Download - GPCR Edition – Week 1
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GPCR Edition – Week 1
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Amino Acid
Structure
Amino Acids: Misc.
GPCR Structure
Chemical Interactio
ns
Protein Secondary & Tertiary Structure
Potpourri
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GLYCINE
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VALINE
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CYSTEINE
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Histidine
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TRYPTOPHAN
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THE AMINO ACID ARGININE HAS THIS
GROUPING OF AMINO ACIDS, ALONG WITH
LYCINE AND HISTIDINE (IF THE PH IS JUST
RIGHT)POSITIVELY CHARGED
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THIS AMINO ACID CAN BE ABBREVIATED AS
“GLN” OR “Q”
GLUTAMINE
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THE AMINO ACID ARGININE IS
ABBREVIATED AS “ARG” AS WELL AS THIS ONE LETTER
R
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“ALPHA” REFERS TO THIS ELEMENT THAT IS COVALENTLY BONDED TO AN AMINO GROUP, A CARBOXYL GROUP, A
HYDROGEN, AND A SIDE CHAIN
CARBON
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THIS NUMBER IS THE NET NEGATIVE OR
POSITIVE CHARGE OF THE FOLLOWING
SHORT OLIGOPEPTIDE:DEKHR
+1
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GPCRS ARE ALSO KNOWN AS
HETPAHELICAL RECEPTORS, MEANING
THEY HAVE THIS NUMBER OF ALPHA
HELICESSEVEN
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PHOSPHOLIPID
GPCRS ARE EMBEDDED INTO A
MEMBRANE BILAYER COMPOSED OF THIS TYPE OF BIOLOGICAL
MOLECULE
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GPCRS ARE VERY DIFFICULT TO
CRYSTALLIZE AND OFTEN TIMES HAVE
CRYSTALLIZATION “HANDLES” FUSED TO
THEM. THIS ONE IS SIMILAR TO WHAT WE
USED IN OUR EXPERIMENT.T4 LYSOZYME
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THIS CLASS OF GPCRS HAS A LARGE
EXTRACELLULAR DOMAIN WITH A
“VENUS-FLYTRAP” STRUCTURE WHERE
LIGANDS BINDCLASS C
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CLASS A GPCRS HAVE THIS CONSERVED
SEQUENCE MOTIF OF THREE AMINO ACIDS
THAT MEDIATES COUPLING TO G
PROTEINSDRY, ASP-ARG-TYR
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THE ATTRACTION OF A CATION TO AN ANION IS REFERRED TO AS THIS
TYPE OF NON-COVALENT CHEMICAL
INTERACTIONIONIC/
ELECTROSTATIC
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HYDROGEN BOND
THE NON-COVALENT INTERACTION SHOWN
HERE
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THIS NON-COVALENT IS WHAT DRIVES NON-POLAR AMINO ACIDS
TO ORIENT THEMSELVES
TOWARDS THE INTERIOR OF A
PROTEIN AND AWAY FROM WATERHYDROPHOBIC
EFFECT
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CARBOXYL
A PEPTIDE BOND IS A COVALENT CHEMICAL
INTERACTION BETWEEN THE AMINO GROUP OF ONE AMINO ACID AND THIS GROUP
OF THE OTHER
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HYDROGEN BONDING BETWEEN THE CARBONYL
OXYGEN AND AMINO GROUP HYDROGEN OF TWO AMINO ACIDS 4 RESIDUES APART STABILIZES THIS TYPE OF
STRUCTUREALPHA HELIX
DAILY DOUBLE
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THIS IS THE SIMPLEST ARRANGEMENT A
POLYPEPTIDE CHAIN CAN MAKE IN TERMS
OF SECONDARY STRUCTURE
ALPHA HELIX
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THIS AMINO ACID’S RIGIDITY RESULTS IN ITS LOW PROBABILITY OF BEING FOUND IN
AN ALPHA HELIX
PROLINE
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THE PARTIAL POSITIVE AND NEGATIVE CHARGE OF AN ALPHA HELIX N- AND C-
TERMINUS, RESPECTIVELY, IS REFERRED TO AS THIS
HELIX DIPOLE
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THIS IS THE NAME OF THE CHART THAT MEASURES THE PROBABILITY OF
PARTICULAR PSI AND PHI ANGLES TO BE
FOUND IN SECONDARY STRUCTURERAMACHANDRAN
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THIS PROTEIN STRUCTURAL MOTIF IS
NAMED AFTER A COMMON
ARCHITECTURAL DESIGN FOUND IN THE
HELLENIC REPUBLICGREEK KEY MOTIF
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THIS LEVEL OF PROTEIN STRUCTURE IS THE
ARRANGEMENT OF 2 OR MORE SEPARATE
POLYPEPTIDE CHAINS (SUBUNITS)
QUATERNARY
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GPCRS ARE COMPOSED PRIMARILY
OF THIS TYPE OF SECONDARY STRUCTURE
ALPHA HELIX
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THE FUNCTIONAL AND FOLDED STRUCTURE OF A PROTEIN IN ITS
NORMAL ENVIRONMENT IS KNOWN AS THIS
NATIVE CONFORMATION
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THE FORMATION OF A PEPTIDE BOND BETWEEN
TWO AMINO ACIDS RESULTS IN THE
CREATION OF THIS MOLECULE, WHICH IS WHY THE REACTION IS
CALLED CONDENSATIONWATER
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WHICH UNIVERSITY IS THE ONLY ONE IN NCAA HISTORY TO
HOLD THE NATIONAL TITLE IN BOTH
BASKETBALL AND FOOTBALL?
UNIVERSITY OF FLORIDA