Engineering Innovations for Future Healthcare
James Goh, PhD Head and Professor, Department of Biomedical Engineering, NUS
President, International Federation of Medical and Biological Engineering
NO DISCLOSURE TO MAKE
Gaps identification
+3.9% CAGR (2011-2018)
How would Future Medicine looks like?
Wearables
Genomics
Proteomics
Internet of things
Drones
Robotics
3D printing
Nanotechnology
Telehealth
Data Analytics
Machine Learning
Artificial Intelligence
Future Medicine
Patient-centered, physician-directed teams
Value-driven: high quality at lowest cost
Connected and integrated – culturally and
digitally
Delivers measurable quality health care
Data management – health tracking, records,
data mining
Innovation: • Needs oriented
• Un-predictability
• Complexity – cross
disciplinary
• Time limited
• Disruptive
• Fanatical commitment
Drivers:
• Ageing population
• Rise in chronic diseases
• Shortage of health workers
• Shift from Independence to Interdependence
Big Data will get even Bigger
• Healthcare data (records, profile, images, fitness data…)
will grow exponentially with increased digitization
• Need for game-changing products and services portfolios
for big data management
• Increasingly customized and in real-time
Health Centric Devices and Digital Health • Rise of connected health with increased
fitness awareness
• Web portals will enable healthcare
agencies to remotely manage thousands
of wireless health devices
Microfluidic Technologies for Personalized Oncology
Exosomes Micro-
vesicles
Cancer
Cells CTCs
Detection &
Isolation
Single Cell
Analysis
Isolation &
Extraction
Patient blood Blood Salvage System
(CTC Dialysis)
CTC
Culture
Isolation
from urine
CTChip Technology Genetic & molecular Analysis
Medical Report
Name : XXXXXXX
XXXXX XXXX XXXX
XXXXX
XXXXX
XXX
XXX
XXXXX
CTC Analysis:
Cell Count XXX
Druggable Mutation – XXXX
XXXXXX
XXXXX
CTCs, plasma,
ctDNAs, buffy coat
Personalized treatment
CTCs for Targeted Therapy & Personalized Medicine
Prof Chwee-Teck LIM
Development of Integrated Photo Therapy Device (IPTD)
1
Yeo ELL, Cheah JUJ, Lim BY, Thong PSP, Soo KC,
Kah JCY*. Protein Corona around Gold Nanorods as a
Drug Carrier for Multimodal Cancer Therapy, ACS
Biomaterials Science & Engineering, submitted.
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20
40
60
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100
120
0 1 2 3 4
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20
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60
80
100
1200 10 20 30 40
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Ce
ll via
bili
ty (
%)
[NR] (pM)
[Ce6] (nM)
[Dox] (nM)
B
Ce
ll via
bili
ty (
%)
[NR] (pM)
NR-HS-Ce6-Dox
NR-HS-Ce6
NR-HS-Dox
Ce6 + Dox
NR-HS alone
Ce6 alone
Dox alone
A
[Dox] (nM)
[Ce6] (nM)
Dr. James CY Kah
Development of Integrated Photo Therapy Device (IPTD)
Yeo ELL, Thong PSP, Soo KC, Kah JCY*. Exploiting the Protein Corona around Gold Nanorods for Simultaneous Dual Modal Therapy in vivo,
ACS Nano, submitted.
0 min 10 min 20 min1 min
Saline
NR-MS-Ce6(PDT+PTT)
NR-MS(PTT)
MS-Ce6(PDT)
Rapid fiber-optic Raman endoscopy for real-time in vivo
cancer diagnosis in gastrointestinal tracts
Bergholt et al, Gastroenterology, 146(1), 27-32 (2014).
www.endofotonics.com
OD=1.8 mm
In vivo Raman endoscopy in determining lesion margins for endoscopic submucosal dissection
Summary
• Growth of MedTech R&D funding
• Drivers of MedTech growth
• Convergence of Technologies
– Advances in Omics
– Exciting Engineering Innovations
– Data Analytics and Machine Learning
• Immense opportunities and possibilities
Up Coming IFMBE-Sponsored Conferences
13
ASIA-PACIFIC CONFERENCE ON MEDICAL AND
BIOLOGICAL ENGINEERING 2017
November 2017, Sydney, Australia