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Cell mediated immunity
By:- Dinesh Kumar student of M.Sc. Zoology Govt. Science college Gwalior(M.P.)
Introduction
Human life is a battle field in human beings.
Dinesh Kumar
History of immunology
1. Thucididas (430 BC.)Plague The foundation of immunity
2. Variolation (15th Century)Base on the practical and understanding that the immunity
Dinesh Kumar
Dinesh Kumar
Karl landsteiner (1868-1943)Discovered of primary blood group and 1940Discovered antigen system Rh 1901 nobel prize for blood grouping
Alexander Fleming(1881-1955)Fleming is a British bacteriologist antibacterial1945 For his discovered penicillin
Dinesh Kumar
Antigen is a foreign substance which binds to antibody.
Dinesh Kumar
Ability of the body to fight against infectious agents .
Dinesh Kumar
Innate immunity Adaptive immunity
Dinesh Kumar
Immune Response › Immune response is the response
of the body against an › Infectious agent.
Dinesh Kumar
First line of defense – innate immunity
Second line of defense – adaptive immunity
Physical barrier Cell Mediated (IR)
Phagocytosis
Anti microbial substance
Inflammation
Humoral (IR)
Fever
Dinesh Kumar
Types Component Physical barriers skin, Mucous membrane bacteriaAntimicrobial substances complement, interferons, lysozymes, lactenins acid
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Phagocytosis Neutrophils
Monocyts Inflammation
Macrophages
Fever
Dinesh Kumar
Dinesh Kumar
Tissue damage
Vasodilation--------------- Tissue redness
EdemaMigration of at the injury
Phagocytosis invandingmicrobes
Tissue Repair
Tissue damage
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Target cell Target cell
VirusVirus Interferon
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Target cell Target cell
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TranscriptionTranscriptionTranslationTranslation
Host cell Host cell
Viral protein
Target cell Target cell
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TranscriptionTranscriptionTranslationTranslation
Host cell Host cell
Viral protein
Viral protein
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TranscriptionTranscriptionTranslationTranslation
Host cell Host cell
Viral protein
Viral protein
Dinesh Kumar
TranscriptionTranscriptionTranslationTranslation
Host cell Host cell
Viral protein
Viral proteinVirusVirus Destyoy Destyoy
Dinesh Kumar
Dinesh Kumar
The are two components of adaptative immunity
Humoral Immunity Cell – Mediated immunity
Dinesh Kumar
Humoral immunity refers to the immunity brought about by antibodies
Dinesh Kumar
Cell-mediated immunity involves T lymphocytes which recognize an antigen kill by different ways.
Dinesh Kumar
Dinesh Kumar
Cell Function
B-lymphocytes Antibody formation
T-lymphocytes Release of cytokines
Natural killer cells Cytotoxis
Dendrite cells Phagocytosis, antigen presenting cell
Mononuclear Phagcytic cells
Phagocytosis
Mast cells Allerigic rection
Neutrophils Phagocytosis, inflamestion
Eosinophils Allerigic rection
Basophils Hypersensitivity Dinesh Kumar
Acknowledgment of Dr. D.K. Sharma ,Dr. Trapti Sharma
Dinesh Kumar
Faculty of Zoology DepartmentS.M.S. Govt. Science college Gwalior (M.P.)
Dinesh Kumar