IMPLANTABLE POLYMER BASED DELIVERY SYSTEM FOR TAILORED DRUG RELEASE PROFILE
By Tamasree Majumder Reg No. 152772310030 ,1st sem M.Pharm (Pharmaceutics) NSHM Knowledge Campus, Kolkata-Group Of InstitutionsUnder the guidance of Dr. Sutapa Biswas Majee , Associate Professor ,Department of Pharmaceutics,NSHM Knowledge Campus, Kolkata-Group of Institutions
Importance of IDDS
1.Less use of needle2.More patient compliance3.Steady state of drug release4.Site specific drug
administration5.Significantly lower dose of
drug required
TYPES OF IMPLANT BASED DELIVERY SYSTEM
a. Closed loop insulin deviceb. Contraceptive device(IUD)c. Infusion pumpd.Ophthalmic Inserte. Implantable intrathecal pumpf. Osmotic Pump
Closed loop insulin device
• novel glucose-sensitive polymer membrane technology used.• hdrogels are used as
polymers• Presence of bioresponsive
gel• controls tightly fluctuations
in insulin concentrations
-
Marketed formulation:
Marketed formulations Name of company1. OmniPod® Insulin Management System
Insulet Corp., Bedford, MA
2. Solo™ MicroPump Insulin Delivery System
Medingo US, Inc., Tampa, FL
3. Finesse™ Calibra Medical Inc., Redwood City, CA
4. Cellnovo Pump Cellnovo Ltd., formerly Starbridge Systems, London, UK)
Contraceptive Device (IUD)
1.non-biodegradable polymer used .2.Contain hormonal products generally3.Preload applicator for easier insertion4.Long acting reversible contraception5.Contains Barium sulphate in the drug core to make it detectable by X-Ray
Marketed products of contraceptive implantsMarketed product
Hormones involved
dose Length of duration of action
1.Norplant® Levonorgestrol 75mg 5yrs
2.Nexplanon® Etonogestrol 68mg Upto 3yrs
3.Implanon® Progestin only 68mg Upto 2yrs
Implantable Infusion Pumps
delivers drug to specific site through tubes or catheters
Two types of mechanism- 1.syringe driven and 2.elastrometric pump driven
refilling done by peristaltic repeater pump or through a a one-way valve using a syringe
Marketed products of some infusion pumps1.PLUM A+ Infusion
Pump2.PLUM 360 Infusion
Pump3.Sapphire Plus Infusion
System4.Sapphire Infusion
System5.Omnipod Insulin
infusion Pump
Ophthalmic insert • substantially pure polymeric
materials are used• mechanism of drug release is
diffusion, bioerosion and osmosis• Natural polymers like collagen
used• synthetic polymers like
HPMC,MC etc are used
Marketed formulations of opthalmic inserts:
Marketed product
Used in diseases Onset of action
Occusert
Lacrisert
Miosis
Kerato conjuctivitis,,keratitis,lachremal sensitivity
Within 10-30mins
Within 20 mins
Implantable intrathecal pump
Battery driven programmable device
used to deliver medication in the spaces between the spinal cord and the protective sheath surrounding the spinal cord
baclofen, morphine, or ziconotide may be delivered
Marketed productsMarketed intrathecal pump
Drug delivered
1. LIORESAL® INTRATHECAL
Baclofen
2. Synchromed II opoid
3. Prometra pump a preservative-free morphine sulfate sterile solution
osmotic pump
Schematic diagram of an osmotic pump A. Driven by osmosisB. Biodegradable in natureC. Can be well explained by the Higuchi ModelD. Plasticizers like dialkyl thalates,sodium benzoates
etc form the formation of the wall forming the osmotic pump
Marketed product of Osmotic Pump
Type of compartment marketed formulation
1.Single compartment LiRIS®, IntelliDrug
2.Bicompartmental ALZET® , Ivomec SR® Bolus , DUROS® ,
3.Multicompartment Acuros
CONCLUSON“Implanted delivery system Shows Promise in Delivering Drugs” - The Wall Street Journal
i. Textbook of Industrial Pharmacy Drug Delivery Systems and Cosmetics and Herbal Drug Technology , Edited by Shova Rani R Heermath , page 81-83
ii. S. Sershen, J. West, Implantable, polymeric systems for modulated drug delivery, Advanced Drug Delivery Reviews 54 (2002); 1225–1235
iii. Karen H. Knight, Frances M. Brand, Ali S. Mchaourab, Giorgio Veneziano , Implantable Intrathecal Pumps for Chronic Pain: Highlights and Updates, Croat Med J. (2007);48:22-34 ,22-25
iv. Mai Nguyen-Misra, Implantable Polymers, Biointerface Conference, 2012 , 31-34
v. Simon Herrlich , Sven Spieth , Stephan Messner , Roland Zengerle , Osmotic micropumps for drug delivery , Advanced Drug Delivery Reviews 64 (2012) 1617–1627.