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EMGanalysis of MUP
and IPStålberg
STÅLBERG
2 normal motor units2 normal motor units2 normal motor units2 normal motor units
STÅLBERG
MyopathyMyopathy
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2
STÅLBERG
Reinnervated motor unitReinnervated motor unit
A
B
C
D
E
MU
ElectrodesElectrodes
Stålberg
ConcEMG
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3
New MU over the cannula
A
B
7
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4
oppositeside of nmj
end of propat tendon
slowly propSFAPrepolaristion
T
T
T
T
duration
startat nmj
phase
Stålberg
Parameters used in MUP analysisParameters used in MUP analysis
parameterparameter significancesignificance measurementmeasurement
• amplitude # fibres/0.5mm peak-peak• area # fibres/2 mm within dur• duration # fibres in 2.5 mm slope criteria• phases temp dispersion 0-cross + 1• turns “ change in dir• rise time closeness to fibre neg-pos peak• satellites extreme delay late spike• jiggle n-m transm shape stability
Stålberg,Nandedkar
This example: Multi MUP analysis
techniques to decompose a mixed signal into its constituentstechniques to decompose a mixed signal into its constituents
Decomposition;Decomposition;
Stålberg
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Multi-MUP, result
500 uV
10 ms
NormalNormal
NeuropathyNeuropathy
MyopathyMyopathy
MultiMulti--MUP analysis in different MUP analysis in different disordersdisorders
Stålberg
ongoingreinnervation
normal
late stage
A
B
Dynamics of reinnervation
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normal
Jiggle, ALS
Parameters to quantifyParameters to quantify
• shape of individual MUPs
• jiggle
• fullness
• recruitment (early, reduced)
• dynamic changes with time (fatigue)
Stålberg
Reference values - log amp
MUSCLENR: 26 Deltoideus
AGE
8070605040302010
log
ampl
(uV
)
4
3
2
1
sex
female
male
Total Population
Rsq = 0,0691
MUSCLENR: 26 Deltoideus
AGE
8070605040302010
log
ampl
(uV
)
4
3
2
1
sex
female
male
Total Population
Rsq = 0,0691
Stålberg
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Summary of ref values Summary of ref values -- log amplog amp
514352424152613411228545675N =
Frontalis
Vastus lateralis
Tibialis anterior
Ext dig brevis
Gastroc med
Abductor pollicis
Flex c rad
Biceps brachii
Deltoideus
Trapezius
Triceps
Ext dig comm
Interosseus dorsalis
Mea
n +
- 2
SD
log
ampl
(uV
)
4,0
3,5
3,0
2,5
2,0514352424152613411228545675N =
Frontalis
Vastus lateralis
Tibialis anterior
Ext dig brevis
Gastroc med
Abductor pollicis
Flex c rad
Biceps brachii
Deltoideus
Trapezius
Triceps
Ext dig comm
Interosseus dorsalis
Mea
n +
- 2
SD
log
ampl
(uV
)
4,0
3,5
3,0
2,5
2,0
Muscles
Stålberg
InterferenceInterferencepatternpattern
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EMG EMG -- interference patterninterference pattern
Normal
Myopathy
Neuropathy
1 s
1 mV
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Interference pattern analysisin normal, neuropathic and myopathic conditions
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envelopenss
SLIGHT MYOPTAHY
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MODERATE NEUROGENIC
envelopenss
envelopenss
CENTRAL WEAKNESS
SLIGHT MYOPATHY (TYPE 2 ?)
envelopenss
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MyopathyMyopathy
• spont (m) fib/psw myotonic CRD• spont (n)• MUP ↓ ampl ↓ dur• shape poly• jiggle• recruitment early• TA/FFT myopathic• fullness normal• FD ↑• jitter normal
Stålberg
Inactive neurogenicInactive neurogenic
• spont (m) • spont (n)• MUP ↑ ampl ↑ dur• shape• jiggle• recruitment late• TA/FFT neurog.• fullness ↓• FD ↑• jitter
Stålberg
Subacute neurogenicSubacute neurogenic
• spont (m) fib/psw CRD• spont (n) neuromyot myokymia• MUP ↑ ampl ↑ dur• shape poly• jiggle ↑• recruitment late• TA/FFT neurog.• fullness ↓• FD ↑• jitter ↑
Stålberg
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Myasthenic patternMyasthenic pattern
• spont (m) (fib/psw)• spont (n)• MUP• shape• jiggle ↑• recruitment• TA/FFT• fullness• FD normal• jitter ↑
Stålberg
Central weaknessCentral weakness
• spont (m) • spont (n)• MUP normal• shape normal• jiggle normal• recruitment irregular• TA/FFT• fullness ↓• FD normal• jitter
Stålberg
Comparison of electrophysiological parameters
Parameters normal myopathy den/reinn axon loss CB central
SFEMG FD n n n n
Conv MUP n n n n
Conv IP n myo neur
Macro n n n n n
MUNE n n n n n
TMS n n n abn
Stålberg
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Reasons for performing QEMG
• standardized way of measuring
• improved sensitivity
• new parameters
• results can be transferred– from one time to the other - follow up
– from one physician to the other
– from on lab to the other
• reliable results also from less experienced EMGers
• good for training Stålberg