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Number 61 June 2016 Editor: David W. Warne
Executive Committee (ExCom) 2016 Editorial
Officers Members
President,News Editor, Webmaster
David W. Warne (CH) Chris Metcalfe (UK) Katherine Lee (AU)
Vice-President KyungMann Kim (US) Chris Weir (UK) Stanislav Katina (CZ)Secretary Vana Sypsa (GR) Hein Putter (NL) Thomas Jaki (UK)Treasurer Zdenek Valenta (CZ) Jeremy Taylor (US) Toshiro Tango (JP)
Website and Email Addresses
www www.iscb.infoPermanent Office [email protected] [Rita Schou ]
Social Media
LinkedIn http://www.linkedin.com/groups?home=&gid=4795649
Facebook https://www.facebook.com/groups/139123109663/Twitter @ISCB_Info
ISCB News: Correspondence Address
ISCB News Editor [email protected] [David W. Warne]ISCB Book Review Editor [email protected] [Jindra Reissigova]
Chairs/Secretaries of Subcommittees (SCs) 2016
Student ConferenceAwards
Nadine Binder (DE) Katherine Lee (AU)
Statistics in RegulatoryAffairs
Harbajan Chadha-Boreham(FR)
Nicole Close (US)
National Groups Zdenek Valenta (CZ) Anca Vitcu (RO)
Epidemiology Saskia Le Cessie (NL) Christina Bamia (GR)
Education Erik Cobo (ES) Thomas Jaki (UK)
Conference Organising David W. Warne (CH) Geir Egil Eide (NO)
NG Representatives/Deputies/Treasurers/Webmasters/Websites 2016
Zdenek Valenta [email protected] Maly [email protected]
CzechRep.
Jindra Reissigová [email protected]
sites.google.com/site/iscbcr/home
Julia Singer [email protected] Boda [email protected]
Hungary
Péter Vargha [email protected]
efabis.univet.hu:8080/biostat
Krystyna Szafraniec [email protected] Alicja Cicha-Mikołajcz alicja.cichamikolajczyk@
gmail.com
Poland
Kinga Sałapa [email protected]
www.iscb.pl
Anca Vitcu [email protected] Ignat [email protected]
Romania
Elena Mitocariu [email protected]
iscbrng.vv.si
Jelena Kotur- Stevuljević
Dejan Ćurčić [email protected]
-
It’s only a few weeks to go until ISCB37 Birmingham, andit will be another large conference. Cindy Billingham andNigel Stallard of the LOC and SPC have written an article toprovide an overview of the event, and the full draftprogramme is included in this News. More details can befound at www.iscb2016.info where you can download thecomplete programme and the conference “app”.
Important Society business will be discussed at the AnnualGeneral Meeting (AGM) in Birmingham, to which allparticipants of the meeting are invited. The Agenda providedby ISCB Secretary Vana Sypsa is printed in this News. We willdiscuss the President’s mid-year Report, the TreasurerZdenek Valenta’s Financial Report of 2015, both included inthe News. Finally, the Subcommittees (SCs) will present briefupdates of their activities and we’ll have a preview of nextyear’s conference and plans for future years. Material will beplaced on ISCB’s website to review before the AGM.
It’s less than a year until the next ISCB Election and now isthe time to think whether you would like to become amember of the ExCom. The process is explained later in theNews. The Officers and ExCom would like to see people fromall parts of the ISCB membership becoming candidates.
Thanks to the contributors to this News: Zdenek Valentaand Nadine Binder on behalf of the NatG and StCA SCs forinformation about the 2016 CASc and StCA awards to bepresented in Birmingham, as well as Karla Hemming on behalfof the Conference Fund for Developing Countries (CFDC)awards committee. Thanks too to our Treasurer ZdenekValenta (Financial Report for ISCB 2015) and Secretary VanaSypsa (AGM agenda), new Book Review Editor JindraRessigova and the 3 book reviewers, Enrico Chavez foranother cartoon, and Rita Schou of the ISCB Office forkeeping everything under control.
Index
ISCB Membership .......................................................................................2ISCB President’s Mid-Year Message............................................................3ISCB Membership Progression....................................................................3Book Review by Miland Joshi (UK) ..............................................................4Oct. 2016 - Elections for the ExCom 2017-18: Final Warning! ....................5Books for Review by Jindra Reissigová (Book Review Editor) .....................6Book Review by Douglas Dover (CA)...........................................................8ISCB Treasurer’s Mid-Year Report: ISCB Accounts 2015 .............................9ISCB37 Birmingham, UK: 21-25 August 2016: Welcome!..........................11ISCB37 Birmingham 2016: Conference Awards for Scientists: Winners....12ISCB37 Birmingham 2016: Student Conference Awards: Winners............12ISCB37 Birmingham 2016: Biometrical Journal Special Issue ....................12ISCB37 Birmingham 2016: Students’ Day..................................................13ISCB37 Birmingham 2016: ISCB Annual General Meeting Agenda............14
ISCB37 Birmingham 2016: Conf. Fund for Developing Countries (CFDC).. 14Book Review by Matthias Herpers (DE).................................................... 31Cartoon Corner ........................................................................................ 32ISCB GENERAL INFORMATION.................................................................. 33Advertising Rates ..................................................................................... 33Society’s Aims .......................................................................................... 33Changes of Address or Email .................................................................... 33Information on Submitting Articles .......................................................... 33ISCB Office & Executive Committee: Contact Details ............................... 34ISCB Membership and Googlegroups Emailing Lists................................. 35ISCB Subcommittees: Contact Details ...................................................... 36ISCB Membership Information................................................................. 38ISCB Membership Subscription ................................................................ 39ISCB Calendar ........................................................................................... 40
ISCB News #61 Page 2 June 2016
ISCB Membership
ISCB membership continues to grow to another new record June total. The idea of introducing a €20 surcharge for late subscription may have had an impact.Also new members who have joined ISCB by attending the conference in Birmingham have been added to the membership database on an ongoing basisfrom April. If you haven’t yet logged on to the Members Area of the www.iscb.info website, please have a go; if you need any help, please [email protected].
Date end end Dec Dec Dec Dec Dec Dec Dec Nov Nov Dec Nov Nov Nov Nov Nov Dec Nov Dec Dec Dec Dec Dec Jun Dec Jun
*=host Conference 89 92 93 94 95 96 97 98 99 00 01 02 03 04 05 06 07 08 09 10 11 12 13 14 15 15 16 17 18 19
Total 261 596 715 698 725 702 685 729 818 797 837 825 756 758 620 808 800 921 862 880 864 993 1028 1084 635 1141 883
# Countries 23 32 32 31 33 34 37 37 41 40 45 41 40 38 39 40 41 42 39 42 41 43 42 55 41 50 45
1. UK 50 90 176* 120 144 121 128 169* 135 151 153 141 190* 140 109 133 117 114 124 114 99 130 130 121 61 144 189*
2. Poland [NatGrp] 11 11 24 24 30 21 19 26 34 37 41 41 43 40 49 54 62 66 71 78 82 88 88 84 86 76
3. Germany 30 67 75 84 71 78 72 70 186* 90 87 77 61 57 51 73 48 59 72 61 53 78 113* 107 44 108 70
4. Romania [NatGrp] 2 4 1 1 1 19 21 30 28 30 31 36 2 67 58 67 72 75 77 68
5. Hungary [NatGrp] 1 21 17 18 19 25* 27 29 29 33 34 41 48 42 38* 50 44 43 44 42 48 48 49 52 52 52 52
6. Czech Rep. [NatGrp] 1 1 1 1 1 1 2 2 1 1 1 1 3 17 36 28 44* 30 30 41 40 43 42 42 43
7. Netherlands 14* 30 38 33 36 29 31 39 35 33 38 39 33 87* 35 44 41 39 49 56 38 57 55 55 38* 111 42
8. France 30 52 62 50 73 67 52 52 49 53 37 93* 31 41 30 57 41 49 49 119* 48 60 66 70 23 72 42
9. USA 18 45 40 39 41 40 79* 66 76 77 89 78 75 57 51 67 62 74 67 64 93 66 63 57 36 57 37
10. Japan 2 6 7 5 7 4 10 13 20 12 11 10 10 10 17 17 27 20 26 24 22 9 38 30 11 27 25
11. Australia 6 9 11 6 9 8 11 9 10 12 8 9 14 8 6 11 11 10 13 18 17 23 31 24 16 25 21 *
12. Denmark 4 58* 38 31 30 32 26 35 38 39 36 46 41 37 37 40 34 154* 54 60 39 50 39 29 17 29 20
13. Canada 6 12 14 14 11 13 15 14 9 9 10 14 16 8 12 12 19 22 18 18 68* 14 17 24 15 27 18
14. South Korea 3 1 1 1 6 6 6 5 6 15 22 12 18
15. Switzerland 14 25 22 80* 33 29 24 25 23 18 23 26 22 23 23 55* 28 26 28 30 15 20 29 37 12 32 17
16. Norway 13 18 25 22 12 18 10 10 11 10 16 16 12 14 12 13 12 19 21 15 15 70 34 27 13 24 17
17. Austria 4 9 11 13 11 16 13 11 15 18 15 13 16 17 15 14 16 17 15 15 9 10 15 45* 10 15 16
18. Belgium 13 22 27 30 30 32 35 29 25 33 36 33 23 27 24 23 32 33 33 32 24 32 35 21 8 28 15 *
19. Turkey 1 1 1 1 2 2 3 4 7 2 3 1 2 5 5 20 11
20. Sweden 23 51 53 54 58 64 51 45 38 44 88* 50 36 34 24 23 19 27 19 18 12 26 13 18 8 15 11
21. Italy 16 33 37 32 32 33 26 33 26 63* 29 25 15 25 15 23 24 20 10 15 8 24 9 16 7 9 11
22. Greece 1 1 1 1 1 3 1 6 1 2 2 3 50* 5 7 7 5 7 11 8 4 13 8
23. Spain 10 12 18 12 46* 23 14 16 12 11 11 8 7 15 5 9 8 5 14 14 4 13 10 17 6 8 8 *
24. Taiwan 1 1 1 1 1 1 3 7 4 3 5 2 5 6
25. India 1 1 1 1 1 1 1 1 2 1 2 2 3 2 2 3 4 4 3 8 8 6 7 3 3 5
26. Finland 2 7 7 9 9 9 7 5 10 9 18 11 7 11 10 6 8 8 9 8 6 9 11 4 3 7 3
27. South Africa 1 4 1 3 2 2 2 2 2 3 3 3 2 3 3 3 2 5 2 4 4 1 2 1 5 3
28. Russia 1 3 3 3 2 2 1 4 3 2 1 1 1 1 1 2 4 3
29. Slovakia 1 1 2 2 2 2 1 1 1 3 3 3 3 3
30. Bulgaria 1 2 1 1 2 3
31. Ireland 1 2 3 4 3 4 4 2 3 2 3 1 1 2 1 3 3 3
32. Sri Lanka 1 1 1 3
33. Iran 1 1 1 1 4 1 3 5 1 2 1 6 3 2 1 9 2
34. Slovenia 1 2 3 2 1 1 3 2 1 2 1 2 3 3 4 5 5 4 3 6 4 2 7 7 9 2
35. Israel 1 3 4 4 4 4 3 3 4 10 13 10 7 8 3 4 2 2 1 2 2 3 2 7 1 5 2
36. Portugal 1 3 5 2 2 2 2 5 5 3 4 3 3 1 1 1 2 6 2 7 2 3 1 10 2 3 2
37. Singapore 3 6 4 5 8 5 7 2 4 6 2 4 1 3 3 5 1 1 3 2
38. New Zealand 1 1 2 1 2 2 2 3 3 3 1 2 2 2 5 2 1 3 1 2 3 1 7 1
39. Thailand 1 1 1 1 2 1 1 2 2 2 3 1 3 5 1
40. Brazil 2 1 1 1 1 2 2 2 2 2 2 1
41. Luxembourg 1 1 2 1 3 1 2 1
42. Kenya 1 1 1 1 1 1 1
43. Colombia 1 1 1 1 1 1 1
44. Nigeria 1 1
45. Egypt 1 1 1
46. Serbia [NatGrp] 2 13 13 10 11 16 16
47. Bangladesh 1 4
48. China 1 1 2 3 3 3 3 3 3 3 2 2 2 2 3 1 2
49. Mexico 1 1 1 1 1 1 2 2 2 1 1 1 1 2 1 2
50. Estonia 2 1 1 1 1 1 3 2
51. Pakistan 1 1 1 1 2
52. Malaysia 2 1 2 2 1 1 1 1 1 3 3 2 1 1 2 3 2 1 1 1
53. Qatar 1 1 1 1
54. Vietnam 1 1 3
55. Jordan 2
56. Gambia 1 2
57. Venezuela 2 1 1
58. Saudi Arabia 1 1 3 1
59. Indonesia 1 1 1 1
60. Croatia 1 1 1 1
61. Kuwait 1 1 1
62. Cyprus 1
63. Argentina 1 1
64. Algeria 2
65. Cuba 2 2 2 2 2 2 1 1 1 1
66. United Arab Emirates 1 1
67. Chile 1
68. Malawi 1 1 1
69. Lithuania 2
70. Sudan 1
71. Ukraine 1 1
72. Philippines 1
73. Zimbabwe 1
74. Oman 1
ISCB News #61 Page 3 June 2016
ISCB President’s Mid-Year Message
From David W. Warne
Firstly, and most importantly, the Ballot for choosing the newExecutive Committee and Officers (Vice-President, Secretaryand Treasurer) for 2017-18 is fast approaching. An article in thisNews lists which positions are open for nominations andexplains the process.
I would like each of you to consider submitting a nominationform by the deadline of 31 August 2016. Do you have somethingto contribute to the Society? Do you think there are not enoughpeople from your country or region involved in the Society’sdecision-making? Are there not enough members of theCommittee who are women? Is it always the same old group ofpeople making decisions or should we have some new bloodbringing new, fresh ideas?
The Society is beginning to look for Conference Candidates for2020 and later. If you and your friends and colleagues would liketo organise an ISCB conference, now is the time to explore theinitial ideas. A good conference can take 5 years fromconception to birth!
As announced in Utrecht, the Society has found a new journal topublish some of the best papers presented at the annualconference. This will allow us to continue the tradition of havingan ISCB Special Issue, which goes back about 30 years. Latestnews is that 12 papers from Utrecht were submitted to theBiometrical Journal. This process will be continued for ISCB37Birmingham, please see the article in this News.
The organisers of ISCB36 Utrecht took a risk and set theconference fee low to try to encourage more people to attendand to avoid having too profit. Now that the accounts are beingfinalised, it’s clear they got things just right.
The ISCB Treasurer’s report from Zdenek Valenta, shows thatthe financial results of 2015 were positive confirming that theSociety is financially very healthy. This is clearly correlated withmore members joining the Society by attending the annualconference.
This year’s conference, ISCB37 Birmingham, promises to be again veryexciting. The organising and scientific committees have done almostall their work and are awaiting the arrival of us, the ISCB members inthe final week of August, Sunday 21 to Thursday 25. Full details areincluded in this News.
If you attended the conference in Utrecht, you will have seen manyinteresting sessions and attended some of the social activities. Butperhaps you’re not aware the Society is active between conferences,especially its 6 Subcommittees (SCs). Have you thought about joiningone of them? The following summarises their activities.
The Student Conference Awards SC continues to review how it canimprove its processes and find new ways to get students involved inISCB. See the article below about a special Students Day planned forBirmingham.
The Statistics in Regulatory Affairs SC is planning to launch aWikipedia website linking to various guidances on biostatistics. Theyhave had an abstract accepted for ISCB37 in Birmingham and so pleaselook out for their poster P-182.
The National Groups SC has been very active with the organisation ofseveral seminars within each NG country.
Members of the Epidemiology SC will present updates of the STRATOSinitiative in Birmingham, and the initiative continues to grow andrecruit more members to its various work streams. The rest of theEpid SC is considering whether to continue its work on other topics.
The Education SC again has asked for proposals and suggestions forbiostatistics courses in 2016. Two courses will be given:
Budapest, Hungary, Nov 2016, Stephen Senn: Statistical issues in drugdevelopment
Krakow, Poland, 22-23 Sep 2016, Stijn Vansteelandt: Models for CausalInference
Lastly, the Conference Organising SC continues to discuss ways toimprove conferences and will advise the Society’s Officers on futureconference candidates.
ISCB Membership Progression
ISCB Membership 1992-2016
596
715698
725702
685
729
817797
838 825
780760
619
808 800 808 800
921
862880
864
992
1028
1084
1141
0
430 439 428 442 434 448480 469
518 523483
433 436467
450467
448413
458437
517475
547
596635
883
0
200
400
600
800
1000
1200
Dec
92
Dec
93
Dec
94
Dec
95
Dec
96
Dec
97
Dec
98
Dec
99
Dec
00
Dec
01
Dec
02
Dec
03
Dec
04
Nov
05
Nov
06
Nov
07
Nov
06
Nov
07
Dec
08
Nov
09
Dec
10
Nov
11
Dec
12
Dec
13
Dec
14
Dec
15
Dec
16
end mid
ISCB News #61 Page 4 June 2016
Book Review by Miland Joshi (UK)
Marschner, Ian C Inference Principles for Biostatisticians CRC 2015 9781482222234
The title of this book suggests something differentfrom the usual textbook on Statistical Inference in twoways: a wider perspective and guidance on strategy(“Principles”), and an emphasis on applications inMedical Statistics. A look at the bibliography shouldreassure readers; many of the entries are well-knownitems used in advanced undergraduate or Masters’courses in Statistics.
From the preface, this book occupies a special place inthe curriculum: assuming basic mathematical andstatistical knowledge, it tries to lay a foundation forlater courses in special topics like statistical modellingand clinical trials. This would make it a goodintroductory text for Master’s students (or possiblyadvanced undergraduates). The features on the backcover mention R functions, but the reader should notethat this only applies to a restricted set of simulationprograms, filling 7 pages in Appendix 2 – and that’s all.Thus R is very much a minor part of the book, formingno part of the main text, which is a concise text onstatistical inference. An introductory intensive revisionof probability theory is followed by chapters onestimation, likelihood, and hypothesis testing, and afinal chapter on Bayesian methods. Profile likelihoodsare discussed briefly (without diagrams, butconditional, marginal and partial likelihoods aredismissed immediately after being mentioned byname, the reader being referred to Cox’ 2006 book as astarting point. If these are to be mentioned at all, itwould be helpful to also be given some idea of whatthey mean and how they are used in Biostatistics. Theapproaches of Likelihood ratio, Wald tests and scorestests are compared, but as with profile likelihood, nodiagrams are included. In this section, the Neyman-Pearson lemma is mentioned informally without proofand dismissed as unimportant.
The chapter on Bayesian methods mentions the subjectivenature of priors, but there is no discussion of evidence-based priors. If priors cannot be justified in this way, theyrisk being treated either as purely subjective (and so foreversuspect) or just a computational convenience –a startingpoint in a process that yields a useful answer.
In a similar way that earlier chapters did with unusuallikelihoods, the Bayesian chapter refers to MCMC as beyondthe scope of the book and refers the reader to otherauthors. To be fair, it only claims to be a brief introduction.
One strength of the book is that an extended exampleillustrating the methods is given at the ends of mostchapters. Exercises are also included, though withoutanswers. There is a helpful Appendix summarising factsabout common distributions, making the book useful forreference.
The fact that the book is intended as a foundation for morespecialised courses partly explains why the reader issometimes referred to further reading e.g. on unusuallikelihoods, or MCMC. Even if so it would be helpful for thebook to be more self-contained. Other things that wouldhelp to this end would be more teaching diagrams and theprovision of R code throughout the text, not to mentionsolutions to exercises. All this would, of course, make thebook larger.
All in all, this may be a useful book when accompanying ataught course which is part of a curriculum leading to morespecialised courses, but as it stands, I would not recommendit for self-learning.
ISCB News #61 Page 5 June 2016
Oct. 2016 - Elections for the ExCom 2017-18: Final Warning!
From Vana Sypsa, Secretary and David W. Warne, Nominations Officer
In accordance with the Constitution, we ask for nominations for positions on the Executive Committee for2017-18. At the end of 2016, the situation will be:
David W Warne Will retire as President andbecomes Past President for one year, 2017.
KyungMann Kim After being Vice-President for 2015-16,will become President for 2017-18 andPast-President for 2019.
Vana Sypsa Will end her 2nd term as Secretary andis not eligible for re-election as Treasurer or Secretary butis eligible for election as Vice-President.
Zdenek Valenta Ends his 1st term as Treasurer andis eligible for re-election as Treasurer, Secretary or Vice-President.
Chris MetcalfeJeremy Taylor
End their 2nd terms as Ordinary members andare not eligible for re-election as Ordinary members, butare eligible for re-election as Treasurer, Secretary or Vice-President.
Chris Weir, Hein PutterKatherine Lee ,Stanislav KatinaThomas Jaki, Toshiro Tango
End their 1st terms as Ordinary members andare eligible for re-election as Ordinary members, or asTreasurer, Secretary or Vice-President.
David W Warne Wishes to continue as News Editor and Webmaster.
Nominations for
Vice-President,
Secretary,
Treasurer and
8 ordinary members
are therefore sought.
To make a nomination, please download the form from theweb[www.iscb.info/files/folders/nominations/iscb_template_nomination_2016.doc] and send it to the Chair of the ISCBNominations Committee, David W. Warne([email protected]).
Each nomination will require the signatures of the Proposer,a Seconder and of the Nominee confirming a willingness toserve. Completed and signed nomination forms must bereceived no later than 31 August 2016 (scanned forms sentby email are acceptable.)
If there are more nominees than vacant positions, anelectronic ballot will be held.
NB Please note the following important clauses from theISCB Constitution(http://www.iscb.info/files/folders/constitution_2012-12-31.pdf):
(6.02) The Committee shall consist of the four Officers and at leastfive but not more than eight other members (“Ordinarymembers”), plus the Past President, who shall serve only for thecalendar year immediately following the Presidency, and co-optedmembers.
(6.03) The Ordinary members, who shall be Members for at leastthe calendar year prior to nomination, must be elected by ballot;their full term of office shall be two calendar years and they shallbe eligible for re-election for one further full term up to amaximum of four consecutive calendar years.
(6.06) The Executive Committee must meet at least once at aConference of The Society and at least once during any calendaryear; at least thirty days notice of such meetings must be given toall Executive Committee members by the Secretary.
(6.07) Meetings of the Executive Committee shall normally bearranged by agreement among members present at an earliermeeting or by agreement among The Officers.
Meetings may also be called by agreement of a majority of the fullcurrent membership of the Executive Committee.
(6.08) Any member of the Executive Committee who fails toattend Committee meetings for two consecutive calendar yearswithout providing sufficient explanation for absence to thePresident and Secretary shall cease to be a member, and cannot bere-elected.
(15.06) Nominations must be proposed and seconded byMembers, are subject to the agreement of the Nominee, and mustbe accompanied by the names and signatures of all three.
*No Member may be nominated for the posts of two Officers atthe same ballot, but may be nominated both as an Officer and asan Ordinary member of the Executive Committee.
ISCB News #61 Page 6 June 2016
Books for Review by Jindra Reissigová (Book Review Editor)
Important note to potential reviewers:
We regularly receive books from publishers for review inthe Newsletter. We are most grateful for these“donations”, the reviews of which we regard as a serviceto you, our members. Regretfully, some individuals,despite repeated reminders, neither return a review, northe book to ISCB... When requesting a book, pleaseremember that you’re making a commitment to theSociety to do a little work in return for keeping the book.
Please do a little work in return for keeping the book andyour name will be published in the News!
For the format and length, please see recent issues ofISCB News. You can send the review in a variety offormats but plain text email, html, RTF or Word arepreferred. The reviews may be edited for clarity (Englishgrammar and spelling, punctuation etc.).
For updates between Newses, please see:
http://www.iscb.info/Members-Area/Books-for-Review.html
Author(s) Books for review: Title Publisher Year ISBN
1. Casals, Jose, Garcia-Hiernaux, Alfredo, Jerez, Miguel,Sotoca, Sonia, Trindade, Alexandre A
State-Space Methods for Time Series Analysis: Theory,Applications and Software
CRC 2016 9781482219593
2. Chang, Mark Monte Carlo Simulation for the Pharmaceutical Industry CRC 2011 9781439835920
3. Chang, Mark Adaptive Design Theory and Implementation Using SAS and R (2nd
ed.)CRC 2014 9781482256598
4. Chen, Joshua, Quan, Hui Multiregional Clinical Trials for Simultaneous Global New DrugDevelopment
CRC 2016 9781498701464
5. Cheung, Ying Kuen Dose Finding by the Continual Reassessment Method CRC 2011 9781420091519
6. Chow, Shein-Chung Design and Analysis of Bioavailability and Bioequivalence Studies(3rd ed.)
CRC 2009 9781584886686
7. Jones, Byron, Kenward, Michael G Design and Analysis of Cross-Over Trials (3rd ed.) CRC 2014 9781439861424
8. Khan, Iftekhar Design & Analysis of Clinical Trials for Economic Evaluation &Reimbursement: An Applied Approach Using SAS & STATA
CRC 2015 9781466505476
9. Kupper, Lawrence L, Neelon, Brian, O’Brien, Sean M. Exercises and Solutions in Biostatistical Theory CRC 2010 9781584887225
10. Lawson, Andrew B, Banerjee, Sudipto, Haining,Robert P, Ugarte, Dolores, Maria
Handbook of Spatial Epidemiology CRC 2015 9781482253016
11. Li, Jialiang, Ma, Shuangge Survival Analysis in Medicine and Genetics CRC 2013 9781439893111
12. Liu, Jen-pei, Chow, Shein-Chung, Hsiao, Chin-Fu Design and Analysis of Bridging Studies CRC 2012 9781439846346
13. Matsui, Shigeyuki, Buyse, Marc, Simon, Richard Design and Analysis of Clinical Trials for Predictive Medicine CRC 2015 9781466558151
14. Sverdlov, Oleksandr (ed.) Modern Adaptive Randomized Clinical Trials: Statistical andPractical Aspects
CRC 2015 9781482239881
15. Wang, Jixian Exposure–Response Modelling: Methods and PracticalImplementation
CRC 2015 9781466573208
16. Yang, Harry, Zhang, Jianchun, Yu, Binbing, Zhao, Wei Statistical Methods for Immunogenicity Assessment CRD 2015 9781498700344
17. Young, Walter R, Chen, Ding-Geng Clinical Trial Biostatistics and Biopharmaceutical Applications CRC 2015 9781482212181
18. Zhao, Wei, Yang, Harry (eds.) Statistical Methods in Drug Combination Studies CRC 2014 9781482216745
ISCB News #61 Page 7 June 2016
Books for Review (continued)
Author(s) Reviews in this issue: Title Publisher Year ISBN Reviewer (country)
Marschner, Ian C Inference Principles for Biostatisticians CRC 2015 9781482222234 Miland Joshi (UK)
Peace, Karl E Design and Analysis of Clinical Trials withTime-to-Event Endpoints
CRC 2009 9781420066395 Matthias Herpers (DE)
van Buuren, Stef Flexible Imputation of Missing Data CRC 2012 9781439868249 Douglas Dover (CA)
Author(s) Sent recently: Title Publisher Year ISBN Reviewer (country)
Ahn, Chul, Heo, Moonseoung,Zhang, Song
Sample Size Calculations for Clustered andLongitudinal Outcomes in Clinical Research
CRC 2015 9781466556263 Sada Nand Dwivedi (IN)
Ahn, Chul, Heo, Moonseoung,Zhang, Song
Sample Size Calculations for Clustered andLongitudinal Outcomes in Clinical Research
CRC 2015 9781466556263 Beth Stuart (UK)
Anderson, Stewart J Biostatistics - A Computing Approach CRC 2012 9781584888345 Caroline Haig (UK)
Baio, Gianluca Bayesian Methods in Health Economics CRC 2012 9781439895559 Anna Bartkowiak (PL)
Baldi Antognini, Alessandro,Giovagnoli, Alessandra
Adaptive Designs for Sequential TreatmentAllocation
CRC 2015 9781466505759 Sada Nand Dwivedi (IN)
Berry, Scott M,Carlin, Bradley P, Lee, J Jack,Muller, Peter
Bayesian Adaptive Methods for Clinical Trials CRC 2010 9781439825488 Susanne Urach (AT)
Collett, David Modelling Survival Data in Medical Research(3rd ed.)
CRC 2014 9781439856789 Giulia Barbati (IT)
Commenges, Daniel, Jacqmin-Gadda, Helene
Dynamical Biostatistical Models CRC 2015 9781498729673 Per Kragh Andersen (DK)
Cosmatos, Dennis,Chow, Shein-Chung (eds.)
Translational Medicine: Strategies andStatistical Methods
CRC 2008 9781584888727 Erik Cobo (ES)
Crowley, John, Hoering, Antje Handbook of Statistics in Clinical Oncology (3rd
ed.)CRC 2012 9781439862001 Attila Dávid (HU)
De Leon, Alexander R,Chough KC
Analysis of Mixed Data - Methods andApplications
CRC 2013 9781439884713 Abhik Ghosh (NO)
Fullerton, Andrew S, Xu, Jun Ordered Regression Models: Parallel, Partial,and Non-Parallel Alternatives
CRC 2016 9781466569737 Marek Brabec (CZ)
Gandrud, Christopher Reproducible Research with R and RStudio CRC 2014 9781466572843 Caroline Haig (UK)
Geskus, Ronald B Data Analysis with Competing Risks andIntermediate States
CRC 2015 9781466570351 Sophie Tézenas du Montcel(FR)
Gibbons, Robert D, Amatya,Anup
Statistical Methods for Drug Safety CRC 2015 9781466561847 Maria de Ridder (NL)
Golbeck, Amanda L, Olkin,Ingram , Gel, Yulia R (eds.)
Leadership and Women in Statistics CRC 2015 9781482236446 Marianne Huebner (US)
Klein, John P,van Houwelingen, Hans C,Ibrahim, Joseph G,Scheike, Thomas H
Handbook of Survival analysis CRC 2014 9781466555662 Jordi Cortés Martínez (ES)
Li, Jialiang, Ma, Shuangge Survival Analysis in Medicine and Genetics CRC 2013 9781439893111 Victor Moreno (ES)
Marschner, Ian C Inference Principles for Biostatisticians CRC 2015 9781482222234 Cono Ariti (UK)
Newcombe, Robert G Confidence Intervals for Proportions andRelated Measures of Effect Size
CRC 2012 9781439812785 David W. Warne (CH)
Ng, Tie-Hua Noninferiority Testing in Clinical Trials - Issuesand Challenges
CRC 2014 9781466561496 Beth Stuart (UK)
Author(s) Sent a long time ago: Title Publisher Year ISBN Reviewer (country)
Jackson, J Edward A User’s Guide to Principal Components Wiley 2003 9780471471349 Nicole Close (US)
Rothman, Mark D,Wiens, Brian L, Chan, Ivan SF
Design and Analysis of Non-inferiority Trials CRC 2011 9781584888048 Sebastien Marque (FR)
Shoukri, Mohamed M Measures of Inter-observer Agreement andReliability (2nd ed.)
CRC 2010 9781439810804 Elisabeth Svensson (SE)
Publisher Webpages: (checked 17June2016)
Cambridge University Press http://www.cambridge.org/ch/academic/subjects/statistics-probability/
CRC (Taylor and Francis) https://www.crcpress.com/statistics
Oxford University Press https://global.oup.com/academic/category/medicine-and-health/medical-statistics-and-methodology
Springer https://www.springer.com/gp/statistics
Wiley* http://eu.wiley.com/WileyCDA/Section/id-351216.html
*Details of Wiley special offers can be found on the ISCB website as follows:
http://www.iscb.info/Members-Area/Welcome.html which includes the book discount and
http://www.iscb.info/Join-Us/Special-Offer-to-Members---Wiley.html which includes the Statistics in Medicine special rate.
ISCB News #61 Page 8 June 2016
Book Review by Douglas Dover (CA)
van Buuren, Stef Flexible Imputation of Missing Data CRC 2012 9781439868249
As an applied biostatistician, the introductory chapterspoke directly to me. It began motivating the issues inmultiple imputation from the perspective of applied dataproblems and problematic approaches to them.
Chapter 2 provides the theory and definitions underlyingmultiple imputation. The concepts are clearly explainedwith practical intuitions always given in parallel. Sectionsdelving deeper into theoretical issues are clearly marked,and can be read or skipped at the reader’s preferencewithout loss of continuity.
The meat of this book begins in Chapter 3. The first partassumes an ignorable missing data mechanism, thesecond part does not in the analysis of univariate missingdata. The chapter begins by building up the theory behindwhat needs to be included in any multiple imputationmethod and goes on to describe a number of methods fora variety of data types. In fact, this chapter is really the“gentle introduction to the practice of multipleimputation”. Foundational examples start with simplescenarios that are gradually and clearly expanded upon.At each step, R code is shown and illustrations visuallyshow the effects of different approaches. For every majorconcept there is a half-page “Algorithm Box”, a shortsummary in pseudo-code of the algorithm beingdiscussed. These, in conjunction with the explanatorytext, made things extremely clear and easy to grasp.Much to my pleasure, the theory was complemented witha constant commentary on the performancecharacteristics of the methods – circumstances when theyworked well, areas where the performance characteristicswere not yet know, how many iterations are sensible touse in practice. This was particularly helpful to build theframework of potential methods that would work in mycircumstances.
Moving from univariate to multivariate missing dataoccurs in Chapter 4. Patterns of missing data are clearlyexplained and illustrated, and then methods are clearly
linked back to this structure. In essence, Chapter 4 readslike a meta-algorithm chapter: for multivariatemissingness, identify the pattern, work within it applyingthe same concepts introduced in the univariate chapter.Of course, the joint and fully conditional methods specificto multivariate data are discussed in detail, as are thereperformance characteristics. My only regret at the end ofthis chapter was that there was no discussion on thedesign of missingness (although there is a paragraph laterin Chapter 10 citing some references). The description ofthe patterns of missingness touched on the fact thatcertain designs could be intentionally created. Adiscussion of how best to do this would have made this amuch richer chapter for those who influence datacollection in addition to carrying out the analysis.
Chapter 5 pull together the theory and explicitly identifiesthe decision points needed in any analysis. A number ofspecific data situations are discussed. Performancecharacteristics and practical rules of thumb continue tobe present, along with the example data. Chapter 6 goeson to describe how to actually analyse data once themultiple imputations have been carried out. The basicprinciples as well as special cases are covered.
Chapters 7-9 cover detailed examples of missing datasituations and approaches. The context is fully explained,the issue identified, methods applied and results shown,and pitfalls identified and dealt with. These chaptersclearly draw upon the author’s real-life analyses, makingthem invaluable experiences to learn from. The finalchapter summarises the risks and rewards of usingmultiple imputation and directs the reader to sources fora variety of emerging and specialized applications ofmultiple imputation.
Overall, this book does an excellent job of bringing onefrom no knowledge of multiple imputation to a workingknowledge of multiple imputation.
ISCB News #61 Page 9 June 2016
ISCB Treasurer’s Mid-Year Report: ISCB Accounts 2015
From Zdenek Valenta
Although wrapping up the Utrecht conferenceaccounts experienced some delays, the accountdetails were reviewed during the Officers’ andExCom Skype teleconference on 26 and 27 May2016, respectively. Minor issues with tracking theSociety membership dues paid as part of Utrechtconference registration were resolved thanks to adiligent work of Rita Schou in the Copenhagen ISCBOffice. In accord with Utrecht LOC’s proposal, theOfficers and ExCom decided to honour half of notpreviously agreed costs claimed by the Utrechtconference organising agency related to extra hoursspent on the job. However delicate that issue mayappear, the future LOCs need to pay detailedattention to agreed costs to avoid last minute claimsby the PCO.
A summary of the ISCB’s financial standing as of 31December 2015 is shown below. It will be furtherdiscussed during the ExCom meeting and the AnnualGeneral Meeting at ISCB37 in Birmingham, UK, inAugust 2016.
The accounts of ISCB36 in Utrecht, the Netherlands,are going to be audited by an internal ISCB auditaccording to §10.07 in the ISCB’s Constitution.Subsequently, the Society’s full accounts for thefiscal year 2015 will be audited byPricewaterhouseCoopers StatsautoriseretRevisionspartnerselskab in Copenhagen, Denmark.The PWC approval may be expected in July 2015 thelatest.
Based on the preliminary financial report for 2015, theSociety's financial standing has slightly improved with asurplus of €17,608.
The Society’s expenses steadily increased from €46,489 in2011 to €55,942 in 2012, €49,393 in 2013, €53,202 in2014 and €76,625 in 2015. The latter increase reflects theSociety’s decision to provide financial support toresearchers from developing countries using a so-called‘15k’ or ‘CADC’ fund. Total support worth 14,340 EUR wasprovided in 2015 using this fund and the Society willcontinue this support scheme in 2016.
Society’s recent income was €59,210 in 2012, €85,600 in2013, €123,922 in 2014 and €94,233 in 2015. Despitefairly moderate Utrecht conference fees and a fairamount of support being allocated to various award andsupport schemes (StCA, CASc and 15k/CADC), the ISCBequity position went up in 2015 by more than €18,000.
The income from membership fees has grown steadilyfrom €22,280 in 2011, €25,460 in 2012, €26,240 in 2013,€27,900 in 2014 and €29,420 in 2015, reflecting acontinual enlargement of the ISCB membership base.
In 2015 the equity position of the ISCB increased from€388,613 as of 31 December 2014 to €406,221 as of 31December 2015.
ISCB News #61 Page 10 June 2016
ISCB Treasurer’s Mid-Year Report
INTERNATIONAL SOCIETY FOR CLINICAL BIOSTATISTICS:FINANCIAL REPORT for JANUARY-DECEMBER 2015
Draft 5 2015 Euro 2014 Euro
IncomeMembership fees 29,420.00 27,900.00Conference surplus 64,513.26 94,358.97Course surplusAdvertising 300.00 1,350.00Earned interestCurrency gains 312.58
Total income 94,233.26 123,921.55
ExpenditurePermanent Office:
Consumables 6.69Postage & freight 45.82 44.50Telecommunication & internet 2,485.46 2,044.88Ballots 68.43 2,911.24Printing & photocopying 65.71Administration 15,375.00 15,000.00
17,981.40 20,066.33Officers & ExCom:
Conference fees 4,400.00 5,825.00Accommodation 4,410.45 2,737.87Travel expenses 2,849.22 2,659.97Other expenses 1,120.97 523.43
12,780.64 11,746.27Awards (Students, Scientists):
Conference fees 2,760.00 2,050.00Accommodation 4,524.80 1,575.00Travel expenses 4,058.39 2,018.81Other expenses 158.00 53.43
11,501.19 5,697.24President’s Invited Speaker
Conference fees 440.00Accommodation 141.34Travel expenses 75.59Other expenses
656.93 0.00Workshops / Courses:
Honorarium 1,900.00Accommodation 50.00Travel expenses 750.00 194.00Other expenses 800.00
750.00 2,944.00Newsletter:
Office expenses 11,176.87 6,428.94AccommodationTravel expenses
11,176.87 6,428.94Other items:
Bank charges 1,729.41 999.13Interest 354.68Audit 2,200.00 2,270.00Currency fluctuations 265.46 -0.58National Groups travel support 2,889.35 3,050.93Conference Awards Developing Countries 14,339.43
21,778.33 6,319.48Total expenditure 76,625.36 53,202.26NET INCOME: 17,607.90 70.719.29
AssetsBank accounts:
Nordea DKK account 139,020.49 139,400.34Nordea Euro account 185,965.14 134,992.70
324,985.63 274,393.04Others:
Accounts receivable 593.28Vienna, 2014 99,746.03Utrecht, 2015 89,598.41 30,000.00Birmingham, 2016 5,811.94
95,410.35 130,339.31Total Assets 420,395.98 404,732.35Liabilities
Owing to Permanent Office 11,158.23 10,888.85Audit 2,200.00 2,270.00Prepayment account, members 40.00 40.00Accounts payable 776.80 2,920.45
Total Liabilities 14,175.03 16,119.30Assets less Liabilities 406,220.95 388,613.05
EQUITY brought forward 388,613.05 317,893.76Profit/loss by 31 December 2014 70,719.29Profit/loss by 31 December 2015 17,607.90EQUITY carried forward 406,220.95 388,613.05
Draft 5: 28Jun2016Conversion rate: 31-12-2015 100 EUR = 746.25 DKK
ISCB News #61 Page 11 June 2016
ISCB37 Birmingham, UK: 21-25 August 2016: Welcome!
From Lucinda Billingham (LOC Chair) and Nigel Stallard (SPC Chair)
The city of Birmingham is proud to host the 37th
annual conferenceof ISCB. The Local Organising Committee and Scientific ProgrammeCommittee have been working together to create an excitingscientific and social programme.
We have 25 world-class invited speakers including two outstandingkeynote plenary speakers, 245 contributed oral presentations andaround 200 posters. We have 6 pre-conference courses includingtwo half-day courses that cover a broad range of topics. We havere-introduced the mini-symposium on Thursday with a choice oftwo key themes that are also available to non-participants of theconference.
In addition this year we have introduced a new Student Day onThursday which is open to recently graduated or current PhDstudents with the aim to stimulate discussion on how to be a goodresearcher and how to come up with biostatistical researchprojects of ongoing or future interest.
Birmingham is the second largest city in the UK and is situated rightin the heart of England. It is a city of culture, combined with superbshopping, great night life and award winning restaurants and hasstrong links to the scientific community through the University ofBirmingham. The conference venue is the world class InternationalConvention Centre in the centre of the city located on the historicBirmingham canal, next to the stunning new library, the largest inEurope, and surrounded by smart city squares with cafes,restaurants and bars. It is within easy walking distance of the newBirmingham New Street station and a wide range of hotels.
Pre-Conference Courses (Sunday)
An industry approach to Bayesian phase I oncology trials:methodology and implementation - Simon Wandel, BeatNeuenschwander
Demystifying causal inference in randomised trials - Ian White,Graham Dunn, Sabine Landau, Richard Emsley
Network meta-analysis for decision making - David Phillippo,Sofia Dias
Analysis of single and multi-omic data (SNP array, geneexpression and methylation) and their integration in diseaseassociation studies - Juan R Gonzalez
Exploratory subgroup analyses in clinical trials - GerdRosenkranz
An introduction to the joint modelling of longitudinal andsurvival data, with applications in R - Dimitris Rizopoulos
If you have already registered for the conference but have not yetregistered for a course, please contact our Event ManagementTeam ([email protected]).
Mini-Symposium (Thursday)
Statistical methods in rare diseases and small populations
Strengthening Analytical Thinking for Observational Studies(STRATOS)
Students’ Day
Plenary Sessions (Monday & Wednesday):
On Monday, the ISCB President’s Invited Speaker, Diego Kuonen,will talk about ‘A Swiss Statistician’s “Big Tent” Overview of BigData and Data Science in Pharmaceutical Development’
On Wednesday, the conference Keynote Address will be deliveredby the esteemed David Spiegelhalter. His talk will be on ‘TheStatistics of Sex’.
Invited Sessions (Monday - Wednesday):
23 invited speakers will contribute to 7 special sessions selected bythe Scientific Programme Committee:
Statistical issues in stratified or personalised medicine andbiomarker discovery
Infectious disease epidemiology
Statistical methods in pharmaco-epidemiology and drug safety
Evidence synthesis and medical decision-making
Adaptive designs for oncology clinical trials
Research showcase from the MRC Network of Hubs for TrialsMethodology Research
Myths and pitfalls in survival analysis
Contributed Talks and Posters (Monday – Wednesday)
245 contributed talks and 200 posters available throughout theconference will cover topics ranging from observational studies toadaptive clinical trials and from small populations to big data.
Excursions (Tuesday)
Open Top Bus Tour of Birmingham and a chance to exploreWinterbourne House and Garden at the University
Visit to Stratford-upon-Avon, the birthplace of Shakespeare
Black Country Living Museum, one of the UK’s largest open-airmuseums, highlighting the industrial heritage of the local area
Malvern Hills Hike to see the beauty of the Worcestershire andHerefordshire countryside
Baddesley Clinton National Trust House and Garden, amedieval moated manor house
Social events
Student Gathering will be held on Sunday evening at a popularbar in the city centre
Welcome Reception will be held on Monday evening at theBirmingham Museum and Art Gallery.
Conference Dinner will be held on Wednesday evening at thefamous Edgbaston Cricket Ground with live music from TheSubterraneans
Need more information?
Please visit our website: www.iscb2016.info
Follow us on Twitter: @iscb2016
Email: [email protected]
Don’t miss the opportunity to join us in Birmingham for the firstISCB Conference in the UK since 2003.We look forward to seeing you!
ISCB News #61 Page 12 June 2016
ISCB37 Birmingham 2016: Conference Awards for Scientists: Winners
From Zdenek Valenta
In 2016, the ISCB National Groups Subcommittee (NatG SC) received a totalof 10 eligible applications for the Conference Awards for Scientists (CASc).The applications came from Bangladesh (2), Hungary (2), Nepal (2), Pakistan(1), Poland (2) and Turkey (1). The SC appears to be moving in the rightdirection by attracting the applications from mostly non-NatG countries.
All 12 NG SC members took part in the evaluation process this year whichwe believe contributed to an overall fairness of the selection process.
The SC members provided the assessment of each application by assigningthe grades between 1 and 5, with high scores reflecting excellence and lowones suggesting a rather poor quality of submission. The NatG SC memberswere also asked to express explicitly in words whether in their opinion thescientific contribution qualified the applicant for receiving the CASc award.
This year the National Groups Subcommittee decided to grant 3 ISCB CAScawards, listed below. The group of winning applicants achieved distinctivelyhigher total scores as compared to the remaining 7. This is why this year theSC had no problem in identifying the winning CASc applicants.
The 3 winning papers will be presented by their authors at contributedsections of the ISCB 2016 in Birmingham, UK. The winners are entitled toreceive free registration to the Birmingham Conference, freeaccommodation, one free short course of their choice, and attendance atthe Conference Dinner, as well as full travel support.
Congratulations to the 3 winners!
Name Country Title Session
Iveta Selingerová Czech Republic Kernel estimation as alternative to (semi)parametric models in survival analysis:simulated and real data
C13: Survival data analysis 4Mon 22 - 16:00
Iftakhar Alam Bangladesh A comparison between the continual reassessment method and D-optimum designfor dose finding in phase I clinical trials
C23: Early phase clinical trials 1Tue 23 - 09:00
Hasinur Khan Bangladesh On The Performance of Adaptive Pre-processing Technique in Analysing High-dimensional Censored Data
C33: Big data in healthcare 2Wed 24 - 09:00
ISCB37 Birmingham 2016: Student Conference Awards: Winners
From Nadine Binder
For the 2016 Annual Conference, we received 18 StCA applications: 2applications came from Australia, Belgium, Sri Lanka, and the UnitedKingdom; 1 application came from Canada, Czech Republic, France,Germany, Greece, India, Italy, Nigeria, Sweden, and The Netherlands.The sub-committee selected 3 students after a double-blind review ofthe submitted abstracts and summary papers from each applicant (listedbelow).
I would like to take the opportunity to thank the subcommittee forjudging the applications and for giving good care and deliberation in thedecision process. Thanks also to the President for valuable comments.
Reacting to last years’ accident that one application had not arrived inthe SC Chair’s email inbox. This year all applications were sent to boththe SC Chair and the SC Secretary. This worked smoothly and can easilybe continued in the future.
In addition, the subcommittee has taken actions for making the annualconferences a stimulating place with good networking opportunities for allyoung researchers. We established a young statisticians’ gathering during theconference in 2013, which has continued since and will take place at this years’conference on Sun 21 August – thanks to the LOC.
We furthermore developed a new event for the 2016 conference: TheStudents’ Day, which will take place on Thu 25 August. It comprisespresentations with advice from experienced researchers, but also contributionsfrom students, focussing on research methods, challenges and experiences.You may find the programme within this News.
Name Country University Title Session
Agnieszka Król France Bordeaux The use of tumor dynamics and non-target lesions to predict survival withmultivariate joint frailty models
C31: Survival data analysis 8Wed 24 - 09:00
ChristosThomadakis
Greece Athens Longitudinal and time-to-drop-out joint models can lead to seriously biasedestimates when the drop-out mechanism is at random
C34: Missing data 3Wed 24 - 09:00
Nicole Erler NetherlandsRotterdamBayesian imputation of time-varying covariates in linear mixed models C17: Missing data 2Mon 22 - 16:00
ISCB37 Birmingham 2016: Biometrical Journal Special Issue
From Nigel Stallard
The organisers of ISCB 2016 and the editors of Biometrical Journalintend to publish a selection of manuscripts of articles arising from theISCB 2016 in the Biometrical Journal as a special issue.
This Special Issue aims to publish on a fast track, high quality papers oncutting edge biostatistical methods for clinical research presented (orallyor as posters) at ISCB 2016. Although papers on any topic covered by theconference may be submitted to the special issue, papers areparticularly encouraged in the areas of Stratified and personalisedmedicine, Innovative clinical trial design, Survival data analysis andAdvances in statistical issues in epidemiology.
All papers will be subject to strict peer review according the rules of thejournal with an online publication scheduled for Sep 2017. The reviewprocess will be handled by the Special Issue guest editors: Nigel Stallard(University of Warwick, Chair of the Scientific Programme Committee),and three others to be determined.
Manuscript submission: The organisers of ISCB 2016 and the editors ofthe journal invite participants of the conference to be prepared tosubmit manuscripts as follows.
The submission of manuscripts will be handled through the website ofBiometrical Journal and the established electronic procedures. Please submityour manuscript to Manuscript Central. Indicate at Step 1 that the submissionis to a special issue and at Step 4 of the submission process enter "ISCB 2016"in the Special Issue Information field. You can submit you manuscript onlybetween 1 Sep and 1 Nov 2016.
Submitted manuscripts should fully comply with the Author Guidelines ofBiometrical Journal. It is recommended to use the style file of the journal andto adhere to the general aims and scope of Biometrical Journal as given in theInstructions to Authors (PDF).
Please note that the Biometrical Journal is devoted to Reproducible Research,details can be found on its website. Authors who intend to submit programs (Rlanguage and SAS preferred), original data sets and details of simulations areasked to indicate this already at submission and to download “ready to run”material such that in can be examined during the review process for thisSpecial Issue.
If you need any further information, please contact Nigel Stallard.
ISCB News #61 Page 13 June 2016
ISCB37 Birmingham 2016: Students’ Day
From Nadine Binder
This year, the Student Conference Awards subcommittee was pleased tooffer a new Students' Day on Thu 25 Aug. This day is open forregistration to recently graduated, ongoing or almost finished PhDstudents. The aim of the day is to stimulate discussion on how to shapea research career, e.g. on how to come up with competitive researchprojects.
Three experienced biostatistical researchers are going to give careeradvice on strategies for success in biostatistical research. A total of 14
students, ranging from just starting to almost finishing their PhD, will sharetheir ideas of doing good research and discuss research challenges they arefacing by means of their research projects. The detailed programme can befound below.
Registrations for the Student’s Day can be made through the conferenceregistration system. Participation is free for delegates already registered for theconference. We are looking forward to a stimulating exchange of experiences.
Draft Programme:(subject to changes)
09:00-09:15 Welcome
09:15-09:45 Robin Henderson Biostatistical Research Skills
Session 1 Challenges in clinical trials
09:45-10:00 Michael J Grayling Blinded and unblinded sample size re-estimation procedures for stepped wedge cluster randomised controlled trials
10:00-10:15 Caroline Kristunas A comparison of unequal cluster sizes in stepped-wedge cluster randomised trials
10:15-10:30 Jane Candlish Statistical design and analysis of proportionate intervention trials: a systematic review. Challenges in undertakingmethodological systematic reviews
10:30-10:45 Discussion
10:45-11:00 Refreshments
Session 2 Bayesian techniques
11:00-11:15 Gemma Clayton Quantitative, qualitative or both?
11:15-11:30 Davood RoshanSangachin
Adaptive Tolerance Range for Clinical Biomarkers using Bayesian Approaches
11:30-11:45 John Dennis Personalised medicine research in type 2 diabetes: study findings may be dependent on how response to a therapy isinitially defined
11:45-12:00 Laure Wynants Feeling stuck in research: lessons learned from studying heterogeneity in measures of clinical utility
12:00-12:15 Discussion
12:15-13:15 Lunch
13:15-13:45 Katherine Lee Developing a Career in Biostatistics
Session 3 Longitudinal and time-to-event data
13:45-14:00 Stefan NygaardHansen
Estimating a cumulative incidence under calendar time trends
14:00-14:15 Morten Overgaard Jack-knife pseudo-observations and their use in regression analyses
14:15-14:30 Shivam Pandey Association of childhood head growth with adult systolic blood pressure: findings from the New Delhi Birth Cohort
14:30-14:45 Marie-Cécile Fournier The use of joint model for longitudinal and time-to-event data: an application on kidney transplantation
14:45-15:00 Discussion
15:00-15:15 Refreshments
Session 4 Programming and simulation methods
15:15-15:30 Daniela Zöller Julia – a serious alternative to R for biostatisticians?
15:30-15:45 Tanja Berger Simulation study on the estimability of distribution parameters in the context of observations below the lower limitof quantification (LLOQ)
15:45-16:00 Julia Krzykalla Simulating high-dimensional molecular data
16:00-16:15 Discussion
16:15-16:45 Hans vanHouwelingen
The Future of Biostatistics
16:45-17:00 Discussion and Farewell
ISCB News #61 Page 14 June 2016
ISCB37 Birmingham 2016: ISCB Annual General Meeting Agenda
From Vana Sypsa
The Annual General Meeting (AGM) will be held on Wednesday 24 August 2016 from 1200-1300 at the ISCB Conference Site, in the Plenary Hall.The draft agenda is the following:1 President's report2 Treasurer's report3 Subcommittee reports and motion for continuation:
3.1 Student Conference Awards3.2 Statistics in Regulatory Affairs3.3 National Groups3.4 Epidemiology3.5 Education3.6 Conference Organising
4 Update about future ISCB meetings:2017 Vigo and news about 2018+
5 Any Other BusinessNB Materials will be presented in summary form only to allow time for questions and discussion. For more detailed information, please see:http://www.iscb.info/Members-Area/AGM-2016-08-24-Birmingham.htmlALL participants of the ISCB meeting, including newcomers to ISCB are, by definition, ISCB members and are most welcome to attend the AGM. Please takepart and see what the Society does apart from the annual conference!
ISCB37 Birmingham 2016: Conf. Fund for Developing Countries (CFDC)
From Karla Hemming, KyungMann Kim and Koos Zwinderman
1. Announcement
In 2014, the ISCB Executive Committee approved a one-time budget of€15,000 to provide financial support to those from the developing countriesfor participation at the ISCB conference. This financial support is madeavailable only to those from the developing countries according to theWorld Bank List low and middle income countries, who submit an abstractfor either oral or poster presentation and are subsequently selected by theSPC for presentation.
After the ISCB36 in Utrecht in 2015, the Executive Committee decided toextend this funding scheme to ISCB37 in Birmingham in 2016. Theapplicants were to indicate their request for financial support at the time ofabstract submission with an application letter on the letterhead of theirinstitution of employment or study.
The selection for the award was based on the SPC’s determinationregarding the abstracts for oral/poster presentation. For the ISCB37 inBirmingham 2016, this was administered by the CFDC Subcommitteecomposed of Karla Hemming (ISCB37 LOC Member Liaison), KyungMann
Kim (ISCB Vice-President), and Koos Zwinderman (ISCB Past-President2015). The CFDC awardees were informed by Karla Hemming.
Funds can be used to defray the cost of travel/ accommodation/ annualconference registration fees. Up to €1,500 per participant was to beprovided if less than 10 winners are selected. Otherwise, €15,000 was to bedivided equally among the selected considering whether the applicationswere from Europe or from outside Europe.
The CFDC review process is separate from the Conference Award forScientists (CAS) administered by the NG Subcommittee and from theStudent Conference Awards (StCA) administered by the Student ConferenceAward Subcommittee. Those who applied for the CAS or the SCA and notselected were automatically considered for the CFDC support if theyqualified.
2. Implementation
This year there were 43 eligible applications, including those who hadapplied for the StCA or CASc awards but not selected. A selection had to bemade based on the SPC merit rating. The committee selected 10 applicantsfor the CFDC in travel/ accommodation/ annual conference registration fee.
3. Winners
Name Country Abstract title Session
Multilevel Modeling of Binary Outcome in Three Level Complex HealthSurvey Data
C46: Advances in statistical issues in epidemiology 3Wed 24 - 16:00
Adverse effect of tobacco use on pregnancy outcome: a multi-centerhospital based case control study in urban settings of Karachi, Pakistan
Poster: Analysis of observational studiesMon 22 - AM
Shafquat Rozi Pakistan
Predictors of smoking uptake in male adolescents attending public andprivate schools in Karachi, Pakistan: Multilevel modeling of survey data
Poster: Analysis of observational studiesWed 24 – AM
Nabil Awan Bangladesh A Post-stratification Approach for Efficient Estimation in Two-stageRandomized Clinical Trials
C12: Adaptive trial design and analysisMon 22 - 14.00
Havva Didem Ovla Turkey Investigation of Adjustment Techniques for Type I Error Rate Increased byMultiplicity in SNP Analyses
C28: Causal inference and mediation analysisTue 23 - 11.00
Vineet Kumar Kamal India A comparison of the hybrid CART-LOGIT model and tree based randomforest model for prognostication of patients with traumatic brain injury
C45: Analysis of observational studiesWed 24 - 16.00
Jayani Hapugoda Sri Lanka Joint Modeling of Survival and Count Variables: Joining the Discrete TimeHazard model with the Poisson Regression model
C35: Inference in infectious diseasesWed 24 - 09.00
Sunethra AbeysingheArachchige
Sri Lanka A novel approach for jointly modeling survival times and recurrentepisodes of disease progression
C19: Survival data analysisTue 23 - 09.00
Shaila Sharmin Bangladesh Analysis of Unobserved Heterogeneity Incorporated with AcceleratedFailure Time Models: Bayesian versus Classical
C01: Survival data analysisMon 22 - 11.00
An application of the latent class modelling to predict risk of mortalityamong cases of acute poisoning
C45: Analysis of observational studiesWed 24 - 16.00
Kashif Shafique Pakistan
Complex measures of health inequalities for family planning methodsamong women: Demographic and health survey data
Poster: Analysis of observational studiesMon 22 - AM
Ozgur Asar Turkey Early detection of patients with high risk of developing end-stage renaldisease in primary care
C47: Longitudinal data analysisWed 24 - 16.00
Khanal ShankarPrasad
Nepal Comparison of Cox Proportional Hazards Model and Accelerated FailureTime Models in the Survival of Acute Liver Failure Patients
Poster: Survival data analysisWed 24 PM
ISCB37 Birmingham, UK: 21-25 August 2016: Draft Programme
ISCB News #61 Page 15 June 2016
Overview 1:see also http://www.birmingham.ac.uk/facilities/mds-cpd/conferences/iscb-2016/programme/programme.aspx
From To Sun 21 Aug Mon 22 Aug Tue 23 Aug Wed 24 Aug Thu 25 Aug
09:00 09:30 Welcome, Introduction
09:30 10:00
10:00 10:30
President's Invited Speaker:Diego Kuonen
I4: Evidencesynthesis and
medical decision-making
C19-C24
I6: Research showcasefrom the MRC Network of
Hubs for TrialsMethodology Research
C31-C36
MS1: Statisticalmethods in rare
diseases and smallpopulations
MS2: Strengtheninganalytical thinking forobservational studies
(STRATOS)
Students' Day
10:30 11:00
Courses 1-5
Refreshments Refreshments Refreshments Refreshments
11:00 11:30 Refreshments
11:30 12:00
Keynote Speaker:David Spiegelhalter
12:00 12:30
I1: Statistical issues instratified or personalisedmedicine and biomarker
discovery
C01-C06
I5: Adaptivedesigns for
oncology clinicaltrials
C25-C30
MS1 (cont) MS2 (cont) Students' Day(cont)
12:30 13:00
continued
lunch
ISCB Annual General Meeting
13:00 13:30
lunch
13:30 14:00
lunch
lunch
lunch
14:00 14:30
14:30 15:00
MS1 (cont) Students' Day(cont)
15:00 15:30
Courses 1-4(cont)
Course 6
I2: Infectious diseaseepidemiology
C07-C12
I7: Myths and pitfalls insurvival analysis
C37-C42
MS2 (cont)
Refreshments
15:30 16:00 Refreshments Refreshments Refreshments
16:00 16:30
16:30 17:00
Students' Day(cont)
17:00 17:30
continued I3: Statistical methods inpharmaco-epidemiology
and drug safety
C13-C18
Conference Excursions(pre-paid tickets only)
C43-C49
17:30 18:00
18:00 18:30
18:30 19:00
19:00 StudentGathering
Welcome Reception at BirminghamMuseum and Art Gallery(pre-booked tickets only)
Conference Dinner at EdgbastonStadium (pre-paid tickets only)
ISCB37 Birmingham, UK: 21-25 August 2016: Draft Programme
ISCB News #61 Page 16 June 2016
Overview 2:
From To Plenary
Sun 21 Aug
08:00 09:30
09:30 11:00 PCC1:An industry approach toBayesian phase Ioncology trials:methodology andimplementation
PCC2:Demystifying causalinference in randomisedtrials
PCC3:Network meta-analysisfor decision-making
PCC4:Analysis of single andmulti-omic data (SNP array,gene expression andmethylation) and theirintegration in diseaseassociation studies
PCC5:Exploratory subgroup analyses in clinical trials
11:00 11:30 Refreshments
11:30 13:00 PCC1: (cont) PCC2:(cont) PCC3: (cont) PCC4: (cont) PCC5: (cont)
13:00 14:00 Lunch
14:00 15:30 PCC1: (cont) PCC2:(cont) PCC3: (cont) PCC4: (cont) PCC6:An introduction to the joint modelling of longitudinal andsurvival data, with applications in R
15:30 16:00 Refreshments
16:00 17:30 PCC1: (cont) PCC2: (cont) PCC3: (cont) PCC4: (cont) PCC6: (cont)
17:30 19:00
19.00 Student Gathering
Mon 22 Aug
08:00 09:00
09:00 09:30 Welcome andIntroduction:
Cindy Billingham, LOC Chair, Nigel Stallard, SPC ChairDavid Adams, Pro-Vice-Chancellor, Head of College of Medical and Dental Sciences and Dean of Medicine, University of BirminghamDavid Warne, ISCB President
09:30 10:30 President's InvitedSpeaker:
Diego Kuonen: "A Swiss Statistician’s “Big Tent” Overview of Big Data and Data Science in Pharmaceutical Development"
10:30 11:00 Refreshments and Posters
11:00 12:30 I1: Statistical issues instratified or personalisedmedicine and biomarkerdiscovery
C1 Survival data analysis1
C2 Meta analysis andmedical decision making1
C3 Advances instatistical issues inepidemiology 1
C4 Cluster randomisedand stepped wedgetrials 1
C5 Missing data 1 C6 Other 1
12:30 14:00 Lunch and Posters
14:00 15:30 I2: Infectious diseaseepidemiology
C7 Survival data analysis2
C8 Survival data analysis3
C9 Statistics in rarediseases and smallpopulations 1
C10 Meta analysis andmedical decision making2
C11 Stratified andpersonalised medicine 1
C12 Adaptive trial designand analysis 1
15:30 16:00 Refreshments and Posters
16:00 17:30 I3: Statistical methodsin pharmaco-epidemiology and drugsafety
C13 Survival dataanalysis 4
C14 Survival dataanalysis 5
C15 Stratified andpersonalised medicine 2
C16 Adaptive trial designand analysis 2
C17 Missing data 2 C18 Analysis ofobservational studies 1
17:30 19:00
19.00 Welcome Reception at Birmingham Museum and Art Gallery (pre-booked tickets only)
ISCB37 Birmingham, UK: 21-25 August 2016: Draft Programme
ISCB News #61 Page 17 June 2016
Tue 23 Aug
08:00 09:00
09:00 10:30 I4: Evidence synthesisand medical decision-making
C19 Survival dataanalysis 6
C20 Stratified andpersonalised medicine 3
C21 Statistics in rarediseases and smallpopulations 2
C22 Analysis ofobservational studies 2
C23 Early phase clinicaltrials 1
C24 Other 2
10:30 11:00 Refreshments and Posters
11:00 12:30 I5: Adaptive designs foroncology clinical trials
C25 Survival dataanalysis 7
C26 Meta analysis andmedical decision making3
C27 Cluster randomisedand stepped wedgetrials 2
C28 Causal inferenceand mediation analysis 1
C29 Longitudinal dataanalysis 1
C30 Big data inhealthcare 1
12:30 13:00 Lunch (Packed Lunch)
13:00 Conference Excursions (pre-paid tickets only)
Wed 24 Aug
08:00 09:00
09:00 10:30 I6: Research showcasefrom the MRC Network ofHubs for TrialsMethodology Research
C31 Survival dataanalysis 8
C32 Analysis ofobservational studies 3
C33 Big data inhealthcare 2
C34 Missing data 3 C35 Inference ininfectious diseases
C36 Other 3
10:30 11:00 Refreshments and Posters
11:00 12:00 Keynote Speaker: David Spiegelhalter: The Statistics of Sex
12:00 13:00 ISCB Annual General Meeting
13:00 14:00 Lunch and Posters
14:00 15:30 I7: Myths and pitfalls insurvival analysis
C37 Stratified andpersonalised medicine 4
C38 Adaptive trial designand analysis 3
C39 Cluster randomisedand stepped wedge trials 3
C40 Statistics in rarediseases and smallpopulations 3
C41 Advances in statisticalissues in epidemiology 2
C42 Causal inferenceand mediation analysis 2
15:30 16:00 Refreshments and Posters
16:00 17:30 C43 Survival dataanalysis 9
C44 Early phase clinicaltrials 2
C45 Analysis ofobservational studies 4
C46 Advances in statisticalissues in epidemiology 3
C47 Longitudinal dataanalysis 2
C48 Diagnostic tests C49 Other 4
17:30 19:00
19:00 Conference Dinner at Edgbaston Stadium (pre-paid tickets only)
Thu 25 Aug
08:00 09:00
09:00 09:30
09:30 10:30 MS1: Statistical methods inrare diseases and smallpopulations
MS2: Strengtheninganalytical thinking forobservational studies(STRATOS)
Students' Day
10:30 10:45 Refreshments
10:45 11:00 Refreshments
11:00 12:15 MS1 (cont) MS2 (cont) Students' Day (cont)
12:15 12:30 Lunch
12:30 13:15 Lunch Lunch
13:15 14:00 1330: MS1 (cont) Students' Day (cont)
14:00 15:00 MS2 (cont)
15:00 15:15 Refreshments
15:15 15:30 Students' Day (cont)
15:30 17:00
ISCB37 Birmingham, UK: 21-25 August 2016: Draft Programme
ISCB News #61 Page 18 June 2016
Details:Sun 21 Aug
09:30-17:30PCC1: An industry approach toBayesian phase I oncology trials:methodology and implementation
SimonWandel,BeatNeuenschwander,Basel,Switzerland
09:30-17:30PCC2: Demystifying causal inference inrandomised trials
Ian White,Cambridge,UK,GrahamDunn,Manchester,UK,SabineLandau,London, UK,RichardEmsley,Manchester,UK
09:30-17:30PCC3: Network meta-analysis fordecision-making
DavidPhillippo,Sofia Dias,Bristol, UK
09:30-17:30PCC4: Analysis of single and multi-omicdata (SNP array, gene expression andmethylation) and their integration indisease association studies
Juan RGonzalez,Barcelona,Spain
09:30-13:00PCC5: Exploratory subgroup analysesin clinical trials
GerdRosenkranz,Basel,Switzerland
14:00-17:30PCC6: An introduction to the jointmodelling of longitudinal and survivaldata, with applications in R
DimitrisRizopoulos,Rotterdam,Netherlands
Mon 22 Aug
09.00-09.30Welcome and Introduction
09.30-10.30President's Invited Speaker
A Swiss Statistician’s “Big Tent”Overview of Big Data and Data Sciencein Pharmaceutical Development
DiegoKuonen,StatooConsulting,Switzerland
Mon 22 Aug
11:00-12:30I1 Statistical issues in stratified orpersonalised medicine and biomarkerdiscovery
Applied systems medicine for therapyprediction and clinical trial design inpersonalized oncology
FrederickKlauschen,Charité -UniversitätsmedizinBerlin,Germany
Methods for integrated analysis ofomics datasets: prediction and biology
JeanineHouwing-Duistermaat, Universityof Leeds,UK
Adaptive enrichment designs NigelStallard,WarwickMedicalSchool,University ofWarwick,UK
11:00-12:30C1 Survival data analysis 1
Using the PP-plot Area Test and aDivergence Measure for ImprovedSurvival Analyses Within Clinical Trials
Trevor Cox
On the use of net survival methods forpopulation-based studies in clinicaltrials to correct misspecificationproblem and selection effect.
Goungounga Juste
The impact of selection andchronological bias on test decisions insurvival analysis
MarciaRückbeil
Analysis of Unobserved HeterogeneityIncorporated with Accelerated FailureTime Models: Bayesian versus Classical
ShailaSharmin
Approximate Bayesian methods in curesurvival models: Coupling P-splineswith Laplace approximations for fastinference.
OswaldoGressani
Mon 22 Aug
11:00-12:30C2 Meta analysis and medical decisionmaking 1
Meta-analysis using individualparticipant data: 10 reasons why one-stage and two-stage models may givedifferent results
DanielleBurke
Derivation of percentage study weightsin one-stage and two-stage individualparticipant data meta-analysis models
RichardRiley
Comparison of bivariate methods formeta-analysis of diagnostic testaccuracy studies with individual patientdata
ChristopherPartlett
Individual participant data meta-analysis for external validation andrecalibration of a prognostic model
J. Ensor
One Stage Meta-analysis of JointLongitudinal and Time-to-EventOutcomes
Maria Sudell
11:00-12:30C3 Advances in statistical issues inepidemiology 1
Age-at-onset subsets of bipolar Idisorders: a critical insight intoadmixture analyses
Clairemontlahuc
Using family relationships to improveconsistency of identification ofAboriginal people in linkedadministrative data
AlisonGibberd
Multi-way interaction among binary riskfactors on the additive scale
MichailKatsoulis
Testing for centre effects on hospitalmortality in ICU patients withhematologic malignancies usingpermutation tests
Lucie Biard
Investigating the assumptions neededwhen imputing missing diseaseinformation due to death in cohortstudies with discrete follow-up visits
NadineBinder
ISCB37 Birmingham, UK: 21-25 August 2016: Draft Programme
ISCB News #61 Page 19 June 2016
Mon 22 Aug
11:00-12:30C4 Cluster randomised and steppedwedge trials 1
Modeling differential clustering andtreatment effect heterogeneity inparallel and stepped wedge clustertrials
KarlaHemming
The Implications of DifferentialClustering for the Analysis of ClusterRandomised Trials with a BinaryOutcome
ChrisRoberts
Impact of non-uniform correlationstructure in multiple-period clusterrandomised trials
AndrewForbes
The design of cluster randomized trialswith random cross-classifications
MirjamMoerbeek
Spatial Regression and Spillover Effectsin Cluster Randomized Trials
NealAlexander
11:00-12:30C5 Missing data 1
Imputation of systematically andpartially missing predictors in individualparticipant data (IPD) meta-analysis
ShahabJolani
Statistical methods for the ExtremePhenotype Sampling design
TheaBjørnland
A sparse factor model approach toanalysis of high dimensional data withmissing covariate
Soeun Kim
Analysing correlated multiple outcomesmeasures using multivariate models.
VictoriaVickerstaff
Cox regression model with an intervalcensored binary time-varying covariate
Yang-j Kim
11:00-12:30C6 Other 1
A comparison of shrinkage anticipationand correction in Cox regression
MichaelKammer
Confidence Bands for the MeanResidual Life function
AmirhosseinJalali
Modeling agreement between two fixedscorers on a bounded scale
SophieVanbelle
Analysis of multivariate longitudinalordinal endpoints: neurologists borrowfrom social statistics
LorenzoTanadini
Non-Concave Penalized Log-Likelihoodin Linear Mixed-Effect Models and theRegularized Selection of Fixed Effects
Abhik Ghosh
Mon 22 Aug
14:00-15:30I2 Infectious disease epidemiology
Statistical Methods for real-timemonitoring of health outcomes
PeterDiggle,Liverpool/Lancaster
Inferring time-dependent basicreproduction numbers from serialseroprevalence data on hepatitis A
Neil Hens,Hasselt
Outbreak analysis and modelling: theZika challenge
ChristlDonnelly,ImperialCollege,London
14:00-15:30C7 Survival data analysis 2
On the improvement of predictionaccuracy for survival models
MaralSaadati
Effect of non-proportionality of thehazard ratio in sample size estimationand its relationship with othermeasures.
MoisésGómezMateu
Estimation of net survival with pseudoobservations
KlemenPavlic
Cox Regression for Doubly TruncatedData
MichaMandel
The statistical analysis of recurrentevent processes subject to interval-censoring and resolution
Hua Shen
14:00-15:30C8 Survival data analysis 3Parametric multi-state survival models:flexible modelling allowing transition-specificdistributions with application to estimatingclinically useful measures of effectdifferences
MichaelCrowther
Motivating multistate modeling ofrecurrent composite endpoints inrandomized cardiovascular trials viabias analyses with directed acyclicgraphs
Antje Jahn
Multi-state models for cardiovasculardisease
FrancescaGasperoni
Estimation of transition probabilities innon-Markov multi-state models
Hein Putter
Nonparametric estimation for multi-state models under cross-sectionalsampling
Jacobo deUña-Álvarez
Mon 22 Aug
14:00-15:30C9 Statistics in rare diseases and smallpopulations 1
Efficient tests to demonstrate thesimilarity of dose response curves withregard to small sample sizes
KathrinMöllenhoff
A Selection Bias AdjustedRandomization Test
DianeUschner
A framework for scientific evaluation ofrandomization procedures in smallclinical trials
Ralf-DieterHilgers
Assessment of randomizationprocedures with respect to multipleobjectives
DavidSchindler
N-of 1 trials, Statistical Inference &Rare Diseases
StephenSenn
14:00-15:30C10 Meta analysis and medical decisionmaking 2
Inconsistency in network meta-analysis: a critical comparison ofmethods
SuzanneFreeman
Two new methods to fit models fornetwork meta-analysis with randominconsistency effects
Martin Law
Network meta-analysis for theintegrated evaluation of targetedtherapies with binary outcomes
TanjaProctor
Quantifying the Effects of Bias:Decision-Invariant Bias Intervals forBayesian Network Meta-Analysis
David M.Phillippo
Incorporating external information onbetween-study heterogeneity innetwork meta-analysis
RebeccaTurner
ISCB37 Birmingham, UK: 21-25 August 2016: Draft Programme
ISCB News #61 Page 20 June 2016
Mon 22 Aug
14:00-15:30C11 Stratified or personalised medicineand biomarker discovery 1
Group Sequential Designs andBiomarker Decision Making - SimilarBut Different
ChrisHarbron
A novel adaptive biomarker enrichmentclinical trial design for time-to-eventoutcomes
DeepakParashar
Do targeted clinical trials profit fromthe inclusion of biomarker-negativepatients?
ChristinaBeisel
A Design for Phase II Clinical Trials inStratified Medicine with Efficacy andToxicity Outcomes and PredictiveVariables
KristianBrock
Current biomarker-guided clinical trialdesigns: a comparison of statisticalcharacteristics
MirantaAntoniou
14:00-15:30C12 Adaptive trial design and analysis1
Using an equivalence weight approachto incorporate historical control data inthe design of a new trial
MaxineBennett
Quantifying the estimated treatmenteffect in trials planning interimanalyses with potential early stoppingfor futility.
StephenWalter
A Post-stratification Approach forEfficient Estimation in Two-stageRandomized Clinical Trials
Nabil Awan
Correcting for selection bias andcorrelation in time-to-event analysis inadaptive designs
JosephineKhan
Point and interval estimation forconfirmatory two-stage adaptive trialswith multiple endpoints
PeterKimani
Mon 22 Aug
16:00-17:30I3 Statistical methods inpharmacoepidemiology and drug safety
The self-controlled case series method:introduction and investigating theassumptions
HeatherWhitaker,The OpenUniversity
The emerging and merging fields ofbenefit-risk and health technologyassessments
Shahrul Mt-Isa, MerckSharp &Dohme
Pharmacoepidemiology: rightquestions? right answers?
StephenEvans andElizabethWilliamson,LondonSchool ofHygiene andTropicalMedicine
16:00-17:30C13 Survival data analysis 4
Stabilised Aalen-Johansen estimator ofthe transition probabilities to protectagainst too small risk sets
ArthurAllignol
Non-parametric simulation and a novelwild bootstrap resampling procedurefor the multistate Aalen-Johansenestimator
TobiasBluhmki
Kernel estimation as alternativeto(semi)parametric models in survivalanalysis: simulated and real data
IvetaSelingerova[CAScwinner]
On the maximum penalised likelihoodapproach for semiparametricproportional hazard models witharbitrary censoring
Dominique-LaurentCouturier
Translational Statistics in Time to EventStudies
John Newell
Mon 22 Aug
16:00-17:30C14 Survival data analysis 5
A unified competing risks modellingusing mixture distributions
Jun Ma
Investigating hospital heterogeneitywith a competing risks frailty model
AnjaRueten-Budde
Analysis of interval censored failuretime data with competing risk
Yang-JinKim
Multiple imputation for missingcovariate data in stratified cause-specific hazards models
MichaelLauseker
Interpretation of effect estimates incompeting risks survival models: Asimulated analysis of organ-specificprogression-free survival in arandomised phase III cancer trial
PradeepVirdee
16:00-17:30C15 Stratified or personalised medicineand biomarker discovery 2
Artificial Neural Networks SurvivalModel for Predicting Outcomes ofGastric Cancer Patients in Presences ofCensored data
HamidNilsazDezfouli
Optimism bias correction in omicstudies: assessment of penalizedmethods on simulated data
Pascal Roy
Using multiple biomarkers to informpersonalised treamtentrecommendations
MatthiasPierce
Simultaneous confidence intervals fortreatment effects in subgroups inbiomarker stratified designs
Fang Wan
Why don't we all lose weight equallyon Low Calorie Diet? Proteomicsexplanation to weight loss variability inoverweight and obese subjects
IrinaIrincheeva
ISCB37 Birmingham, UK: 21-25 August 2016: Draft Programme
ISCB News #61 Page 21 June 2016
Mon 22 Aug
16:00-17:30C16 Adaptive trial design and analysis2Accurate and powerful p-values for adaptivedesigns with binary endpoints
StephaneHeritier
Extending a running exploratory time-to-event trial into a confirmatory trial
Ute vonWangenheim
Practical challenges of running adaptivetrials in an academic trials unit
Jane Holmes
Adaptive Designs in clinical trials fromScientific Advice to Marketing Authorisation:lessons learnt from submissions to theEuropean Medicines Agency
OlivierCollignon
Response-Adaptive Randomization andAdaptive Design in Small Population ClinicalTrials: Pitfalls and Advantages
Franz König
16:00-17:30C17 Missing data 2Comparison of multiple imputation methodsfor systematically and sporadically missingmultilevel data
VincentAudigier
Multiple Imputation of cross-classifiedmultilevel models
ShahabJolani
Reference based sensitivity analysis forclinical trials with missing data via multipleimputation: Investigation of Rubin'svariance estimate
Suzie Cro
Applying multiple imputation to multi-itempatient reported outcome measures:advantages and disadvantages of imputingat the item, sub-scale or score level
InesRombach
Bayesian imputation of time varyingcovariates in linear mixed models
Nicole Erler[StCA winner]
Mon 22 Aug
16:00-17:30C18 Analysis of observational studies 1Propensity score methods in the estimationof treatment effect modification inobservational studies
AntoniaMarsden
Propensity score matching to support thecomparison between patients with andwithout treatment switch in a randomizedtrial on chronic myeloid leukaemia
MarkusPfirrmann
Propensity score methods versus covariateadjustment - a practical evaluation in fourcardiovascular cohort studies
John Gregson
Propensity score analysis with partiallyobserved confounders: how to use multipleimputation?
ClémenceLeyrat
More efficient methods to take into accountPrognostic Scores in observational studies
David Hajage
Tue 23 Aug
09:00-10:30I4 Evidence synthesis and medicaldecision-makingDecision making under alternativeinterpretations of the evidence
TomTrikalinos,BrownUniversity,ProvidenceRI, USA
Complex evidence syntheses to inform NICEclinical guidelines
Sofia Dias,University ofBristol, UK
Meta-analysis of prediction modelsand decision making
EwoutSteyerberg,Erasmus MC,Rotterdam,Netherlands
09:00-10:30C19 Survival data analysis 6Using dynamic prediction to inform theoptimal intervention time for individuals inan abdominal aortic aneurysm screeningprogramme
MichaelSweeting
Multiple imputation of time-dependentcovariates in survival analysis: Two-stagejoint model with multiple continuousmarkers
MargaritaMoreno-Betancur
Extension of the association structure injoint models to include weighted cumulativeeffects
Katya Mauff
A novel approach for jointly modelingsurvival times and recurrent episodes ofdisease progression
SunethraAbeysingheArachchige
Joint Modelling Approach for Longitudinaland Competing-Risks Data via H-likelihood
IL DO HA
09:00-10:30C20 Stratified or personalised medicineand biomarker discovery 3A statistical framework for using externalinformation in updating prediction modelswith new biomarkers
Jeremy Taylor
The Wally plot approach to assess thecalibration of prediction models
Paul Blanche
treatment selection markers: benefitfunctions, marker-selections & indicationbias
KoosZwinderman
Reporting of prognostic tumour markerstudies after the introduction of theREMARK guideline needs improvement
Sue Mallett
Diagnostic Method for Optimal PersonalizedTreatment Rules
Xin Qiu
Tue 23 Aug
09:00-10:30C21 Statistics in rare diseases andsmall populations 2Multi-armed platform trials in smallpopulations using a two-step testingprocedure incorporating efficacy and safety
Gerald Hlavin
Optimal exact tests for multiple binaryendpoints
Robin Ristl
Using re-randomisation make randomisedtrials in rare diseases more feasible
BrennanKahan
Implementation of a flexible trial design inrelapsed Ewing’s sarcoma
VeronicaMoroz
Rare events bias of logistic regression Rok Blagus
09:00-10:30C22 Analysis of observational studies 2
Guidelines for the use and presentationof funnel plots
IlonaVerburg
Causal diagrams, expert opinion andstructure learning: vetting the expert
JessicaKasza
Instrumental Variable Estimation Underthe Semiparametric Accelerated FailureTime Model
MenggangYu
Comparing approaches for ConfoundingAdjustment in Secondary DatabaseAnalyses: High-Dimensional PropensityScore versus two machine learningalgorithms: Random Forest and Elastic Net
MohammadEhsanulKarim
Use of the prevented fraction to estimatethe number of cases of stroke that can beavoided by using lipid lowering drugs in theFrench Three-City cohort
MalamineGassama
09:00-10:30C23 Early phase clinical trials 1A comparison between the continualreassessment method and D-optimumdesign for dose finding in phase I clinicaltrials
M. IftakharAlam[CAScwinner]
A method for dose-finding based on aweighted differential entropy that does notrequire a monotonicity assumption
PavelMozgunov
A Bayesian decision-theoretic approach toincorporating pre-clinical information intophase I clinical trials
Haiyan Zheng
Adapted Bayesian design for Phase I/IIclinical trials
Yuh-Ing Chen
Simulation-based adjustment forexploratory biomarker subgroupselection in phase II
Heiko Götte
ISCB37 Birmingham, UK: 21-25 August 2016: Draft Programme
ISCB News #61 Page 22 June 2016
Tue 23 Aug
09:00-10:30C24 Other 2
Recommendations on multiple-testingadjustment in multi-arm trials withcorrelated hypotheses
DenaHoward
Using emerging trial data to updatecost effectiveness decision models
BenjaminThorpe
tSNR as Variable Selection Techniquein Genome-Wide Data Analysis
Nazatulshima Hassan
The efficient choice of a primary binaryendpoint for sample size assessment
Marta BofillRoig
Type I error and power for detectinghospitals with high or low 30-daymortality.
Doris ToveKristoffersen
11:00-12:30I5 Adaptive designs for oncologyclinical trials
Bayesian Adaptive Trial Design WithMultiple Efficacy Endpoints forHeterogeneous Subpopulations
LindsayRenfro,Mayo Clinic,US
Design and implementation of platformtrials for biomarker-driven questions
MatthewSydes, MRCCTU at UCL,London, UK
A Decision Theoretic Approach toOptimize Clinical Trial Designs forTargeted Therapies
Martin Posch,MedicalUniversity ofVienna
11:00-12:30C25 Survival data analysis 7
Parametric Estimation of SurvivalDistributions in Two-StageRandomization Designs
SifisoVilakati
Direct likelihood inference on the cause-specific cumulative incidence function: aflexible parametric subdistribution hazardsregression model
SarwarIslam
Flexible assessment of non-linearcovariate effects in a pseudo-valueregression model
UlrikePötschger
Incorporating the time-dependency inROC methodology for censored clinicalevent
Adina NajwaKamarudin
Can methods incorporating repeat biologicalmeasurements improve cardiovascular riskprediction?
JessicaBarrett
Tue 23 Aug
11:00-12:30C26 Meta analysis and medical decisionmaking 3
When should we use multivariatemeta-analysis? Predictors of Borrowingof Strength in 43 bivariate meta-analyses within Cochrane
MiriamMacDonald
Investigating the extent ofheterogeneity due to studycharacteristics in meta-analysis
KirstyRhodes
Bayesian Predictive Power: Choice ofPrior and some implications
KasparRufibach
Meta-analysis of standardised meandifferences from randomised trials withtreatment-related clustering
RebeccaWalwyn
The albatross plot: a novel graphicaltool for presenting results of diverselyreported studies in a systematic review
SeanHarrison
11:00-12:30C27 Cluster randomised and steppedwedge trials 2
Stepped wedge cluster randomisedtrials: a review of the statisticalmethodology used .
MichaelCampbell
Stepped-Wedge design effects whenthe clusters are not equal in size
Alan Girling
Estimability and bias of the treatment effectin a classical cohort stepped wedge designunder consideration of carry-over effectsand autoregressive covariance structure.
AnnChristinaFoldenauer
Accounting for time in mixed effectsmodels in a stepped wedge clusterrandomised trial design
AleciaNickless
Sample size calculations for a SteppedWedge Cluster Randomised Trial mustconsisder the impact of adjusting fortime
PatrickMcElduff
Tue 23 Aug
11:00-12:30C28 Causal inference and mediationanalysis 1Adjusting for bias in unblinded randomizedcontrolled trials.
AmandSchmidt
Using marginal structural models toestimate direct and indirect effects incluster randomised trials
GordonForbes
Investigation of AdjustmentTechniques for Type I Error RateIncreased by Multiplicity in SNPAnalyses
HavvaDidem Ovla
Constant effect assumption versusindividualized medicine
Erik Cobo
Causal Inference under Selection VanessaDidelez
11:00-12:30C29 Longitudinal data analysis 1
Bayesian Inference for a Joint Model ofMultiple Longitudinal Measures andMultiple Recurrent Events
SamuelManda
Utilising the Coxian phase-type distributionto represent patient survival within a jointmodelling framework
ConorDonnelly
Marginal quantile regression with aworking association matrix
DavideBossoli
Comparison of a flexible complex and asimple discriminant analysisapproaches for longitudinally collecteddata
Riham Elsaeiti
Permuting longitudinal data despite allthe dependencies
SarahFriedrich
11:00-12:30C30 Big data in healthcare 1
Identifying potentially interestingcovariates for genetic risk scores underdata protection constraints in consortia
DanielaZöller
Regularized redundancy analysis forhigh dimensional data
Michel Hof
Comparison of em and two-step clustermethod for mixed data: an application
Ozge Pasin
OLS versus quantile regressions fromtiny to big data: application toelectrocardiography data.
Bernard GFrancq
Statistical methods to compare NextGeneration Sequencing Pipelines
Pascal Roy
ISCB37 Birmingham, UK: 21-25 August 2016: Draft Programme
ISCB News #61 Page 23 June 2016
Wed 24 Aug
09:00-10:30I6 Research showcase from the MRCNetwork of Hubs for TrialsMethodology Research
The MRC Hubs for Trials MethodologyNetwork: Improving health byimproving trials
Jane Blazeby,School ofCommunityMedicine,
Implementation of an adaptive, model-based dose-finding design in anoncology trial
Christina Yap,CancerResearch UKClinical TrialsUnit,UniversityBirmingham,UK
TAILoR: Lessons from a multi-armmulti-stage clinical trial in HIV/AIDS
Thomas Jaki,LancasterUniversity, UK
Laying the groundwork for a trial:biomarker identification
AndreaJorgensen,University ofLiverpool, UK
Novel designs for trials with multipletreatments and biomarkers
JamesWason, MRCBiostatisticsUnit,Cambridge,UK
09:00-10:30C31 Survival data analysis 8
Pre-test estimation in the illness-deathmodel
MarRodríguez-Girondo
The use of tumor dynamics and non-target lesions to predict survival withmultivariate joint frailty models
AgnieszkaKrol[StCAwinner]
Explained variation in shared frailtymodels for multi-center studies ofsurvival
AndreasGleiss
Assessing impact of center on survivaloutcomes in the presence of missingdata
Liesbeth deWreede
Dynamic prediction of time topregnancy leading to live birth incouples with unexplained reasons fortheir infertility
DavidMcLernon
Wed 24 Aug
09:00-10:30C32 Analysis of observational studies 3An application of model-fitting for marginalstructural modeling in the context of a raredisease observational cohort study withmissing exposures
Hyang Kim
Improving prognostic accuracy when usinglongitudinal biomarkers from multiplesources
Marta Garcia-Finana
General linear models for investigating theassociation between gene module co-expression and a continuous trait
TrishantaPadayachee
A tool for identification of familial colorectalcancer risk
Anna Rieger
Combining clinical and omics data toconstruct a predictor and assess itspredictive value – comparison of severalstrategies
WilliSauerbrei
09:00-10:30C33 Big data in healthcare 2On The Performance of Adaptive Pre-processing Technique in Analysing High-dimensional Censored Data
HasinurRahaman Khan[CASc winner]
External validation of clinical predictionmodels using big data from e-health recordsor IPD meta-analysis
Richard Riley
Robust classification of high dimensionaldata in health care
Anna MariaPaganoni
Selecting a predictive function for survivalanalysis with gene expression data
Victor L. Jong
Use of time varying propensity scores to mimicproperties of randomised controlled trials:evaluating the effect of allopurinol in gout usingthe Clinical Practice Research Datalink
TrishnaRathod
09:00-10:30C34 Missing data 3A causal modelling framework for the defacto estimand in clinical trials with noobservation after treatment dropout
Royes Joseph
Conducting sensitivity analyses todepartures from MAR in the multipleimputation framework using the Not atRandom Fully Conditional Specificationprocedure
Finbarr Leacy
Developing a sensitivity analysis frameworkfor addressing informative missingness inthe analysis of clinical trials
AlexinaMason
Longitudinal and time-to-drop-out jointmodels can lead to seriously biasedestimates when the drop-out mechanism isat random
ChristosThomadakis[StCA winner]
Randomization based Inference - How todeal with missing observations
NicoleHeussen
Wed 24 Aug
09:00-10:30C35 Inference in infectious diseasesEstimation of covariate effect on serologicalresponse rate based on bivariate interval-censored measurements
Yin BunCheung
A Bayesian SEIR model with nonparametricdisease transmission rate to analyse thepropagation of Ebola in Sierra Leone
PhilippeLambert
Inference in a stochastic SEIR epidemicmodel using Sequential Monte Carlomethods
WilfriedBonou
Joint Modeling of Survival and CountVariables: Joining the Discrete Time Hazardmodel with the Poisson Regression model
Jayani (J.C.)Hapugoda
Stochastic simulations for HIV spreading inhyperendemic settings
StéphanieBlaizot
09:00-10:30C36 Other 3
Robust bivariate meta-analytic-predictive priors for including historicalinformation on control rates andtreatment effects in paediatric clinicaltrials
ClaraDominguezIslas
New correlated-errors-in-variablesregressions in method comparisonstudies.
Bernard GFrancq
A recursive partitioning approach forsubgroup identification in individualpatient data meta-analysis
DipeshMistry
How European regulators deal withsubgroups during the procedure ofobtaining a Marketing AuthorisationApplication
JulienTanniou
Tubular quantile and expectile contoursStenWillemsen
11:00-12:00Keynote Lecture
The statistics of sex DavidSpiegelhalter,University ofCambridge,UK
12:00-13:00ISCB Annual General Meeting All!
ISCB37 Birmingham, UK: 21-25 August 2016: Draft Programme
ISCB News #61 Page 24 June 2016
Wed 24 Aug
14:00-15:30I7 Myths and pitfalls in survivalanalysis
Prevalent cohort studies andunobserved heterogeneity
Neils Keiding,Departmentof PublicHealth,Section ofBiostatistics,University ofCopenhagen,Denmark
The elusive concept of frailty: Aglimpse into survival, heterogeneityand causality
Odd O. Aalen,DepartmentofBiostatistics,Institute ofBasic MedicalSciences,University ofOslo, Norway
Competing risks, immortal time bias:two myths in survival analysis?
JanBeyersmann,Institute ofStatistics,UlmUniversity,Germany
14:00-15:30C37 Stratified or personalised medicineand biomarker discovery 4
Incorporating the time in ROCmethodology for better medicaldecision making
RuwanthiKolamunnage-Dona
Spatial mixed-effect modelling fornovel imaging biomarkers of malarialretinopathy from a clinicalobservational study
GabrielaCzanner
Choosing the number of classes inBayesian finite mixture models usingthe posterior distribution ofthe mixing proportions
Joost vanRosmalen
A Prediction predictive model for riskstratification of cognitative impairmentpost stroke
MarionFahey
Instrumental variable methods forexploring mechanisms in stratifiedmedicine
RichardEmsley
Wed 24 Aug
14:00-15:30C38 Adaptive trial design and analysis3Optimal group sequential tests for delayedresponses with non-binding futilityboundaries
Lisa Hampson
Interim analyses incorporating short- andlong-term endpoints for binary correlatedoutcomes
JuliaNiewczas
Bayesian stopping rules for binary-endpointtrials
Vincent vander Noort
Bayesian Hierarchical Classification andInformation Sharing for Clinical Trials WithSubgroups and Binary Outcomes
J. Jack Lee
Performance of Subgroup Selection Rules inAdaptive Oncology Trials with Time-to-eventOutcome
JohannesKrisam
14:00-15:30C39 Cluster randomised and steppedwedge trials 3Optimal design of cluster randomised trialswith baseline data
AndrewCopas
Choosing a two-stage design for a clusterrandomised trial with one-way cross-over:the benefits of incompleteness
RichardHooper
Missing binary outcomes under covariatedependent missingness in clusterrandomised trials
AnowerHossain
Linked cluster-randomised trials of complexinterventions: A "split-block" design
RebeccaWalwyn
Split-plot designs in healthcare: an overview BeatrizGoulao
14:00-15:30C40 Statistics in rare diseases andsmall populations 3
Predictive performance of multinomiallogistic prediction models - a simulationstudy
Valentijn deJong
Meta-analysis of two studies in thepresence of heterogeneity withapplications in rare diseases
ChristianRöver
Dynamic borrowing through empiricalpower priors that control type I error
StavrosNikolakopoulos
Performance of heterogeneityestimators under a sparse - eventsmeta analysis in small populations.
Konstantinos Pateras
Clinical drug development in epilepsyrevisited: a proposal for a new paradigmstreamlined using extrapolation
IanWadsworth
Wed 24 Aug
14:00-15:30C41 Advances in statistical issues inepidemiology 2
Self-controlled case series with multipleevent types
YonasGhebremichael-Weldeselassie
Risk Prediction Using Nested Case-Control Data
Agus Salim
The resurrection of time as acontinuous conceptin biostatistics,demography and epidemiology
BendixCarstensen
Determining the likely place of HIVacquisition for migrants in Europecombining subject-specific informationon migration history, risk factors andbiomarkers data
NikosPantazis
Limitations of the incidence densityratio for the analysis of adverse events
Ralf Bender
Wed 24 Aug
14:00-15:30C42 Causal inference and mediationanalysis 2
Modeling time-varying exposure forinverse probability of treatmentweights: extending the R ipw package
NathalieGRAFFEO
Using multiple imputation and selectingthe best multivariable fractionalpolynomial (MFP) model to balancepredictors of mortality betweentreatment groups
SuzanneIngle
Multiple imputation methods forestimating causal treatment effects intrials with non-compliance
KarlaDiazOrdaz
Causal inference in a multi-state modelfor work, unemployment, highereducation, sickness absence anddisability.
Rune Hoff
An extension of missingness graph forrepeated measurements of multi-dimensional markers
VahéAsvatourian
ISCB37 Birmingham, UK: 21-25 August 2016: Draft Programme
ISCB News #61 Page 25 June 2016
Wed 24 Aug
16:00-17:30C43 Survival data analysis 9
Stratifying population life tables bysocioeconomic status and comorbidityby using a control population
HannahBower
A probabilistic record linkage model forsurvival data
Michel Hof
The use of registry data to extrapolateresults from randomised clinical trials(RCTs): an example in metastaticmelanoma
ReynaldoMartina
Analysing epidemiological data in thepresence of informative censoring:using external data to estimate aparticipant-specific change in thehazard at time of censoring
EdmundJones
Dynamic prediction of survival usinglandmarking in large longitudinalobservational patient databases:challenges and solutions
Ruth Keogh
16:00-17:30C44 Early phase clinical trials 2
Comparison of phase II designs usingtime-to-event endpoint with a reducedfollow-up.
Lisa Belin
A Bayesian weighted quasi-likelihooddesign for phase I/II clinical trial withrepeated dose administration inpreterm newborns.
MorenoUrsino
Decision-theoretic design for a series ofphase II trials with correlatedtreatment effects
Siew WanHee
Improving phase II oncology trial usingbest observed RECIST response as anendpoint by modelling continuoustumour measurements
CHIEN-JULIN
Decision Making in Basket Trials: AHierarchical Weights Approach
ThomasBengtsson
Wed 24 Aug
16:00-17:30C45 Analysis of observational studies 4Interclass correlation coefficients forexplaining inter-hospital variations in lengthof stay
Lynne Moore
Prognosis research and the importance ofmeasuring predictors at the intendedmoment of use: an illustrative example fromgeneral practice
RebeccaWhittle
A comparison of the hybrid CART-LOGITmodel and tree based random forest modelfor prognostication of patients withtraumatic brain injury
Vineet KumarKamal
An application of the latent class modellingto predict risk of mortality among cases ofacute poisoning
KashifShafique
GROUP SEQUENTIAL METHODS APPLIED INPSYCHOLOGICAL RESEARCH ON ASUBJECTIVE WELL-BEING SURVEY INAUSTRIA
KlemensWeigl
16:00-17:30C46 Advances in statistical issues inepidemiology 3Multilevel Modeling of Binary Outcome inThree Level Complex Health Survey Data
Shafquat Rozi
Multilevel regression and poststratificationfor addressing participation bias in healthsurvey data
John Carlin
Scaled logistic regression Erik Van Zwet
Which Performance Measures to use inExternal Validation of a MultivariablePrognostic or Diagnostic Prediction Model?
HarbajanChadha-Boreham
Breast cancer tumour growth models understable disease population assumptions
GabrielIsheden
16:00-17:30C47 Longitudinal data analysis 2Dynamic Allocation schemes using credibleintervals and multivariate generalised mixedmodels.
David Hughes
A Comparison of Estimation Approaches forGeneralized Additive Mixed Models withBinary Outcomes
MuhammadMullah
Investigating momentary level change inintensive longitudinal data
Lesley-AnneCarter
Early detection of patients with high risk ofdeveloping end-stage renal disease inprimary care
Ozgur Asar
Accounting for uncertainty in the timing ofseroconversion in combined models for pre-and post-treatment CD4 counts in HIV-patients
Oliver Stirrup
Wed 24 Aug
16:00-17:30C48 Diagnostic tests
On Evaluation of Reliability,Repeatability, and Reproducibility inLaboratory Testing
SamirSALAH
Meta-analysis of test accuracy studiesusing imputation for partial reporting ofmultiple thresholds
J. Ensor
Empirical assessment of univariate andbivariate meta-analyses for comparingthe accuracy of diagnostic tests
YemisiTakwoingi
The cost of not having a perfectreference
Ana Subtil
Does ignoring clustering in multicenterdata influence the performance ofprediction models? A simulation study
LaureWynants
16:00-17:30C49 Other 4
Combining imaging and visual fieldoutcomes for clinical trials in glaucoma:is estimation of treatment effectsimproved?
KatyMorgan
Endogenous estimation of wait listdynamics
DanielaBond-Smith
Design and analysis of the Ebola_Txtrial evaluating convalescent plasma forEbola virus disease in Guinea
JozefienBuyze
Dynamics in efficacy outcomes ofcontrol group regimens in clinical trialsover time: An analysis of HER2+ breastcancer trials with Herceptin pluschemotherapy
EvelineNüesch
Safety analysis for personalised, flexibetreatment regimens
CorneliaDunger-Baldauf
ISCB37 Birmingham, UK: 21-25 August 2016: Draft Programme
ISCB News #61 Page 26 June 2016
Thu 25 Aug
09:30-15:00 MS1: Statistical methods inrare diseases and smallpopulations
Designs for Clinical Trials inRare Cancers
09.30-09.45 Overview on IRCI and statisticalissues in design of clinical trials inrare cancers
Cindy Billingham,Birmingham, UK
09.45-10.15 How do you design trials insmaller populations? A framework
Tim Morris, London,UK
10.15-10.45 Approximate analysis ofcovariance in trials in rarediseases, in particular rare cancers
Stephen Senn,Luxembourg
10:45-11:15 Refreshments11.15-11.45 The BALLAD study Jim Paul, Glasgow,
UK11.45-12.30 Panel Discussion12:20-13:30 Lunch
Statistical methods forextrapolation
13.30-14.00 Using historical data to informextrapolation decisions in children
Lisa Hampson,Lancaster, UK
14.00-14.30 An Extrapolation Framework toSpecify Requirements for DrugDevelopment in Children
Gerald Hlavin,Vienna, Austria
14.30-15.00 A unified approach forextrapolation and bridging adultinformation in early phasepaediatric dose-finding studies
Sarah Zohar, Paris,France
09:00-15:30 MS2: Strengthening analyticalthinking for observationalstudies (STRATOS)
09.00-09.25 Steps to derive guidance forvariable selection and functionselection
Willi Sauerbrei,Frieburg, Germany
09.25-09.50 Initial data analysis – a temporaryview
Saskia LeCessie,Leiden, Netherlands
09.50-10.15 Evaluating Diagnostic Tests andPrediction Models: a review ofexisting guidance
Gary Collins,Oxford, UK
10.15-10.40 On some practical issues in theanalysis of survival data
Maja Pohar-Perme,Ljubljana, Slovenia
10:40-11:00 Refreshments11.00-11.25 Study design: title tba tba
11.25-11.50 Measurement error in nutritionalepidemiology: challenges, currentpractice, and the scope forimprovement’
Ruth Keogh,London, UK
09.50-10.15 Key topics for guiding design andanalysis of high-dimensional data’
Harald Binder,Mainz, Germany
12.15-12.40 Causal questions and principledanswers: exposures, populations,and effect estimation’
Bianca De Stavola,London, UK
12.40-14.00 Lunch14.00-14.45 Discussions on the future of
STRATOS
Open session
14.45-15.30 Discussions on the future ofSTRATOS
Internal meeting forSTRATOS members
09:00-17:00 Students' Day09:00-09:15 Welcome: Nadine Binder09:15-09:45 Biostatistical Research Skills Robin Henderson
Session 1: Challenges in clinical trials09:45-10:00 Blinded and unblinded sample size re-
estimation procedures for stepped wedgecluster randomised controlled trials
Michael J Grayling
10:00-10:15 A comparison of unequal cluster sizes instepped-wedge cluster randomised trials
Caroline Kristunas
10:15-10:30 Statistical design and analysis ofproportionate intervention trials: asystematic review. Challenges inundertaking methodological systematicreviews
Jane Candlish
10:30-10:45 Discussion10:45-11:00 Refreshments
Session 2: Bayesian techniques11:00-11:15 Quantitative, qualitative or both? Gemma Clayton11:15-11:30 Adaptive Tolerance Range for Clinical
Biomarkers using Bayesian ApproachesDavood RoshanSangachin
11:30-11:45 Personalised medicine research in type 2diabetes: study findings may be dependent onhow response to a therapy is initially defined
John Dennis
11:45-12:00 Feeling stuck in research: lessons learnedfrom studying heterogeneity in measures ofclinical utility
Laure Wynants
12:00-12:15 Discussion12:15-13:15 Lunch13:15-13:45 Developing a Career in Biostatistics Katherine Lee
Session 3: Longitudinal and time-to-event data13:45-14:00 Estimating a cumulative incidence under
calendar time trendsStefan NygaardHansen
14:00-14:15 Jack-knife pseudo-observations and theiruse in regression analyses
Morten Overgaard
14:15-14:30 Association of childhood head growth withadult systolic blood pressure: findings fromthe New Delhi Birth Cohort
Shivam Pandey
14:30-14:45 The use of joint model for longitudinal andtime-to-event data: an application on kidneytransplantation
Marie-CécileFournier
14:45-15:00 Discussion15:00-15:15 Refreshments
Session 4: Programming and simulation methods15:15-15:30 Julia – a serious alternative to R for
biostatisticians?Daniela Zöller
15:30-15:45 Simulation study on the estimability ofdistribution parameters in the context ofobservations below the lower limit ofquantification (LLOQ)
Tanja Berger
15:45-16:00 Simulating high-dimensional molecular data Julia Krzykalla:16:00-16:15 Discussion16:15-16:45 The Future of Biostatistics Hans van Houwelingen
16:45-17:00 Discussion and Farewell
ISCB37 Birmingham, UK: 21-25 August 2016: Draft Programme
ISCB News #61 Page 27 June 2016
Poster Sessions: All poster presenters should be at their poster to answer questions during the refreshment break at the time indicated below.
# Poster Title Author Day, time
Causal inference and mediation analysis001Causal Path Framework for Factors Influencing Anemia in Pregnant Women in
IndiaMona Pathak Mon AM
002Mediation analysis combined with competing risk approach: Total and indirecteffects of smoking on the risk of total hip and knee replacement. Prospectivedata from the Nord-Trøndelag Health Study (The HUNT Study).
Milada CvancarovaSmåstuen
Mon PM
003Causal Modelling in non-inferiority and equivalence trials MartinaMcMenamin
Tue AM
Advances in statistical issues in epidemiology005Estimating case fatality risk and reproduction number for Ebola disease using
daily notification dataZheng Chen Wed PM
006Improving Prediction of Post-Neonatal Mortality Risk with Multilevel Model Bhaskar Thakur Mon PM
007Spatial Smoothing of Low Birth Weight Rate in Bangladesh using BayesianHierarchical Model
Mohammad SamsulAlam
Mon PM
008Title: Composite scores and health outcomes: Further investigation of theestimated associations
EvangeliaChristodoulou
Tue AM
009Prediction models for future clustered data without removing the randomintercept: A Bayesian approach
Haifang Ni Wed AM
010Determining the influence of missing data on estimates of ambient pollutionexposure-mortality risk.
Matthew Gittins Wed PM
011Monte-Carlo analysis of multilevel binary logit model to improve theprediction
Bhaskar Thakur Tue AM
012New approaches to estimate the Population Attributable Fraction in SurvivalAnalysis: a practical case in the EPIC Study
Catalina BonetBonet
Tue AM
Analysis of observational studies013rANCOVA - A Robust Method for Covariate Adjustment in Observational
StudiesThomas Forstner Tue AM
014Domain structures of the EORTC QLQ-HCC18 and QLQ-C30 for patients withhepatocellular carcinoma
Wei-Chu Chie Wed AM
015The effect of N-acetylcysteine on cardiac toxicity of Aluminum phosphidepoisoning
MortezaHajihosseini
Wed PM
016Prevalence of Non-Communicable Disease in General Population, East of Iran,2014- 2015: WHO 25˟25 Target
MortezaHajihosseini
Tue AM
017On the advancees about the use of parametric copulas in a observationalstudies framework
Charles Fontaine Mon PM
018Adverse effect of tobacco use on pregnancy outcome: a multi-center hospitalbased case control study in urban settings of Karachi, Pakistan
Shafquat Rozi Mon AM
019Predictors of smoking uptake in male adolescents attending public andprivate schools in Karachi, Pakistan: Multilevel modeling of survey data
Shafquat Rozi Wed AM
020Investigating the Impact of Missing Confounders in Propensity Score Analysesof Treatment Effects
Eleni Frangou Wed PM
021Complex measures of health inequalities for family planning methods amongwomen: Demographic and health survey data
Kashif Shafique Mon AM
022Evaluation of medication persistency using Korean National Health InsuranceService-Cohort Sample Database
Ye-Jee Kim Mon PM
023Restricted cubic splines for cyclic data Lara Lusa Tue AM
# Poster Title Author Day, time
024The impact of rare outcomes on statistical power and correctness of theinterpretation of results
Rianne van denBroeke
Wed AM
025Performance of the marginal structural Cox model for estimating individualeffects of treatments given in combination in observational study: asimulation study
Clovis LusivikaNzinga
Wed PM
026Truncated Logistic Regression Method in Matched Case-Control Studies Muzaffer Bilgin Mon PM
Diagnostic tests027A comparison of one-sided testing procedures in evaluating the performance
of the diagnostic testKanae Takahashi Mon AM
028A clinical prediction score for appendicitis ChumponWilasrusmee
Tue AM
029COMPARISON OF DIAGNOSTIC PERFORMANCE OF REPEATEDMEASUREMENTS AND BASELINE MEASUREMENT OF TROPONIN-I INPREDICTING DEATH IN AN EMERGENCY SETTING
Naime Meric Konar Tue AM
030Balancing Sample Distributions for Cut Point Determination of Biomarkers inSurvival Data
JungBok Lee Wed AM
031The determination of the optimal cutoff value for two continuous variable:ROC Analysis or Logistic Regression Analysis?
Serdal Kenan KÖSE Wed AM
Pharmacoepidemiology and drug safety032A novel method for detecting adverse drug interactions in spontaneous
reporting systemsMasahiko Gosho Tue AM
033Comparison of Probit, Logit and Spearman-Kärber Methods in QuantalResponse Assays via Simulation
Merve Sevinc Wed PM
034A meta-analysis of the safety of bevacizumab therapy in patients with solidtumors
Almut Mecke Mon AM
Big data in healthcare035A practical approach to using propensity score matching when analysing a
large non-randomised dataset: The long-term survival for patientsundergoing volatile versus IV anaesthesia for cancer surgery
Kabir Mohammed Mon PM
036The Effect of Low-dose Radiation Exposure on Cataract from nationwidecohort data in Korea (2002-2013)
Taemi Youk Wed AM
037Monitoring the impact of the Preterm Birth Prevention Program: evaluation ofclinical effectiveness using historical controls
Dorota Doherty Tue AM
038Penalized Canonical Corelation Analysis combining genomic, proteomic,laboratory and clinical phenotypic data
Wouter Ouwerkerk Mon AM
Longitudinal data analysis039Trajectories of Future Spherical Equivalent Refraction in School-aged Children
using the Longitudinal Data from the Guangzhou Twins Eye StudyJing Xie Wed PM
040Joint Modeling of Bottle Use, Daily Milk Intake from Bottles, and Daily EnergyIntake in Toddlers
Yungtai Lo Mon AM
041Use of z-scores to concurrently model fetal measurements alongsidechildhood lung function (FEV1) in relation to asthma outcomes
Shona Fielding Mon PM
042Measuring outcomes associated with prescription drugs using routinelyrecorded primary care data
Lauren A. Barnett Tue AM
043The Effect of Co-morbidity on The Modelling of Migraine Prognosis Didem DericiYildirim
Wed AM
ISCB37 Birmingham, UK: 21-25 August 2016: Draft Programme
ISCB News #61 Page 28 June 2016
# Poster Title Author Day, time
044Risk of mortality associated with changing electrolyte values in malnourishedAfrican HIV-infected adults given vitamins and minerals in lipid-nutritionalsupplements (LNS-VM): a randomised controlled trial
Andrea Rehman Wed PM
045Adaptive Tolerance Range for Clinical Biomarkers using Bayesian Approaches Davood RoshanSangachin
Mon AM
046Evolution Profiles in Body Mass Index for Spinocerebellar Ataxia Type 1, 2, 3and 6: influence of the size of the subgroup
Diallo Alhassane Mon PM
047A multi-state approach instead of "ventilator-free days" composite outcome inintensive care studies.
Denis Frasca Tue AM
048A joint model approach to discriminant analysis with two continuouslongitudinal biomarkers and discrete response
Malihe Nasiri Wed AM
049BAYESIAN ANALYSIS OF RECEIVER OPERATING CHARACTERISTIC CURVESFOR ORDINAL SCALED DATA UNDER STOCHASTIC ORDERING
Eun Jin Jang Wed PM
Missing data050Imputation of Missing Data for a Continuous Variable with anOrdinal form of
Risk Function: When to Apply the Transformation?Saiedeh Haji-Maghsoudi
Wed PM
051A Bayesian Nonignorable Nonresponse Model for Three-way Tables fromSmall Areas
Namkyo Woo Mon AM
052Parameter estimations for various distributed data with observations below alower limit of quantification
Tanja Berger Mon PM
053Dealing with missing data in an Individual Participant Data Meta-Analysis:one-stage versus two-stage methods
Thomas Debray Tue AM
054Methods to handle survival bias in the analysis of hospital length of stay Lynne Moore Mon PM
055Variable Selection with multiply imputated data when fitting a Coxproportional hazards model: a simulation study
Olga Kalinina Tue AM
056Tipping Point Analyses in Studies with Survival Outcome Yuliya Lokhnygina Wed AM
Survival data analysis057An application of landmarking in survival analysis: Mortality risk in a primary
care COPD populationDavid Culliford Tue AM
058Estimating sample size in the presence of competing risks - cause-specifichazard or cumulative incidence approach?
Bee-Choo Tai Wed AM
059Survival analysis adjusting for centre in a multicentre randomised trial - theeffect of a large centre with many events, and an alternative method ofadjustment using propensity scoring.
Catriona Keerie Wed PM
060How serious is bias in effect estimation in randomised trials with survival datagiven risk heterogeneity and informative censoring?
RoseanneMcNamee
Tue AM
061Survival benefit in liver transplantation by categories of severity scores usingthe Model For End-Stage Liver Disease (MELD) and the Donor Risk Index(DRI).
Audrey Winter Mon PM
062Robustness of Estimation Methods in a Survival Cure Model with MismeasuredCovariates
Aurélie Bertrand Tue AM
063SURVIVAL PATTERN, TREATMENT OUTCOMES AND PROGNOSTICDIFFERENTIALS AMONG DIRECTLY OBSERVED TREATMENT STRATEGYTUBERCULOSIS PATIENTS IN A TERTIARY FACILITY, SOUTH-WESTERNNIGERIA.
Oluwatosin AkinsolaWed AM
064Methods for imputation of time to graft-versus-host-disease followingtransplant of allogeneic haematopoietic stem cells from umbilical cord blood
Elinor Curnow Wed PM
065Visualizing survival data using Bayesian imputation Shirin Moghaddam Mon AM
066R²-type curve to evaluate dynamic predictions Marie-CécileFournier
Mon PM
# Poster Title Author Day, time
067Reduced sample size requirements for time to event studies Rory Wolfe Tue AM
068A high dimensional mixture model for time-to-event data Bussy Simon Wed AM
069Accelerated Failure Time Model with one covariate subject to random rightcensoring
Hervé MartinezAZOBOU ANANTIA
Wed PM
071Evaluating time dependent factors on peritoneal dialysis survival using timedependent coefficient models
MaryamSeyedTabib
Mon PM
072Comparison of survival curves; a simulation study Emre Demir Tue AM
073Comparison of approaches for extrapolating survival curves for clinical trialsdata using flexible parametric modelling
Lynsey Chudleigh Wed AM
074Exploring and understanding survival data using Cox proportional hazardsand Aalen's additive model
François Lefebvre Wed PM
075Quantifying the association between progression-free and overall survival incancer trials
Enya Weber Mon AM
076A modified version of average hazard ratio for overall survival when longpost-progression survival is expected.
Shogo Nomura Mon PM
077Modelling neurological outcomes in patients with successful cardiopulmonaryresuscitation following cardiac arrest in the presence of incomplete data
Zdenek Valenta Tue AM
078Flexible parametric survival models for registry data: How much freedom dowe have in selecting the degrees of freedom?
ElisavetSyriopoulou
Wed AM
079Reconstructing paired individual patient level data for Progression-free andOverall Survival from summary information
Rebecca Boucher Wed PM
080Cox proportional hazards regression with tree-structured modeling in patientswith nasopharyngeal cancer
Niyet Evdönderen Mon AM
081Generalizations of the c-index for survival data Natasa Kejzar Mon PM
082Practical aspects of multistate modeling with multipletime scales Bendix Carstensen Wed AM
083Additive hazard models with a shared frailty for semi-competing risks data Jinheum Kim Tue AM
084Dynamic predictions of metastasis free survival in bladder cancer NURIA PORTA Wed PM
085Comparison of Nonparametric Randomization Based Analysis of Covarianceand Cox Proportional Hazards Models: An application on patients with chronicobstructive pulmonary disease (COPD)
Serdal Kenan Kose Mon AM
086Penalized likelihood parameter estimation for semiparametric additive hazardsmodel with interval-censored data using method of multipliers
Kasun Rathnayake Mon PM
087An evaluation of statistical methods for predicting timelines for reachingtarget number of events in clinical trials with time-to-event endpoints
Emma Clark Tue AM
088Proportion of expected life lost as a metric of the overall impact of cancer Mark Rutherford Wed PM
089Comparison of different approaches to estimate alternative survival measuresin population-based cancer research
Dimitra-KleioKipourou
Mon PM
090Using pseudo residuals to study predictive ability of scoring systems afterTransarterial Chemoembolization of Hepatocellular Carcinoma
Irene Schmidtmann Tue AM
091The Assessment of Cardiovascular Risk Factors with Respect to Cut-off Pointsby Using Joint Models
Nezhat Shakeri Wed AM
092Comparison of Cox Proportional Hazards Model and Accelerated Failure TimeModels in the Survival of Acute Liver Failure Patients
Khanal ShankarPrasad
Wed PM
093Analyzing relative survival of groups that outlive the population - the Frencholympians study
Maja Pohar Perme Mon AM
094Identification of multiple influential observations in weibull regression Mohd asrul affendiAbdullah
Mon PM
Meta analysis a medical decision making
ISCB37 Birmingham, UK: 21-25 August 2016: Draft Programme
ISCB News #61 Page 29 June 2016
# Poster Title Author Day, time
095Network Meta-Analysis using Individual Participant Data: when do benefitsarise?
Thomas Debray Mon AM
096A network meta-analysis for comparison among vonoprazan and proton pumpinhibitors for gastroesophageal reflux disease treatment
Toshiro Tango Wed AM
097Network meta-analysis for the effect of lifestyle and metformin for delaying orpreventing type 2 diabetes by consistency and inconsistency models
Kazue Yamaoka Wed PM
098Network-meta analysis of preclinical studies - feasibility of a novel application Laura Gray Mon AM
099Effectiveness of Neoadjuvant Chemotherapy in Breast Cancer Patients: ASystematic Review and Multivariate Meta-analysis
Mona Pathak Wed PM
100Performance of screening questionnaires for obstructive sleep apnea duringpregnancy: A systematic review and meta-analysis.
Pawin Numthavaj Tue AM
101A method of multivariate t distribution for random effect multivariate meta-analysis
Wong-Shian Huang Wed AM
102Evaluation of published indirect comparisons and network meta-analyses Ralf Bender Mon PM
103The calibrated model-based concordance improved assessment ofdiscriminative ability in patient clusters of limited sample size
David van Klaveren Mon AM
104A Bayesian Hierarchical Meta-Regression Approach for Cross-Design Synthesis Pablo Emilio Verde Mon PM
105Efficacy of calcium and vitamin D supplementation on preeclampsia inpregnancy: A systematic review and network meta-analysis
SasivimolRattanasiri
Tue AM
106Role of Interleukin-10 (-1082G/A) gene polymorphism with the risk ofIschemic Stroke: A Meta-analysis
Arun Yadav Tue AM
107Statistical methods to model complex associations in individual participantdata meta-analysis
Nadine Marlin Wed PM
108The Prognostic Effect of Serum Magnesium Concentration in Patients withHeart Failure: A systematic review and meta-analysis
ThunyaratAnothaisintawee
Mon AM
109Updating and Combining Lung Cancer Prediction Models Eoin Gray Mon PM
110External Validation of Eight Lung Cancer Prediction Models Eoin Gray Tue AM
111Combining Evidences from Multiple Binary matched-Pairs Data using aBayesian approach
Toru Ogura Wed AM
112Investigating effect modification of the Incredible Years parentingintervention using individual participant data meta-analysis
Victoria Harris Wed PM
113Diagnostic accuracy of echocardiographic measurements as predictors of fluidresponsiveness in mechanically ventilated children: a systematic review andmeta-analysis
Atiporn Ingsathit Mon AM
114Estimating baseline survival from few studies: combining simple parametriccurves, elicitation, and model averaging
Sandro Gsteiger Mon PM
115Application of Bayesian Meta-Analysis in Combining Different Sources ofEvidence for Two Correlated Outcomes OSA and BMI
Shakir Hussain Tue AM
116Using network meta-analysis and decision-analytic modelling to evaluate theeffectiveness and cost-effectiveness of public health interventions to preventfalls in children under 5 years
Stephanie Hubbard Wed AM
117Evaluating the inclusion of Real World Evidence in Network Meta-Analyses toconnect disconnected networks - A Case Study in Rheumatoid Arthritis
David Jenkins Wed PM
118Multivariate network meta-analysis incorporating dose-response constraints:application to overactive bladder syndrome
Rhiannon Owen Mon AM
119Meta-analysis of time-to-event data with small treatment effects Dimitris Stogiannis Mon PM
120A comparison of methods for modeling between-study variance structure innetwork meta-analysis
Yusuke Yamaguchi Mon AM
Stratified or personalised medicine and biomarker discovery
# Poster Title Author Day, time
121Risk stratification of oral cancer patients using a combined prognostic factorincluding lymph node density and biomarker
Ki-Yeol Kim Tue AM
122Incorporating data from patients with missing biomarker status intobiomarker-based trial designs
Cornelia UrsulaKunz
Wed AM
123Bayesian Adaptive Patient Enrollment Restriction to Identify a SensitiveSubpopulation using a Continuous Biomarker in a Randomized Phase 2 Trial
Shoichi Ohwada Wed PM
124HLA haplotype (phase) reconstruction based on very large, arbitrary samples Ian James Mon AM
125Design of clinical trial for immunotherapy products: impact of biomarkerstratification and delayed effect for the TIME study.
Bérangère BASTIENMon PM
126Comparing multivariate and multiple univariate tests for sets of biomarkers Måns Thulin Tue AM
127An interactive tool to assess subgroup analyses (and the resulting bias) Nicolas Ballarini Wed AM
128The clinical course of osteoporosis in HIV-infected patients: Application ofmultistate models with interval censored data
Nuria Perez-Alvarez Mon AM
129Treatment Moderator Profile: an application to randomised controlled trialdata.
Jennifer Hellier Tue AM
130Use of multivariable analysis to identify predictive biomarkers linkinggenomics data with clinical outcomes in the Triple Negative Trial (TNT)
Holly Tovey Wed AM
131Experimental design and statistical analysis to assess biomarker quantification C Mercier Mon PM
132Penalized Regression for Truncated Data: Selecting Genetic Risk Factors forPsoriatic Arthritis
Ying Wu Wed PM
133Multi-allelic risk assessment in complex disease association studies Elizabeth McKinnon Mon AM
Cluster randomised and stepped wedge trials134Latent Transition Model for Evaluation of School-Based Prevention Program Depeng Jiang Tue AM
135DISSSECT Study: Dementia Improving Staff Stress and Satisfaction -Evaluation by Cluster Trial
Muhammad SaifulIslam
Wed AM
136The MILESTONE study: Improving Transition from Child to Adult MentalHealth Care
Jane Warwick Wed PM
137Measuring the efficiency of randomization methods Dominik Grathwohl Mon AM
138A graphical method for judging the quality of a randomization method Dominik Grathwohl Mon PM
139A comparison of planned and actual cluster sizes in stepped-wedge clusterrandomised trials
Laura Gray Wed PM
140Impact of non-participation on power in cluster randomised trials: anapplication to mass drug administration interventions for trachoma control
Tansy Edwards Tue AM
141Should Complex Intervention trials be powered for a single primary outcomeonly?
Ranjit Lall Wed AM
142Robustness of cost-effectiveness analyses of data from cluster randomizedtrials against violations of the normality assumption for cost data
Md. Abu Manju Mon AM
Adaptive trial design and analysis143A simulation-based topographical framework for comparing the impact of
interim phase stopping strategies under different scenariosMansour T ASharabiani
Wed AM
144Application of adaptive design methods - A literature review. Pankaj Mistry Wed PM
145Exploration on non-inferiority test methods with non-linear margin Arsène BrunelleSANDIE
Mon AM
146An Adaptive Design in a Phase 3 Vaccine Study with Limited Follow-up Bart Michiels Wed AM
147Challenges in clinical nutritional research: How adaptive design can help? Jérôme Tanguy Mon PM
Early phase clinical trials148Comparing sampling methods for pharmacokinetic studies using the derived
parametersHelen Barnett Tue AM
149Sample Size Determination for The Assessment of Average Bioequivalence Chieh Chiang Wed PM
ISCB37 Birmingham, UK: 21-25 August 2016: Draft Programme
ISCB News #61 Page 30 June 2016
# Poster Title Author Day, time
150Antibiotics Clinical Trials--Conduct and CDISC Implementation Challenges Denis Boisvert Mon AM
151Curtailed two-stage designs in randomized phase II clinical trials Yun Chan Chi Mon PM
152An assessment of the design, conduct and dissemination of Phase I clinicaltrials
Bethan Copsey Mon AM
153Dose individualization based on multiple gene mutations for molecularlytargeted agents
Akihiro Hirakawa Wed PM
154Model-based Dose Escalation Designs in R with crmPack Wai Yin WinnieYeung
Wed AM
155Alternatives to the 3+3 design in early phase trials on very rare diseases Maria Chiara Magri Mon AM
156Concentration-QT Analysis as a Promising Tool to Characterize the Risk of QTProlongation Early in the Clinical Development Program
Katie Patel Mon PM
Statistics in rare diseases and small populations157Determination of the prior distributions on Bayesian model parameters. Paméla EL Hajj Tue AM
158Effect of 10 different polymorphisms on preoperative volumetriccharacteristics of glioblastoma multiforme - results of a pilot study
Aenne Glass Wed AM
159Confidence intervals for standardized mortality and incidence ratios: dealingwith few counts
David Petroff Wed PM
160Influence of risk factors and the outcome of the TEOAE test on hearing lossin neonates registered in the Polish Universal Neonatal Hearing ScreeningProgram
Grazyna Greczka Mon AM
Other161All that glitters is not gold: A critical appraisal of the randomized controlled
blinded trial design (RCT)Jan ChristofSchuller
Tue AM
162Improved FWER-controlling methods for large-scale multiple testing underarbitrary dependence
Eunjung Song Wed AM
163A Comparison Study of the Methods for Combining Dependent P-Values Ozan Cinar Wed PM
164A review of outcome measures in IVF randomised controlled trials. Jack Wilkinson Mon AM
165Assessment of protocol deviations as part of central monitoring of clinicaltrials
Arne Ring Wed PM
166Minimisation with random component applied to unequal groups Sharon Tuck Mon PM
167Sample size requirements for clinical efficacy and cost-effectiveness in cancertrials using Bayesian and Frequentist approaches.
iftekhar khan Wed AM
168How to improve upon time to Statistics Report Julien Sauser Wed PM
169Universal SAS macro for generate Statisitcal Analysis Report in one click for I-IV phase Clinical Trials.
Andrey Myslivets Mon PM
170Clinical trials in organ donation and transplantation in the UK- benefits andchallenges
Laura Pankhurst Mon AM
171Maximin efficiencies for parallel, AA/BB and AB/BA designs under treatmentdependent costs and outcome variances
Math Candel Mon PM
172A paradox when comparing two correlated agreement coefficients Bernard G Francq Tue AM
173The usage of analytic hierarchy process in health studies Handan Ankaralı Wed AM
174Digital efficiency in Health Services Research: successful implementation of arapid and large scale randomised controlled trial
Victoria Cornelius Wed PM
175Cost Effectiveness Analysis of Renin-Angiotensin Aldosterone Systemblockade on Progression of ESRD in Thailand
OraluckPattanaprateep
Mon AM
176Cost-effectiveness analysis of statin used in preventing breast cancer: derivedby the potential outcome mean from a Thai cross-sectional study
UmapornUdomsubpayakul
Mon PM
# Poster Title Author Day, time
177Non-inferiority trials: inconsistent guidelines, inconsistent reporting? A reviewof selected journals
Sunita Rehal Wed AM
178Validation of a French version of the ADHD-rating scale IV in children withADHD and epilepsy.
Catherine Mercier Tue AM
179Assessing the Long Term Performance of the Hospital Anxiety and DepressionScale (HADS) for Stroke Patients: Item Response Theory (IRT) Analysis
Salma Ayis Wed PM
180Statistical design and analysis of proportionate intervention trials: asystematic review.
Jane Candlish Mon AM
181Improving quality of biomedical scientific research Marta Vilaró Mon PM
182Statistics in Regulatory Affairs in www.wikipedia.org: Initiative of the ISCBStatistics in Regulatory Affairs Subcommittee (SiRA SC)
Juan V. Torres Mon PM
183The advantages of using embedded trials to investigate participant retention:an example using social pressure to affect retention in a health cohort study.
Sarah Cotterill Mon PM
184The impact of the timing of diagnostic imaging on patient outcomes Daniela Bond-Smith Wed AM
185The Reliability and Validity of Instruments Measuring Pattern Identification inKorean Medicine: A Systematic Review
Mi Mi Ko Wed PM
186RIPOSTE: Steps towards improving the design and analysis of laboratory-based biomedical studies
Dawn Teare Tue AM
187Thyroid Nodules: a highly specific combined molecular and cytologicalpredictor of malignancy
Hélène Lasolle Mon PM
188An efficient multiple testing procedure for large-scale brain connectivityanalysis
Donghwan Lee Wed AM
189Use of Image Processing Analysis in Medicine and an Application Fezan Mutlu Wed PM
190Two-sample Equivalence Test of Means in High-dimensional Data Jen-pei Liu Wed PM
191On the analysis of patient-derived high-content cancer micro tissue cultureimages
Ilmari Ahonen Mon AM
192Predicting breast cancer results: a comparison of multilayer perceptron andlogistic regression methods
BatuhanBAKIRARAR
Mon PM
193Which estimation method does best at estimating α, β and σ in Type 1 Tobit Model?
Busra Emir Mon AM
194The Use of Fractional Polynomials inBinary Logistic Regression Models forClinical Trials
Serhat Hayme Tue AM
195LASSO type Penalized Spline Regression for Binary Data Muhammad Mullah Wed AM
196On the robustness of modeling using the negative binomial distribution Júlia Singer Wed PM
197A comparison to Dropping related variables Solution and Penalized Regressionto solve the problem of Multicollinearity
Maryam Shahdoust Mon AM
198Item Analysis and Detection of Differential Item Functioning with Four-Parameter Non-Linear Regression Model
Adéla Drabinová Mon PM
199Statistical Modelling of Skewed Data in Randomised Controlled Trials UsingTransformations and Two-Part Models
James Griffin Tue AM
200Multivariate analysis of paired data: a review of methods for paired organsystems
Virginia Chiocchia Wed AM
201A statistical test for the difference between two quantiles from independentpopulations
Martina Mittlboeck Mon AM
202Robust novel tolerance intervals versus agreement intervals in a Bland-Altman plot.
Bernard G Francq Mon PM
ISCB News #61 Page 31 June 2016
Book Review by Matthias Herpers (DE)
Peace, Karl E Design and Analysis of Clinical Trials with Time-to-Event Endpoints CRC 2009 9781420066395
This book aims to provide a thorough overview over the design, analysisand interpretation of clinical trials in which the time to an event is thecritical endpoint. Although this book is a compilation of contributions byvarious authors, it is less heterogeneous than one might expect. However,being a compilation, this is not the standard textbook that you want to getin order to learn time-to-event analysis. Chapters 1-6 give an introductionto the theory of time-to-event analysis, how to design clinical trial with suchendpoints and applicable parametric, semi-parametric and Bayesianmethods for analysis. These chapters are, however, more a refresher forreaders who are already familiar with time-to-event analysis than a detailedintroduction and explanation of the theory of time-to-event analysis. Thatbeing said, and assuming that you do have a general knowledge of thetheory behind time-to-event analysis, this book will be tremendouslyhelpful when you have to practically apply that knowledge to a specificdataset.
All the following chapters (7-22) deal with a specific situation one mightencounter when having to plan and analyse clinical trials with time-to-eventendpoints. The structure of each chapter is similar: First the methodsneeded are introduced then the analysis of such data is discussed followedby an example, a discussion and a list of references. Sometimes the analysisis demonstrated by an example so that there is no extra section for anexample but this homogeneous structure of each chapter makes the readerforget that each chapter was written by different authors. Although someare putting more weight on the theory part while others put more one thepractical example, it still does not feel like a compilation but like a bookbeing written by a single author. Karl Peace did a good job as editor of thisbook.
In chapter 7, Generalized Log-rank Methods (GLR) are introduced as analternative to the Cox proportional hazard (CPH) model for small trials.Theory and examples are given for a scenario with no tied events times andfor tied event times. The authors also give the link between the GLR and theCPH method, showing that the GLR test is asymptotically similar to the CPHestimator but more efficient in trials with up to 100 subjects per group.
Chapter 8 deals with a problem that is often neglected in clinical trials,namely that through application of a treatment the underlying hazardfunction may change, thus violating the assumption of the CPH model thatthe underlying hazard function remains constant over time. The authors ofthis chapter show how the change point can be detected and how it can betested for. If such a change in hazard occurs the solution would be apiecewise analysis. The example demonstrates this for a hazard functionwith one change point, leading to a 2-piece model being applied. Theauthors also show how this could be generalized to a k-piece model butthey also give the downside of this approach: The theory behind suchpiecewise models is more complex and the computational resourcesneeded are quite high. Although it is clear that violation of the proportionalhazard (PH) assumption could be a problem and that piecewise modelling isan intuitive solution (with a quite complex theory behind the immediatelyunderstandable approach), I am missing a discussion of when the problemsintroduced to the CPH model through violation of the PH assumption arereally that troublesome that application of the more complex piecewisemodel is justified.
Chapter 9 to me seems a little bit out of order as it deals with graphicalmethods for the analysis of time-to-event data. Graphical methods are avital part of analyzing time-to-event data and also in assessing the fit ofyour model. And for exactly that reason, I would have expected thatchapter earlier in the book, where the theory and methods are recapped.
Chapter 10 is a practical example of problem that can occur in a specificindication, in this case, pain. The endpoint analysed in pain studies is usuallya time-weighted summary score, representing the longitudinal effect of thetreatment. However this endpoint may be confounded through rescuetreatments. It is obviously unethical to deny patients such a rescuetreatment if their pain is not sufficiently relieved by the study treatment.The authors show how to deal with the consequences of this intervention.Usually a patient with rescue medication is not eligible for analysis, but onthe other hand analyzing only those patients without rescue medication isclearly biased. So the practical question is how to impute the data afterrescue medication is given, as the data up until that point are clearly validfor analysis. Different imputation methods, such as LOCF, BOCF and WOCFare discussed and the concept of analyzing the time-to-rescue as additionalindicator for efficacy is introduced. Two real-life examples are presentedand their analysis is discussed in detail. Overall a practical and good
example of problems one can encounter in real life and one way to dealwith them.
Staying with pain trials, chapter 11 uses such studies as an example of howto deal with paired endpoints. The authors discuss various methods,parametric and non-parametric, to analyse paired endpoints. Methods arepresented for sample size estimation as well as for analysis for completeand for censored endpoints. Although two examples at the end illustratethe application of the presented methods, this practical part is rather short,making this chapter one of those that have a more theoretical focus.
Chapter 12 is written by Karl Peace himself. Using antibiotic trials asexample, he shows that some methods which compare the status of apatient at the end of a given time (in this example the micro-biotical cureand the clinical cure) but neglecting the time to cure. Peace gives a practicalexample of a trial where the time to cure was taken into account. Overall arather short chapter but a good reminder that when designing a trial oneshould ask the question “does time matter” more often.
Leaving the strict interventional setting of a clinical trial, chapter 13 dealswith the challenges one has when designing a trial investigating prevention.Prevention studies typically have a healthier population, resulting in lowerevent rates and therefore higher sample sizes. Also the endpoint is notalways unambiguous and one might have to deal with multiple events perpatient. Although time-to-first-event analysis is well established andaccepted from a regulatory perspective, analysis of multiple events can be atopic in clinical trials as well and should be considered more often, at leastas a sensitivity analysis. Using a cardiovascular phase III study as example,the authors go through the issues coming through the preventive endpointand show how they dealt with them. Especially the point of multiple eventsper patients and ways to analyse multiple events is noteworthy and in myopinion would have deserved a chapter of its own, making this chapter evenmore valuable to the reader.
Chapter 14 discusses some issues related to the design and analysis of trialswith anti-viral therapies. In contrast to the previous chapters, this chapterdeals not with specific statistical problems and methodological solution butappears more like a guideline on what to consider when designing andanalyzing an anti-viral trial. The statistical methods used for time-to-eventanalysis are straightforward: CPH modelling and Kaplan-Meier-Estimates. Toall but an inexperienced statistician, this is a chapter one might easily skipwithout missing something.
In chapter 15, the reader is presented with a problem one is more likely tohave in the pharmaceutical sector: Successful treatment resulting in cure.While that is a very desired outcome of research, it is a problem instatistical analysis when dealing with time-to-event data. If a proportion ofpatients in a study is actually cured, their hazard function is zero and the PHassumption of the CPH model is violated. Cure rate models are the solutionto this problem and the authors present these type of models withexamples from a melanoma study and a prostate cancer trial. These typesof models will have to be considered more often as treatment of canceradvances and (proportions of) patients being actually cured happens moreoften.
Staying with cancer studies, chapter 16 introduces the problem of multiple(non-fatal) competing risks. This chapter covers a lot of problems, like usingprogression free survival as endpoint, having tumour shrinkage and/orcomplete remission as an additional indicator of efficacy, which one mayface in an oncology study in only 12 pages. How to deal with such problemsis shown at the example of a leukaemia trial but given the shortness of thechapter, this can only be an introduction of the problems and giving thereader the methodological key words how to deal with them. Consequently,the discussion gives a lot of books in which one may find more detailedinformation. Overall too short but at least one might find a starting point ofwhere to look further, if faced with such problems.
(ctd…)
ISCB News #61 Page 32 June 2016
Book Review by Matthias Herpers (DE) (continued)
Having just complained about chapter 16 being too short, a suggestion ofhow to get more space follows immediately afterwards. Leave out chapter17 and give the resulting free pages to chapter 16. Chapter 17 is adescription of the design and analysis of a cancer prevention trial. Apartfrom the fact that issues of prevention trials have been covered in aprevious chapter of this book, this chapter is structured and written morelike a primary publication of a study in a medical journal and not like a textaddressing a specific statistical problem to a statistical audience. Overall Iwould think this chapter is misplaced in this book.
Chapter 18 highlights the problem that even the best analysis method willfail, if the underlying model selected is wrong. Taking the reader again to asituation in which the PH assumption of the CPH model is violated, theauthors present the LASSO method known for variable selection in thelinear model as a robust alternative to the Cox models partial likelihoodmethod, especially for censored data. Although the authors show insimulations, as well as in application to data from a leukaemia and a braintumour study, that the LASSO method is better, they also point out that theLASSO method has issues of its own, namely the computationally effortneeded in application, making it suitable for small data sets only and thenon-parametric nature of the method, making it lose its benefit as soon asthe PH assumption approximately holds. As mentioned earlier (chapter 8), ifan alternative is presented that has issues of its own, I am missing aguideline on how much the PH assumption must be violated in order tojustify a switch to the LASSO method.
Chapter 19 deals with a problem that is not faced in the design or analysisof a study but in using its results. The authors present two algorithms ofhow treatment decisions can be made based on study data. Although usinga cancer study and, therefore, time-to-event data as example, we aredealing here with a problem of machine learning algorithms. Neitherirrelevant nor uninteresting, I do think that it is misplaced in this book.
Chapter 20 addresses a problem we may face more often in the future,namely that Adverse Event (AE) data should be analysed beyond crudeincidence rates. AE data are time-to-event data and should be analysed
appropriately, if one wants to use the full information available. It may bedue to the multiple issues that are involved in AE data, competing risks andmultiple events being just two of them. As these have been coveredbeforehand, this chapter focuses on using covariate information to detectAE signals that may not be detected in crude incidences only. Unfortunatelythe theory was only applied to a simulation study and not used in a practicalexample. However, it is clear that AE data are currently evaluatedinsufficiently and due to the time-to-event nature of AE data, methodspresented in this book may be needed in the future, as the analysis of safetydata may become more important.
Chapters 21 and 22 seem a little bit misplaced as well, as they deal withstatistical analysis of animal experiments in determining carcinogenicity.Chapter 21 deals with general issues in such trials: Was a sufficient numberof animals exposed over a long enough duration of time so that enoughanimals had a reasonable chance to develop cancer? Did the distribution ofgroups lead to homogeneity? Which methods are applicable if the numberof tumour occurrences are low? Are false-positive and false-negative errorscontrolled adequately? Are test results consistent with (reliable) historicalfindings? Statistical methods used to produce trustworthy results in suchstudies are presented. Chapter 22 presents Bayesian methods for such trialsbut as mentioned already, both chapters are not really in place in a bookthat focuses on clinical trials.
Overall, this book provides a good overview of problems one may facewhen having to deal with time-to-event data and how these could behandled. Furthermore it gives examples of where time-to-event data arecurrently not analysed with time-to-even methods, notably AE data.Although there are some points for critique and some chapters fall behindothers in terms of quality or appropriateness, and I feel that some topicswould deserve
more space, I would recommend this book to every practitioner who has todeal with time-to-event data. The reader can easily skip chapters that arenot relevant but those chapters that are relevant will justify purchasing thisbook.
Cartoon Corner
From Enrico Chavez
ISCB News #61 Page 33 June 2016
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ISCB Office & Executive Committee: Contact Details
Who SCs Address Tel: Email:
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+45 2682 7970 [email protected] Permanent Office:
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David W. WarneConf
Chemin du Petit-Bel-Air 115,CH-1226 Thônex, Switzerland
+41 22 700 63 80 [email protected]
Consultant Biostatistician, Geneva, Switzerland. Over the last 20 years, my main activities in medical statistics have involved designing clinical developmentprojects, and the design, conduct, analysis and reporting of clinical trials in infertility, leading to approval by various health authorities. I am especiallyinterested in non-inferiority and equivalence studies and in the practical aspects of clinical trials such as randomization and use of Bayesian methods. In2010, I moved into a new role focussing on processes, quality and outsourcing. In 2013, I started working as a consultant for various pharmaceutical, biotechand nutrition companies. Since 2015, Academic Fellow of the Research Center for Statistics, Geneva School of Economics and Management, Université deGenève.
I joined ISCB in 1992 as Newsletter Editor and have attended all the annual meetings from 1993 and taken part in most of the Executive Committee meetingsover the last 20 years. As well as editing over 40 issues of the ISCB News, I was chair of the Communications Subcommittee from 1999-2007 and run theSociety’s emailing lists. I have been a member of the Subcommittees on Conference Organising since 2004 and Membership from 2007-12. I was the chair ofthe Local Organising Committee and co-chair of the Scientific Programme Committee of ISCB27 in Geneva in 2006. In 2007, I was honoured to be made a LifeMember of ISCB. I look forward to continue helping with the organisational aspects of the Society and its annual meetings and, as an Officer of the ExCom, Iwould like to help ISCB maintain its reputation for providing highly successful annual meetings and courses.
Vice-President,
KyungMann KimEduc
Department of Biostatistics and MedicalInformatics, University of Wisconsin Schoolof Medicine and Public Health, 600Highland Ave, K6/438 CSC, Madison, WI57392-4675, USA
+1 608 265 6380 [email protected]
Professor of Biostatistics and Statistics, University of Wisconsin-Madison. His current area of research includes sequential analysis, cluster data analysis andclinical and translation research in cancer, cardiovascular disease, obesity and gerontology. He is very active in professional services to the US NationalInstitutes of Health (NIH) and as data monitoring committee member on many NIH- and industry-sponsored clinical trials in various diseases.
He has been a member of the Society since 1998. He served as an elected member of the ISCB Executive Committee during 2006-2010 and as a member andchair of the Student Conference Award Subcommittee during 2006-2010 and a member of the Membership Subcommittee during 2007-2010. Served as ISCBTreasurer from 2011-14.
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Vana SypsaEduc,Epid
Department of Hygiene, Epidemiology andMedical Statistics, Athens UniversityMedical School, M. Asias 75, 11527, Athens,Greece
+30 210 7462193 [email protected]
Assistant Professor of Epidemiology and Preventive Medicine, Dept. of Hygiene, Epidemiology and Medical Statistics, Athens University Medical School. Ireceived a BSc in Mathematics from the University of Athens, an MSc in Biometry form the University of Reading, UK, and obtained my PhD at the Universityof Athens. During the 18 years I have been working as a Biostatistician in the University of Athens, I have been involved in the design and analysis of severalprojects, including clinical trials and epidemiological studies. My current area of research is modelling of infectious diseases and, in general, infectiousdiseases epidemiology.
I served as an elected member of ISCB Executive Committee during 2005-2008, as chair of the Epidemiology Subcommittee during 2009-2012 and asmember of the Subcommittee for Student Conference Awards during 2005-2011.
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Zdenek ValentaConf,NatG
Dept. of Medical Informatics & Biostatistics,Institute of Computer Science AS CR, PodVodarenskou vezi 2, CZ-182 07 Prague,Czech Republic
+420 266 052 094 [email protected]
Works as Senior Research Scientist at the Department of Medical Informatics & Biostatistics of the Institute of Computer Science, Czech Academy of Sciencesin Prague. His professional interests include analysing data from clinical and epidemiological studies and teaching medical statistics from pre-graduate topostgraduate level. He also serves as a member of Faculty of 1000 in the field of Research and Methodology.
He currently serves as a member of the ExCom of the ISCB and was appointed as Officer for years 2015-2016 (Treasurer). He also serves as a chair of theISCB’s sub-committee for National Groups and is a chair of the Czech National Group of the ISCB.
ISCB News #61 Page 35 June 2016
ISCB Office and Executive Committee: Contact Details (continued)
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Chris MetcalfeStCA,NatG
School of Social and Community Medicine,University of Bristol, Canynge Hall, 39Whatley Road, Bristol, BS8 2PS, UK
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Chris Weir SiRA
Edinburgh Health Services Research Unit,Centre for Population Health Sciences,University of Edinburgh Medical School,Teviot Place, Edinburgh, EH8 9AG, UK
+44 131 650 3230 [email protected]
Hein PutterNatG,StCA
Department of Medical Statistics andBioinformatics, Leiden University MedicalCenter, Postzone S-5-P, PO Box 9600, 2300RC, Leiden, Netherlands
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Jeremy TaylorEduc,StCA
Department of Biostatistics, University ofMichigan, 1415 Washington Heights, AnnArbor, MI, 48109, USA
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Katherine LeeConf,StCa
Murdoch Children’s Research Institute,Royal Children’s Hospital, Flemington Road,Melbourne, VIC 3185, Australia
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Institute of Mathematics and Statistics,Faculty of Science, Masaryk University,Kotlářská 267/2, 611 37 Brno, Czech Republic
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ISCB News #61 Page 36 June 2016
ISCB Subcommittees: Contact Details
Please contact the chairs/secretaries of these subcommittees for further information.
Title & Email Terms of Reference Members Email addresses
Chair:
1. David W. Warne (CH) [email protected]
Secretary:
2. Geir Egil Eide (NO) [email protected]
Members:
3. Jacobo de Una Alvarez (ES) [email protected]
4. Jörg Assmus (NO) [email protected]
5. Katherine Lee (AU) [email protected]
6. Koos Zwinderman (NL) [email protected]
7. Lucinda Billingham (UK) [email protected]
8. Maarten Schipper (NL) [email protected]
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Conference Organising
1. Bring together ISCB conferenceorganisers or ISCB members who have aninterest in sharing and passing on theirknowledge and experience to help futureISCB conference organisers.2. Document processes and systems forassisting ISCB conference organisers.3. Review and update the documentswhenever necessary and promote theirusage for improving the procedures orconferences.
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11. Shona Fielding (UK) [email protected]
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To support and organise one or two daycourses on contemporary methods inclinical biostatistics in locationsrepresented by the Society. Guidelines anda list of courses offered in the past areavailable.
12. Wenle Zhao (US) [email protected]
Chair:
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Secretary:
2. Christina Bamia (GR) [email protected]
Members:
3. Adriano Decarli (IT) [email protected]
4. Agus Salim (AU) [email protected]
5. Catherine Quantin (FR) [email protected]
6. Ewout Steyerberg (NL) [email protected]
7. Harbajan Chadha-Boreham (FR) [email protected]
8. Nathalie Stoer (SE) [email protected]
9. Tim Ramsay (CA) [email protected]
10. Vana Sypsa (GR) [email protected]
Epidemiology
1. Advise the Scientific ProgrammeCommittee of the annual ISCB meetings, ifneeded, on relevant topics in epidemiologyfor establishing invited sessions andchoosing invited speakers.
2. Establish connections withEpidemiological Societies and organisemutual sessions, courses or workshops atour conferences or elsewhere.
3. Generate awareness and discussions inthe Society of guidelines for conducting,analysing and reporting epidemiologicalstudies.
11. Willi Sauerbrei (DE) [email protected]
ISCB News #61 Page 37 June 2016
How to Contact the ISCB Subcommittees (continued)
Title & Email Terms of Reference Members Email addresses
Chair:
1. Zdenek Valenta (CZ) [email protected]
Secretary:
2. Anca Vitcu (RO) [email protected]
Members:
3. Arnošt Komárek (CZ) [email protected]
4. Chris Metcalfe (UK) [email protected]
5. David W. Warne (CH) [email protected]
6. Gordana Jovic (UK) [email protected]
7. Hein Putter (NL) [email protected]
8. Kinga Salapa (PL) [email protected]
9. Laszlo Tothfalusi (HU) [email protected]
10. Stanislav Katina (CZ) [email protected]
11. Tomasz Burzykowski (BE) [email protected]
National Groups
1. To help those who are interested informing a National Group through theapproval process.2. To review the arrangements with thecurrent National Groups, specificallyregarding financial matters.3. To set rules and standards for funding ofISCB members of National Groups andothers from countries with exchangecontrol restrictions or barriers.4. The Subcommittee administers theConference Awards for Scientists for theannual ISCB meetings.
12. Zsolt Lang (HU) [email protected]
Chair:
1. Harbajan Chadha-Boreham (FR) [email protected]
Secretary:
2. Nicole Close (US) [email protected]
Members:
3. Chris Weir (UK) [email protected]
4. Christoph Gerlinger (DE) [email protected]
5. Christos Nakas (GR) [email protected]
6. Jonathan Siegel (US) [email protected]
7. Jørgen Seldrup (FR) [email protected]
8. Juan Vicente Torres-Martin (ES) [email protected]
9. Martin Schumacher (DE) [email protected]
10. Ralf Bender (DE) [email protected]
11. Stanislav Katina (CZ) [email protected]
Statistics in RegulatoryAffairs
The subcommittee on Regulatory Affairswill review, comment upon and seek toinfluence the development of regulatoryrequirements, guidelines and otherdocuments concerning the scientificaspects of data generation, collection,management, analysis, and reporting. Ingeneral, the subcommittee will seek outand handle all regulatory issues in thename of the Society with the approval ofthe President or in his/her absence, theVice-President.
12. Tim Friede (DE) [email protected]
Chair:
1. Nadine Binder (DE) [email protected]
Secretary:
2. Katherine Lee (AU) [email protected]
Members:
3. Carl-Fredrik Burman (SE) [email protected]
4. Chris Metcalfe (UK) [email protected]
5. Dimitris Rizopoulos (NL) [email protected]
6. Hein Putter (NL) [email protected]
7. Jeremy Taylor (US) [email protected]
8. Richard Cook (CA) [email protected]
9. Thomas Jaki (UK) [email protected]
Student ConferenceAwards
Student conference awards are availablefor registered postgraduate students toattend the annual conference and presenta paper. The Subcommittee shall receivesubmissions, judge them, and administerthe awards. The rules and procedures areannounced in a timely issue of theNewsletter and on the ISCB annualconference webpage.
10. Ulrich Mansmann (DE) [email protected]
ISCB News #61 Page 38 June 2016
ISCB Membership Information
The International Society for Clinical Biostatistics(ISCB) was founded in 1978 to stimulate research intothe principles and methodology used in the designand analysis of clinical research and to increase therelevance of statistical theory to the real world ofclinical medicine.
The ISCB organises an annual scientific meeting whichmembers and non-members are able to attend. Themain objective of the annual scientific meetings is tocreate an opportunity for the exchange ofknowledge, experience and ideas among clinicians,statisticians and members of other disciplines, suchas epidemiologists, clinical chemists and clinicalpharmacologists, working or interested in, the field ofclinical biostatistics.
The scientific meetings cover a broad spectrum ofbiostatistical interests and regularly include sessionson the design and analysis of clinical trials,epidemiology and statistical methodology, as well asfrom time to time considering more specialist issuessuch as, for example, education of biometricians andbiometrics users, pharmacokinetics, medicaldatabases and pharmaco-epidemiology.
Meetings in recent years have been held in Geneva(2006), Alexandroupolis (2007), Copenhagen (2008),Prague (2009), Montpellier (2010), Ottawa (2011),Bergen (2012), Munich (2013), Vienna (2014) andUtrecht (2015). The next meetings will be held inBirmingham (2016), Vigo (2017), Melbourne (2018)and Leuven (2019).
The Annual General Meeting of the ISCB is organisedto coincide with the scientific meeting. Membershipof the Society is drawn from around 50 countriesworldwide and the number of members is about1140.
The ISCB also organises courses to cover particularstatistical topics and are given by the foremostresearchers in the field. These are run to precede orfollow on from the annual scientific meeting, or arerun as separate events.
The composition of the Executive Committee(ExCom) for 2016 is as follows:Officers
President,News Editor, Webmaster
David W. Warne (CH)
Vice-President KyungMann Kim (US)Secretary Vana Sypsa (GR)Treasurer Zdenek Valenta (CZ)
MembersChris Metcalfe (UK)Chris Weir (UK)Hein Putter (NL)Jeremy Taylor (US)Katherine Lee (AU)Stanislav Katina (CZ)Thomas Jaki (UK)Toshiro Tango (JP)
The ISCB also has special Subcommittees dealing withparticular aspects of biostatistics.
The Society publishes a Newsletter twice ayear. The ISCB News editor is David W. Warne. Itemsfor inclusion in the Newsletter should be sent to himvia email to: [email protected]
Membership of the Society is open to all with aninterest in biostatistics. The current annual (to31 December 2016) Ordinary membership fee is €40.The Full-time Student and Retired Membership fee is€10. There are reduced fees for members (€20) andstudents (€5) from Developing Countries, as definedby the World Bank list. All who subscribe after Maywill have to pay an extra fee of €20.
Applications for membership should be sent by email to:
ISCB Permanent Office
Bregnerodvej 132,
DK-3460 Birkerod,
Denmark
Tel: +45 2682 7970
email: [email protected]
www: www.iscb.info
ISCB News #61 Page 39 June 2016
ISCB Membership Subscription
INTERNATIONAL SOCIETY FOR CLINICAL BIOSTATISTICS
2016 Membership SubscriptionSurname: First name:
Title (Prof/Dr/etc): Post held:
Institute/Company:
Address:
Post code and country:
Phone No.: E-mail:
Fax No.:
Member No.:
Please provide your email address in order to log on to the Members’Area of ISCB’s website; it may be used to send you the electronic ISCBNews in the future, and is needed for voting.
RegistrationJan.-May
Late registrationJun.-Dec.
ISCB membership to 31 December 2016:
SUBSCRIPTION: EUR 40 EUR 60 Regular members
(please tick one only) EUR 10 EUR 30 Student Member (applicable to undergraduate or postgraduate -Mastersor PhD- students) (students should provide a letter from their supervisoror head of department)
EUR 10 EUR 30 Retired members
EUR 20 EUR 40 DC members Developing Country
EUR 5 EUR 25 DC student members Developing Country
Have you previously been a member of ISCB? Yes No
New members: Please send this Membership Subscription form to [email protected] details will be uploaded to the Members’ Area of ISCB’s website,
and you will be notified when you can follow the procedure below.Current members: Please log on to the Members’ Area with your e-mail address.
PAYMENT IS MADE BY: On-line
Go to http://www.iscb.info/Members-Area.html
Apply for your password by clicking on “forgotten password”
Type your email address and click on “Send password” You receive your password by email
Log on to the Members’ Area using your e-mail address and your password.
Click Renew membership on the left-hand bar –accept conditions – accept order – select payment method – Maestro / Master Card / Visa / Visa Electron / JCB - and completepayment. You will receive an email from us confirming that you have renewed your membership once your payment is completed.
Your address details and membership category are already entered into the system. In the Members’ Area you can edit your ProfileSettings, except your e-mail address. Please contact [email protected] if you wish to change your e-mail address.
Please note that ISCB’s online payment facility is a secured system; your credit card information cannot be accessed or used for any otherpurpose.
PS: Danish VISA/Dankort cards are not supported.If you wish to pay your membership fee by bank transfer we ask you kindly to contact the Permanent Office for ISCB’s bank accountdetails ([email protected]).
Please return this form either by e-mail to: [email protected]
or by post to: ISCB Permanent OfficeBregnerodvej 132DK-3460 BirkerodDenmark
Tel: +45 2682 7970
ISCB News #61 Page 40 June 2016
ISCB Calendar
ISCB is affiliated to ISI. For the latest conference information, see:
http://www.isi-web.org/index.php/activities/calendar
7-10Aug
ODRS 2016 You are warmly invited to Ordered Data and their Applicationsin Reliability and Survival Analysis: An International Conference in Honourof N. Balakrishnan for his 60th Birthday held at McMaster University inHamilton, Ontario, Canada. In addition there will be a student workshopgiven by Udo Kamps (RWTH Aachen, Germany) and Barry Arnold(University of California at Riverside, USA). Location: Hamilton, Ontario,Canada Email: [email protected] Website:http://odrs.math.mcmaster.ca
8-12Aug
26th Colombian Symposium on Statistics This event is organized by theNational University of Colombia gathering local and international expertsin the main research areas of Statistics. Location: Hotel Malibú Sincelejo,Sucre - Colombia Website: http://simposioestadistica.unal.edu.co/ E-mail:[email protected]
9-11Aug
The 3rd International Statistical Conference 2016 (ISM-III) TheInternational Statistical Conference has been organised since 2012, whichwas intended to build and encourage the cooperation amongst itsmembers. This conference has been an icon to ISM as biennial eventjointly organised with local universities in Malaysia. Location: Universityof Malaya, Kuala Lumpur, Malaysia Phone: +603-79674323 Fax: +603-79674143 E-mail: [email protected] Website:http://www.ism3.um.edu.my/
24-28Aug
13th Iranian Statistical Conference The conference will be organized byIranian Statistical Society, Scheduled every two years, the conference is amajor Iranian event for statistics and probability, covering all theirbranches, including theoretical, methodological, applied andcomputational statistics and probability, and stochastic processes.Location: Shahid Bahonar University of Kerman Contact: Mohsen MadadiE-mail: [email protected] Website: http://isc13.uk.ac.ir/
5-7Sep
MBC2 3rd International Workshop on Model-Based Clustering andClassification The workshop aims at providing a focus on the state-of-the-art research in the field of model-based clustering and classification aswell as a forum of scientific discussions and comparisons among youngand senior researchers. Topics concern methodological, applied andcomputational issues in model-based clustering and classification. Theworkshop will take place in Catania (Italy) on Sep 5-7, 2016 with thesupport of the Italian Statistical Society and the Classification and DataAnalysis Group (CLADAG). Confirmed Main Lecturers: Marco Alfò (Roma,Italy), Christophe Biernacki (Lille, France), Christian Hennig (London, UK),David Hunter (PennState, USA), Richard Samworth (Cambridge, UK).Location: Collegio d’Aragona, Catania, Italy Contact: [email protected]: http://mbc2.unict.it/
5–8Sep
RSS 2016 International Conference Now in its 24th year, the conferencehas gained prestige for its focus on current statistical issues, how it fostersthe exchange of ideas and information and the quality of its speakers.Plenary speakers in 2016 will include Christl Donnelly (Imperial CollegeLondon), Anne Glover (former Chief Scientific Adviser, EuropeanCommission) and Xiao-Li Meng (Harvard University). This annualconference regularly attracts over 450 participants from all over theworld, ranging from senior academic statisticians through to newgraduates and postgraduate students, with strong representation fromthe public sector as well as statisticians and data scientists working inindustry or as independent consultants. There is also a growing group ofpeople who have an interest in statistics but who don’t work in the field.Location: University of Manchester, UK; Manchester is the 2016 EuropeanCity of Science. Website: www.rss.org.uk/conference2016 Contact:[email protected]
14–16Sep
Austrian Statistics Days 2016 Österreichische Statistiktage 2016 The mainthemes are: - Forecasting, - Market research, - Migration- and integrationstatistics, - Trends regarding the assessment of quality of life, -Visualisation. The list of keynote speaker contains (by now): Prof. HeinzFassmann (University of Vienna) und Dr. Holger Kolb (Expert Council ofGerman Foundations on Integration and Migration) on the topic ofmigration, Prof. Natalia and Gennady Andrienko (Fraunhofer Institute forIntelligent Analysis and Information Systems) on the topic ofVisualisations of time series, Prof. David Harvey (University ofNottingham) on the topic of forecasting in the area of financial bubbles,and Prof. Filomena Maggino (University of Florence) on the structure ofindicators about quality of life. Location: MODUL University Vienna,Austria E-Mail: [email protected] Website: www.osg.or.at
20–22Oct
2016 Women in Statistics and Data Science Conference The AmericanStatistical Association invites you to join the 2016 Women in Statistics andData Science Conference - the only one for the field tailored specificallyfor women! WSDS will gather academic, industry, and governmentprofessionals and students working in statistics, biostatistics, and datascience. Location: Charlotte, North Carolina, USA E-mail:[email protected] Website: www.amstat.org/meetings/wsds/2016
15-17Dec
Conference on Experimental Designs and Analysis (CEDA) 2016Experimentation is one of the most common activities in scientificresearches and industrial processes. An experiment is cost-efficient onlywhen it is carefully designed and its results are correctly analyzed. TheCEDA 2016 will highlight the most recent advances in the design andanalysis of experiments and demonstrate their applicability topractitioners in scientific and industrial communities. In addition, itprovides an excellent platform to share research ideas among seniormentors, junior researchers and Ph.D. students/graduates. This is thesecond CEDA and the first CEDA was held in Taiwan in 2014. Location:Taipei, Taiwan Website: http://www3.stat.sinica.edu.tw/ceda2016Contact Name: Frederick Kin Hing Phoa E-mail:[email protected]
19-22Dec
10th ICSA International Conference The ICSA International Conference isheld every three years in one of the cities in Asia. The theme of thisconference is Global Growth of Modern Statistics in the 21st Century.James O. Berger of Duke University, Tony Cai of University ofPennsylvania, Kai-Tai Fang of Beijing Normal University – Hong KongBaptist University United International College (UIC), Zhi-Ming Ma of theAcademy of Math and Systems Science, CAS, Marc A. Suchard of the UCLAFielding School of Public Health and David Geffen School of Medicine atUCLA, Lee-Jen Wei of Harvard University, and C. F. Jeff Wu of GeorgiaInstitute of Technology will deliver keynote presentations. Location:Shanghai Jiao Tong University, Shanghai, China Website:http://www.math.sjtu.edu.cn/conference/2016icsa/content.aspx?info_lb=22&flag=1 E-mail: [email protected]
2017:2–7Jul
IWSM 2017 With Short Course by Prof. Tom Snijders on Social NetworkModelling. This is the 32nd International Workshop on StatisticalModelling. The IWSM is one of the major activities of the StatisticalModelling Society, founded with the purpose of promoting andencouraging statistical modelling in its widest sense, involving bothacademic and professional statisticians and data analysts. The spirit of theworkshop has always been to focus on problems motivated by real lifedata and on solutions that make novel contributions to the subject, toencourage interaction as there are no parallel sessions, and to welcomeboth junior and senior statisticians. Location: Groningen, the NetherlandsWebsite: http://iwsm2017.webhosting.rug.nl/ Contact: MarcoGrzegorczyk, [email protected]
2017:9-13Jul
38 Annual Conference of the International Society for ClinicalBiostatistics The International Society for Clinical Biostatistics (ISCB) wasfounded in 1978 to stimulate research into the principles andmethodology used in the design and analysis of clinical research and toincrease the relevance of statistical theory to the real world of clinicalmedicine (moreinfowww.iscb.info). Like previous annual conferences ofISCB the 2017 conference will provide a scientific forum for internationalexchange of theory, methods and applications of biostatistics in medicalresearch and practice among clinicians, statisticians and members ofother disciplines, such as epidemiologists, clinical chemists and clinicalpharmacologists, working or interested in the field of clinicalbiostatistics. Location: Vigo, Spain Website:http://jacobo.webs.uvigo.es/Flyer_ISCB38.pdf E-mail:http://jacobo.webs.uvigo.es
2017:16-21 Jul
International Statistical Institute, 61st
ISI World Statistics CongressIncludes meetings of the Bernoulli Society, the International Associationfor Statistical Computing, the International Association of SurveyStatisticians, the International Association for Official Statistics, theInternational Association for Statistics Education, the International Societyfor Business and Industrial Statistics, and The International EnvironmetricsSociety. Location: Marrakesh, Morocco Information: ISI PermanentOffice, P.O. Box 24070, 2490 AB The Hague, The Netherlands. E-mail: Contact Phone: +31–70–3375737 Fax: +31–70–3860025Website: www.isi2017.org/
2018:Aug 26-30
ISCB39. Melbourne, Australia
2019:Jul 14-18
ISCB40. Leuven, Belgium
2020+: ISCB41, 42, 43… ?ISCB is looking for enthusiastic local organisers of conferences from 2020onwards. If you would like to know more about what this involves,please contact any of the ISCB Officers, ExCom or SCs who can let youmore about what has to be done, when.Initial proposals for 2020 should be sent to the Officers by 01 Aug 2016at the latest.