule
Inner part form renal capsule
End bind to colaca
80 transverse S-shaped tubule
Continus to pronephric duct
Outer end bind to mesonephric duct
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3.Metanephros Source one: Ureteric bud Source two: Metanephrogenic blastema Time : begin at 5th week, exist forever Function : begin at 3th month, urinary function Position : rise gradually
Mesonephric duct
Mesonephric tubule
Metanephros
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Ureteric bud
End of mesonephri
c duct (adjacent to colaca)
Ureter
Renal pelvis, renal calyce
Collecting tube
Prolong
Enbranchment> 12
(The end branched as T)
Source one
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Cap-shaped cell cluster
Metanephrogenic blastema
(Mesoderm of the mesonephric ridge)
S-shaped tubule
Connect with colle
cting tubule
Renal t
ubule
Renal caps
ule Glomerulus
Source two
Renal corpuscle
Nephron+
Metanephric tubule
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Mesonephric tubule
Ureteric bud
Metanephrogenic blastema
Renal pelvis
Collecting tubule
Renal calyce
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From its original location (adjacent to the developing baldder) to its
mature location (in the retroperitoneum just caudal to the diaphrag
m)
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Colaca4-7th week
Ureorectal septum
Urogenital sinus
Anorectal canal
Upper part
Middle part
Lower part
Male Female
Urinary bladder
Upper part of urethra
Lower part of urethra
Urinary bladder
Urethra
Vestibula of vagina
Development of urinary bladder and urethra
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A B
C D E
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Ureter Mesonephric duct
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Abnormality in urinary system
1. Polycystic kidney 2. Horseshoe kidney
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3. Single kidney
Right single kidney Left single kidney
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4. Double ureter 5. Ectopic kidney
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6. Urachal fistula 7. Exstrophy of bladder
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Development of gonad
Gonad differentiation at 7th week
Developmental stage: Sex undifferentiated stage → Sex differentiated stage
Reproductive tracts :2 → 1
Proper current : → Feamle
Testis determining factor, TDF
TDF determine the differentiation to testis.
The gene of TDF located at sex determining region of the Y (SRY).
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1. Development of
undifferentiated gonad
Gonadal ridge 6th week
Primitive s
ex cord Superfacail epithelium →cell cord
Endoderm cell of yolk sac
3rd to 4th week
Proliferation differentiation
Promordial germ cells
6th weekMigration in 1 week
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Large and round endoderm cells in yolk sac
Promordial germ cells
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Migration of promordial germ cells
Dorsal mesentary of the gut
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2. Development of testis
Primary sex cord (TDF)
Mesenchymal cells
Interstitial cells
Cells of sex cord Promordial germ cells
Sustantacular cells Spermatogonium +
+ Testis
Seminiferous tubule
Seperated from surface 7th week
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3. Development of ovary
Mesenchymal cells
Stroma
Cells of sex cord Primordial germ cells
Follicular cells Ooginum+ + Ovary
Secondary sex cord (Cortical cord )
Primordial follicel
16th week
After 8 weeks
Primary sex cord
Degeneration
Superfacial epithelium No TDF
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Testis Rete testis
Tubule rectus
Seminiferous tubule
Follicle
Ovary
Spermatogonium
Sustantacular cell
Seminiferous tubule Follicle
Primary oocyte
Follicular cell
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4 . Descend of testis and ovary
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Development of reproductive tracts
1. Undifferentiated stage
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2. Differentiation of male reproductive tract
Mesonephric tubule
Most of ── degeneration
Some of ── efferent ducts
Mesonephric duct
Proximal part ── epididymal duct
Distal part── ductus deferens and ejaculatory duct
Paramesonephric duct
Regression──
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3. Differentiation of female reproductive tract
Paramesonephric d
uct
Upper and middle segment : oviduct
Lower segment: uterus
regressionMesonephric duct and tubule
Sinus tubercle :Vaginal plate Vagina
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Abnormality of reproductive system
1. Cryptorchidism
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2. Congenital inguinal hernia
3. Double uterus
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4. Vaginal atresia
5. Hypospadias
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6. Hermaphroditism