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Endocrinology 4
Immune Endocrine Interactions
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Immune System Review
• Innate
• Adaptive
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Cytokines
• Chemokines– Chemotactic
• Inflammatory – TNF etc
• Anti-inflammatory– IL – 6
• Growth factors– Interferon
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Cytokines Communication
• Autocrine– Self
• Paracrine– Neighbor
• Juxtacrine– Specific neighbor
• Endocrine– blood
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Important Cytokines
• Tumor necrosis factor– Pro-inflammatory– Mobilization of anti-microbial substances– Denial of TNF increases infections– Can induce production of other cytokines as
well as cortisol– Can induce apoptosis in T-cells and tumor
cells
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Important Cytokines
• Interleukin 10– Anti-inflammatory– Immunostimulatory
• Production of B cells
• Interleukin 6– Increased in response to variety of stresses– Acute phase proteins
• Protease inhibitors• Microbial recognition proteins(C-reactive)• Cytokine antagonists• Activation of lipolysis
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Stress Response
• Stressor
• Stress-response
• Systems stimulated by stress– Hormonal
• Cortisol• Endorphins
– Sympathetic nervous system• Epinephrine• norepinephrine
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Stress Response
• Increases energy availability
• Increased oxygen uptake
• Changes in blood flow
• Inhibition of non-essential systems
• Decreased pain perception
• Enhancement of memory and sensory function
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Stress Response
• Systems Inhibited by Stress– GnRH, FSH, LH – GH and somatomedins
• Short term stress my increase GH in humans
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Stress Response
• Metabolic– Insulin inhibited– Glucagon, glucocorticoids, cathecholamines
increase– Body becomes catabolic
• Cardiovascular– HR, BP go up– Vasopressin goes up– Blood flow changes
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Stress Response
• Gastrointestinal– Gastric hormones decrease– Can stress make H. pylori infections worse?
• Reproductive– Sex hormones drop– GnRH inhibited by endorphins and CRH– Implantation less likely because of diminished
progesterone
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Stress response Pathology
• Catabolism• Increased CV tone• Suppression of
digestion• Suppression of
growth• Suppression of
reproduction• Suppression of
immunity
• Fatigue, myopathy• Hypertension• Ulcers
• Psychogenic dwarfism
• Anovulatory, impotence
• Impaired disease resistance