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Lecture 8 Slides
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First, a little cell biology….
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fig 19-1
The mitochondrion (plural mitochondria)
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fig 19-1
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Krebs cyclefeatures andfunctions…
fig 16-13
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making citrate asymmetric
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Stereochemistry of isocitrate production
box 16-3
misprint
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Stereochemistry of isocitrate production
box 16-3
misprint
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Stereochemistry of isocitrate production: corrected
box 16-3
correction
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Stereochemistry of isocitrate production
but…. WHY?
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Why isn’t this reaction random?
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Stereochemistry of isocitrate production
Alexander “Sandy”Ogston
this result implies enzyme has asymmetric “landing site”
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this result implies enzyme has asymmetric “landing site”
Stereochemistry of isocitrate production
box 16-3
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Stereochemistry of isocitrate production
box 16-3
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implies enzyme has asymmetric “landing site”
but…
Stereochemistry of isocitrate production
box 16-3
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also means the substrate, citrate, was MADE asymmetrically!
is this hard to imagine?box 16-3
CH2-COO-
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fig 16-8
Citrate synthase…
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Krebs cycle and energy revenue
fig 16-13
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Krebs cycle and energy revenue
table 16-1
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fig 16-14
a molecular antique fromthe days whenbefore it wasa cycle…
a fermentation!
NADH
FADH2
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the amphibolic Krebs cycle…
fig 16-15
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the amphibolic Krebs cycle: anapleurotic reactions
fig 16-15
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the anaplerotic reactions
table 16-2
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the anaplerotic reactions
table 16-2
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an example: pyruvate carboxylase
table 16-2
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Biotin! activation of CO2 in pyruvate carboxylase
fig 16-16
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fig 16-16
Biotin! activation of CO2 in pyruvate carboxylase
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fig 16-16
Biotin! activation of CO2 in pyruvate carboxylase
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fig 16-16
Biotin! activation of CO2 in pyruvate carboxylase
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fig 16-16
Biotin! activation of CO2 in pyruvate carboxylase
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fig 16-16
Biotin! activation of CO2 in pyruvate carboxylase
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Regulationof the Krebscycle at multiple reactions…
fig 16-18
three bigenergy drops areregulated
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Regulationof the Krebscycle...
three bigenergy drops areregulated
fig 16-18
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Regulationof the Krebscycle...
three bigenergy drops areregulated
fig 16-18
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Regulationof the Krebscycle...
three bigenergy drops areregulated
fig 16-18