![Page 1: Dr Rachael Neiderer - GP CME North/Sat_Plenary_0835... · Cyclosporine •0.05% to 2.0% used for severe allergic eye disease (vernal, atopic) •Steroid sparing agent •Available](https://reader034.vdocument.in/reader034/viewer/2022051918/600acdb3742c02353e15dd1e/html5/thumbnails/1.jpg)
Dr Rachael NeidererOphthalmologist
Auckland
8:35 - 8:50 Managing Allergic Conjunctivitis & Why Sodium
Chromoglycate is Out
![Page 2: Dr Rachael Neiderer - GP CME North/Sat_Plenary_0835... · Cyclosporine •0.05% to 2.0% used for severe allergic eye disease (vernal, atopic) •Steroid sparing agent •Available](https://reader034.vdocument.in/reader034/viewer/2022051918/600acdb3742c02353e15dd1e/html5/thumbnails/2.jpg)
Allergic conjunctivitisRachael Niederer
Greenlane Clinical Centre, Auckland
![Page 3: Dr Rachael Neiderer - GP CME North/Sat_Plenary_0835... · Cyclosporine •0.05% to 2.0% used for severe allergic eye disease (vernal, atopic) •Steroid sparing agent •Available](https://reader034.vdocument.in/reader034/viewer/2022051918/600acdb3742c02353e15dd1e/html5/thumbnails/3.jpg)
Case
• 9 year old boy with red eye
• Itchy +++
• Watering ++
• Both eyes affected R > L
![Page 4: Dr Rachael Neiderer - GP CME North/Sat_Plenary_0835... · Cyclosporine •0.05% to 2.0% used for severe allergic eye disease (vernal, atopic) •Steroid sparing agent •Available](https://reader034.vdocument.in/reader034/viewer/2022051918/600acdb3742c02353e15dd1e/html5/thumbnails/4.jpg)
Is it allergic conjunctivitis
Differential diagnosis
• Allergic conjunctivitis
• Infectious conjunctivitis (esp viral)
• Blepharitis (usually older)
• Foreign body
• Scleritis
• Other: corneal ulcer, uveitis, angle closure
![Page 5: Dr Rachael Neiderer - GP CME North/Sat_Plenary_0835... · Cyclosporine •0.05% to 2.0% used for severe allergic eye disease (vernal, atopic) •Steroid sparing agent •Available](https://reader034.vdocument.in/reader034/viewer/2022051918/600acdb3742c02353e15dd1e/html5/thumbnails/5.jpg)
History
Allergic conjunctivitis Viral conjunctivitis Blepharitis
Onset Bilateral, sudden or gradual
Sudden, may occur in one eye first
Gradual
Itch +++ + Nil
Vision Normal Normal Normal
Photophobia Nil Nil Nil
POHx Prev allergic Sx Nil Hx gritty eyes
PMHx Atopy Recent URTI Rosacea
RED FLAGS• Blurred vision• Photophobia• Severe pain,
unable to sleep
![Page 6: Dr Rachael Neiderer - GP CME North/Sat_Plenary_0835... · Cyclosporine •0.05% to 2.0% used for severe allergic eye disease (vernal, atopic) •Steroid sparing agent •Available](https://reader034.vdocument.in/reader034/viewer/2022051918/600acdb3742c02353e15dd1e/html5/thumbnails/6.jpg)
Examination
Allergic conjunctivitis Viral conjunctivitis Blepharitis
Lids FolliclesPapillae
Follicles CrustingBlocked glands
Discharge Watery, mucoid Watery, mucoid Nil
Vision Normal Normal Normal
Cornea Normal Normal Normal
Pupil Normal Normal Normal
RED FLAGS• Blurred vision• Corneal lesion• Abnormal pupil
![Page 7: Dr Rachael Neiderer - GP CME North/Sat_Plenary_0835... · Cyclosporine •0.05% to 2.0% used for severe allergic eye disease (vernal, atopic) •Steroid sparing agent •Available](https://reader034.vdocument.in/reader034/viewer/2022051918/600acdb3742c02353e15dd1e/html5/thumbnails/7.jpg)
Blepharitis
![Page 8: Dr Rachael Neiderer - GP CME North/Sat_Plenary_0835... · Cyclosporine •0.05% to 2.0% used for severe allergic eye disease (vernal, atopic) •Steroid sparing agent •Available](https://reader034.vdocument.in/reader034/viewer/2022051918/600acdb3742c02353e15dd1e/html5/thumbnails/8.jpg)
HSV dendritic ulcer
![Page 9: Dr Rachael Neiderer - GP CME North/Sat_Plenary_0835... · Cyclosporine •0.05% to 2.0% used for severe allergic eye disease (vernal, atopic) •Steroid sparing agent •Available](https://reader034.vdocument.in/reader034/viewer/2022051918/600acdb3742c02353e15dd1e/html5/thumbnails/9.jpg)
Microbial keratitis (corneal ulcer)
![Page 10: Dr Rachael Neiderer - GP CME North/Sat_Plenary_0835... · Cyclosporine •0.05% to 2.0% used for severe allergic eye disease (vernal, atopic) •Steroid sparing agent •Available](https://reader034.vdocument.in/reader034/viewer/2022051918/600acdb3742c02353e15dd1e/html5/thumbnails/10.jpg)
Foreign body
![Page 11: Dr Rachael Neiderer - GP CME North/Sat_Plenary_0835... · Cyclosporine •0.05% to 2.0% used for severe allergic eye disease (vernal, atopic) •Steroid sparing agent •Available](https://reader034.vdocument.in/reader034/viewer/2022051918/600acdb3742c02353e15dd1e/html5/thumbnails/11.jpg)
Scleritis
![Page 12: Dr Rachael Neiderer - GP CME North/Sat_Plenary_0835... · Cyclosporine •0.05% to 2.0% used for severe allergic eye disease (vernal, atopic) •Steroid sparing agent •Available](https://reader034.vdocument.in/reader034/viewer/2022051918/600acdb3742c02353e15dd1e/html5/thumbnails/12.jpg)
Allergic conjunctivitis
• Acute hayfever conjunctivitis
• Seasonal allergic conjunctivitis
• Perennial allergic conjunctivitis
• Vernal keratoconjunctivitis
• Atopic keratoconjunctivitis
![Page 13: Dr Rachael Neiderer - GP CME North/Sat_Plenary_0835... · Cyclosporine •0.05% to 2.0% used for severe allergic eye disease (vernal, atopic) •Steroid sparing agent •Available](https://reader034.vdocument.in/reader034/viewer/2022051918/600acdb3742c02353e15dd1e/html5/thumbnails/13.jpg)
Vernal keratoconjunctivitis
• Age 9-19
• Boys > girls
• Warm climates
• Itching, redness, may have photophobia
• Signs: papillae, limbitis
• May develop shield ulcer
![Page 14: Dr Rachael Neiderer - GP CME North/Sat_Plenary_0835... · Cyclosporine •0.05% to 2.0% used for severe allergic eye disease (vernal, atopic) •Steroid sparing agent •Available](https://reader034.vdocument.in/reader034/viewer/2022051918/600acdb3742c02353e15dd1e/html5/thumbnails/14.jpg)
Shield ulcer
![Page 15: Dr Rachael Neiderer - GP CME North/Sat_Plenary_0835... · Cyclosporine •0.05% to 2.0% used for severe allergic eye disease (vernal, atopic) •Steroid sparing agent •Available](https://reader034.vdocument.in/reader034/viewer/2022051918/600acdb3742c02353e15dd1e/html5/thumbnails/15.jpg)
Atopic keratoconjunctivitis
• Adult onset
• Itch, photophobia, watering
• Signs: redness, fine papillary inflammation
• Periorbital atopic eczema
• Risk of secondary infection
• May develop corneal new vessels
![Page 16: Dr Rachael Neiderer - GP CME North/Sat_Plenary_0835... · Cyclosporine •0.05% to 2.0% used for severe allergic eye disease (vernal, atopic) •Steroid sparing agent •Available](https://reader034.vdocument.in/reader034/viewer/2022051918/600acdb3742c02353e15dd1e/html5/thumbnails/16.jpg)
Management
Simple things
• Stop rubbing!!
• Cold compresses
• Allergen avoidance
• Avoid non specific triggers: sun (sunglasses), wind, salt water (goggles)
• Topical lubricants (consider preservative free)
![Page 17: Dr Rachael Neiderer - GP CME North/Sat_Plenary_0835... · Cyclosporine •0.05% to 2.0% used for severe allergic eye disease (vernal, atopic) •Steroid sparing agent •Available](https://reader034.vdocument.in/reader034/viewer/2022051918/600acdb3742c02353e15dd1e/html5/thumbnails/17.jpg)
Topical treatment
• Topical antihistamine (e.g. livostin)
• Mast cell stabiliser• Sodium chromoglycate: need to use 6x daily, may
take 2 weeks to achieve therapeutic effect
• Lodaxamide (lomide): 2500x more potent inhibition of histamine release (animal models), more effective inhibition eosinophil activity, good for maintenance therapy but need very frequent dosing in acute exacerbation
![Page 18: Dr Rachael Neiderer - GP CME North/Sat_Plenary_0835... · Cyclosporine •0.05% to 2.0% used for severe allergic eye disease (vernal, atopic) •Steroid sparing agent •Available](https://reader034.vdocument.in/reader034/viewer/2022051918/600acdb3742c02353e15dd1e/html5/thumbnails/18.jpg)
Combined therapy
Dual action antihistamine and mast cell stabiliser
• Zaditor (ketotifen)
• Olopatadine (patanol)• Antihistamine, mast cell stabiliser and some cytokine inhibition
• Efficacy at least 12 hours
• Use twice daily
![Page 19: Dr Rachael Neiderer - GP CME North/Sat_Plenary_0835... · Cyclosporine •0.05% to 2.0% used for severe allergic eye disease (vernal, atopic) •Steroid sparing agent •Available](https://reader034.vdocument.in/reader034/viewer/2022051918/600acdb3742c02353e15dd1e/html5/thumbnails/19.jpg)
Steroids
• Great at relieving symptoms
• Short course can be very useful to get on top of symptoms
PROBLEMS:
• If diagnosis wrong, can make things worse
• Need to monitor intraocular pressure, can get quite marked pressure elevation, especially in children
• Long term risks: cataract, glaucoma
Need to be prescribed by ophthalmologist
![Page 20: Dr Rachael Neiderer - GP CME North/Sat_Plenary_0835... · Cyclosporine •0.05% to 2.0% used for severe allergic eye disease (vernal, atopic) •Steroid sparing agent •Available](https://reader034.vdocument.in/reader034/viewer/2022051918/600acdb3742c02353e15dd1e/html5/thumbnails/20.jpg)
Cyclosporine
• Immunosuppressant – initially used to treat transplant rejection
• Binds to cyclophilin in lymphocytes (especially T lymphocytes), preventing transcription and release of interleukin
• Directly inhibits eosinophil and mast cell activation
• Commonly used to treat dry eye and atopic disease in dogs
![Page 21: Dr Rachael Neiderer - GP CME North/Sat_Plenary_0835... · Cyclosporine •0.05% to 2.0% used for severe allergic eye disease (vernal, atopic) •Steroid sparing agent •Available](https://reader034.vdocument.in/reader034/viewer/2022051918/600acdb3742c02353e15dd1e/html5/thumbnails/21.jpg)
Cyclosporine
• 0.05% to 2.0% used for severe allergic eye disease (vernal, atopic)
• Steroid sparing agent
• Available as aqueous solution (Restasis 0.05%) or pharmacy compounded in oil
• Get reduced conjunctival fibroblast proliferation and increased tearing
![Page 22: Dr Rachael Neiderer - GP CME North/Sat_Plenary_0835... · Cyclosporine •0.05% to 2.0% used for severe allergic eye disease (vernal, atopic) •Steroid sparing agent •Available](https://reader034.vdocument.in/reader034/viewer/2022051918/600acdb3742c02353e15dd1e/html5/thumbnails/22.jpg)
Other options
Systemic immunosuppression
Surgery
• Debridement giant papillae
• Superficial keratectomy
![Page 23: Dr Rachael Neiderer - GP CME North/Sat_Plenary_0835... · Cyclosporine •0.05% to 2.0% used for severe allergic eye disease (vernal, atopic) •Steroid sparing agent •Available](https://reader034.vdocument.in/reader034/viewer/2022051918/600acdb3742c02353e15dd1e/html5/thumbnails/23.jpg)
Summary
• Large spectrum of disease
• Remember the simple treatments
• Stop rubbing!!
• Most common causes of visual loss are steroid complications and corneal scarring
Thank you Professor McGhee, Dr Trevor Gray, Dr Sue Ormonde and Dr David Pendergrast