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HORMONES THATHORMONES THAT
REGULATE CALCIUMREGULATE CALCIUM
METABOLISMMETABOLISM• PARATHYROID ( PTH )
• CALSITRIOL
•CALSITONIN
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DEVIATION OF CALCIUM REGULATION : LIVE THREATENING
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1 KG CALCIUM IN OUR BODY, 9 ! IN BONE
1! OF BONE CALCIUM IS FREELY EXCHANGEABLE "ITH
EXTRACELLULAR FLUID CALCIUM
PLASMA CALCIUM :
COMPLEX "ITH ORGANIC ACID
PROTEIN BOUND (ALBUMIN # GLOBULIN)
IONIZED FORM : IMPORTANT FOR BIOLOGIC ACTIVITY 1$1 % 1$& ''*L
CONC$ CHANGE : MUSCLE PARALYSIS
COMA
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HYPOALBUMIN : DECREASE CALCIUM PLASMA
ACIDOSIS : INDREASE IONIZED FORM CALCIUM
ALKALOSIS : ENHANCE BINDING TO ALBUMIN
DECREASE IONIZED FORM
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PTH (PARATHYROID HORMONE)
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PREPROPARATHYROID HORMONE
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PTH ACTION
G PROT
AC
PTH
REC
CAMP
KINASE
BIOLOGIC RESPONS
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PTH AFFECTS CALCIUM HOMEOSTASIS
1$ INCREASE DISSOLUTION OF BONE
+$ REDUCE RENAL EXCRETION OF CALCIUM
&$ INCREASE CALCITRIOL IN INTESTINE C ABSORPTION
-$ INCREASE RENAL EXCRETION OF PHOSPHATE
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PATHOPHYSIOLOGY
TYROID SURGERY, AUTOIMMUNE DISEASE HYPOPARATHYROIDISM
SERUM : CALCIUM PHOSPHATE
MUSCLE CRAMP
TETANY
LARINGOSPASM
DEATH
CATARACT
PSEUDOHYPOPARATHYROIDIMS (INHERITED)
NORMAL PTH, DEFECT IN G PROT OR DO"NSTREAM CAMP SIGN$
SHORT STATURE,
SHORT METACARPAL METATARSAL
MENTAL RETARDATION
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SECONDARY HYPERPARATHYROIDISM
RENAL FAILURE
DECREASE PRODUCE OF CALCITRIOL
IN RENAL PARENCHYMA
CALCIUM ABSORBPTION IN GUT
PTH
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CALCITRIOL
DIET
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CALCITRIOL ACTION
CALCITRIOL EFFECT :
INCREASE ABSORPTION OF CALCIUM AND PHOSPHATE
THROUGH NUCLEAR RECEPTOR
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PATHOFPHYSIOLOGY
RICKETS
LO" PLASMA CALCIUM AND PHOSPHATE
SKELETAL DEFORMITY
INHERITED AD : DEFECT IN CONVERSION +.OH/D& TO CALCITRIOL
AR : DEFECT IN CALCITRIOL NUCLEAR RECEPTOR
VIT D DEFICIENCY IN ADULT OSTEOMALACIA
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CALCITONIN
&+ AMINO ACID
PRODUCED BY PARAFOLLICULAR CELL OF TYHROID
ROLE IN CALCIUM HOMEOSTASIS : UNCLEAR