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INTOXIKATIONDETOXIFIKATION
Raymond Theodorus Berend PahlplatzMD, clinical metal toxicologistTreasurer of [email protected]@[email protected]
INTRACELLULAREXTRACELLULAR
IBCMTPersonal
Clinic
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OUTLINE
Importance of INTRACELLULAR vs EXTRACELLULAR
H.H. Reckeweg – six phases table of disease
Traditional tests measure extracellularly
Release of spectrophotometer in 2013
Three observations of validity
Treating the intracellular environment
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A study by the Environmental Protection Agency (EPA) in 1976 showed that
INTOXICATION & DETOXIFICATION
five tested chemicals were present in 100% of all test takers.
It included:
1. Dioxine
2. Styrene
3. Xylene
4. Ethylphenol
5. Dichloorbenzene
Tens to hundreds of chemicals are
found in the fatty tissue of humans.
The question is not, whether we suffer
from toxins, but to what extent.
History & Facts
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Carcinomata caused by the environment [-Chromium-(VI)- Arsenic – Nickel – Cadmium]
Male mortality from cancer NOT related to smoking, increased by 200% since
1940.
Female mortality from cancer NOT related to smoking, increased by 200%
since 1940.
Hormone-sensitive tumors are those of the breast, uterus, cervix, ovaries,
prostate, testes, and colon.
Immune system disorders:
Autoimmunity – toxic metals
Mercury is correlated with thyroid problems, MS
In principle, all metals or non-metals may induce autoimmunity.
History & Facts
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The Cell Membrane
Transport protein
Globularprotein
Glycoprotein CarbohydrateHydrophilic
endings
DoubleLayer
Phospolipids
SinglePhospolipid
HydrophobicTail
EXTRACELLULAR
CYTOPLASMA
Alpha helix protein
Surfaceprotein
Integral protein
Peripheral protein
Cholesterol
Glycolipid
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EXTRACELLULAR INTRACELLULAR
HUMORAL MATRIX CELLULAR
EXCRETION INFLAMMATION
membranes
DEPOSIT
ECM
IMPREGNATION
Cytoplasma
DEGENERATION
Organelles
NEOPLASMA
Nucleus
General M
Skin E
Muscle M
Lungs B
Gastro-intest. R
Cardiovasc. A
Neurological A
THERAPY N
Fever
Rash Eczema
Antibiotic
Aminocetaphen
Silent
Silent
TonsillitisAntibiotic
Diarrhea
Asthma
Arrhythmia
Crohn’s disease Colon cancer
Alzheimer’s disease
Corticosteroids
More drugs
SAUNA
SPORTSNAC, SULPHUR DETOX LIPOSOMALS STEM CELLS.
RESVERATROL
BERBERINE
Oligoscan
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EXTRACELLULAR INTRACELLULAR
HUMORAL MATRIX CELLULAR
EXCRETION INFLAMMATION
membranes
DEPOSIT
ECM
IMPREGNATION
Cytoplasma
DEGENERATION
Organelles
NEOPLASMA
Nucleus
General Hg Hg Hg Hg
Hg Hg Hg Hg
M Hg
Skin Hg Hg Hg Hg
Hg Hg Hg Hg
Hg Hg Hg Hg Hg
Hg Hg Hg Hg
Hg Hg Hg
Hg Hg
E Hg Hg Hg
Muscle M
Lungs B Hg Hg
Gastro-intest. Hg Hg Hg Hg Hg
Hg Hg Hg Hg
Hg Hg Hg
Hg Hg
R Hg Hg
Cardiovasc. A
Neurological A
THERAPY N
RECKEWEG
PROVOCATION TESTFULL MINERAL BLOOD
ANALYSISHAIR MINERAL
ANALYSIS
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Spectrophotometer
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First observation in 2013 Female 54HypertensionObesity
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First observation in 2013
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First observation in 2013
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First observation in 2013
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First observation in 2013
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First observation in 2013
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The following research was performed in the clinic of
Peter J. van der Schaar MD PhD CMT, in Leende, the Netherlands
For each patient a provocation test (PT) was performed with
DTPA and DMPS
According to IBCMT’s protocol
For each patient a spectrophotometric analysis (SA) was performed.
Wat follows is the differences and correlations between both tests.
Conclusion: particularly in patients with high oxidative stress there is
a strong negative correlation between the SA and the PT.
The first research
Hg
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Provocation test / Zell-Screening
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-40
-20
0
20
40
60
80
100
120
140
160
0 500 1000 1500 2000 2500 3000
Hg
pro
voca
tio
n t
est
Hg spectrophotometry
Correlation Hg -0,6238 pearson correlation
This is especially the case in people with HIGH oxidative Stress in the SA!
Provocation Test / Spectrophotometric Analysis
X 100,000
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A high Mercury content in the OS correlates with high oxidative stress.
In people with high oxidative stress and a high mercury load in the SA,
chelation or provocation with even the most potent DMPS
will not excrete any Mercury in urine.
In people with normal oxidative stress it is not possible to predict whether there is a high elimination of toxic metals in the provocation test.
This is expected because Mercury has a strong affinity for mitochondria. They are very rich in Sulfur.
Sulfur has a very high binding coefficiency for Mercury (Hg).
The concentration of Hg increases 5600-fold from the extracellular to the intra-mitochondrialenvironment.
No other metal shows any significant correlation.
In these cases IBCMT recommends to always perform a provocation test.
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Pro-oxidation Antioxidation HM in Spectrophotometer HM in Provocation test Excretion capability
Green Green Low to high Normal / high Good
Provocation test / Spectrophotometric Analysis
Pro-oxidation Antioxidation HM in Spectrophotometer HM in Provocation test Excretion capability
Red Red Very high Normal Poor
Excretion Capability
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The second observation
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What do we advise here?
NO Calcio !!!
Vitamin D3 (or sun light)
Vitamin K2
Isoflavones (Soy)
Silicium !!!
Single Nucleotide
Polymorphisms
Vitamin D Receptor
9 out of 9
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Spectrophotometry
Hair mineral analysis
INTRACELLULAREXTRACELLULAR
SNP D3
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With this knowledge:
Would you still prescribe calcium?
If you do, then the risk for osteoarthritis, cardiovascular
disease, and certain tumor types will increase!
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Element Hair analysis Spectrophotometry
Calcium Very high Very low
Magnesium Normal Normal
Phosphorus Low Low
Silicon Not measured Low
Sodium Normal Normal
Potassium High Normal
Copper Normal Normal
Zinc Low Low
Iron High Normal
Manganese Low Low
Element Hair analysis Spectrophotometry
Chromium Low Low
Vanadium Not measured Normal
Boron Very low Normal
Cobalt Very low Normal
Molybdenum Very low Normal
Iodine Not measured Low
Lithium Very low Normal
Germanium Not measured Normal
Selenium Very low Normal
Sulphur Not measured Normal
Differences between HMA and SA:
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Element Hair analysis Spectrophotometry
Calcium Very high Very low
Magnesium Normal Normal
Phosphorus Low Low
Silicon Not measured Low
Sodium Normal Normal
Potassium High Normal
Copper Normal Normal
Zinc Low Low
Iron High Normal
Manganese Low Low
Element Hair analysis Spectrophotometry
Chromium Low Low
Vanadium Not measured Normal
Boron Very low Normal
Cobalt Very low Normal
Molybdenum Very low Normal
Iodine Not measured Low
Lithium Very low Normal
Germanium Not measured Normal
Selenium Very low Normal
Sulphur Not measured Normal
Differences between HMA and SA:
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Element Hair analysis Spectrophotometry
Calcium Very high Very low
Magnesium Normal Normal
Phosphorus Low Low
Silicon Not measured Low
Sodium Normal Normal
Potassium High Normal
Copper Normal Normal
Zinc Low Low
Iron High Normal
Manganese Low Low
Element Hair analysis Spectrophotometry
Chromium Low Low
Vanadium Not measured Normal
Boron Very low Normal
Cobalt Very low Normal
Molybdenum Very low Normal
Iodine Not measured Low
Lithium Very low Normal
Germanium Not measured Normal
Selenium Very low Normal
Sulphur Not measured Normal
Differences between HMA and SA:
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Element Hair analysis Spectrophotometry
Calcium Very high Very low
Magnesium Normal Normal
Phosphorus Low Low
Silicon Not measured Low
Sodium Normal Normal
Potassium High Normal
Copper Normal Normal
Zinc Low Low
Iron High Normal
Manganese Low Low
Element Hair analysis Spectrophotometry
Chromium Low Low
Vanadium Not measured Normal
Boron Very low Normal
Cobalt Very low Normal
Molybdenum Very low Normal
Iodine Not measured Low
Lithium Very low Normal
Germanium Not measured Normal
Selenium Very low Normal
Sulphur Not measured Normal
Differences between HMA and SA:
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Element Hair analysis Spectrophotometry
Calcium Very high Very low
Magnesium Normal Normal
Phosphorus Low Low
Silicon Not measured Low
Sodium Normal Normal
Potassium High Normal
Copper Normal Normal
Zinc Low Low
Iron High Normal
Manganese Low Low
Element Hair analysis Spectrophotometry
Chromium Low Low
Vanadium Not measured Normal
Boron Very low Normal
Cobalt Very low Normal
Molybdenum Very low Normal
Iodine Not measured Low
Lithium Very low Normal
Germanium Not measured Normal
Selenium Very low Normal
Sulphur Not measured Normal
Differences between HMA and SA:
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Iron
Serum ↓
Ferritin ↑↑
Hb ↓
Do you prescribe Fe?
Magnesium
Serum Normal
Full blood ↓
Spectro-A ↓-↓↓
Do you prescribe Mg?
Zinc
Serum nl - ↓
Full blood ↓-↓↓
Spectro-A ↑-↑↑
Do you prescribe Zn?
NO !YES, of course
NO !
Also in regard to full mineral blood analysis, there are
many discrepancies with the spectrophotometric analysis.
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Liver problems (NAFLD)
2dd500 mg Berberin
2 pumps/day of Liposomal GSH
1dd200 μg Selenomethionine
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The third observation
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1dd10 mg Methylcobalamine
2 pumps/day of Liposomal GSH
1dd200 μg Selenomethionine
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Metabolic syndrome without NAFLD
Ketogenic diet
Liposomal Resveratrol /
Curcumin
Liposomal Glutathione
Zinc lozenges
Vitamin B complex with
active ingredients
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Spectrophotometer
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An innovative technology
Measurement of minerals, trace elements and toxic metals
Quickly and non-invasively
QUANTITATIV (PPM) in the SKIN
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Description
• Inventor: brasilian MD PhD; development Luxemburg
• Medical CE Certificate : Classe IIa
• ISO 13485
• EU/USA/Canada/Asia/Australia
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• The energetic absorption of minerals is between 180 und 1000Nanometers.
• A titre d'exemple, voici les différentes longueurs d'onde de certains minéraux: Ca: 422,7 nm; K: 766,5 nm; Na:589,0 nm; Cu: 324,7...
• Algorithmic calculations are performed for skin thickness, whereafter the spectrophotometric results are expressed as:
Microgramm per Gramm
PPM
• According to the Law of Beer / Lambert the light absorbance of amaterial sample is directly related to the concentration of theattenuating material and the thickness of the material sample.
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Four steps:
Hold the SA device on four points of the palm of the hand Spectrophotometric Analysis
Algorithmic calculations Results
1 2
3 4
The fifth step is actually the most difficult one
INTERPRETATION: truehealthmedicalschool.org
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Tests for toxic metals
Blood: only applicable in acute intoxication
Full blood analysis: an intracellular test for blood only
Hair analysis: shows what has been present in blood for a long time
Spectrophotometry: LIVE measurement in the skin
THE KEY DIFFERENCE IS
THE CELLULAR MEMBRANE
Provocation test: very usefull to test excretion capability, but extracellular
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EXTRACELLULAR INTRACELLULAR
HUMORAL MATRIX CELLULAR
EXCRETION INFLAMMATION
membranes
DEPOSIT
ECM
IMPREGNATION
Cytoplasma
DEGENERATION
Organelles
NEOPLASMA
Nucleus
General Hg Hg Hg Hg
Hg Hg Hg Hg
M Hg
Skin Hg Hg Hg Hg
Hg Hg Hg Hg
Hg Hg Hg Hg Hg
Hg Hg Hg Hg
Hg Hg Hg
Hg Hg
E Hg Hg Hg
Muscle M
Lungs B Hg Hg
Gastro-intest. Hg Hg Hg Hg Hg
Hg Hg Hg Hg
Hg Hg Hg
Hg Hg
R Hg Hg
Cardiovasc. A
Neurological A
THERAPY N
RECKEWEG
LOW OXIDATIVE STRESS
PROVOCATION TESTFULL MINERAL BLOOD
ANALYSISHAIR
SPECTROPHOTOMETRY
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EXTRACELLULAR INTRACELLULAR
HUMORAL MATRIX CELLULAR
EXCRETION INFLAMMATION
membranes
DEPOSIT
ECM
IMPREGNATION
Cytoplasma
DEGENERATION
Organelles
NEOPLASMA
Nucleus
General M Hg Hg Hg Hg Hg
Hg Hg Hg
Skin Hg Hg E Hg Hg Hg Hg Hg
Hg Hg Hg
Hg Hg Hg Hg Hg
Hg Hg Hg Hg
Hg Hg Hg Hg Hg
Muscle M
Lungs Hg Hg B
Gastro-intest. Hg Hg R Hg Hg Hg Hg Hg
Hg Hg Hg Hg
Hg Hg Hg Hg Hg
Cardiovasc. A
Neurological A
THERAPY N
Zell-Screening
HIGH OXIDATIVE STRESS
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How to reach the intracellular environment?
1. Liposomes
2. IV therapies with electrical stimulation
3. Phycocyanine
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What are liposomals?
A Liposome is a spherical vesicle with at least one lipid bilayer.
Nutrient
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What is the major advantage of liposomals?
Liposomals are ideal to deliver nutrients
which are poorly absorbed
into the cells.
Liposomals are also ideal to deliver nutrients
which would be rapidly metabolized
after oral ingestion by the liver.
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Which nutraceuticals benefit from Liposomals?
ALLFor instance Curcumin
In most studies 6 grams are used.
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“Liposomes are considered as effective
drug carriers because of their ability to
solubilize hydrophobic compounds and
to alter their pharmacokinetic properties.
In rat oral administration of liposomal
curcumine showed high bioavailability of
curcumin. In addition, a faster rate and
better absorption of curcumin were
observed as compared to the other
forms.”Takahashi M, Uechi S, Takara K, Asikin Y, Wada K.
Evaluation of an oral carrier system in rats: bioavailability
and antioxidant properties of liposome-encapsulated
curcumin.
J Agric Food Chem. 2009;57:9141–9146.
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Which liposomals to take?
Liposomals with an optimal size
for the molecules
they are carrying.
Liposomals are also ideal to deliver nutrients
which would be rapidly metabolized
after oral ingestion by the liver.
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Which liposomals can we provide?
Liposomal Resveratrol/Curcumine
Liposomal C
Liposomal Glutathione
Liposomal DHA
Liposomal Q10
Liposomal D3-K2
Liposomal Quercetine
Liposomal Magnesium
Liposomal Selenium
Liposomal B complex activated!
Liposomal Lutein, Astaxanthine, Zeax.
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PHYCOCYANIN
Bone marrow stimulant; red, white and platelets
Inhibition on CML (chronic myeloid leukaemia cells)
Stimulation of NK-cells (natural killer cells)
Decrease of type 1 allergies: IgE
Free radical quenching
70x stronger than SOD
Anticarcinogenesis
Antiviral
Natural chelating agent for metals and chemicals
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Laminaria japonica
Liposomal Glutathione
Male, 42 chronic sinusitis
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Patient with high oxidative stress from a very
polluted area in Belgium.
Treatment plan
Provocation test with DTPA / DMPS
Combination of Laminaria japonica
Phycocyanine
Liposomal glutathione
Monthly injections with DMPS
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THANK YOU FOR YOUR ATTENTION