Download - Electrical testing of pacemaker
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Msn Pavan Kumar,DM,NIMS.
Electrical Testing Of Pacemaker& Pacemaker Complications
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Electrical Testing Of PacemakerPacemaker complications
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Electrical Testing Of Pacemaker
Pacemaker components Battery Pacing impedance Pulse generator
1. Output circuit 2. Sensing circuit 3. Timing circuit4. Rate adaptive sensor5. Modes and mode switching
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Battery :Lithium iodine battery
High energy density , Long shelf life , Predictable loss of
batteryBOL (vol) – 2.8v BOL (res) - <1komhs
Electrical Testing Of Pacemaker
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Pacing impedance :Pacing impedance refers to the opposition to
current flow. Three sources contribute to pacing impedance:
1. Pacing lead conductor coil2. Electrode-tissue interface
Electrode resistance Polarization
Normal lead impedance vary from 250-1200ohms.Single impedance value may be of little use with
out previous values for comparison.
Electrical Testing Of Pacemaker
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1. Pulse generator output circuit Capture threshold , Pacing threshold , stimulation
threshold Minimum amount of energy required to constantly
cause depolarization Volts and pulse duration
Electrical Testing Of Pacemaker
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2.0 v 1.5 v 1 v
Electrical Testing Of Pacemaker
1. Pulse generator output circuit
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Electrical Testing Of Pacemaker
1. Pulse generator output circuit
Site At implantation
Acute Chronic
Atrium <1.5mv 3-5 times threshold voltage
Twice theThreshold voltage
Ventricle
<1mv With PW 0.5ms
With PW of 0.5ms
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1. Pulse generator output circuit High Pacemaker Output can
causeReduce longevity Diaphragmatic stimulationMuscle Sti. in Unipolar
pacemakersPatient may “feel” heart beat
Algorithm for checking pacemaker output threshold every beat and maintaining threshold just above it - Auto capture.
Electrical Testing Of Pacemaker
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Electrical Testing Of Pacemaker
2. Pulse generator sensing circuit : Ability of the device to detect intrinsic beat of
the heart Measured - peak to peak magnitude (mv) &
slew rate(mv/ms)
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2. Pulse generator sensing circuit :
Electrical Testing Of Pacemaker
Reduce Lower Rate below intrinsic rate to inhibit pacing and ensure intrinsic activity
Increase sensitivity setting while observing EGM. The sensitivity value at which sensing is lost on the EGM is the sensing threshold.
Sensitivity threshold safety is twice the attained valve. Sensitivity Slew rate
Atrium 1-2mv(0.5mv) > 0.5 v/s
ventricle 2-3mv > 0.75 v/s
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3. Pulse generator timing circuit :a. Lower rate limit (LRL)b. Hysteresis ratec. Refractory and blanking periodsd. Ventricular safety pacing interval .e. Upper rate response .
Electrical Testing Of Pacemaker
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3. Pulse generator timing circuit : Lower rate interval - lowest rate that the pacemaker
will pace . A paced or non-refractory sensed event restarts the
rate timer at the programmed rate.
Electrical Testing Of Pacemaker
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Condition LRL (beats/mt)
Infrequent pauses 40-50
Chronic persistent bradycardia 60-70
Relative bradycardia detrimental (long QT)
70-80
Detrimental fast heart rates (angina)
50-60
VVI 60-70
3. Pulse generator timing circuit :
Electrical Testing Of Pacemaker
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3. Pulse generator timing circuit : Hysteresis : Hysteresis allows the rate to drop below the programmed pacing
LRL. Advantages of hysteresis :
1. Encourages native rhythm – maintain AV sync in VVI , prolong battery life
2. Prevent retrograde conduction – avoids pacemaker syndrome
Electrical Testing Of Pacemaker
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AV delay (AVI) – pacemaker equivalent of PR interval.Sensed vs paced AVI – paced AVI is programmed at 125-
200ms , sensed AV interval is programmed at 20-50ms shorter than paced.
Dynamic AV delay allow pacemaker to respond to exercise
3. Pulse generator timing circuit :
Electrical Testing Of Pacemaker
sAVI – 150mspAVI – 200ms
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AV delay (AVI)Longer AVI :
Good AV conduction – maintains AV synchrony , long battery life
Achieved by following methods :Programming longer AVI , managed ventricular pacing , AV delay hysteresis .
Shorter AVI:HOCM – RV apical pacing decreases HOCM gradientCRT – usually 80-120ms , for 100%ventricular pacing and
optimize COPhysiological response to faster heart rates can be answered
3. Pulse generator timing circuit :
Electrical Testing Of Pacemaker
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Refractory and blanking periods :
Refractory period – sensing present but no action
Blanking period - sensing absent and hence no action
3. Pulse generator timing circuit :
Electrical Testing Of Pacemaker
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Blanking periods :3. Pulse generator timing circuit :
Electrical Testing Of Pacemaker
Blanking period
Time Importance
Atrial blanking period
50-100ms Non programmable ,Avoid atrial sensing of its own paced beat
Post ventricular atrial blanking period
220ms Avoid sensing of ventricular beatLong PVAB decreases detection of AF,AFL
Ventricular blanking period
50-100ms Non programmable,Avoid ventricular sensing of its paced beat
Post atrial ventricular blanking period
28ms if the PAvB period is too long, R on T - ventricular tachyarrhythmia.
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Refractory period:
Refractory period Importance
Ventricular refractory period (VRP)
Prevent sensing of T wave .
Atrial refractory period (ARP)
AVI (120-200ms) .
Post ventricular atrial refractory period
Avoid sensing retrograde P waves (PMT) , far field R waves .
3. Pulse generator timing circuit :
Electrical Testing Of Pacemaker
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3. Pulse generator timing circuit :
Electrical Testing Of Pacemaker
Ventricular safety pacing/ventricular triggered period/cross talk sensing window : Atrial pacing in DDD
Trigger ventricular sensing
PAVB - pAVI
False inhibition of ventricular pacing circuit
Asystole
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Rate responsive pacing refer to ability of pacemaker to increase its lower rate in response to physiological stimulus
Sinus node dysfunction , AF patients – fail to increase heart ratesHRR should start with in 10s of exercise , peak at 90 – 120s and
should return to baseline with in 60 – 120s after exercise.Fastest rate at which pacemaker will pace upper rate response.If intrinsic atrial rate exceeds URR then wenckebach or 2:1 AVBChoosing URR : young patients (150b/mt) , old angina
(<110b/mt).Various sensors (activity , minute ventilation , QT)
4. Pulse generator rate responsive pacing:
Electrical Testing Of Pacemaker
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4. Pulse generator rate responsive pacing:
Electrical Testing Of Pacemaker
Wenckebach
2:1 AVB
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4. Pulse generator modes:
Electrical Testing Of Pacemaker
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5. Pulse generator modes switching:
Electrical Testing Of Pacemaker
DDD / VDDAtrial tachyarrythmias
Sensed atrial events
Trigger fast ventricular rates
Palpitations. Dyspnoea. And Fatigue.
DDIR / VVIR
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5. Pulse generator modes switching:
Electrical Testing Of Pacemaker
Programming mode switching Mode switching occurs when the sensed atrial rate exceeds a programmed atrial tachycardia detection rate. By definition, this value must be faster than the URL (maximum tracking rate). Atrial tachycardia detection is typically programmed to 175-l88bpm or thereabouts.AMS base rate is higher than LRI.
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Electrical Testing Of Pacemaker
Pacemaker follow up guidelines:Transtelephonic monitoring guidelinesMedicare
guidelinesSingle chambered pacing
Dual chambered pacing
1st month q 2 week 1st month q 2 weeks
2nd -48th month q 12 week
2nd – 30th month q 12weeks
49th – 72nd month q 8 week
31st – 48th month q 8 weeks
73rd month and later q 4 weeks
49th month and later q 4week
NASPE guidelinesSingle or dual pacing
1st visit 6 – 8 week post implant , if symptomatic prior to this
5th month
From 6th month q 3month
Battery wear present q 1month
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Electrical Testing Of PacemakerPacemaker complications
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Pacemaker complications
Pocket complications
Pocket hematoma
Infection
Erosion
Wound pain
Allergic reactions
Pacemaker complications
Lead dislodgement
Pneumothorax /air embolism
Cardiac perforation
Extracardiac stimulation
Venous thrombosis
Coronary sinus dissection
Twidller syndrome
Pacemaker malfunction
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Pocket hematoma : The risk of haematoma is increased in patients taking
antithrombotic or anticoagulant drugs (Goldstein et al., 1998). Most small hematomas can be managed conservatively with
cold compress and withdrawal of antiplatelet or antithrombotic agents.
Occasionally, large hematomas that compromise the suture line or skin integrity may have to be surgically evacuated.
Needle aspiration increases risk of infection and should not be done.
Pacemaker complications
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Pocket hematoma : In patients requiring oral anticoagulants (warfarin), to take
INR of about 2.0 at the time of implantation is safe (Belott & Reynolds, 2000).
Unfractionated heparin or low-molecular-weight heparin are always discontinued prior to device implant and ideally avoided for a minimum of 24 hours post implantation.
Administration of anticoagulants can be resumed within 48-72 h after implantation if there is no evidence of substantial hematoma formation.
Pacemaker complications
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Device-related infections : The reported incidence of pacemaker-related infection ranges
from 0.5% to 6% in early series The use of prophylactic antibiotics and pocket irrigation with
antibiotic solutions has decreased the rate of acute infections following pacemaker implantations to <1 to 2 percent in most series
The mortality of persistent infection when infected leads are not removed can be as high as 66%.
DM, malignancy, operator inexperience, advanced age, corticosteroid use, anticoagulation, recent device manipulation, CRF, and bacteremia from a distant focus of infection.
Pacemaker complications
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Device related infection : Device infection is defined as either:
(a) deep infection - infection involving the generator pocket and/or the intravenous portion of the leads, with bacteremia, requiring device extraction or
(b) superficial infection - characterized by local inflammation, involving the skin but not the generator pocket, and treated with oral antibiotics.
Pacemaker complications
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Pacemaker complications
Device related infection :
2007;49;1851-1859 J. Am. Coll. Cardiol.
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Pacemaker complications
Device related infection :
2007;49;1851-1859 J. Am. Coll. Cardiol.
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Pacemaker complications
Device related infection :
2007;49;1851-1859 J. Am. Coll. Cardiol.
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Wound pain : Infection , Pacemaker implanted too superficially ,
Pacemaker implanted too laterally , Pacemaker allergy .Skin erosion : Incidence has been estimated around 0.8% .Old age ,
infection. Surgical revision of pocket and reimplantation . Allergic reactions : Always rule out infection before coming to diagnosis of
allergy
Pacemaker complications
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Lead dislodgement: Relatively common – 5-10%
of patients(ICD database 2001)
Atrial more common than ventricular(2-3% vs. 1%)
Micro dislodgement , macro dislodgement
Increased pacing threshold , failure to pace and sense
Active fixation (decreases risk)
Pacemaker complications
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Pneumothorax , : Uncommon complication – 1.6-
2.6% During or 48 hrs after procedure Inadvent puncture and laceration
of subclavian vein , artery or lung Related to operator experience
and underlying anatomy Avoided by
1. Venogram – flouroscpic puncture
2. Axillary venous access (Martin etal’96)
3. One way mechanism sheath
Pacemaker complications
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Cardiac Perforation : Uncommon but potentially serious complication - lower
than 1%. Acute (<5 days) , subacute(5d-1month) , chronic
(>1month) Increasing stimulation threshold , RBBB pattern for RV
pacing, intercostal muscle or diaphragmatic contraction, friction rub, and pericarditis, pericardial effusion, or cardiac tamponade.
CXR , ECHO , CT Lead withdrawal and repositioning ; surgical back up
Pacemaker complications
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Pacemaker complications
Cardiac Perforation :
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Extracardiac stimulation The diaphragm or pectoral or intercostal muscles Diaphragmatic stimulation - direct stimulation of the
diaphragm (left) or stimulation of the phrenic nerve (right). Early postimplantation period , dislodgment of the pacing
lead. MC in patients with LV coronary vein branch lead placement
for CRT Output pacing importance (testing and treatment) Pectoral stimulation - incorrect orientation of the
pacemaker or a current leak from a lead insulation failure or exposed connector.
Pacemaker complications
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Venous thrombosis : Venous thrombosis occurs in 30% to 50% of patients and
only 1-3% of patients become symptomatic. Manifestations vary from usually asymptomatic, acute
symptomatic thrombosis, and even SVCS . Early or late after pacemaker implantation. Predictors of severe stenosis are multiple pacemaker
leads , previous pacing , double coils , hormone therapy . Asymptomatic (no treatment) , symptomatic
(anticoagulants – endovascular stents – surgical correction ).
Pacemaker complications
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Twiddler syndrome:
Pacemaker complications
Obese women with loose, fatty subcutaneous tissueSmall size of the implanted generator
with a large pocket Twisting of pulse generator in long axis
Lead dislodgement and lead fracture
Failure to capture
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The prevelance of this syndrome is 0.07% (Gungor et al., 2009)
Rotated along the transverse axis it is referred by us as the reel syndrome.
Pocket should be revised. Avoid by
Limit the pocket size, Suture the device to the
fascia The patients not to
manipulate their device pocket
Twiddler syndrome:
Pacemaker complications
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Failure to captureFailure to outputSensing abnormalities(under and over
sensing)Specific mode complications
1. Pacemaker related tachycardia2. Pacemaker syndrome
Pacemaker malfunction
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Failure to capture:Pacing artifact present but no evoked potential .Causes
1. Lead dislodgement or perforation2. Lead maturation(inflammation/fibrosis)(exit block)3. Battery depletion4. Circuit failure(coil fracture , insulation defect)5. Capture management algorithm failure6. Inappropriate programming7. Pseudo malfunction8. Functional non capture9. Metabolic , drugs , cardiomyopathies
Pacemaker malfunction
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Electrocardiographic tracing from a patient with a DDDR pacemaker. All ventricular pacing artifacts but one failed to result in ventricular depolarization—
that is, failure to capture
Failure to capture:
Pacemaker malfunction
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Failure to capture:
Pacemaker malfunction
Pacing threshold
Normal Increased
Battery depletionFunctional non capture
Impedance
Normal DislodgementExit block
Decreased
Insulation failure/break
Increased Lead fracture Loose screw
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Failure to output:Absence of pacing stimuli and hence no capture .Causes
1. Pseudo malfunction - hysteresis , PMT termination , sleep rate
2. Over sensing - EMI ; T P R over sensing ; Myopotential/diaphragmatic ; Cross talk ; Make break signals
3. Open circuit - lead fracture , loose screw , air in the pocket , incompatible lead .
4. Battery depletion5. Recording artifact.
Pacemaker malfunction
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Failure to output:
Pacemaker malfunction
VVIR pacemaker This patient had a pacemaker programmed to a unipolar sensing configuration. The sensing of myopotentials led to symptomatic pauses,
and reprogramming the pacemaker to a bipolar sensing configuration prevented subsequent myopotential over
sensing.
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Application of magnet
Failure to output:
Pacemaker malfunction
Eliminates pauses
Pauses persistent
Impedance
Normal
Decreased
Insulation failure/break
Increased Lead fracture Loose screw
Battery depletion
Over sensingPseudo malfunction
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Battery depletion :Elective replacement indicators (ERI)
1. Low voltage(2.1-2.4)2. Low pacing rate on magnet application3. Elevated battery impedance4. Increased pulse width duration5. Restricted programmability6. Change to simpler pacing mode
End of life (EOL)1. Low voltage(≤2.1vol)
Pacemaker malfunction
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Pacemaker undersensing :Pacing artifact present but no sensing(sensed beat
doesn’t reset cycle)Causes are
1. Defect in signal production – scar /fibrosis , BBB , ectopic , cardioversion , defibrillation , metabolic.
2. Defect in signal transmission – lead fracture /dislodgement , insulation failure , partial open circuit.
3. Defect in pacemaker – battery depletion , sensing circuit abnormalities , committed DVI.
Pacemaker malfunction
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Pacemaker malfunction
Pacemaker undersensing :
VVI pacemaker
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Pacemaker over sensing :Present as failure to paceCauses
1. EMI 2. T , P , R over sensing .3. Cross talk4. Myopotential
(unipolar)5. Make break signals
Pacemaker malfunction
Cross talk :
High atrial outputHigh ventricular
sensitivityLow VBP
Ventricular sensing of paced atrial impulse
Pts with Poor AV conduction – Ventricular Asystole
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Electromagnetic interference :
Pacemaker malfunction
Source Pacer damage
Inhibition
Rate increase
Asynchronous noise
Uni/bipolar
Cardioversion/Defibrillation
Y N N N U/B
Anit theft devices /Weapon detector
N Y N N U
Phone (cell/cordless)
N Y Y Y U/B
Ablation Y Y Y N U/B
Diathermy/lithotripsy
Y Y Y Y U/B
FM radioTV transmitter
N Y N Y U
MRI/PET Y Y(N) Y(N) Y(N) U/B
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Pacemaker syndrome :Seen in 20% of PPI (5%
severe symptomatic)VVI/DDD/AAIPulsations in neck , fatigue
, cough ,chest fullness , headache , chocking sensation , PND , confusion , syncope , pulmonary edema.
Rx : VVI – program hysteresis , or change to DDD ; DDD –atrial lead reprogrammed or changed
Pacemaker malfunction
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Pacemaker mediated tachycardia :
Pacemaker malfunction
Dual chamberVPC , intact retrograde
conduction , PVARP<VA .Px , Rx :
1. PVARP > VA2. Long PVARP after VPC3. Absent atrial sensing
after VPC
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Pacemaker Testing
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Pacemaker Testing
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Pacemaker Testing
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Thank you
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Hey:Share with me please.