Download - Fluids,Electolytes Balance
![Page 1: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/1.jpg)
FLUIDS ELECTROLYTES BALANCE
Dr Krunal Karade
![Page 2: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/2.jpg)
BASIC PHYSIOLOGY : BODY WATER1)The human body consists of about 50-
70% liquids & 30-50% solids by weight. The liquid portion varies with age , sex & fat content (as fat contain very little water) .
2)In adult male TBW: 60% In adult female: 50% In neonates: 80% In TBW Thin > than obese individuals.
![Page 3: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/3.jpg)
TOTAL BODY WATER:Body wt% Total body
water%
Total 60 100intracellular 40 67(2/3)extracellular 20 33(1/3)a) Plasma 5 8b) Interstitial 15 25
![Page 4: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/4.jpg)
NORMAL WATER BALANCE:Oral (or IV)fluid intake & urine output are
important measurable parameters of body fluid balance.
To determine daily fluid requirement of body we should know insensible fluid input & loss:
![Page 5: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/5.jpg)
SO HIGHER AMOUNT OF WATER IS LOST DURING EXERCISE ,ABNORMAL SWEATING, PYREXIA, BURN & SURGERY.IN NORMAL PERSON DAILY INSENSIBLE LOSS IS 700 ML ,SO DAILY FLUID REQUIREMENT = U.O. +700 ML.
![Page 6: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/6.jpg)
FLUID AND ELECTROLYTE TRANSPORT PASSIVE
TRANSPORT SYSTEMSDiffusionFiltrationOsmosis
ACTIVE TRANSPORT SYSTEMPumpingRequires
energy expenditure
![Page 7: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/7.jpg)
FLUID TYPES Isotonic
Hypotonic
Hypertonic
![Page 8: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/8.jpg)
ISOTONIC SOLUTION No fluid shift because solutions are
equally concentrated Normal saline (NS)solution (0.9% NaCl)
![Page 9: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/9.jpg)
HYPOTONIC SOLUTION Lower solute concentration Fluid shifts from hypotonic solution into
the more concentrated solution to create a balance (cells swell)
Half-normal saline solution (0.45% NaCl)
![Page 10: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/10.jpg)
HYPERTONIC SOLUTION Higher solute concentration
Fluid is drawn into the hypertonic
solution to create a balance (cells
shrink)
5% dextrose in normal saline (DNS)
![Page 11: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/11.jpg)
REGULATORY MECHANISMS OF FLUID Baroreceptor reflex
Volume receptors
Renin-angiotensin-aldosterone
mechanism
Antidiuretic hormone (ADH)
![Page 12: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/12.jpg)
BARORECEPTOR REFLEX Respond to a fall in arterial blood
pressure Located in the atrial walls, vena cava,
aortic arch and carotid sinus Constricts afferent arterioles of the
kidney resulting in retention of fluid
![Page 13: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/13.jpg)
VOLUME RECEPTORS Respond to fluid excess in the atria and
great vessels Stimulation of these receptors creates a
strong renal response that increases urine output
![Page 14: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/14.jpg)
RENIN-ANGIOTENSIN-ALDOSTERONE Renin
Enzyme secreted by kidneys when arterial pressure or volume drops
Interacts with angiotensinogen to form angiotensin I (vasoconstrictor)
![Page 15: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/15.jpg)
RENIN-ANGIOTENSIN-ALDOSTERONE Angiotensin
Angiotensin I is converted in lungs to angiotensin II using ACE (angiotensin converting enzyme)
Produces vasoconstriction to elevate blood pressure
Stimulates adrenal cortex to secrete aldosterone
![Page 16: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/16.jpg)
RENIN-ANGIOTENSIN-ALDOSTERONE Aldosterone
Mineralocorticoid that controls Na+ and K+ blood levels
Increases Cl- and HCO3- concentrations and fluid volume
![Page 17: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/17.jpg)
ALDOSTERONE NEGATIVE FEEDBACK MECHANISM When ECF & Na+ levels drop secretion
of ACTH by the anterior pituitary release of aldosterone by the adrenal cortex fluid and Na+ retention
![Page 18: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/18.jpg)
ANTIDIURETIC HORMONE Also called vasopressin Released by posterior pituitary when
there is a need to restore intravascular fluid volume
Release is triggered by osmoreceptors in the thirst center of the hypothalamus
Fluid volume excess decreased ADH Fluid volume deficit increased ADH
![Page 19: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/19.jpg)
FLUID IMBALANCES Dehydration Hypovolemia Hypervolemia
![Page 20: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/20.jpg)
DEHYDRATION Loss of body fluids increased
concentration of solutes in the blood and a rise in serum Na+ levels
Fluid shifts out of cells into the blood to restore balance
Cells shrink from fluid loss and can no longer function properly
![Page 21: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/21.jpg)
CLIENTS AT RISK Confused Comatose Bedridden Infants Elderly Enterally fed
![Page 22: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/22.jpg)
WHAT DO YOU SEE? Irritability Confusion Dizziness Weakness Extreme thirst urine output
Fever Dry skin/mucous
membranes Sunken eyes Poor skin turgor Tachycardia
![Page 23: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/23.jpg)
WHAT DO WE DO? Fluid Replacement - oral or IV over 48
hrs. Monitor symptoms and vital signs Maintain I&O Maintain IV access Daily weights Skin and mouth care
![Page 24: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/24.jpg)
HYPOVOLEMIA Isotonic fluid
loss from the extracellular space
Can progress to hypovolemic shock
Caused by:Excessive fluid loss (hemorrhage)
Decreased fluid intake
Third space fluid shifting
![Page 25: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/25.jpg)
WHAT DO YOU SEE? Mental status
deterioration Thirst Tachycardia Delayed
capillary refill
postural hypotension
Urine output < 30 ml/hr
Cool, pale extremities
Weight loss
![Page 26: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/26.jpg)
WHAT DO WE DO? Fluid
replacement Albumin
replacement Blood
transfusions for hemorrhage
Dopamine to maintain BP
MAST trousers for severe shock
Assess for fluid overload with treatment
![Page 27: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/27.jpg)
HYPERVOLEMIA Excess fluid in the extracellular
compartment as a result of fluid or sodium retention, excessive intake, or renal failure
Occurs when compensatory mechanisms fail to restore fluid balance
Leads to CHF and pulmonary edema
![Page 28: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/28.jpg)
WHAT DO YOU SEE? Tachypnea Dyspnea Crackles Rapid, bounding
pulse Hypertension
Increased CVP, pulmonary artery pressure and pulmonary artery wedge pressure
Increased JVP Acute weight
gain Edema
![Page 29: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/29.jpg)
EDEMA Fluid is forced into tissues by the
hydrostatic pressure First seen in dependent areas Anasarca - severe generalized edema Pitting edema Pulmonary edema
![Page 30: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/30.jpg)
WHAT DO WE DO? Fluid and Na+
restriction Diuretics Monitor vital
signs Hourly I&O Breath sounds
Monitor ABGs and labs
Maintain IV access
Skin & mouth care
Daily weights
![Page 31: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/31.jpg)
DISTRIBUTION OF ELECTROLYTES:
![Page 32: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/32.jpg)
ELECTROLYTE IMBALANCES Hyponatremia/ hypernatremia
Hypokalemia/ Hyperkalemia Hypocalcemia/ Hypercalcemia
Hypophosphatemia/
Hyperphosphatemia
Hypochloremia/ Hyperchloremia
![Page 33: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/33.jpg)
SODIUM
Major extracellular cation
Attracts fluid and helps preserve fluid
volume
Combines with chloride and bicarbonate
to help regulate acid-base balance
Normal range of serum sodium 135 -
145 mEq/L
![Page 34: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/34.jpg)
SODIUM AND WATER If sodium intake suddenly increases,
extracellular fluid concentration also rises
Increased serum Na+ increases thirst and the release of ADH, which triggers kidneys to retain water
Aldosterone also has a function in water and sodium conservation when serum Na+ levels are low
![Page 35: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/35.jpg)
SODIUM-POTASSIUM PUMP Sodium (abundant
outside cells) tries to get into cells
Potassium (abundant inside cells) tries to get out of cells
Sodium-potassium pump maintains normal concentrations
Pump uses ATP, magnesium and an enzyme to maintain sodium-potassium concentrations
Pump prevents cell swelling and creates an electrical charge allowing neuromuscular impulse transmission
![Page 36: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/36.jpg)
HYPONATREMIA Serum Na+ level < 135 mEq/L Several types
DilutionalDepletionalHypovolemicHypervolemic Isovolemic
![Page 37: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/37.jpg)
TYPES OF HYPONATREMIA Dilutional - results from Na+ loss, water
gain Depletional - insufficient Na+ intake Hypovolemic - Na+ loss is greater than
water loss; can be renal (diuretic use) or non-renal (vomiting)
Hypervolemic - water gain is greater than Na+ gain; edema occurs
Isovolumic - normal Na+ level, too much fluid
![Page 38: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/38.jpg)
WHAT DO YOU SEE? Primarily neurologic symptoms
Headache, N/V, muscle twitching, altered mental status, stupor, seizures, coma
Hypovolemia - poor skin turgor, tachycardia, decreased BP, orthostatic hypotension
Hypervolemia - edema, hypertension, weight gain, bounding tachycardia
![Page 39: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/39.jpg)
WHAT DO WE DO? MILD CASE
Restrict fluid intake for hyper/isovolemic hyponatremia
IV fluids and/or increased po Na+ intake for hypovolemic hyponatremia
SEVERE CASE Infuse hypertonic
NaCl solution (3% or 5% NaCl)
Furosemide to remove excess fluid
Monitor client in ICU
![Page 40: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/40.jpg)
HYPERNATREMIA Excess Na+ relative to body water Occurs less often than hyponatremia Thirst is the body’s main defense When hypernatremia occurs, fluid shifts
outside the cells May be caused by water deficit or over-
ingestion of Na+ Also may result from diabetes insipidus
![Page 41: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/41.jpg)
WHAT DO YOU SEE? Think S-A-L-T
Skin flushedAgitationLow grade feverThirst
Signs of hypovolemia
![Page 42: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/42.jpg)
WHAT DO WE DO? Correct underlying disorder Gradual fluid replacement Monitor for cerebral edema (headache,
loss of coordination , weakness, and decreasing levels of consciousness including disorientation, loss of memory, hallucinations, psychotic behavior, and coma)
Monitor serum Na+ level
![Page 43: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/43.jpg)
POTASSIUM Major intracellular cation Untreated changes in K+ levels can lead
to serious neuromuscular and cardiac problems
Normal K+ levels = 3.5 - 5 mEq/L
![Page 44: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/44.jpg)
BALANCING POTASSIUM Most K+ ingested is excreted by the
kidneys Three other influential factors in K+
balance :Na+/K+ pumpRenal regulationpH level
![Page 45: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/45.jpg)
SODIUM/POTASSIUM PUMP Uses ATP to pump potassium into cells Pumps sodium out of cells Creates a balance
![Page 46: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/46.jpg)
RENAL REGULATION Increased K+ levels increased K+ loss in
urine Aldosterone secretion causes Na+
reabsorption and K+ excretion pH: Potassium ions and hydrogen ions
exchange freely across cell membranes In Acidosis hyperkalemia (K+ moves out
of cells) In Alkalosis hypokalemia (K+ moves
into cells)
![Page 47: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/47.jpg)
HYPOKALEMIA Serum K+ < 3.5 mEq/L Can be caused by GI losses, diarrhea,
insufficient intake, non-K+ sparing diuretics (thiazide, furosemide)
![Page 48: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/48.jpg)
WHAT DO YOU SEE? Think S-U-C-T-I-O-N
Skeletal muscle weaknessU wave (ECG changes)Constipation, ileusToxicity of digitalis glycosides Irregular, weak pulseOrthostatic hypotensionNumbness (paresthesias)
![Page 49: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/49.jpg)
WHAT DO WE DO? Increase dietary K+ Oral KCl supplements IV K+ replacement Change to K+-sparing diuretic Monitor ECG changes
![Page 50: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/50.jpg)
IV K+ REPLACEMENT Mix well when adding to an IV solution
bag Concentrations should not exceed 40-60
mEq/L Rates usually 10-20 mEq/hr NEVER GIVE IV PUSH POTASSIUM
![Page 51: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/51.jpg)
HYPERKALEMIA Serum K+ > 5 mEq/L
Less common than hypokalemia Caused by altered kidney function,
increased intake (salt substitutes), blood transfusions, meds (K+-sparing diuretics), cell death (trauma)
![Page 52: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/52.jpg)
WHAT DO YOU SEE? Irritability Paresthesia Muscle weakness (especially legs) ECG changes Irregular pulse Hypotension Nausea, abdominal cramps, diarrhea
![Page 53: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/53.jpg)
WHAT DO WE DO? MildWhat Do We Do?
Loop diuretics (Lasix)Dietary restriction
ModerateKayexalate
Emergency10% calcium gluconate for cardiac effectsSodium bicarbonate for acidosis
![Page 54: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/54.jpg)
CALCIUM 99% in bones, 1% in serum and soft
tissue (measured by serum Ca++) Works with phosphorus to form bones
and teeth Role in cell membrane permeability Affects cardiac muscle contraction Participates in blood clotting
![Page 55: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/55.jpg)
CALCIUM REGULATION Affected by body stores of Ca++ and by
dietary intake & Vitamin D intake Parathyroid hormone draws Ca++ from
bones increasing low serum levels (Parathyroid pulls)
With high Ca++ levels, calcitonin is released by the thyroid to inhibit calcium loss from bone (Calcitonin keeps)
![Page 56: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/56.jpg)
HYPOCALCEMIA Serum calcium < 8.9 mg/dl Ionized calcium level < 4.5 mg/Dl Caused by inadequate intake,
malabsorption, pancreatitis, thyroid or parathyroid surgery, loop diuretics, low magnesium levels
![Page 57: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/57.jpg)
WHAT DO YOU SEE? Neuromuscular
Anxiety, confusion, irritability, muscle twitching, paresthesias (mouth, fingers, toes), tetany
Fractures Diarrhea ECG changes
![Page 58: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/58.jpg)
WHAT DO WE DO? Oral or IV calcium replacement
Calcium gluconate for postop thyroid or
parathyroid client
Cardiac monitoring
![Page 59: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/59.jpg)
HYPERCALCEMIA Serum calcium > 10.1 mg/dl Ionized calcium > 5.1 mg/dl Two major causes
CancerHyperparathyroidism
![Page 60: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/60.jpg)
WHAT DO YOU SEE? Fatigue, confusion, lethargy, coma Muscle weakness, hyporeflexia Bradycardia cardiac arrest Anorexia, nausea/vomiting, decreased
bowel sounds, constipation Polyuria, renal calculi, renal failure
![Page 61: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/61.jpg)
WHAT DO WE DO? If asymptomatic, treat underlying cause Hydrate the patient to encourage
diuresis Loop diuretics Corticosteroids
![Page 62: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/62.jpg)
BASIC PRINCIPLES OF FLUID THERAPY : Advantage: 1)Accurate ,controlled & predictable way
of administration. 2)Immediate response due to direct
infusion in intravascular compartment. 3)Prompt correction of serious fluid &
electrolyte disturbances.
![Page 63: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/63.jpg)
INDICATION:1) Conditions when oral intake is not possible
e.g. coma , anesthesia ,surgery.2) Severe vomiting & diarrhoea.3) Moderate to severe dehydration & shock4) Hypoglycemia where 25% dextrose is life
saving.5) As a vehicle for various I.V. medication e.g.
antibiotics , chemotherapeutic agents , insulin, vasopressor agents.
6) Total parenteral nutrition.7) Treatment of critical problems:
shock ,anaphylaxis ,cardiac arrest & forced diuresis in drug overdose ,poisoning.
![Page 64: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/64.jpg)
CONTRAINDICATION:1) I.V. fluid should be avoided if patient is
able to take oral fluid.2) Preferable to avoid I.V. fluid in patient
with congestive heart failure or volume overload.
![Page 65: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/65.jpg)
COMPLICATIONS: 1)Local- Heamatoma , infiltration &
infusion phlebitis. 2)Systemic- circulation overload with
cardiac problem , rigors ,air embolism & septicaemia.
3)Others- fluid contamination, fungus in I.V. fluids, mixing of incompatible drugs ,improper technique of infusion , iv set or iv catheter related problems.
![Page 66: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/66.jpg)
CLASSIFICATION OF I.V. FLUIDS: 3 GROUPS 1)Maintenance fluids: Its replaces fluid lost from
lungs ,skin ,urine & faeces. These losses are poor in salt so this maintenance fluid should be hypotonic to plasma .e.g. 5% dextrose ,dextrose with 0.45%NaCL solution.
2)Replacement Fluids: formulated to correct body fluid deficit caused by losses such as gastric drainage, vomiting ,diarrhoea ,fistula drains , intestinal oedema, oozing from trauma, infection, burns,ect. E.g. Riger’s lactate, Isotonic saline, DNS , isolyte-M,P &G.
3)Special fluids: Special fluids are used for the special indications such as hypoglycemia , hypokalemia & metabolic acidosis.e.g 25% dextrose , inj dextrose ,inj potassium chloride & inj sodium bicarbonates.
![Page 67: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/67.jpg)
![Page 68: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/68.jpg)
DEXTROSE SALINE (DNS): 5% DEXTROSE WITH 0.9% NACL Indication:1) correction of salt depletion
& hypovolemia with supply of energy. 2)Correction of vomiting or nasogastric
aspiration induced alkalosis & hypochloremia along with supply of calories.
3)fluid compatible with blood transfusion.
Contraindications: 1)Anasarca 2) Hypovolemic shock.
![Page 69: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/69.jpg)
RINGER’S LACTATE: Indication: 1) correction of severe
hypovolemia rapidly. 2)for replacing fluid in postoperative patients,
burns ,fractures ,peritoneal irrigation ect. 3)Diarrhoea induced hypovolemia. 4) In diabetic ketoacidosis 5)For maintaining normal ECF fluid &
electrolyte balance during & after surgery. Contraindication: in liver disease ,in severe
CHF ,Rl & blood product in one IV line is contraindicated , calium In RL binds with certain drugs (amphotericin ,ampicillin).
![Page 70: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/70.jpg)
NORMAL SALINE(NS): NACL 0.9% Indication:1)water & salt depletion as in
diarrhoea , vomitting ,excessive diuresis.
2)Treatment of hypovolemic shock. 3)Irrigation of washing of body fluids. 4)As a vehicle for certain drugs & can be
given safely with blood. Contraindications:Avoid in hypertensive
or preeclampsia ,CHF ,renal disease & cirrhosis. Dehydration with severe hypokalemia.
![Page 71: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/71.jpg)
5% DEXTROSE:Indication:1)Fluid to provide adequate
calories to body.2)For pre & post operative fluid
replacement.3)For I.V. administration of various drugs4) For treatment of ketosis in
starvation ,diarrhoea ,vomiting & high grade fever.
Contraindication: Cerebral oedema , Neurosurgical procedures, stroke.
![Page 72: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/72.jpg)
ISOLYTE-P Indication: 1)Used as maintenance fluid
in infants & children to provide daily water & electrolytes.
2)Excessive water loss or inability to concentrate urine.(DI)
Contraindication: Renal failure, Hypovolemic shock.
![Page 73: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/73.jpg)
FLUID REQUIREMENT IN SURGICAL PATIENT: Patients awaiting surgery need to be kept fasting
for a few hours prior to & after the surgery hence fluid loss during this period needs to be replaced.
Replacement as follows: 1)Fluid requirement during starvation- 2ml/kg/h
of fasting ,replaced over 2-3 hrs. 2)Maintenance requirement- 2ml/kg/hr of
surgery. 3)Third space losses-a)minimal dissection-4ml/kg/hrb) Moderate dissection-6ml/kg/hrc) Large amount of dissection- 8ml/kg/hr of
surgery
![Page 74: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/74.jpg)
IF HAEMATOCRIT FALL BELOW <25%-BLOOD LOSS IS REPLACED BY BLOOD TRANFUSION.IF HAEMATOCRIT >25%- BLOOD LOSS IS REPLACED WITH EQUAL AMOUNT OF COLLOID [ PLASMA EXPANDER (DRAW FLUID INTO THE BLOODSTREAM)ALBUMINPLASMA PROTEINDEXTRAN] OR 3 TIMES THE VOL WITH CRYSTALLOID.A PATIENT UNDERGOING SURGERY SHOULD RECEIVE =FLUID DEFICIT DUE TO STARVATION+MAINTENANCE FLUIDS+3RD SPACE LOSSES+ REPLACEMENT OF BLOOD LOSS.ADEQUACY OF FLUID REPLACEMENT CHECKED WITH HAEMODYNAMIC STABILITY & U.O. & IN MAJOR SURGERY BY CENTRAL VENOUS PRESSURE MONITORING.
![Page 75: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/75.jpg)
WHAT TO GIVE: Starvation losses: replaced by an
infusion of 5% dextrose. Maintenance & 3rd space losses : By RL.
![Page 76: Fluids,Electolytes Balance](https://reader034.vdocument.in/reader034/viewer/2022051512/544f0b4ab1af9f1f638b55ad/html5/thumbnails/76.jpg)