I N T R O D U C T I O N
While the demand for minimally invasive
procedure treatments increases, the fillers
market is facing the publication of concer-
ning reports of immediate or late reactions
to Hyaluronic Acid (HA) fillers or other che-
mically based filling substances. The pa-
tients and the scientific community itself are
trending to natural and biocompatible der-
mal fillers as a safe and effective solution to
avoid adverse outcomes.
In response to the physician and patient
need, Advanced Aesthetic Technologies, Inc.
(AAT), a Boston, MA USA based company,
employing bio-technologies in the aesthetic
medical field, has launched Algeness®, the
100% natural and biodegradable injectable
implant, the culmination of 10 years of scien-
tific and clinical research.
W H A T I S A L G E N E S S ® ?
Algeness® is a biomaterial resulting from a sophi
sticated manufacturing process consisting of a
purified agarose gel (polysaccharide), derived
from the purification of AgarAgar processed
from red algae. Totally biocompatible to the
human body and absorbable, Algeness®, does not
contain crosslinked synthetic chemicals (BBDE
or PEG) associated with Hyaluronic acid (HA)
fillers and thus is 100% natural. The molecular
and biophysical properties of Algeness® make it
a breakthrough in the filler’s injection technology.
For the first time in aesthetic medicine history, a
100% natural, biodegradable and mouldable filler is
available to the aesthetic market for a more defined
youthful look.
Algeness agarose gel structure
Agarose is an hydrocolloid molecule water is contained in its structure
A G A R O S E M O L E C U L E
OH
OH HOn
H OO
OO
O
OH
OH
W H A T I S T H E S C I E N C E B E H I N D
A L G E N E S S ® A L L N A T U R A L B I O D E G R A D A B L E I M P L A N T ?
Algeness® is the culmination of 10 years of
scientific and clinical research to find the most
natural, biocompatible material to fill wrinkles
and compensate for volume loss in facial soft
tissues. Extensive research has been conducted
to master the correlation of the agarose struc-
ture and the physiological response; in fact,
utilizing different concentrations of agarose, it
was possible to obtain various three dimensio-
nal structures that interacted differently with
the vital and functional parameters of the cell.
Algeness® agarose is derived from the purifica-
tion of Agar-Agar, which in turn is derived from
red algae of the genus of gelidium.
Agarose which is h ighly purified is free of any
protein, a source for most bacteria, making it
highly biocompatible. Formulations of agarose
form stable gels with small amounts of material
(1% of agarose and 99% saline water making the
product able to be shaped for a more defined
natural look.
Chemically, agarose is a polysaccharide of a long
chain of disaccharide units formed by two rings
of 6 atoms. On each ring there is one oxygen and
5 Carbon atoms and only one OH group.
The agarose, being chemically inert does not
bind ions and does not precipitate when injec-
ted subcutaneously. Being free from toxicity to
micro-organisms and free from impurities, Alge-
ness® is well tolerated within the human body.
This production process is only achieved by a
limited number of highly specialized facilities.
They have the rights to international patents to
produce highly purified, high quality agarose
under rigid physical-chemical, and bacteriolo-
gical controls, as well as quality standards of
ISO 13485 and ISO 9001
W H A T A R E T H E B E N E F I T S O F A L G E N E S S ®
A L L N A T U R A L V O L U M I Z I N G B I O D E G R A D A B L E I M P L A N T ?
n Hydrocolloid gel 100% biocompatible
and biodegradable
n Immediate volumizing: “What you see
is what you get” The physician and the
patient can see and evaluate the result
of the injection immediately after the
procedure.
n No need to wait to see the hydrophi-
lic reaction associated with all HA fillers
that can take 2-4 weeks for the full
effect to be realized.
n Free of solvents and chemicals; all
natural.
n Long lasting results remaining over
12 months proven by clinical studies.
n Non allergenic; Algeness® offers ex-
cellent tolerability and biocompatibility
with a negligible immunological reaction.
n Minimal irritation & inflammation
due to the absence of foreign body
reactions
n Extremely low migration, the product
stays where it has been injected with
excellent persistence.
A L G E N E S S ® : A C O M P L E T E R A N G E O F 1 0 0 %
N A T U R A L F I L L E R S F O R F A C E R E J U V E N A T I O N
A G A R O S E M O L E C U L E
OH
OH HOn
H OO
OO
O
OH
OH
•
•
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•
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•
•
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ALGENESS® LD 1%
Indications
Tear trough
Lips
Depth of injection:
subdermal
ALGENESS® HD 1.5%
Indications
Marionette lines,
wrinkles and furrows
Lip augmentation
and contouring
Oral commissure
Oro-mandibular folds
Depth of injection:
subdermal
ALGENESS® VL 2.5%
Indications
Medium-deep volumizing
Wrinkles, furrows and folds
Cheeks, jawline and chin
Nasolabial folds
Non-surgical rhinoplasty
Depth of injection:
Subdermal
Subcutaneous
ALGENESS® DF 3.5%
Indications
Deep volumetric filling
Cheeks, jawline and chin
Malar-zygomatic arch
Submalar
Depth of injection:
Subcutaneous
Supraperiosteal
Agarose (High density)
Deep sub-dermal Agarose (High density)
hypo-dermis and supra peri-osteal
S U P E R F I C I A LH Y P O D E R M I S
M U S C L E
D E R M I S
D E E P H Y P O D E R M I S
B O N E
3,5%
2,5% Agarose (Low density)Sub-dermal
1,5%A L G E N E S S
F I L L E R S
D E P T H
O F I N J E C T I O N
1% Agarose (Low density)Sub-dermal
A L G E N E S S ® S C I E N T I F I C R E S E A R C H
Currently there are 3 studies that were published
and there are a number of unpublished studies
executed on the new Algeness® 3.5% DF.
Wake Forest University in the United
States performed animal studies which
were completed in 2013 and 2014 with the
2.5% Algeness VL and the 3.5% Algeness
DF compared to Restylane, Juvederm and
Radiesse. The Wake Forest comparative
study showed that after 6 months 2.5%
and 3.5% performed better compared to
the other fillers, showing Algeness® lasted
longer, did not show unpredictable changes
due to inflammatory reactions or water
absorption, and exhibited less migration.
Four clinical studies were conducted in
Italy and Denmark in 2006/2007 where
Algeness® performed well with minimal
side effects and no serious problems were
reported. The effects of Algeness® lasted a
minimum of 6 months but was not compared
directly to Restylane or other filler materials.
These studies demonstrated the safety and
efficacy of Algeness® fillers. Algeness® HD
was extensively studied in the lips and was
found to be very effective with no reports of
adverse reactions.
Dr. Giovanni Montealegre, Professor of
Plastic Surgery at the National University of
Colombia, in Bogota, completed a 50 subject
study to evaluate the safety and efficacy of
Algeness® for the correction of nasolabial
folds in comparison to Juvederm. Both
Juvederm and Algeness® have similar and
comparable effects on safety and duration.
Algeness® offers excellent tolerability and
biocompatibility, is safe, natural and has a
negligible immunological reaction. Over the
first six months of observations, the results
are comparable with Juvederm.
In 2016 a 30 subject study of the volumizing
effects of Algeness® and Voluma will
commence in Belgium with Dr. Joan
Vandeputte, in Italy, Dr. Giovanni Salti, and in
Germany with Dr. Tatjana Pavicic.
Also started in 2016, is a prospective,
randomized, within-subject controlled study
of the effectiveness and safety of Algeness®
VL 2,5% Natural Agarose Subdermal Filler
Injectable Gel versus Restylane Perlane™
Injectable Gel, for the correction of moderate
and severe nasolabial folds. The principal
investigator is Nicolo Scuderi, MD, Professor
at University of Rome.
Q&AQ. What is the difference with
other fillers?
A. Unlike all other fillers,
Ageness® is 100% natural and
biodegradable. Algeness®
achieves its volumizing youth-
ful effects without the require-
ment of any added chemicals,
solvents or cross-linked agents
and is completely and safely
absorbed over time by the bo-
dy’s natural mechanisms.
Q. What areas could be proble-
matic using Algeness®?
A. Never inject Algeness® su-
perficially. It is strongly recom-
mended not to use Algeness®
fillers in the periorbital area.
Q. Into which layers of the
skin is it possible to inject
Algeness®?
A. The higher concentration
Algeness® biodegradable
implant should be injected
deeply and never superficially.
We therefore suggest that the
VL and DF only be used in the
subdermal, subcutaneous or
supraperiosteal spaces.
Q. Is there a difference in the
injecting technique between
Algeness® and HA?
A. There is a slight difference
in the injectability of HA versus
Algeness® due to the difference
in density of the material and
the depth of the injection.
Algeness® is injected deeply
and slowly. A thorough mas-
sage is performed to mold the
product, avoid formation of
lumps and obtain the desired
immediate result.
Q. Is it possible to inject
Algeness® in an area where
Radiesse (or a similar filler) was
injected previously?
A. We see no reason why
Algeness® cannot be used in
an area where other injectables
have been injected. Howe-
ver, this needs to be studied
further.
Q. Is it painful?
A. All injections cause a sense
of pain; however, the physician
may decide to apply anesthetic
cream to the injection site to
numb the area.
Q. What kind of result can the
patient expect?
A. Algeness® subcutaneous fil-
ler is able to achieve a youthful
and natural look by filling-out
lines around the mouth, the na-
so-labial fold as well as crow’s
feet and forehead wrinkles. It
can also re-plump your lips and
add volume and lift to your
cheeks.
Q. How long will it last?
A. Algeness® corrective effects
typically last for about 12 mon-
ths or longer depending on the
injection amount and depth of
injection.
Q. What are the side effects?
A. Depending on the area
injected, the procedure is
relatively painless, although
there may be some mild dis-
comfort during treatments to
the sensitive nose or lip areas.
There may be some redness
around the site of injection for
1-2 days. Thanks to its unique
all natural bio-compatibility,
post-treatment allergic reac-
tions are minimized.
Q. What is the recovery time?
A. Treatment times may vary
from 20-25 minutes, depen-
ding on the correction level
requested by the patient. The
recovery time can be from
a few hours to several days
depending on the area treated.
Usually, patients receiving
Algeness® treatments return to
normal activities straight after
injection.
A G A R O S E M O L E C U L E
OH
OH HOn
H OO
OO
O
OH
OH
IMMEDIATE VOLUMIZING:
[ WHAT YOU SEE
IS WHAT YOU GET ]
THE PHYSICIAN
AND THE PATIENT
CAN SEE AND EVALUATE
THE RESULT
OF THE INJECTION
IMMEDIATELY
AFTER THE PROCEDURE.
HYDROCOLLOID GEL
BIOCOMPATIBLE
AND BIODEGRADABLE.
100%
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A d v a n c e d A e s t h e t i c Te c h n o l o g i e s , I n c
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