Download - Humoral and Cellular Immunity
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Humoral and Cellular Immunity
•Cellular immunity – Host defenses that are mediated by antigen-specific T cells and various nonspecific cells of the immune system.
•Humoral immunity – Host defenses that are mediated by antibody present in the plasma, lymph and tissue fluids.
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The Complement System
Ricklin and Lambris 2007
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Functions of the Complement System
•Viral neutralization
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The Complement System
Components of the Complement System:
proteins and glycoproteinssynthesized mainly by liver5% of serumcirculate as zymogens
Designation of complement components:
numerals (C1-C9)letter symbols (factor D)trivial names (homologous restriction factor)
cleavage products – “a” and “b”
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Complement Activation Pathways
Immunobiology (Garland Science 2005)
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The Complement System
Complement Activation:
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The Complement System
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The Complement System
Classical Pathway requires antibody interaction:
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The Complement System
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•The three complement pathways converge at the membrane-attack complex (MAC).
Consequences of Complement Activation
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Consequences of Complement Activation
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Regulation of the Complement System
Regulation can occur at multiple steps in the complement system:Before assembly of convertase activityAfter assembly of convertaseAssembly of membrane attack complex (MAC)
Turnberg and Botto, 2003
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Microbial Evasion•Some microbes can evade complement-mediated damage.
Schneider, et al 2007