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Early onset narcolepsy
Fang Han M.D.Department of Medicine, People’s Hospital
Peking University, China
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Child Narcolepsy in Chinese: an old disease
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Incidence of childhood narcolepsy during 5-year follow-upin a neurological clinic in Beijing Children’s Hospital
It is estimated that the incidence of childhood narcolepsy was between 0.04%-0.063% in a pediatric neurology clinic during 5-year follow-up. This is equivalent to the prevalence of adult patients in Hongkong Chinese.
Wing YK, et al. 2001
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Area distribution of Narcolepsy
BJ 184
JS 10
LN 23
SD 27 SX 27
SC 6
TJ 7
JL 12
QH 2
HB 95
HN 37
AH 7HUB 3
SX 10
GS 2
XJ 2
HLJ 20
Tibet 2
NMG 27
ZJ 5
SH 5
HN 3
YN 3 GD 3
NX 5
JX 1
FJ 1
GZ 2
This lab has 70-80% (total around 700) diagnosed narcolepsy in China300/700 had onset <10 Year old
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Pat
ient
Num
ber
020406080
100120140160180 Chinese n=462
Japanese n=465
AGE OF ONSET
Between Sep. 1998 to Sep. 2007, 580 patients diagnosed as narcolepsy, and the data of 462 is presented
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• Early on set narcolepsy has more severe daytime sleepiness and high rate of cataplexy, and MSLT testing showed more SOREMs.
• More familial effect indicated that genetic effect might play a more important role in the development of symptoms in early onset narcoleptics