INDEX
Volume 230, July-September, 1984
A23187, cutaneous vascularpermeability (guinea pigs),550
Access schedule, ethanol con-sumption patterns and (rats),658
Acetazolamide, phosphate excre-tion, prostaglandin E� effects
(dogs), 601Acetylcholine
radiolabled, release, Met-en-kephalin and (guinea pigs),493
receptor-ionic channel corn-plex, (±)-depentylperhydro-histrionicotoxin effects(frogs), 619
Acetyl-Co A:arylamine N-acetyl-transferase, induction rnodu-
lation, a’pha adrenergic drugs
(rats), 431Actin, interaction with myosin,
calcium antagonists and vas-odilators (cows), 141
Action potential, transrnernbrane,adenosine and iseprenalineeffects, heart (guinea pigs),483
Acyl glucuronide, diisopropylfluo-rophosphate and clofibricacid clearance (rabbits), 237
Adarn-Vizi, V., see Vizi, E. S., 493Adenosine, negative inotropic ef-
feet, heart (guinea pigs), 483Adenylate cyclase, beta adrenergic
receptor loss and (rats), 614Adipose tissue, bone rnarrow, free
fatty acid release (dogs), 228Adrenal gland, catecholamine in-
hibition, phenytoin (cows),171
Adrenergic nerve, norepinephrinerelease, ouabain and (dogs),527
Adrenoceptor
alpha, central cardiovasculareffects (cats), 232
a’pha and beta, antibody re-sponse and norepmephrine(rnice), 183
a4,ha and beta, a-methyl-sub-stituted phenethylamine in-teractions with (rats), 595
alpha-i and alpha-2, activationby norepinephrine, saphe-not’s vein (dogs), 699
alpha-i and alpha-2, reserve,calcium use and (rats), 587
alpha-2, dopamine release, ret-ma (rabbits), 149
aipha-2 and beta, free fatty acidrelease, bone marrow adipose
tissue (dogs), 228beta, heterogeneity, cold expo-
sure and (rats), 450
Agonista’pha adrenergic, aorta contrac-
tile response (rabbits), 162dopamine receptor, self-admin-
istration (monkeys), 678intrinsic activity, beta adrener-
gic receptor loss and (rats),614
irreversible, discriminativestimulus effects (pigeons),652
muace.rinic receptor subtypes,lower esophageal sphincter
(opossum), 284opiates and partial generaliza-
tion, fentanyl (rats), 193Abmad, A. B., Bennett, P. N. and
Rowland, M.: Influence ofroute of hepatic administra-tion on drug availability, 718
Albuquerque, E. X., see Maleque,
M. A., 619Alkali, desipramine toxicity
(rats), 12Allyl alcohol, hepatoxicity inves-
tigation, perfused liver (rats),755
Alphs, L. and Lovenberg, W.:Modulation of rat pineal ace-tyl-Co A:arylamine N-acetyl-transferase induction by at-ph�i adrenergic drugs, 431
Ambrose, J. M., see Silver, P. J.,141
Amine
biogenic, phenytoin and cats-cholamine transport, adrenalglands (cows), 171
sympathomimetic, nutrientblood flow, intestine (dogs),214
-y-Aminobutyric acidantagonism, naloxone effects
(pigeons), 40medullary mechanisms, blood
pressure regulation (rats), 34Aminoglycoside, antibiotics, kid-
ney epitheial cell line, effectsOn, 742
Amrinone, cardiovascular activi-
ties (cats, guinea pigs, rats),124
Analgesia, hot-plate, spinal andcerebral opioid receptor func-tion (mice), 341
Anaphylatoxin, C3a and C5a, iso-lated blood vessels and(guinea pigs), 749
Antagonista�pha-2, lipid mobilization
(dogs), 228beta adrenoceptor, hydralazine
and, renal hypertension (rab-bits), 205
calcium channel, a�pha adreno-
ceptor reserve and (rats), 587calcium channel, cyprohepta-
dine effects (rats, rabbits),103
calmodulin, [3Hlnitrendipinebinding, smooth and cardiac
muscle (guinea pigs, rabbits,cows), 607
muscarinic receptor subtypes,lower esophageal sphincter(opossum), 284
opiates and partial generaliza-
tion, fentanyl (rats), 193Antibiotics, aminoglycoside, ccl-
lular function effects, kidneyepithelial cell line, 742
Antibody response, beta adreno-ceptor effects on (mice), 183
Anticonvulsantscatecholamine transport inhi-
bition, adrenal glands (cows),171
gating currents, effects on(squid), 75
learning, effects on (pigeons),307
Antidepressantsbrain receptor antagonism by
(humans), 94toxicity, bicarbonate and (rats),
12Antidiuretic hormone, U-50,488
effects, kidney (dogs), 641Antigen, trachea challenged by
(guinea pigs), 534Antinociception, electroacupunc-
ture, Met�-enkephalin-Arg’-Phe7 and Met6-enkephalinmetabolism, peptidase inhib-itors and (rats), 349
Antiparkinsonian agent, (+)-4-propyl-9-hydroxynaphthoxa-
zinc (fish, mice, rats, dogs),569
Aorta, contractile response, aiphaadrenergic agonist (rabbits),162
Appel, J. B., see Cunningham,K. A., 47
AQA-39, calcium channel blocker,indirect stimulatory action(puppies), 336
Arachidonic acidmetabolites, bladder motility
and (rats), 500release, glucocorticoids and
(rats), 175AR-L57, cardiovascular activities
(cats, guinea pigs, rats), 124Asada, A., see Bowaher, D. J., 269Atenolol, hydralazine and, renal
hypertension (rabbits), 205Atkinson, A. J., Jr., see Bowsher,
D. J., 269Atrioventricular node, depres-
sion, KB-944 and (dogs), 632Atrium, beta adrenoceptor heter-
ogeneity, cold exposure(rats), 450
Atropine, AQA-39 and (puppies),336
Avram, M. J., see Bowsher, D. J.,269
Axon membrane, anticonvulsanteffects on (squid), 75
Bahouth, S.. W., Stewart, J. M.and Musacchio, J. M.: Spe-cific binding of a ThI.labeledsubstance P analog to ratsubmaxillary gland, 116
Baldwin, R. W., see Ilium, L., 733Balster, R. L., see Slifer, B. L.,
399Barbiturate, convulsant, effects
on neurons (mice), 82Barcas, P. P., see Willette, R. N.,
34Barkai, A. I., Suckow, R. F. and
Cooper, T. B.: Imipramine
and its metabolites: Relation-ship to cerebral catechol-amines in rats in viuo, 330
Baroreflex, sensitivity, dihydro-
pyridine slow channel cal-cium blocking agents (dogs),376
Baskin, E. P., see Winquist, R J.,103
Begenisich, T., see Morello, R. S.,156
Behaviordisruption, phencyclidine with-
drawal (monkeys), 399exploratory, cholecystokinin
fragments (mice), 438fixed-ratio discrimination ac-
curacy, opioid effects (mon-
keys, dogs), 541repeated acquisition, anticon-
vulsant effects on (pigeons),307
toluene anticonvulsant and an-tipunishment effects (rats),407
Belinsky, S. A., Popp, J. A., Kauf-mann, F. C. and Thurman,R. G.: Trypan blue uptake asa new method to investigate
hepatotoxicity in periportaland pericentral regions of theliverlobule: Studies with allylalcohol in the perfused liver,755
Bemis, K. G., see Rinkema, L E.,550
Bennett, P. N., see Ahmad, A. B.,718
Benowitz, N., see Pentel, P., 12Benzodiazepine
777
778 Index Vol. 230
receptor antagonist, Ro 15-1788, diazepain and tolueneanticonvulsant activity
(rats), 407receptor regulation, changes
after lesions, substantia ni-gra, globus pallidus and en-topeduncular nucleus (rats),
768
Benzomorphan, receptor (rats),110
Bepridil, calmodulin, effects on(cows, chickens, rabbits), 737
Bergstrom, K., see Hartvig, P.,250
Berlan, M., see Tran, M.-A., 228Bicarbonate, desipramine toxicity
(rats), 12Bicuculline, medullary GABA-
ergic mechanisms, bloodpressure regulation (rats), 34
Bidani, A. K., see Churchill, P. C.,302
Bladderepithelial trauma and prosta-
glandins in (rabbits), 445
motility, essential fatty aciddeprivation and (rats), 500
Blockadebeta adrenergic receptor, di-so-
talol (dogs), 519calcium, AQA-39, (puppies),
336calcium, beta adrenergic, dihy-
dropyridines (dogs), 367calcium entry, cyproheptadine
and (rats, rabbits), 103
hydralazine and, renal hyper-tension (rabbits), 205
sodium channel, phenytoin(squid), 156
Blood flowhydralazine and beta blockers,
renal hypertension (rabbits),205
nutrient, dopamine- and epi-nephrine-induced intestinal
vasodilation (dogs), 214propranolol elimination and,
liver (rats), 474regional, LY141865 effects
(dogs), 558
Blood gas, arterial concentrationsand pH, diazepam effects,methadone and (rats), 353
Blood pressuresee also Hypertension; Hypo-
tensionaipha adrenergic drugs and
(cats), 232regulation, medullary GABA
ergic mechanisms (rats), 34L-tryptophan effects (rats), 324
Blood vessel, isolated, C3a andC5a anaphylatoxin effects(guinea pigs), 749
Boder,G.B.,seeHayes,J.S., 124
B#{246}hm,M., Bruckner, R., Hack-barth, I., Haubitz, B., Lin-hart, R., Meyer, W., Schmidt,B., Schmitz, W. and Scholz,H.: Adenosine inhibition ofcatecholamine-induced in-crease in force of contraction
in guinea-pig atrial and yen-
tricular heart preparations.
Evidence against a cyclicAMP- and cyclic GMP-de-pendent effect, 483
Bohn, D. L., see Winquist, R. J.,103
Bolt, G. R. and Saxena, P. R.:Interaction of atenolol withthe systemic and regional he-modynamic effects of hydral-azine in conscious renal hy-pertensive rabbits, 205
Bombesin, scratching induced by,benzomorphan receptors(rats), 110
Bone marrow, adipose tissue, freefatty acid release (dogs), 228
Bookstaff, R. C., see Katz, L. B.,670
Botulinum, type C2 toxin, molec-ular pharmacology (mice),665
Bousquet, P., Feldman, J. andSchwartz, J.: Central cardio-vascular effects of alpha ad-renergic drugs: Differences
between catecholamines andimidazolines, 232
Bovermann, K., see Seizinger,B. R., 455
Bowling, H. N., see Hayes, J. S.,124
Bowsher, D. J., Avram, M. J.,Frederiksen, M. C., Asada, A.and Atkinson, A. J., Jr.: Ureadistribution kinetics ana-lyzed by simultaneous injec-tion of urea and inulin: Dem-
onstration that transcapil-lary exchange is rate limiting,269
Bradykinin, capsaicin and, sub-
stance P-ergic responses(rabbits), 469
Brain“C-labeled opiates (monkeys),
250catecholomines, imipramine
and (rats), 330neurotransmitter receptors, an-
tidepressants and (humans),94
Brainstem, aipha adrenergic
drugs and (cats), 232Branch, R. A. see KUpfer, A., 28
Briston, C., see Schaeffer, R. C.,Jr., 393
Bromobenzene metabolite, 2-bro-mohydroquinone, nephrotox-icity (rats), 360
2-Bromohydroquinone, nephro-toxicity induced by (rats),360
Brooks, H. L., see Warltier, D. C.,367, 376
Brossi, A., see Maleque, M. A.,619
Brown, D. M., see Knodell, R. G.,256
Bruckner, R., see B#{246}hm,M., 483Buckner, C. K., see Fishleder,
R. I., 534Buprenorphine,
bombesin-induced scratchingand (rats), 110
discriminative stimulus effects(pigeons), 652
fixed-ratio discrimination ac-curacy and (monkeys, dogs),541
Burks, T. F., see Porreca, F., 341
Caffeine, muscle excitation, sa-licylate effects on (frogs,toads), 478
Calciumantagonist, coronary arteries
and myocardium (humans),514
antagonist, KB-944, cardiacelectrophysiology (dogs), 632
antagonist, vasodilators and,myosin phosphorylation
(cows), 141contractile responses depend-
ent on, inhibition by leuko-trienes, myocardium (guineapigs), 646
entry blocker, cyproheptadineand (rats, rabbits), 103
influx and release, alphaadrenoceptors, artery (rats),413
radiolabeled, 2-nicotinamido-ethyl nitrate and vascularsmooth muscle (rabbits), 462
renal handling, prostaglandin-vasopressin interactions
(rats), 295Calcium channel
antagonist, a’pha adrenoceptorreserve and (rats), 587
blocker, AQA-39 (puppies), 336blocker, cyproheptadine effects
(rats, rabbits), 103blocker, dihydropyridine
(dogs), 367, 376Callahan, P. M., see Cunningham,
K. A., 47Callia, M. L. and de Moraes, S.:
Heterogeneity of beta adre-noceptors in right atria iso-lated from cold-exposed rats,450
Calmodulinantagonists, [3H]nitrendipine
binding, smooth and cardiacmuscle (guinea pigs, rabbits,cows), 607
bepridil effects on (cows, chick-ens, rabbits), 737
vasodilators and myosin phos-phorylation (cows), 141
cAMP, see Cyclic AMPCapsaicin, bradykinin and, sub-
stance P-ergic responses(rabbits), 469
Cardiomyocyte, amrinone andAR-L57 effects (cats, guineapigs, rats), 124
Cardiovascular system
dihydropyridine slow channelcalcium blocking agents,(dogs), 367, 376
vasodilators and myosin phos-phorylation (cows), 141
Carlson, R. W., see Schaeffer,R. C., Jr., 393
Carrageenan, edema responseto, 2,3,7,8-tetrachlorodi-benzo-p-dioxin treatment
and (rats), 670
Carter, R. B. and Leander, J. D.:
Comparison of the effects ofnaloxone and picrotoxin on
schedule-controlled respond-ing in the pigeon: PossibleGABA-antagonistic effects ofnaloxone, 40
Casteels, R., see Kajiwara, M., 462Catatonia, amine-ketamine, pin-
ealectomy and hypophysec-tomy (chicks, rats), 69
Catecholamine,atpha-2 agonists and antago-
fists, dopamine release, ret-ma (rabbits), 149
cerebral, imipramine relation-ship to (rats), 330
imidazoline us. , central cardio-vascular effects (cats), 232
ketamine catatonia (chicks,rats), 69
neuron development, propyl-thiouracil effects (rats), 53
response, erythrosin B effects,ganglia (frogs, bullfrogs), 221
transport inhibition, pheny-tom, adrenal glands (cows),171
Cation, [3H]nitrendipine bindingregulatedby, smooth and car-disc muscle (guinea pigs, rab-bits, cows), 607
Catto, B. A., see Valencia, C. I.,133
Cauvin, C. and Malik, S.: Induc-tion of Ca�� influx and intra-cellular Ca� release in iso-lated rat aorta and mesen-teric resistance vessels bynorepinephrine activation ofatpha-1 receptors, 413
Cerebral cortex, alpha-i receptorsand inositol (rats), 317
Cerebrospinal fluid, phenobarbi-tel in, kidney dysfunctionand (rats), 627
Channel blocker, open, (±)-
depentylperhythohistrionico-toxin on mcotinic receptor-ion channel (frogs), 619
Childers, S. R.: Interaction of opi-ate receptor binding sites andguanine nucleotide regula-tory sites: Selective protec-
tion from N-ethylmaleimide,684
Chilton, S.-M., see Schaeffer, R.C., Jr., 393
2-Chloroadenosine, renal effects(rats), 302
Cholecystokinin, C- and N-tsr-minal fragments, analysis(mice), 438
Chou, J., Tang, J., Del Rio, J.,Yang, H.-Y. T. and Costa,E.: Action of peptidase in-hibitors on methionine5-en-kephalin-arginine6-phenyl-alanine7 (YGGFMRF) andmethionine5 - enkephalin(YGGFM) metabolism andon electroacupuncture anti-nociception, 349
Chromaffin granule, catechol-amine inhibition, phenytoinadrenal glands (cows), 171
Chromatography, gel filtration,
1984 Index 779
venom fraction coagulopathy(dogs), 393
Churchill, M. C. see Churchill, P.C., 302
Churchill, P. C., Bidani, A. K.,Churchill, M. C. and Prada,J.: Renal effects of 2-chlo-roadenosine in the two-kid-ney Goldblatt rat, 302
Cirazoline, central cardiovascular
effects (cats), 232Clineschmidt, B. V., see Martin,
G. E., 569Clofibric acid, clearance, diisopro-
pylfluorophosphate (rabbits),237
Clonazepam, learning, effects on(pigeons), 307
Clonidinecentral cardiovascular effects
(cats), 232free fatty acid release, bone
marrow adipose tissue (dogs),228
Clostridium botulinum, type C2toxin, molecular pharmacol-ogy (mice), 665
Coagulopathy, venom fractions
(dogs), 393Codeine, “C-labeled, kinetics,
brain (monkeys), 250Coleman, J. B., see Wood, R. W.,
407Colpaert, F. C. and Janssen, P. A.
J.: Agonist and antagonist ef-fects of prototype opiatedrugs in rats discriminating
fent.anyl from saline: Char-acteristics of partial general-ization, 193
Complement, activation, anaphy-latoxin effects, isolated blood
vessels (guinea pigs), 749Cone, E. J., see Vaupel, D. B., 20Cooke, J. P., see Flavahan, N. A.,
699Cooper, T. B., see Barkai, A. I.,
330Coronary artery
contractile activity, nifedipineand (humans), 514
PO2 and beta adrenergic respon-siveness (cows, pigs), 692
Cory, R. N., Osman, R. and Maay-
ani, S.: Kinetic characteriza-tion of the rabbit aorta con-tractile response to an alphaadrenergic agonist, 162
Costa, E., see Chou, J., 349Coutinho, S., see Suarez-Kurtz,
G., 478Cowan, A., see Gmerek, D. E., 110
Cox, C., see Wood, R. W., 407Crawley, J. N., St-Pierre, S. and
Gaudreau, P.: Analysis of thebehavioral activity of C- andN-terminal fragments of cho-lecystokinin octapeptide, 438
Crews, F. T., see Heiman, A. S.,175
Crowley, P., see Shiverick, K. T.,
761Cunningham, K. A., Callahan, P.
M. and Appel, J. B.: Discrim-inative stimulus properties oflergotrile, 47
Cyclazocine, fixed-ratio discrimi-nation accuracy and (mon-keys, dogs), 541
Cyclic AMP, adenosine and iso-prenaline antagonism, heart(guinea pigs), 483
Cyclic GMP, adenosine and iso-
prenaline antagonism, heart(guinea pigs), 483
Cyclic nucleotide phosphodester-am, calmodulin antagonisticactivity of bepridil (cows,chickens, rabbits), 737
Cyproheptadine, cardiovascularactions (rats, rabbits), 103
Dachiw, J., see Silver, P. J., 141da Costa, M. J. B., see Suarez-
Kurtz, G., 478Danhof, M., Kisaoka, M. and
Levy, G.: Kinetics of drug ac-tion in disease states. II. Ef-fect of experimental renaldysfunction on phenobarbi-tal concentrations in rats atonset of loss of righting re-flex, 627
Davies, S., see Lauterburg, B. H.,7
Davis, S. S., see Illum, L., 733Del Rio, J., see Chou, J., 349de Moraes, S., see Callia, M. L.,
450(±) - Depentylperhydrohistrioni -
cotoxin, nicotinic receptor-ion channel, effects on
(frogs), 619Desipramine
catecholamine uptake, ganglia(frogs, bullfrogs), 221
toxicity, bicarbonate and (rats),12
Deupree, J. D., Downs, D. A., La-posky, J. E. and Hitchcock,J. J.: Inhibition of catechol-amine transport into chro-maffin granule ghosts iso-lated from bovine adrenal
glands by phenytoin, 171
Dextran, edema response to,2,3,7,8-tetrachlorodibenzo-p-
dioxin treatment and (rats),670
Diabetesautonomic receptors, heart
(rats), 242hepatic drug metabolism
(mice), 256Diazepam
anticonvulsant activity rever-sal, Ro 15-1788 (rats), 407
arterial blood gas concentra-tions and pH, methadone(rats), 353
Dihydropyridineslow channel calcium blocking
agents, baroreflex sensitivity(dogs), 376
slow channel calcium block-ing agents, hemodynamics(dogs), 367
Diisopropylfluorophosphate, do-fibric acid clearance, futilecycle (rabbits), 237
Diltiazem, cardiovascular actions(rats, rabbits), 103
Diureticindacrinone enantiomer, renal
tubular effects (rats), 62water, U-50,488, kidney (rats),
641
Dobutamine, norepinephrine and,antibody response (mice),183
Dombro, K.-R., see Smith, P. A.,221
Dominguez, J. H., see Pitts, T. 0.,601
Dopamine,
agonist, (+)-4-propyl-9-hy-droxynaphthoxazine (fish,mice, rats, dogs), 569
alpha and beta adrenoceptors
and, interaction (rats), 595antagonism, lergotrile (rats), 47erythrosin B effects, ganglia
(frogs, bullfrogs), 221intestinal vasodilation induced
by, nutrient blood flow(dogs), 214
receptor, antidepressant antag-onism (humans), 94
receptor agonist, LY141865,
blood flow and (dogs), 558receptor agonist, self-adminis-
tration (monkeys), 678release, retina, (rabbits), 149
Downie, J. W. and Karmazyn, M.:
Mechanical trauma to blad-der epithelium liberates pros-tanoids which modulate neu-rotransmission in rabbit de-trusor muscle, 445
Downs, D. A., see Deupree, J. D.,171
Droogmans, G., see Kajiwara, M.,462
Drug availability, route of adniin-istration and, liver (rats), 718
Dubocovich, M. L.: Alpha-2 adre-noceptors modulate [3HJdo-pamine release from rabbitretina, 149
Duncalf, D., see Vizi, E. 5, 493Dynorphin, fragment, receptor se-
lectivity, vas deferens (mice),200
Ear artery, 2-nicotinamidoethyl
nitrate, vascular smoothmuscle (rabbits), 462
Edema, carrageenan and dextran,
2,3,7,8-tetrachlorodibenzo-p-dioxin treatment and (rats),670
Electrolyte, transport, loop ofHenle, distal tubule (rats), 62
Electrophoresis, sodium dodecylsulfate-polyacrylamide gel,venom fraction coagulopathy
(dogs), 393Endocrine system, ethanol and $-
endorphinergic system acti-
vation (rats), 455�9-Endorphin, ethanol effects
(rats), 455Endotoxin, paraquat toxicity and
(mice), 284Endplate current, noise analysis,
(±)-depentylperhydrohistri-
onicotoxin on acetylcholinereceptors (frogs), 619
Enkephalin, cyclic, spinal andcerebral opioid receptor func-tion (mice), 341
Entopeduncular nuclens, benzo-diazepine receptor changes,lesions and (rats), 768
Epinephrinealpha and beta adrenoceptors
and, interaction (rats), 595
erythrosin B effects, ganglia
(frogs, bullfrogs), 221free fatty acid release, bone
marrow adipose tissue (dogs),228
intestinal vasodilation inducedby, nutrient blood flow(dogs), 214
norepinephrine metabolismregulation, brain (rats), 577
Ergot, derivative, lergotrile, stim-ulus effects (rats), 47
Erythrosin B, catecholamine re-sponses and, ganglia (frogs,bullfrogs), 221
Esterase, inhibition, acyl glucu-ronide, diisopropylfluoro-phosphate (rabbits), 237
Ethanolj3-endorphinergic system,
chronic effects (rats), 455glutathione suppression, liver
(rats), 7
periodic availability (rats), 658Ethosuximide
ionic channel effects (squid), 75learning, effects on (pigeons),
307Ethylketocyclazocine, bombesin-
induced scratching and
(rats), 110Ethylketazocine, fixed-ratio dis-
crimination accuracy and(monkeys, dogs), 541
N-Ethylmaleimide, opiate recep-tsr binding site and guaninenucleotide regulatory site in-teraction (rats), 684
Evangelists, S., see Maggi, C. A.,500
Excitatory junction potential, 2-nicotinamidoethyl nitrate ef-
fects, vascular smooth mus-dc (rabbits), 462
Fairchild, E. H., see Valencia, C.I., 133
Fatty acid, free, release, epineph-rine, bone marrow adiposetissue (dogs), 228
Feldman, J., see Bousquet, P., 232Fentanyl, discrimination from sa-
line, agonist and antagonistopiate effects (rats), 193
Field, M. J., Fowler, N. and Gie-bisch, G. H.: Effects of en-antiomers and indacrinone
(MK-196) on cation trans-port by the loop of Henle anddistal tubule studied by mi-croperfusion in uiuo, 62
Finet, M., see Godfraind, T., 514Fishleder, R. I. and Buckner, C.
K.: Studies on the relation-ship between contraction andmediator release produced byovalbumin in superfused tra-
780 Index Vol. 230
chea isolated from the ac-tively sensitized guinea pigs,534
Flavahan, N. A., Rimele, T. J.,Cooke, J. P. and Vanhoutte,P. M.: Characterization ofpostjunctional alpha-i andalpha-2 adrenoceptors acti-vated by exogenous or nerve-released norepinephrine inthe canine saphenous vein,699
Fleisch, J. H., see Rinkema, L. E.,550
Fohlmeister, J. F., Adelman, W.J., Jr. and Brennan, J. J.: Ex-citable channel currents andgating times in the presenceof anticonvulsants ethosux-imide and valproate, 75
F#{246}ldes,F. F., see Vizi, E. S., 493Fostedil, KB-944, cardiac electro-
physiology (dogs), 632Fowler, N., see Field, M. J., 62
France, C. P., Jacobson, A. E. andWoods, J. H.: Discriminativestimulus effects of reversibleand irreversible opiate antag-onists: Morphine, oxymor-phazone and buprenorphine,652
Frederiksen, M. C., see Bowsher,D. J., 269
Fuhrman-Lane, C., see Shiverick,K. T., 761
Fujiwara, M., see Murarnatsu, I.,469
Furosemide, interaction with pro-benecid (chinchillas), 706
Ganglia, sympathetic, erythrosinon catecholamine response(frogs, bullfrogs), 221
Gastrointestinal tract, transit,
spinal and cerebral opioid re-ceptor function (mice), 341
Gaudreau, P., see Crawley, J. N.,438
Gentamicin, kidney epithelial cellline, effects on, 742
George, C. F., see Strong, H. A.,726
Giebisch, G. H., see Field, M. J.,62
Gilbert, R., Rattan, S. and Goyal,R. K.: Pharmacologic identi-fication, activation and an-tagonism of two muscarine
receptor subtypes in thelower esophageal sphincter,284
Gillette, J. R., see Lau, S. S., 360Ginos, J. Z., see Woolverton,
W. L., 678Giolitti, A., see Maggi, C. A., 500
Giraud, G. D. and MacCannell, K.L.: Decreased nutrient bloodflow during dopamine- andepinephrine-induced intes-tinal vasodilation, 214
Gland, see specific glandGlobus pallidus, benzodiazepine
receptor changes, lesions and(rats), 768
Glucocorticoid, immunoglobulin,histamine and arachidonic
acid, effects on (rats), 175Glutathione,
depletion, renal and hepatic(rats), 360
synthesis, ethanol suppressionof, liver (rats), 7
Gmerek, D. E. and Cowan, A.: Invivo evidence for benzomor-
phan-selective receptors inrats, 110
Godfraind, T., Finet, M., Lima, J.S. and Miller, R. C.: Contrac-tile activity of human coro-nary arteries and humanmyocardiuni in vitro andtheir sensitivity to calcium
entry blockade by nifedipine,514
Goldberg, L. I., see Woolverton,W. L., 678
Goldberg, M. R, see Ruffolo, R.R., Jr., 595
Goyal, R K., see Gilbert, R, 284
Green, T. P., see Rybak, L. P., 706
Grimaldi, G., see Maggi, C. A., 500Gross, G. J., see Warltier, D. C.,
367, 376Guanidine, alkyl derivatives, nor-
epinephrine release and(rats), 710
Guanine nucleotide
regulatory protein, muscarinicreceptor affinity, heart (rats),424
regulatory sites, opiate receptorbinding site interaction with(rats), 684
Guanine 5’-triphosphate, opiatereceptor regulation (rats),684
Guchhait, R. B., see Stolk, J. M.,577
Hackbarth, I., see B#{246}hm, M., 483
Hahn, R. A. and MacDonald, B.R.: Systemic hemodynamicand regional blood flow ef-fects ofLY141865, a selectivedopamine receptor agonist,558
Handwerger, B. S., see Knodell,
R. G., 256Harden, T. K., see Martin, M. W.,
424Harmon, J. R., see Miska, S. P.,
419Hartvig, P., Bergstrom, K., Lind-
berg, B., Lundberg, P. 0.,Lundqvist, H., L#{224}ngstrom,B., Sv#{228}rd,H. and Rane, A.:Kinetics of “C-labeled opi-ates in the brain of rhesusmonkeys, 250
Hattori, Y. and Levi, R.: Negative
inotropic effect of leuko-trienes: Leukotrienes C4 andD4 inhibit calcium-dependentcontractile responses in po-tassium-depolarized guinea-pig myocardium, 646
Haubitz, B., see B#{246}hm,M., 483Hayashi, S. and Park, M. K.: Neu-
rogenic and myogenic con-tractile responses of dog mes-enteric arteries to reduced K’concentration and their in-
teractions with ouabain, 527Hayes, J. S., Bowling, H. N.,
Boder, G. B. and Kauffman,R.: Molecular basis for thecardiovascular activities of
amrinone and AR-L57, 124Heart
adenosine and isoprenaline an-tagonism (guinea pigs), 483
autonomic receptors, diabetes(rats), 242
KB-944 actions on (dogs), 632
muscarinic receptor affinity(rats), 424
ornithine decarboxylase ontog-eny (rats), 419
rate, medullary GABAergicmechanisms (rats), 34
Heiman, A. S. and Crews, F. T.:Inhibition of immunoglobu-
lin, but not polypeptide base-stimulated release of hista-mine and arachidonic acid byanti-inflammatory steroids,175
Hepatic artery, portal vein us.,
drug availability (rats), 718Hepatotoxicity, investigation
method, trypan blue uptake(rats), 755
Heroin, “C-labeled, kinetics,brain (monkeys), 250
Hers, A., see Schulz, R., 200Hers, A., see Seizinger, B. R, 4552,4,5,2’,4’,5’ -Hexachlorobi-
phenyl, redistribution, preg-nancy (rats), 263
Hidaka, H., see Itoh, H., 737
Hirsch, J. A.: Structure-activityrelationship between guani-
dine alkyl derivatives andnorepinephrine release:
Site(s) and mechanism(s) ofaction, 710
Hisaoka, M., see Danhof, M., 627Histamine
cutaneous vascular permeabil-
ity (guinea pigs), 550receptor, antidepressant antag-
onism (humans), 94release, glucocorticoids and
(rats), 175
Histrionicotoxin analog, (±)-de-pentylperhydrohistrionico-toxin, nicotinic receptor-ionchannel (frogs), 619
Hitchcock, J. J., see Deupree, J.D., 171
Hollinger, M. A.: Potentiation ofparaquat lethality in mice bybacterial lipopolysaccharidepretreatment, 292
H#{246}llt,V., see Seizinger, B. R., 455
Hom, G. J. and Jandhyala, B. S.:Effects of cerebroventricularadministration of ouabain onrenal hemodynamics in anes-
thetized dogs: Evidence for
the participation of renal do-paminergic vasodilator fi-hers, 275
Hori, R., Yamamoto, K., Saito,H., Kohno, M. and Inui,K.-I.: Effect of aminoglyco-side antibiotics on cellularfunctions of kidney epitheial
cell line (LLC-PK,): A modelsystem for aminoglycoside
nephrotoxicity, 742Hormone, see specific hormoneHruby, V. J., see Porreca, F., 341
Hugh, T. E., see Marceau, F., 749Hurst, R., see Porreca, F., 341
Hydantoin, comparative metabo-ham (humans), 28
Hydralazine, beta blockers and,renal hypertension (rabbits),205
Hydrocortisone, immunoglobulin,histamine and arachidonic
acid, effects on (rats), 1755-Hydroxyindoleacetic acid, L-
tryptophan and blood pres-sure (rats), 324
4-Hydroxyniridazole, Schisto-
some japonicum infection(humans), 133
Hydroxyphenobarbital, hypnoticeffect (rats), 627
Hyperglycemia, insulin and, he-
patic drug metabolism, dia-betes (mice), 256
Hyperpolarization, catechol-amine-induced, ganglia
(frogs, bullfrogs), 221Hypertension
alpha-2 adrenoceptors and,phenoxybenzamine (rats),387
renal, hydralazine and betablockade (rabbits), 205
L-tryptophan effects (rats), 324
Hypocalcemia, calcium and mag-nesium handling, prostaglan-
din-vasopressin interactions,kidney (rats), 295
Hypokalemia, ouabain and, mes-enteric artery (rats), 527
Hypophysectomy, amine-keta-mine catatonia (chicks), 69
Hypotensionarterial, LY141865 effects
(dogs), 558venom fraction coagulopathy
and (dogs), 393Hypothyroidism, propylthioura-
cil-induced, catecholamineneuron development (rats),53
Ileostomy, sulfinpyrazone reduc-
tion (humans), 726
Illuin, L., Jones, P. D. E., Bald-win, R. W. and Davis, S. S.:Tissue distribution of poly-(hexyl 2-cyanoacrylate) nan-oparticles coated with mono-clonal antibodies in micebearing human tumor xeno-grafts, 733
Imidazoline, catecholamine us.,central cardiovascular effects(cats), 232
Imipramine, cerebral catechol-
ainines and (rats), 330Immune response, norepineph-
tine and, beta adrenoceptor
mediation (mice), 183
Immunoglobulin, inhibition, glu-cocorticoids (rats), 175
Immunomodulation, antibody re-
sponse, norepinephrine ef-
1984 Index 781
fects (mice), 183Immunoregulation, antibody re-
sponse, norepinephrine ef-fects (mice), 183
Indacrinone, enantiomers, renaltubular effects (rats), 62
Indolamine, pineal, ketamine ca-tatonia (chicks, rats), 69
Inflammation, neurogenic, cap-saicin and bradykinin, irissphincter muscle (rabbits),469
Inotropic agents, amrinone andAR-L57 (cats, guinea pigs,rats), 124
Insulin, hyperglycemia and, he-patic drug metabolism, dia-betes (mice), 256
Intestinemicroflora, sulfinpyrazone re-
duction (humans), 726
nutrient blood flow, dopamine-and epinephrine-inducedvasodilation (dogs), 214
Inui, K., see Hori, R., 742Inulin, urea distribution, trans-
capillary exchange effects(dogs), 269
lonophore, A23187, cutaneous
vascular permeability (gum-ea pigs), 550
Ischemia, intestinal, nutrient flowand vasodilation (dogs), 214
Ishikawa, T., see Itoh, H., 737Isoprenaline, positive inotropic
effect, heart (guinea pigs),483
Isoproterenol, cold exposure and,atria (rats), 450
Itoh, H., Ishikawa, T. and Hidaka,H.: Effects on calmodulinof bepridil, an antianginalagent, 737
Itzhak, Y. and Simon, E. J.: Anovel phencycidine analoginteracts selectively with muopioid receptors, 383
Jacobson, A. E., see France, C. P.,652
Jandhyala, B. S., see Hom, G. J.,275
Janis, R. A., see Luchowski, E. M.,607
Janssen, P. A. J., see Colpaert, F.C., 193
Johnson, R. D., see Minneman,K. P., 317
Jones, J. H., see Martin, G. E.,569
Jones, P. D. E., see Ilium, L., 733Juhn, S. K., see Rybak, L. P., 706
Kajiwara, M., Droogmans, G. andCasteels, R.: Effects of 2-ni-cotinamidoethyl nitrate (Ni-
corandil) on excitation-con-traction coupling in thesmooth muscle cells of rabbitear artery, 462
Karmazyn, M., see Downie, J. W.,445
Katz, L. B., Theobald, H. M.,Bookstaff, R C. and Peter-son, R E.: Characterizationof the enhanced paw edema
response to carrageenan anddextran in 2,3,7,8-tetrachlo-
rodibenzo-p-dioxin-treatedrats, 670
Kauffman, F. C., see Belinsky, S.A., 755
Kauffman, R., see Hayes, J. S.,124
KB-944, calcium antagonist, car-diac electrophysiology (dogs),632
Keiding, S. and Steiness, E.: Flowdependence of propranololelimination in perfused ratliver, 474
Ketamine, catatonia induced by,pinealectomy and hypophy-sectomy (chicks, rats), 69
4-Ketoniridazole, Schistosoma ja-
ponicum infection (humans),133
Kidneyaipha-2 adrenoceptors, phen-
oxybenzamine (rats), 3872-chloroadenosine effects
(rats), 302dysfunction, phenobarbital in
(rats), 627epithelial cell line, aminoglyco-
side antibiotic effects, 742function, U-50,488 effects
(dogs), 641
hypertension, hydralazine andbeta blockade (rabbits), 205
necrosis, bromobenzene metab-olites (rats), 360
tubules, indacrinone enantio-mere and cation transport(rats), 62
tubules, prostaglandin-vaso-
pressin and divalent ion cx-cretion (rats), 295
vasodilator fibers, ouabain ef-fects (dogs), 275
Kimmel, G. L., see Miska, S. P.,419
Knodell, R. G., Handwerger, B.S., Morley, J. E., Levine, A.S. and Brown, D. M.: Sepa-rate influences of insulin andhyperglycemia on hepatic
drug metabolism in mice with
genetic and chemically in-duced diabetes mellitus, 256
Kohno, M., see Hori, R., 742Krieger, A. J., see Willette, R. N.,
34Kuhn, D. M., see Wolf, W. A., 324Kupfer, A., Patwardhan, R,
Ward, S., Schenker, S., Prei-sig, R. and Branch, R. A.:Stereoselective metabolismand pharmacogenetic controlof 5-phenyl-5-ethylhydan-tom (nivranol) in humans, 28
Lac, D. T., see Tran, M.-A., 228Lactation, 2,4,5,2’,4’,5’-hexa-
chlorobiphenyl redistribu-tion (rats), 263
Lafontan, M., see Tran, M.-A.,228
Lakin, M. L., see Winters, W. D.,69
Lang, C. M., see McCormick, G.
Y., 353
L#{226}ngstr#{246}m,B., see Hartvig, P.,250
Laposky, J. E., see Deupree, J. D.,171
Latifpour, J. and McNeill, J. H.:Cardiac autonomic receptors:Effect of long-term experi-mental diabetes, 242
Lau, S. S., Monks, T. J. and Gil-lette, J. R.: Identification of2-bromohydroquinone as ametabolite of bromobenzeneand o-bromophenol: 1mph-cations for bromobenzene-in-duced nephrotoxicity, 360
Lauterburg, B. H., Davies, S. andMitchell, J. R.: Ethanol sup-presses hepatic ghutathionesynthesis in rats in uiuo, 7
Leander, J. D., see Carter, R. B.,40
Learning, anticonvulsant effectsOn (pigeons), 307
Lechene, C., see Roman, R. J., 295Lergotrile, stimulus effects of
(rats), 47
Leukotrienecutaneous vascular permeabil-
ity and (guinea pigs), 550myocardial Ca� influx inhibi-
tion (guinea pigs), 646Levi, R., see Hattori, Y., 646Levine, A. S., see Knodehi, R. G.,
256Levy, G., see Danhof, M., 627Lidocaine, route of administra-
tion, drug availability andliver, (rats), 718
Lima, J. S., see Godfraind, T., 514Lindberg, B., see Hartvig P., 250Linhart, R., see B#{246}hm,M., 483Lipolysis, a4,ha-2 and beta recep-
tars, bone marrow, adiposetissue (dogs), 228
Lipopolysaccharide, endotoxin
pretreatment, paraquat tox-icity and (mice), 284
Lipoprotein, 2,4,5,2’,4’,5’-hexa-chlorobiphenyl distribution,pregnancy (rats), 263
Livercirculation, propranohol ehimi-
nation (rats), 474drug metabolism, insulin and
hyperglycemia effects, diabe-tes (mice), 256
glutathione depletion, bromo-benzene metabohite (rats),
360ghutathione synthesis, ethanol
suppression of (rats), 7route of administration, drug
availability and (rats), 718salicyhamide kinetics (dogs), 89
LLC-PK,, kidney epithehial cellline, aminoglycoside anti-biotic effects on, 742
Loop of Henhe, cation transport,indacrinone enantiomer ef-fects (rats), 62
Lovenberg, W., see Alphs, L., 431Lucchesi, B. R., see Patterson, E.,
519, 632Luchowski, E. M., Yousif, F.,
Triggle, D. J., Maurer, S. C.,Sarmiento, J. G. and Janis,
R. A.: Effects of metal cationsand calmodulin antagonistson [3Hjnitrendipine bindingin smooth and cardiac mus-dc, 607
Ludens, J. H., see Shizgi, G. R.,
641
Lundberg, P. 0., see Hartvig, P.,250
Lundqvist, H., see Hartvig, P., 250LY134046, phenylethanolamine
N-methyltransferase inhibi-tion, central effects ofchronic treatment (rats), 577
LY141865, dopamine receptoragonist, blood flow effects(dogs), 558
Lynch, J. J., see Patterson, E.,519, 632
Maayani, S., see Cozy, R. N., 162
MacCannell, K. L., see Giraud,G.D.,214
MacDonald, B. R., see Hahn, R.A., 558
Macdonald, R. L., see Skerritt, J.H., 82
MacDonall, J. S., see Marcucella,
H., 658Maggi, C. A., Evangelists, S., Gri-
maldi, G., Santiciohi, P., Giol-itti, A. and Mcli, A.: Evidencefor the involvement of arach-idonic acid metabohites inspontaneous and drug-in-duced contractions of rat uri-nary bladder, 500
Magnesium, renal handling, pros-
taglandin-vasopressin inter-actions (rats), 295
Magnesium adenosine triphos-
phate, catecholamine trans-port inhibition, phenytoinand (cows), 171
Maleque, M. A., Takahashi, K.,Witkop, B., Brossi, A. andAlbuquerque, E. X.: A studyof the novel synthetic analog(±)-depentyiperhydrohistri-
onicotoxin on the nicotinicreceptor-ion channel, 619
Mahik, S., see Cauvin, C., 413Maramba, N. C., see Valencia,
C. I., 133Marceau, F. and Hugh, T. E.: Ef-
fect of C3a and C5a anaphy-latoxins on guinea-pig iso-hated blood vessels, 749
Marcucella, H., Munro, I. andMacDonahl, J. S.: Patterns ofethanol consumption as afunction of the schedule ofethanol access, 658
Martin, G. E., Williams, M., Pet-tibone, D. J., Yarbrough, G.G., Chineschmidt, B. V. andJones, J. H.: Pharmaco-logic profile of a novel po-
tent direct-acting dopamineagonist, (+)-4-propyl-9-hy-droxynaphthoxazine [(+)-PHNO], 569
Martin, M. W., Smith, M. M. andHarden, T. K.: Modulation ofmuscarinic chohinergic recep-tar affinity for antagonists in
782 Index Vol. 230
rat heart, 424Mastropaolo, J., see Moersch-
baecher, J. M., 541
Maurer, S. C., see Luchowski, E.M.,607
McCormick, G. Y., White, W. J.,Zagon, I. S. and Lang, C. M.:Effects of diazepam on arte-rial blood gas concentrationsand pH of adult rats acutelyand chronically exposed tomethadone, 353
McCoun, D., see Vaupel, D. B., 20McNeill, J. H., see Latifpour, J.,
242Medulla, GABAergic mecha-
nisms, blood pressure regu-lation (rats), 34
Meffin, P. J., see Rowe, B. J., 237
Mcli, A., see Maggi, C. A., 500
Membrane potentialcatecholamine transport inhi-
bition, phenytoin, adrenalglands (cows), 171
2-nicotinamidoethyl nitrate ef-fects, ear artery (rabbits), 462
Mesenteric arteryreduced K� concentration and
ouabain (dogs), 527resistance vessels, alpha adre-
noceptors and Ca� use(rats), 413
saponin-skinned, calmodulin
antagonistic activity of bepri-dil (cows, chickens, rabbits),737
Messick, K., see Ruffoho, R. R.,Jr., 587
Met-enkephalin, [‘4C)acetylcho-line release and (guinea pigs),
493Met6-enkephalin, metabolism,
peptidase inhibitors and(rats), 349
Met5-enkephahin-Ar�-Phe7, me-tabohism, peptidase inhibi-tars and (rats), 349
Methadonearterial blood gas concentra-
tions and pH, diazepam ef-
fects (rats), 353fixed-ratio discrimination ac-
curacy and (monkeys, dogs),541
3-Methylcholanthrene, steroidmetabolism, effects on, pla-cents (rats), 761
a-Methylnorepinephrine, centralcardiovascular effects (rats),
232Meyer, W., see B#{246}hm,M., 483Microperfusion, renal tubular, in-
dacrinone enantiomer effects
(rats), 62Microsphere, hydralazine and
beta blockers, renal hyper-tension (rabbits), 205
Micturition, reflex, arachidonicacid metabolites and, bladder(rats), 500
Miller, C. H., see Winters, W. D.,69
Miller, R. C., see Godfraind, T.,514
Minneman, K. P. and Johnson,
R. D.: Characterization of at-pha-1 adrenergic receptorslinked to [3Hjinositol metab-ohism in rat cerebral cortex,317
Miska, S. P., Kimmel, G. L., Har-mon, J. R. and Webb, P.: On-togeny of cardiac ornithinedecarboxylase and its betaadrenergic responsiveness inthe rat, 419
Mitchell, J. R., see Lauterburg, B.
H., 7
MK-196, renal tubular effects(rats), 62
Moerschbaecher, J. M., Mastro-paolo, J., Winsauer, P. J. andThompson, D. M.: Effects ofopioids on accuracy of afixed-ratio discrimination inmonkeys and rats, 541
Molinoff, P. B., see Pittman, R.N., 614
Monks, T. J., see Lau, S. S., 360Monoclonal antibody, nanoparti-
dc coating by, tissue distri-bution (mice), 733
Montgomery, D. G., see Patter-son, E., 632
Morello, R. S., Begenisich, T. andYeh, J. Z.: Determination ofthe active form of phenytoin,156
Morgan, E. L., see Ruffolo, R. R.,Jr., 587, 595
Morgan, G., see Winquist, R. J.,
103Morizono, T., see Rybak, L. P.,
706
Morley, J. E., see Knodell, R. G.,256
Morphine
“C-labeled, kinetics, brain
(monkeys), 250
discriminative stimulus effects(pigeons), 652
fixed-ratio discrimination ac-curacy and (monkeys, dogs),541
Mosberg, H. I., see Porreca, F.,341
Munro, I., see Marcucella, H., 658
Munson, A. E., see Sanders, V.M.,183
Muramatsu, I., see Ueda, N., 469Musacchio, J. M., see Bahouth,
S.W., 116Muscle
detrusor, prostanoids and neu-rotransmission (rabbits), 445
iris sphincter, substance P-ergic responses (rabbits), 469
skeletal, contraction, salicylateand (frogs, toads), 478
smooth, reduced K� and oua-bain, mesenteric artery(dogs), 527
smooth, vascular, vasodilatoreffects on (rabbits), 462
Myenteric plexus,
[‘4C�acetylchohine release, Met-enkephahin effects (guineapigs), 493
Myocardium
contractile activity, nifedipine
and (humans), 514potassium-depolarized, Ca�
influx inhibition by leuko-trienes (guinea pigs), 646
Myosin, phosphorylation, vasodi-
lators and (cows), 141Myosin light chain kinase, bepri-
dii effects on (cows, chickens,rabbits), 737
Naloxonephencyclidine withdrawal, ef-
fects on (monkeys), 399
picrotoxin us., schedule-con-trolled responding (pigeons),40
Naltrexone, reversible and irre-versible opiate agonists, (pi-geons), 652
fl-Naphthoflavone, steroid me-tabohism, effects on, placenta(rats), 761
Naphthoxazine, (+)-4-propyl-9-hydroxynaphthoxazine, do-pamine agonist (fish, mice,rats, dogs), 569
Narcotic, tolerance and antago-nism, discriminative stimu-
lus effects (pigeons), 652Nelson, A., see Richelson, E., 94Nephrotoxicity
aminoglycoside, kidney epithe-hal cell line, 742
2-bromohydroquinone-induced(rats), 360
Nervous system
central and sympathetic, devel-opment in hypothyroidism
(rats), 53sympathetic, neurotransmitter,
antibody response and nor-epinephrine (mice), 183
Neuromuscular transmission,electrical excitability, (±)-de-
pentylperhydrohistrionico-toxin on acetylchohine recep-tors (frogs), 619
2-nicotinamidoethyl nitrate ef-
fects, ear artery (rabbits), 462Neuron
catecholaminergic, hypothy-roidism and (rats), 53
convulsant barbiturate effects
on (mice), 82vagal inhibitory, muscarinic
transmission (opossum), 284Neurotransmission, prostanoids
modulating, epithehialtrauma and, bladder (rab-bits), 445
Neurotransmitterreceptor, antidepressants and
(humans), 94sympathetic, antibody response
and norepinephrine (mice),183
Nicorandil, excitation-contrac-
tion coupling, vascularsmooth muscle (rabbits), 462
2-Nicotinamidoethyl nitrate, cx-citation-contraction cou-phing, vascular smooth mus-dc (rabbits), 462
Nifedipinebaroreflex sensitivity altera-
tions (dogs), 376calcium entry blockade, coro-
nary arteries and myocar-dium, (humans), 514
cardiovascular actions (rats,rabbits), 103
Niridazole, metabohites, Schi,sto-soma japonicum infection(humans), 133
Nirvanol, 5-phenyl-5-ethylhy-dantoin, stereoselective me-tabohism (humans), 28
Nitrendipine, radiolabeled, cationand calmodulin antagonisteffects, smooth and cardiacmuscle (guinea pigs, rabbits,cows), 607
Nonsteroidal anti-inflammatory
drugs, arachidonic acid de-pletion and, bladder contrac-tions (rats), 500
Noradrenaline, 2-nicotinamido-ethyl nitrate effects, vascularsmooth muscle (rabbits), 462
Norepinephrine
acetyl-Co A:arylamine N-ace-tyltransferase inductionmodulation (rats), 431
alpha adrenoceptor activation,saphenous vein (dogs), 699
alpha and beta adrenoceptors
and, interaction (rats), 595alpha-i receptor activation,
(rats), 413antibody response, beta adre-
noceptor mediation (mice),183
cold exposure and, atria (rats),450
[3H]inositol metabolism and,cerebral cortex (rats), 317
release, guanidine and (rats),
710release, ouabain effects, mes-
enteric artery (dogs), 527release inhibition, LY141865
effects (dogs), 558
Oates, J., see Strong, H. A., 726Ono, K., see Vizi, E. S., 493Opiate
“C-labeled, brain (monkeys),250
fentanyl us. saline, agonist andantagonist effects (rats), 193
receptor binding sites, guaninenucleotide regulatory site in-teraction with (rats), 684
reversible and irreversible ago-nists, discriminative stimulus
effects (pigeons), 652Opioid
kappa, U-50,488, kidney (dogs),641
peptide precursors, ethanol and$-endorphinergic system ac-tivation (rats), 455
Ornithine decarboxylase, ontog-eny, cardiac (rats), 419
Ortiz, E., see Shiverick, K. T., 761Osman, R., see Cory, R. N., 162Ototoxicity, probenecid-furose-
mide interaction and (chin-chillas), 706
Ouabain
1984 Index 783
Na�,K�-exchange pump inhi-bition, mesenteric artery(dogs), 527
renal hemodynamics and(dogs), 275
Ovalbumin, contraction and me-diator release, trachea(guinea pigs), 534
Oxotremorine, receptor binding,
heart (rats), 424Oxygen tension, beta adrenergic
responsiveness and, coronaryartery (cows, pigs), 692
Oxymorphazone, discriminativestimulus effects (pigeons),652
pA2, cold exposure and beta adre-noceptors, atria (rats), 450
Pan, H. A., Penney, J. B., Jr. andYoung, A. B.: Characteriza-tion of benzodiazepine recep-tor changes in substantia ni-gra, globus pallidus and en-topeduncular nucleus afterstriatal lesions, 768
Pang, P. K. T., see Shew, R. L., 1Parahydroxylation, stereoselec-
tive, nirvanol (humans), 28Paraquat, toxicity, endotoxin and
(mice), 284Parathyroid hormone, uterine
contractility and (rats), 1Park, M. K., see Hayashi, S., 527Patterson, E., Lynch, J. J. and
Lucchesi, B. R.: Antiar-rhythmic and antifibrillatoryactions of the beta adrenergicreceptor antagonist, dl-so-talol, 519
Patterson, E., Montgomery, D.G., Lynch, J. J. and Lucchesi,B. R.: Cardiac electrophys-iologic actions of KB-944(Fostedil), a new calcium an-tagonist, in the anesthetizeddog, 632
Patwardhan, R., see K#{252}pfer,A.,28
Paul, R. J., see Rubanyi, G., 692Penney, J. B., Jr., see Pan, H. S.,
768
Pentel, P. and Benowitz, N.: Ef-ficacy and mechanism of ac-tion of sodium bicarbonate inthe treatment of desipraminetoxicity in rats, 12
Pentylenetetrazol, toluene anti-convulsant and antipunish-ment effects (rats), 407
Peptidase, inhibitors, Met5-en-kephalin-Arg6-Phe7 andMet5-enkephalin metabolism(rats), 349
Peptide, fragments, cholecysto-kinin behavioral activity(mice), 438
Perilymph, probenecid-furose-mide interactions and (chin-chillas), 706
Perry, B. D., see Stolk, J. M., 577Peterson, R. E., see Katz, L. B.,
670Pethidine, “C-labeled, kinetics,
brain (monkeys), 250
Petit, J. P., see Winters, W. D.,69
Pettibone, D. J., see Martin, G.E., 569
Pettinger, W. A., see Smyth, D.D., 387
Phenazocine, bombesin-inducedscratching and (rats), 110
Phencyclidine
analog, mu opioid receptor in-teraction with (mice), 383
analogs and precursors (mice),20
behavioral dependence (mon-
keys), 399Phenethylamine, a-methyl-sub-
stituted, interactions with at-pha and beta adrenoceptors(rats), 595
Phenobarbitalcatecholamine inhibition, ad-
renal glands (cows), 171kidney dysfunction and (rats),
627learning, effects on (pigeons),
307
Phenoxybenzamine
acetyl-Co A:arylamine N-ace-tyltransferase induction(rats), 431
selective alpha-i blockade, kid-ney (rats), 383
Phenylephrine, [3H]inositol me-tabolism and, cerebral cortex
(rats), 317
Phenylethanolamine N-methyl-transferase, chronic inhibi-tion, norepinephrine metab-olism and (rats), 577
5-Phenyl-5-ethylhydantoin, star-eoselective metabolism (hu-mans), 28
Phenytoincatecholamine inhibition, ad-
renal glands (cows), 171learning, effects on (pigeons),
307sodium channel current block-
ing and (squid), 156Phosphatidylinositol, alpha-i ad-
renergic receptors and, cere-bral cortex (rats), 317
Phosphaturia, bicarbonate load-
ing and volume expansion,prostaglandin E2 effects(dogs), 601
Phosphodiesterase, inhibition,amrinone and AR-L57 (cats,guinea pigs, rats), 124
Phosphonic acid, derivative, KB-944, cardiac electrophysiol-ogy (dogs), 632
Phosphorylation, myosin, vasodi-
lators and (cows), 141Physalaemin, substance P recep-
tors and, salivary gland(rats), 116
Picker, M. and Poling, A.: Effectsof anticonvulsants on learn-ing Performance of pigeonsunder a repeated acquisitionprocedure when exposed tophenobarbital, clonazepam,vaiproic acid, ethosuximideand phenytoin, 307
Picrotoxin, naloxone us., sched-ule-controlled responding(pigeons), 40
Pinealectomy, amine-ketaminecatatonia (chicks, rats), 69
Pittman, R. N., Reynolds, E. E.and Molinoff, P. B.: Rela-tionship between intrinsicactivities of agonists in nor-mal and desensitized tissueand agonist-induced loss ofbeta adrenergic receptors, 614
Pitts, T. 0., Dominguez, J. H. andPuschett, J. B.: Interferenceby prostaglandin E2 with thephosphaturic effects of non-hormonal agents, 601
Pituitary gland, ethanol and fi-endorphinergic system acti-vation (rats), 455
Poling, A., see Picker, M., 307Poly(hexyl 2-cyanoacrylate) nan-
oparticles, monoclonal anti-body-coated, tissue distribu-tion (mice), 733
Popp, J. A., see Belinsky, S. A.,755
Porreca, F., Mosberg, H. I., Hurst,R., Hruby, V. J. and Burks,T. F.: Roles of mu, delta andkappa opioid receptors inspinal and supraspinal me-diation of gastrointestinaltransit effects and hot-plateanalgesia in the mouse, 341
Portal vein, hepatic, hepatic ar-tery us., drug availability(rats), 718
Potassiumdepolarized myocardium, Ca�
influx inhibition by leuko-trienes (guinea pigs), 646
permeability, 2-nicotinamido-
ethyl nitrate effects, vascularsmooth muscle (rabbits), 462
Potassium channel, currents andgating (squid), 75
Potassium ion, reduced concen-tration, ouabain and, mesen-teric artery (dogs), 527
Prada, J., see Churchill, P. C., 302Prazosin
chronic, brain catecholamine
metabolism and (rats), 577
[3H)inositol metabolism and,cerebral cortex (rats), 317
Pregnancy
2,4,2’,4’,5’-hexachlorobiphenylredistribution (rats), 263
steroid metabolism, $-naphtho-flavone and 3-methylcholan-threne effects, placenta(rats), 761
Preisig, R., see Kupfer, A., 28Pressor response, alpha adreno-
ceptor-mediated, calcium useand (rats), 587
Probenecid, interaction with fu-
rosemide (chinchillas), 706
PropranololAQA-39 and (puppies), 336elimination, hepatic blood flow
and (rats), 474(+) -4 -Propyl- 9 -hydroxynaph-
thoxazine, dopamine agonist
(fish, mice, rats, dogs), 569Propylthiouracil, hypothyroidism
and catecholamine develop-ment (rats), 53
Prostaglandindepletion, nonsteroidal anti-in-
flammatory drugs and blad-der contractions (rats), 500
epithelial trauma and, bladder(rabbits), 445
Prostaglandin E, vasopressin and,divalent ion excretion, kid-ney (rats), 295
Prostaglandin E�,, phosphaturia
inhibition by (dogs), 601Prostanoid, epithelial trauma
and, bladder (rabbits), 445Protein, phosphorylation, amri-
none and AR-L57, cardio-myocyte (cats, guinea pigs,rats), 124
Puschett, J. B., see Pitts, T. 0.,601
Quinine, muscle excitation, sali-
cylate effects on (frogs,toads), 478
Quinuclidinyl benzilate, musca-
rinic receptor affinity, heart(rats), 424
Rane, A., see Hartvig, P., 250
Rattan, S., see Gilbert, R., 284Receptor
adrenergic, I3Hlinositol metab-olism and, cerebral cortex(rats), 317
agonist, dopamine, LY141865,blood flow and (dogs), 558
alpha-i, norepinephrine acti-vation, calcium influx andrelease, artery (rats), 413
alpha adrenergic, epinephrinelevel reduction, brain (rats),577
benzodiazepine, regulation, �changes after lesions, sub-stantia nigra, globus pallidusand entopeduncular nucleus(rats), 768
benzomorphan-selective (rats),110
beta adrenergic, agonist-in-duced loss of (rats), 614
beta adrenergic, ornithine de-carboxylase ontogeny, heart(rats), 419
beta adrenergic, responsive-ness, PO2 and, coronary ar-tery (cows, pigs), 692
muscarinic, binding, diabetes(rats), 242
muscarinic and cholinergicsubtypes, lower esophageal
sphincter (opossum), 284
muscarinic guanine nucleo-tides, heart (rats), 424
muscarinic, Met-enkephalinand [‘4C)acetylcholine re-lease (guinea pigs), 493
neurotransmitter, antidepres-sant antagonism (humans),94
nicotinic, activation and desen-
sitization, (±)-depentylper-hydrohistrionicotoxin effects
Vol. 230784 Index
(frogs), 619opiate, binding sites, guanine
nucleotide regulatory site in-teraction with (rats), 684
opioid, fixed-ratio discrimina-tion accuracy and (monkeys,dogs), 541
opioid, mu, phencycidine ana-log interaction with (mice),383
opioid, spinal and cerebral, gas-trointestinal transit and hot-plate analgesia (mice), 341
substance P, salivary gland(rats), 116
Renin, 2-chloroadenosine effects(rats), 302
Renwick, A. G., see Strong, H. A.,726
Reserpine, AQA-39 and (pup-pies), 336
Respiratory system, arterial bloodgas concentrations and pH,diazepam effects, methadoneand (rats), 353
Retina, dopamine release (rab-bits), 149
Reynolds, E. E., see Pittman, R.N., 614
Richelson, E. and Nelson, A.: An-tagonism by antidepressantsof neurotransmitter recep-tom of normal human brainin uitro, 94
Righting reflex, loss, phenobarbi-tal-induced, kidney dysfunc-tion and (rats), 627
Rimele, T. J., see Flavahan, N. A.,
699Rinkema, L E., Bemis, K. G. and
Fleisch, J. H.: Productionand antagonism of cutaneousvascular permeability in theguinea pig in response to his-tamine, leuokotrienes andA23187, 550
Roman, R. J., Skelton, M. andLechene, C.: Prostaglandin-vasopression interactions onthe renal handling of calciumand magnesium, 295
Rowe, B. J. and Meffin, P. J.:Diisopropylfluorophosphateincreases clofibric acid clear-ance: Supporting evidencefor a futile cycle, 237
Rowland, M., see Ahmad, A. B.,718
Rubanyi, G. and Paul R. J.: 02-sensitivity of beta adrenergicresponsiveness in isolatedbovine and porcine coronaryarteries, 692
Ruffolo, R R., Jr., Goldberg, M.R and Morgan, E. L.: Inter-actions of epinephrine, nor-epinephrine, dopamine andtheir corresponding a-meth-yl-substituted derivativeswith alpha and beta adreno-ceptors in the pithed rat, 595
Ruffolo, R R., Jr., Morgan, E. L.and Messick, K.: Possible re-lationship between receptorreserve and the differential
antagonism of alpha-i andalpha-2 adrenoceptor-medi-ated pressor responses by cal-cium channel antagonists inthe pithed rat, 587
Rybak, L. P., Green, T. P., Juhn,S. K. and Morizono, T.: Pro-benecid reduces cochlear ef-fects and perilymph penetra-tion of furosemide in chin-chilla, 706
St-Pierre, S., see Crawley, J. N.,438
Saito, H., see Hori, R., 742Salicylamide, dose-dependent ki-
netics (dogs), 89Salicylate, muscle contraction
and (frogs, toads), 478Salivary gland, substance P re-
ceptor (rats), 116Sanders, V. M. and Munson, A.
E.: Beta adrenoceptor media-
tion of the enhancing effectof norepinephrine on the mu-rine primary antibody re-sponse in uitro, 183
Santicioli, P., see Maggi, C. A.,500
Saphenous vein, alpha adrenocep-tore, activation by norepi-nephrine (dogs), 699
Saponin, skinned mesenteric ar-tery, calmodulin antagonisticactivity of bepridil (cows,
chickens, rabbits), 737Sapru, H. N., see Willette, R N.,
34Sarcoplasmic reticulum, calcium
sequestration, salicylate ef-
fects (frogs, toads), 478Sarmiento, J. G., see Luchowski,
E. M., 607
Saxena, P. R., see Bolt, G. R., 205Schaeffer, R. C., Jr., Briston, C.,
Chilton, S.-M. and Carlson,R. W.: Hypotensive and he-mostatic properties of rat-tlesnake (Crotalus uiridis hel-Len) venom and venom frac-tions in dogs, 393
Schenker, S., see Kupfer, A., 28Schistosoma japonicum, nirida-
sole, serum metabolites (hu-mans), 133
Schmidt, B., see B#{246}hm,M., 483Schmitz, W., see B#{246}hm,M., 483Scholz, H., see B#{246}hm,M., 483Schuler, R., see Wood, R. W., 407Schulz, R., W#{252}ster,M. and Hers,
A.: Receptor preference ofdynorphin A fragments in themouse vas deferens deter-mined by different tech-niques, 200
Schwartz, J., see Bousquet, P., 232Seizinger, B. R., Bovermann, K.,
H#{246}llt,V. and Hers, A.: En-hanced activity of the �9-en-dorphinergic system in theanterior and neurointerme-diate lobe of the rat pituitaryafter chronic treatment withethanol liquid diet, 455
Sembi, J., see Strong, H. A., 726Serotonin
antagonism, lergotrile (rats), 47L-tryptophan effects, blood
pressure and (rats), 324Shew, R. L., Yes, J. A. and Pang,
P. K. T.: Direct effect ofparathyroid hormone on ratuterine contraction, 1
Shiverick, K. T., Ortiz, E., Fuhr-man-Lane, C. and Crowley,P.: Effects of �-naphthofla-vone and 3-methylcholan-threne administered to preg-
nant rats on steroid metabo-lism in the isolated basalzone of the placenta, 761
Siegl, P. K. S., see Winquist, R.J., 103
Silver, P. J., Dachiw, J. and Am-brose, J. M.: Effects of cal-cium antagonists and vaso-dilators on arterial myosinphosphorylation and actin-myosin interactions, 141
Simon, E. J., see Itzhak, Y., 383Simpson, L. L.: Molecular basis
for the pharmacological ac-tions of Clostridium botu-
linum type C2 toxin, 665Skelton, M., see Roman, R. J., 295Skerritt, J. H. and Macdonald, R.
L.: Multiple actions of con-vulsant barbiturates onmouse neurons in cell cul-ture, 82
SKF 10,047, fixed-ratio discrimi-nation accuracy and (mon.keys, dogs), 541
SK&F 64139, phenylethanola-mine N-methyltransferaseinhibition, central effects ofchronic treatment (rats), 577
SK&F 29661, chronic, brain cats-cholamine metabolism and
(rats), 577Skin, vascular permeability, his-
tamine, leukotrienes andA23187 (guinea pigs), 550
Slepetis, R. J., see Slotkin, T. A.,53
Slifer, B. L., Balster, R. L. andWoolverton, W. L.: Behav-ioral dependence produced bycontinuous phencyclidine in-fusion in rhesus monkeys,399
Slizgi, G. R., Taylor, C. J. andLudens, J. H.: Effects of thehighly selective kappa opioid,U-50,488, on renal functionin the anesthetized dog, 641
Slotkin, T. A. and Slepetis, R. J.:Obligatory role of thyroid
hormones in development ofperipheral sympathetic and
central nervous system ca-techolaminergic neurons: Ef-fects of propylthiouracil-in-duced hypothyroidism ontransmitter levels, turnoverand release, 53
Smith, M. M., see Martin, M. W.,424
Smith, P. A., Dombro, K.-R and
Zidichouksi, J.: Effect oferythrosin B on hyperpolar-izing responses to catechol-amines in amphibian sympa-thetic ganglia, 221
Smyth, D. D., Umemura, S. andPettinger, W. A.: Alpha-i ad-renoceptor selectivity ofphenoxybenzamine in the rat
kidney, 387
Sodium bicarbonate, desipramine
toxicity (rats), 12Sodium channel
blockade, phenytoin effects(squid), 156
currenta and gating (squid), 75
Sodium pump, erythrosin B inhi-bition, ganglia (frogs, bull-frogs), 221
dl-Sotalol, antiarrhythmic andantifibrillatory actions(dogs), 519
Sphincter, lower esophageal, mus-carinic receptor subtypes in(opussum), 284
Spindler-Vomachka, M. and Vod-icnik, M. J.: Distribution of2,4,5,2’,4’,5’ - hexachlorobi-phenyl among lipoproteinsduring pregnancy and lacta-tion in the rat, 263
Steiness, E., see Keiding S., 474Steroid
anti-inflammatory, histamine
and arachidonic acid (rats),175
metabolism, �9-naphthoflavoneand 3-methylcholanthreneeffects, placenta (rats), 761
Stewart, J. M., see Bahouth, S.W., 116
Stolk, J. M., Vantini, G., Perry,B. D., Guchhait, R. B. andU’Prichard, D. C.: Assess-ment of the functional role ofbrain adrenergic neurons:Chronic effects of phenyleth-anolamine N - methyltrans-ferase inhibitors and alphaadrenergic receptor antago-fists on brain norepineph-rine metabolism, 577
Striatum, kainate lesions, benzo-diazepine receptor changes
after, substantia nigra, gb-bus pallidus and entopedun-cular nucleus (rats), 768
Strong, H. A., Oates, J., Sembi, J.,Renwick, A. G. and George,C. F.: Role of the gut flora in
the reduction of sulfinpyra-zone in humans, 726
Structure-activity relationship,guanidine alkyl derivativesand norepinephrine release(rats), 710
Suarez-Kurtz, G., de Costa, M. J.B. and Coutinho, S.: Inhibi-tory effects of salicylate oncontractility in skeletal mus-dc, 478
Substance Pcapsaicin and bradykinin ef-
fects, iris sphincter muscle(rabbits), 469
1984 Index 785
receptors, salivary gland (rats),116
Substantia nigra pars reticulata,benzodiazepine receptor
changes, lesions and (rats),768
Suckow, R. F., see Barkai, A. I.,330
Sulfide, sulfinpyrazone reduction,gut flora effects (humans),726
Sulfinpyrazone, microbial reduc-tion, intestine (humans), 726
Sulfoconjugation, dose-depend-ent, salicylamide (dogs), 89
Sv#{228}rd,H., see Hartvig, P., 250
Tachycardia, supraventricular,KB-944 and (dogs), 632
Takahashi, K., see Maleque, M.A., 619
Tang, J., see Chou, J., 349Taylor, C. J., see Slizgi, G. R., 641
Temperature, cold exposure, betaadrenoceptors and, atria(rats), 450
Terbutaline, norepinephrine and,antibody response (mice),183
2,3,7,8-Tetrachborodibenzo-p- di-oxin, edema response to car-rageenan and dextran (rats),670
Theobald, H. M., see Katz, L. B.,670
i-Thiocarbamoyl-2-imidazoli-none, niridazole and, Schis-tosoma japonicum infection(humans), 133
Thompson, D. M., see Moersch-baecher, J. M., 541
Thurman, R. G., see Belinsky,S. A., 755
Thyroid hormone, nervous sys-tern catecholaminergic neu-ron development, propyl-thiouracil (rats), 53
Toluene, anticonvulsant and an-tipunishment effects, penty-lenetetrazol and (rats), 407
Tomography, position emission,“C-labeled opiate kinetics,brain (monkeys), 250
Toxicity, desipramine, bicarbon-ate and (rats), 12
Toxin, Clostridium botulinum
type C2, molecular pharma-cobogy (mice), 665
Trachea, antigen challenged(guinea pigs), 534
Tran, M.-A., Lac, D. T., Berban,M. and Lafontan, M.: Inter-play of alpha-2 and beta
Lt� adrenoceptors in the control� � of free fatty acid release from
bone marrow adipose tissue,228
Transcapillary exchange, urea
distribution kinetics (dogs),
269Triggle, D. J. see Luchowski, E.
M.,607Trypan blue, uptake, hepatotox-
icity investigation (rats), 755L-Tryptophan, blood pressure ef-
fects (rats), 324Tumor, xenograft, human, mono-
cbonal antibody-coated nan-oparticles (mice), 733
U-50,488, renal effects (dogs), 641Ueda, N., Muramatsu, I. and Fu-
jiwara, M.: Capsaicin andbradykinin-induced sub-stance P-ergic responses inthe iris sphincter muscle ofthe rabbit, 469
Umemura, S., see Smyth, D. D.,387
U’Prichard, D. C., see Stolk, J. M.,577
Urea, distribution kinetics, trans-capillary exchange effects(dogs), 269
Urthaber, F. and Walker, A. A.:Indirect stimulatory action ofthe calcium channel blockerAQA-39, 336
Uterus, contractility, parathyroidhormone effects (rats), 1
Valencia, C. I., Catto, B. A., Fair-child, E. H., Wilson, S. B.,Maramba, N. C. and Web-ster, L. T., Jr.: Concentra-tion-tirne course of niridazoleand six metabolites in the se-rum of four Filipinos withSchistosomajaponicum infec-tion, 133
Valproate, ionic channel effects
(squid), 75
Valproic acid, learning, effects on(pigeons), 307
Vanhoutte, P. M., see Flavahan,N. A., 699
Vantini, G., see Stolk, J. M., 577Vasculature, dermal, permeabil-
ity, histamine, leukotrienesand A23187 (guinea pigs),550
Vas deferens, receptor selectivityof dynorphin fragments(mice), 200
Vasodilator, 2-nicotinamidoethylnitrate, excitation-contrac-tion coupling, vascularsmooth muscle (rabbits), 462
Vasodilator fiber, ouabain effects,
kidney (dogs), 275Vasopressin, prostaglandins and,
divalent ion excretion (rats),295
renal adenylate cyclase (rats),
387
Vaupel, D. B., McCoun, D. andCone, E. J.: Phencyclidineanalogs and precursors: Re-tarod and lethal dose studiesin the mouse, 20
Venom, hypotensive and hemo-static properties (dogs), 393
Ventricle, refractoriness, dl-so-talol effects (dogs), 519
Verapamil, cardiovascular actions(rats, rabbits), 103
Voltage clamp, ethosuximide andvalproate testing (squid), 75
Vizi, E. S., Ono, K., Adam-Vizi,V., Duncalf, D. and F#{246}ldes,F.F.: Presynaptic inhibitory ef-fect of Met-enkephalin on[‘4C]acetylcholine releasefrom the myenteric plexusand its interaction with mus-carinic negative feedback in-hibition, 493
Vodicnik, M. J., see Spindler-
Vornachka, M., 263
[3H]W-7, calmodulin antagonisticactivity of bepridil (cows,chickens, rabbits), 737
Walker, A. A., see Urthaler, F.,336
Wallace, A. A., see Winquist, R.J., 103
Ward, S., see KOpfer, A., 28Warltier, D. C., Zyvoboski, M. G.,
Gross, G. J. and Brooks,H. L.: Comparative actions ofdihydropyridine slow chan-nd calcium blocking agentsin conscious dogs: Altera-tions in baroreflex sensitiv-ity, 376
Warltier, D. C., Zyvoloski, M. G.,Gross, G. J. and Brooks,H. L.: Comparative actions ofdihydropyridine slow chan-nd calcium blocking agentsin conscious dogs: Systemicand coronary hemodynamicswith and without combinedbeta adrenergic blockade, 367
Waschek, J. A., Rubin, G. M.,Tozer, T. N., Fielding, R. M.,Couet, W. R., Effeney, D. J.and Pond, S. M.: Dose-dc-pendent bioavailabiity andmetabolism of salicylamidein dogs, 89
Webb, P., see Miska, S. P., 419Webster, L. T., Jr., see Valencia,
C. I., 133White, W. J., see McCormick,
G.Y.,353Willette, R N., Barcas, P. P.
Krieger, A. J. and Sapru, H.N.: Endogenous GABAergicmechanisms in the medulla
and the regulation of bloodpressure, 34
Williams, G. E., see Martin, G. E.,
569Wilson, S. B., see Valencia, C. I.,
133Winquist, R. J., Siegl, P. K. S.,
Baskin, E. P., Bohn, D. L.,Morgan, G. and Wallace, A.A.: Calcium entry blocker ac-tivity of cyproheptadine inisolated cardiovascular prep-arations, 103
Winsauer, J. P., see Moersch-
baecher, J. M., 541
Winters, W. D., Petit, J. P.,Lakin, M. L. and Miller, C.H.: Effects ofamine pretreat-ment on ketamine catatoniain pinealectomized or hy-pophysectomized animals, 69
Witkop, B., see Maleque, M. A.,619
Wolf, W. A. and Kuhn, D. M.:Effects of L-tryptophan onblood pressure in normoten-sive and hypertensive rats,324
Wood, R W., Coleman, J. B.,Schuler, R. and Cox, C.: An-ticonvulsant and antipunish-ment effects of toluene, 407
Woods, J. H., see France, C. P.,652
Woolverton, W. L., Goldberg, L.
I. and Ginos, J. Z.: Intrave-nous self-administration ofdopamine receptor agonistsby rhesus monkeys, 678
Woolverton, W. L., see Slifer,B. L., 399
WUster, M., see Schulz, P., 200
m-Xylene, anticonvulsant activ-ity, pentylenetetrazol and(rats), 407
Yamamoto, see Hori, R, 742Yang, H.-Y. T., see Chou, J., 349Yarbrough, G. G., see Martin,
G. E., 569Yee, J. A., see Shew, R. L., 1Yeh, J. Z., see Morelbo, R. S., 156Yohimbine, chronic, brain cate-
cholamine metabolism and(rats), 577
Young, A. B., see Pan, H. S., 768
Yousif, F., see Luchowski, E. M.,607
Zagon, I. S., see McCormick,G. Y., 353
Zidichouski, J., see Smith, P. A.,221
Zyvoloski, M. G., see Warltier,D. C., 367, 376