Integration architecture

• Queryable sources that generate XML• Distributed queries over sources• Query Manager to manage queries• Saved queries as sources that can also be

queried• Leads to potential for query networks

vSPARQLService

RDF Store

vSPARQLService

RDF Store

vSPARQLService

RDF Store

QM DB

vSPARQLService

QM Server

QM Client

RDF Store

QM DB

vSPARQLService

QM Server

QM Client

RDF Store

XML

XML

BIRN fMRI Study

Label using Talairach Demon

Extract centers of activation

BIRN fMRI Study

Schizophrenics vs Healthy Controls

XML

QM DB

vSPARQLService

QM Server

RDF/OWL

XML

QM Client

RDF Store

QM DB

vSPARQLService

DXQueryService

QM Server

RDF/OWL

XML

QM Client

RDF Store

QM DB

vSPARQLService

DXQueryService

QM Server

RDF/OWL

QM Client

RDF Store

XML

QM DB

vSPARQLService

DXQueryService

QM Server

RDF/OWL

QEService

QM Client

RDF Store

XML

QM DB

vSPARQLService

DXQueryService

QM Server

RDF/OWL

QEService

QM Client

RDF Store

XML

QM DB

vSPARQLService

DXQueryService

QM Server

XML RDF/OWL

QEService

QM Client

RDF Store

XML

Region Filtered Healthy(Red)

Schizo-phrenic(Yellow)

Dorso_lateral prefrontalcortex

55 25 30

Brodmann area 6 213 107 106

Frontal lobe 575 288 287

N=1741

QM DB

vSPARQLService

DXQueryService

QM Server

QEService

QM Client

RDF Store

QM DB

RemoteServices

vSPARQLService

DXQueryService

OtherServices

QM Server

Other Client

XML RDF/OWL

XML

QEService

Other Client

QM Client

RDF Store

RDF/OWL

RemoteServices

RemoteServices

vSPARQLService

DXQueryService

OtherServices

Other Client

XML RDF/OWL

XML

Other Client

QM Client

RDF Store

RDF/OWL

RemoteServices

Query ManagerCore

RemoteServices

vSPARQLService

DXQueryService

OtherServices

Other Client

XML RDF/OWL

XML

Other Client

QM Client

RDF Store

RDF/OWL

RemoteServices

Query ManagerCore

Query Manager Core with Plugins

RemoteServices

Other Client Other

Client

RemoteServices

Query Manager

RDF/OWL

RDF/OWL

XML

XML

Query Manager

RDF/OWL

RDF/OWL

XML

XML

Query Manager

BIRN fMRI and FMA

BIRN fMRI FMA

Query Manager

BIRN fMRI, VBM and FMA

BIRN fMRI

FMA

VBM

Query Manager

Electronic Data Capture and Freezer Management

Freezer Management

EDC

Query Manager

Biorepositories

Biorepository

Biorepository

Query Manager

Human Studies Database

Clinical Trials Metadata

Clinical Trials Metadata

Ontology of Clinical Research

Query Manager

Ontology Views

Ontology

Query Manager

Summary

Issues

• Response time• Reliability• Security• Discoverability• Usability• Integration with other systems and methods

Query Manager

Query Manager Future Work

Query Manager

Query Manager

Query Manager

BIRN fMRI

FMA

Brain Imaging View

EDC

Clinical View

Clinical

Imaging

Clinical/Imaging View

Genomic View

Gene

Protein

Others….

Clinical/Imaging Genomic

Translational View

Query Web

Query Web

Translational Medicine

Web

Semantic Web

Internet

Query Web

A Network-centric view of information systems

Bin Zhang

A convergence?

• Biology as an information science• Information science as biology• Networks as the link

Credits

• Todd Detwiler• Onard Mejino• Joshua Franklin• Ron Shaker

• Xenia Hertzenberg• Nolan Nichols• Marianne Shaw• Wayne Warren

• Linda Shapiro• Dan Suciu• Cornelius Rosse

Funding: NLM, NIMH, NHLBI