Download - Introduction to Endobiogeny
![Page 1: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/1.jpg)
INTRODUCTION TO ENDOBIOGENY:AN INTEGRATIVE APPROACH TO MEDICINE
By: Jean Claude Lapraz, MDKamyar M. Hedayat, MD
![Page 2: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/2.jpg)
OBJECTIVES
• Introduce Endobiogeny and its component elements:• Detailed history• Detailed physical exam• Classical labs and imaging studies• Biology of Functions• Integrative assessment, then…• Therapeutic strategy
• Example: application of the concepts of Endobiogeny to the clinical condition of Polycystic Ovarian Syndrome (PCOS)
• Discuss opportunities to learn the Endobiogenic method
![Page 3: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/3.jpg)
![Page 4: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/4.jpg)
VIGNETTE
• 23 year old female presents with 4 year history of oligomenorrhea, hirsutism, acne, failure to conceive, 30 pounds weight gain.
• Laboratory studies reveal low-normal TSH, normal T3, T4, estradiol, dihydro-testosterone, androstenedione, but elevated fasting blood glucose.
• Ultrasound of uterus, ovaries unremarkable• History suggests Polycystic Ovarian Disease,
but endocrine, radiological studies are normal. Does this woman have an endocrine disorder or not?
![Page 5: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/5.jpg)
INTRODUCTION
An introduction to the Endobiogenic conceptA brief review of the history of medicine and its schools of thought
![Page 6: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/6.jpg)
ENDOBIOGENY
• The integrative study of the functional mechanisms of regulation of the organism in its basic structure during homeostasis as well as its functional response to internal and external stressors: • As a whole system• In its individual units of function
• core metabolism• cell, tissue and organ• in and of themselves and in relationship to each other
• Endobiogeny evaluates the qualitative and quantitative state of the human organism and its internal milieu.
![Page 7: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/7.jpg)
EXAMPLE: QUANTITATIVE ASSESSMENT
• Consider a car factory to be like the ovaries. Does the number of cars (amount of estrogen) produced tell you how efficiently the factory (ovaries) is functioning or how well the cars produced drive?
• A quantitative assessment of productivity tells you how many cars are being produced (serum estrogen levels), but not how well those cars drive (endocrine and metabolic activity of estrogen).
• For example, if the output of cars meets demand, but the gear shifter is faulty (altered estrogen-receptor binding), each car carries fewer people than its normal capacity due to decreased torque. In this case, more cars will be needed to carry people.
• “Normal” factory output for this company (body) is insufficient to meet demand
![Page 8: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/8.jpg)
EXAMPLE: QUALITATIVE ASSESSMENT
• But what about a qualitative assessment? There may be supply issues—not enough steel available. The factory cannot produce cars without steel (cholesterol as a precursor to estrogen production)
• Perhaps there are not enough workers on the assembly line (Follicle stimulating hormone) and the workers present are over-worked and will soon decline in productivity (pituitary stress).
• Perhaps there are ample supplies and workers, but the manager is inefficient (hypothalamus) in managing the factory, not regulating supply and demand issues.
![Page 9: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/9.jpg)
EXAMPLE: QUALITATIVE ASSESSMENT• Perhaps the manager is efficient, but the
workers do not always follow his directives (altered thresholds of responsiveness).
• Thus, it is clear that both a quantitative and qualitative assessment of physiological and endocrine activity is necessary to properly understand disease and health.
![Page 10: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/10.jpg)
ENDOCRINE MANAGEMENT
• Thus, Endobiogeny views the endocrine system as the manager of the body, the controller of anabolism and catabolism—which is what life itself is at every level from the cell to the structure of the universe: • destruction and reconstruction• expansion and contraction• growth and apoptosis• birth and death
![Page 11: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/11.jpg)
LEVELS OF MANAGEMENT IN THE BODY
Internal terrain
External Terrain
Neuro-Endocrine
Cell receptors
Enzymes, co-factors, vitamins
Endobiogeny
Standard Medicine
Functional Medicine
Environmental Medicine
Mental-EmotionalMind-Body
Toxins, Microbes, Metals
Neuro-transmitters
![Page 12: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/12.jpg)
PHILOSOPHY
• Endobiogeny integrates the rational and empirical schools of medicine with philosophy to create a single coherent system of medicine:
• PHILOSOPHY: The Endobiogenic approach begins with the ontology (reason for existence) of structures and physiology
• This leads to a logical approach to understanding structural weaknesses in the organism as well as determining the true cause of disease
![Page 13: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/13.jpg)
RATIONALISM
• The rational school of medicine has been the predominant Western school of medicine: • Relies on deductive reasoning, anatomy and
physiology as the basis of its approach to illness.• Nosology: Patients are categorized by disease,
and diseases are categorized by symptoms• Medications are chosen based on biochemical or
empirical effects on symptoms or physiological signs such as blood pressure or laboratory measurements
• Biomedicine (Allopathy) is the best-known form of rational medicine
• Modern herbalism has rationalist tendencies
![Page 14: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/14.jpg)
RATIONALISM (CONT.)• Endobiogeny is based upon:
• Modern physiology and contemporary understanding of neuro-endocrinology
• Consideration of role of genetic polymorphisms, environmental toxins, stress, cytokines, cells, organs, and their products of metabolism in the origins of health and illness.
• Consideration that the organism contains in itself a fundamental auto-pathogenicity (potential for a specific disorder) which implies a particular risk of disease.
• Endobiogeny considers the mechanistic, reductionistic concepts of life insufficient to explain the complexity of the human organism
• Endobiogeny treats the person, not the disease, thus rejecting standardized treatment protocols
![Page 15: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/15.jpg)
EMPIRICISM
• Refers to a system of medicine where the practitioner’s impression of illness and assessment of the individual’s expression of dysfunction is the basis of treatment.
• Empirical medicine considers the energetics of the individual as well as the energetics of the treatment
• Chinese medicine and Homeopathy are forms of empirical medicine.
![Page 16: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/16.jpg)
EMPIRICISM (CONT.)
• Endobiogeny shares an emphasis on detailed history and careful physical exam to understand the unique physical and emotional antecedents of disease and its physiognomic expressions in the individual
• However, Endobiogeny seeks to find coherence in this information through physiological explanations
• In sum, Endobiogeny is an integration that takes into account various levels of the individual: physical, emotional and mental, in their relationship with the endocrine management of the body and everything under its control with its regulatory mechanisms
![Page 17: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/17.jpg)
INTEGRATION OF DATA
• Endobiogeny integrates:• History• Physical Exam• Laboratory data and imaging
• To reach a conclusion regarding the current, dynamic physiological state of the individual in order to formulate a treatment strategy which addresses: • the identified imbalances individually • as well as in their relationship to other
imbalances
![Page 18: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/18.jpg)
TREATMENT OPTIONS
• Endobiogenic treatments consist of various therapeutic elements based on their safety and efficacy with no prejudice to the origin of the treatment:• Phytotherapeutic elements• Homeopathic elements• Pharmaceuticals elements: reasoned usage based
on severity of symptoms, of degree or lack of compensatory physiology.
• Physical manipulations: craniosacral, myofascial, etc.
• Diet and Nutrition• Trace elements• Stress modification, hydrotherapy, acupuncture, etc.
![Page 19: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/19.jpg)
INDIVIDUALIZED MEDICINE
• Endobiogeny is individualized medicine based on: • The patient’s symptomization of illness within the
context of the global functioning of the organism• The physician’s determination of the signs of
physiological and endocrine dysfunction • The physician’s objective assessment of
endocrine relationships • The particular physical, physiological,
psychological and emotional realities of the individual.
![Page 20: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/20.jpg)
CONCLUSION
• Endobiogenic treatment is determined by the totality of the person: • Static and dynamic aspects of the patient’s
constitution • Etiology, ontology, and integration of symptoms • Adaptive and maladaptive aspects of physiology
![Page 21: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/21.jpg)
THE ENDOBIOGENIC METHOD
![Page 22: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/22.jpg)
PATIENT HISTORY
• HISTORY: A detailed history of antecedent events, including perinatal history, childhood personality, illnesses, vaccinations and important emotional events is solicited to establish the constitutional and functional endocrine state of the patient.
• Dietary preferences, sleep habits, dreams, menstrual history, various aspects of behavior and review of systems are explored to establish neuro-endocrine patterns
• The trajectory of structural hormonal imbalances is followed throughout life, not just with respect to the outward manifestation of illness and dysfunction
![Page 23: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/23.jpg)
PHYSICAL EXAM
• A detailed physical exam from head to toe evaluates the phenotypic expression of neuro-endocrine relationships
• Because the endocrine system manages both the structural integrity of the body as well as its functional expression, one is able to look for the phenotypic expressions of endocrine activity and correlate it with the internal state of the patient
• Many of these findings are easily explained by classical endocrinological assessment of hormonal activity
![Page 24: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/24.jpg)
LABORATORY STUDIES
• Classical lab data is based on binary considerations: • disease vs. no disease• normal vs. abnormal value
• The patient in our vignette presented with normal levels of all the relevant hormones. Can we conclude that these hormones are functioning normally, or even that their relative levels are appropriate?
• Of course not. The history, symptoms and physical exam suggest otherwise.
• Thus, it is self-evident that binary considerations cannot be applied with any real assurance of its functional relevance to a system as complex as the human body.
![Page 25: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/25.jpg)
LABORATORY STUDIES
• Biological systems are complex, multi-tiered, dynamic interrelated and integrated systems
Yeast Protein Interaction Network
Bader and Hogue (2002) Nature
Integrated, inter-related system
![Page 26: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/26.jpg)
INTEGRATED SYSTEMS
• Objective quantitative data (laboratory values) are required to assess the organism
• However, one must be able to provide functional descriptions of quantitative and qualitative activity both within a particular unit of activity, from one unit to another, as well as within the system as a whole
• Only then can a truly dynamic and individualized assessment of the patient occur
![Page 27: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/27.jpg)
LABORATORY STUDIES
• The endocrine system, as the manager of the metabolic activity of the body, is the ideal object of evaluation.
• Serum levels of hormones reflect neither the degree of stimulation needed nor the metabolic costs incurred in producing a particular hormone.
1) Raison CL, Miller AH. When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders. Am J Psychiatry. Sep 2003;160(9):1554-1565
2) Chiam K, Tilley WD, Butler LM, Bianco-Miotto T. The dynamic and static modification of the epigenome by hormones: A role in the developmental origin of hormone related cancers. Biochem Biophys Acta. Apr 2009;1795(2):104-109.
3) Gerhard I, Waibel S, Daniel V, Runnebaum B. Impact of heavy metals on hormonal and immunological factors in women with repeated miscarriages. Hum Reprod Update. May-Jun 1998;4(3):301-309.
![Page 28: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/28.jpg)
LABORATORY STUDIES• Serum levels of hormones only reflect
quantitative organ output, not functional activity, which can be affected by:• Hormone receptor binding (affected by over- or
under-expression of other hormones)1
• Intracellular messenger activity1
• Epigenetic changes2 • Heavy metal toxicity3, etc.
1) Raison CL, Miller AH. When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders. Am J Psychiatry. Sep 2003;160(9):1554-1565
Chiam K, Tilley WD, Butler LM, Bianco-Miotto T. The dynamic and static modification of the epigenome by hormones: A role in the developmental origin of hormone related cancers. Biochem Biophys Acta. Apr 2009;1795(2):104-109.
Gerhard I, Waibel S, Daniel V, Runnebaum B. Impact of heavy metals on hormonal and immunological factors in women with repeated miscarriages. Hum Reprod Update. May-Jun 1998;4(3):301-309
![Page 29: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/29.jpg)
LABORATORY STUDIES
• The ideal system of measurement of biological processes thus should examine the metabolic products of hormonal management of cellular activity
• Thus, the ideal laboratory system must• Reflect the complex, integrated and dynamic
nature of biological systems• Describe the functionality of the system in its
• Qualitative function • Quantitative function• Individual unit, relative to other units and as a whole
• Assess the organism at the metabolic and interstitial level
![Page 30: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/30.jpg)
BIOLOGY OF FUNCTIONS
• The Biology of Functions (BoF) quantifies functional abilities of the organism, before and after the effects of adaptation to stressors. Because functionality is dynamic, a dynamic, integrated and evolutionary methodology must be used instead of static lab values
• BoF is based on a number of specific indices defined by mathematical relations between commonly used blood analysis data
• The algorithms that permit the calculation of these indices are based on the physiological relations that exist between the direct or indirect products of hormonal activity: cells, hormones or enzymes (eosinophils, TSH and LDH, for example).
![Page 31: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/31.jpg)
BIOLOGY OF FUNCTIONS
• These relations allow one to visualize the functioning of the organism at every level: maintenance of homeostasis, adaptation, recovery after aggression, immunity, etc.
• Each function is quantified by an index, specified by a level of activity. The index expresses the actual activity of that function, both in and of itself and in relation to the metabolic and tissue needs of the organism.
• The whole set of indices gives an evolutionary assessment of an individual body’s functionality, system by system, organ by organ.
![Page 32: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/32.jpg)
BIOLOGY OF FUNCTIONS
• SUMMARY: Biology of Functions: • Allows one to determine:
• Pathogenic tendencies of the organism • The stage of development and the degree of severity of a potential pathology (i.e. cancer, cardiac disease, degenerative neurological disease)
• Can be used as a tool to track• the natural development of pathology• To derive a rational therapeutic treatment
• To evaluate the efficacy of the treatment over time
![Page 33: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/33.jpg)
POLYCYSTIC OVARIAN SYNDROME (PCOS)
An Endobiogenic Approach
![Page 34: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/34.jpg)
BEYOND BINARY RELATIONSHIPS
• PCOS is a good example of how allopathic medicine is beginning to realize the importance of the qualitative relationship of hormones rather than quantitative ones in and of themselves. The following ratios have been found to be helpful in diagnosing PCOS:• Estradiol to Dihydro-testosterone ratio (Endocr
Regul. 2008 Mar;42(1):13-6)• Glucose to Insulin ratio <4.5 (Endocrinol Metab
Clin North Am. 1999 Jun; 28(2):397-408, vii.)• LH to FSH ratio >3 (Endocrinol Metab Clin North
Am. 1997 Dec; 26(4):893-912.)
![Page 35: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/35.jpg)
WHERE TO PROCEED?
• Despite a growing recognition that the binary nature of laboratory evaluations in not sufficient to understand the spectrum of disease expression, Allopathic medicine lacks an integrated assessment of ontology, etiology and treatment of physiological derangements
• Case in point: Standard of care for PCOS is to treat each endocrino-metabolic derangement separately from each other without considering their inter-relationship
• There is no explanation for why only 50% of PCOS patients are obese or why serum hormone levels may be normal despite physical exam findings suggesting otherwise, or why polycystic ovaries are not a sine qua non of PCOS
![Page 36: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/36.jpg)
REDUCTIONISTIC TREATMENT PLAN
• The allopathic treatment of PCOS consists of a piecemeal approach to inhibiting individual hormones with no concern for how it may affect the global functioning of the organism in its anabolic and catabolic activity• Hirsutism: spironolactone , oral contraceptives 1
• Menstrual irregularities: Oral contraceptives , metformin,pioglitazone, spironolactone
• Hyperglycemia, Hyperinsulinemia: Metformin; pioglitazone
• Infertility: clomiphene, letrozol, metformin, pioglitazone
1. Drug treatments for polycystic ovary syndrome. Radosh L . American Family Physician, April 15, 2009
![Page 37: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/37.jpg)
ENDOBIOGENIC APPROACH
• The Endobiogenic approach considers the ontological role of all these endocrino-metabolic and tissular derangements as being linked to the body’s management of a fundamental structural or functional problem
• Prolactin can be elevated during chronic stress
• Hyperestrogenism is often an attempt to overcome Prolactin’s suppression of LH secretion of progesterone for ovulation
![Page 38: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/38.jpg)
ENDOBIOGENIC APPROACH• Hyperandrogenism: caused by DHEA from the adrenal
gland, which is over-stimulated due to the stress state, and by testosterone from the ovaries due to LH excess, insulin excess, and/or increased theca cell enzyme activity.1
• Hypercholesterolemia with low HDL cholesterol: Cholesterol is the source of all sex hormones and corticosteroids, which are needed to make more and more testosterone, estrogen and progesterone. HDL removes cholesterol from tissues which would be counterproductive to the demand of the tissues for more cholesterol.
• Hyperglycemia and hyperinsulinism reflect an attempt to meet the huge anabolic demands of the body with an appropriate amount of short term energy substrate
1. The biochemical basis for increased testosterone production in theca cells propagated from patients with polycystic ovary syndrome
2. Nelson VL, Qin KN, Rosenfield RL, Wood JR, Penning TM, Legro RS, Strauss JF 3rd, McAllister JM. J Clin Endocrinol Metab. 2001 Dec;86(12):5925-33.
![Page 39: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/39.jpg)
BIOLOGY OF FUNCTIONS (BOF)
• Endobiogenic approach to PCOS involves understanding the totality of endocrinologic, neurologic and metabolic disturbances in relationship to each other.
• A few examples of the 157 indices of the biology of functions are discussed as relevant to PCOS
• When interpreting the BoF, the endocrine system is understood in its • classical vertical activity (i.e. CRHACTH Cortisol), • horizontal activity (i.e. Dopamine CRH TRH
Prolactin), and • radial activity (i.e. TRH Prolactin Insulin;
Estrogen + Cortisol Luteinizing Hormone)
![Page 40: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/40.jpg)
CATEGORIES OF BOF
• Hypothalamic and pituitary level assessment of responsiveness to stimulation and feedback:• -MSH/α-MSH• FSH #1 index• LH #1 index• Index of Estrogen-Somatotropic axis:
![Page 41: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/41.jpg)
BIOLOGY OF FUNCTIONS
• Role of Adrenals vs. Gonads in producing androgens (Androgenic index)
• Efficiency of FSH and LH in producing estrogens and androgens, respectively (Gonadotropic index)
• Anabolic activity of estrogen (Quantative organo-tissular estrogen yield index)
• Progesterone activity (Progesterone index)
![Page 42: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/42.jpg)
BIOLOGY OF FUNCTIONS
• The role of the Hypothalamic-Pituitary-Adrenal axis can be examined in various ways to understand the role of each endocrine gland in adaptive and maladaptive responses to stress• Circulating Cortisol Index• Aromatization of Estrogen Index• Adrenal cortex index
![Page 43: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/43.jpg)
BIOLOGY OF FUNCTIONS
• Role of the Somatotropic axis in general adaptation, maladaptation, and metabolic derangements can also be examined: • Prolactin index• Insulin index• Insulin resistance index• Growth Hormone (GH) growth score• Somatostatin index
![Page 44: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/44.jpg)
BIOLOGY OF FUNCTIONS
• Psychological factors contributing to stress can also be quantified• Global mental activity: Ketonic index• Internal dialogue: Adaptogenic index• Emotional etiology of stress response: Thyroid
relaunching index adjusted
![Page 45: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/45.jpg)
CLINICAL PHYTOTHERAPY
• Endobiogeny has developed a rational system of clinical phytotherapy based on clinical studies, empirical observations and traditional herbalism
• Elevated Prolactin: Strawberry leaf (Fragaria vesca) mother tincture reduces pituitary and adrenal stress response through reduction of ACTH, TSH and Prolactin and aromatization of Adrenal androgens to estrogen
• Elevated Androgens-Estrogen ratio: hops (Humulus lupulus) has estrogenic activity and inhibits LH, reducing total gonadal androgens1
1) Milligan SR, Kalita JC, Pocock V, et al. The endocrine activities of 8-prenylnaringenin and related hop (Humulus lupulus L.) flavonoids. J Clin Endocrinol Metab. Dec 2000;85(12):4912-4915.
![Page 46: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/46.jpg)
CLINICAL PHYTOTHERAPY
• Clinical phytotherapy (cont.)• Estrogen activity: Chaste tree (Vitex agnus
castus) is highly efficacious in its ability to alter receptor sensitivity to estrogen and modulate prolactin activity allowing for increased progesterone activity, restoring prospects for fertility1,2
• Insulin Resistance: Wolfberry (Lycium barbarum) as a fluid extract or bulk herb reduces insulin resistance3
Liu J, Burdette JE, Sun Y, et al. Isolation of linoleic acid as an estrogenic compound from the fruits of Vitex agnus-castus L. (chaste-berry). Phytomedicine. Jan 2004;11(1):18-23.;
Loch EG, Selle H, Boblitz N. Treatment of premenstrual syndrome with a phytopharmaceutical formulation containing Vitex agnus castus. J Womens Health Gend Based Med. Apr 2000;9(3):315-320.
Zhao R, Li Q, Xiao B. Effect of Lycium barbarum polysaccharide on the improvement of insulin resistance in NIDDM rats. Yakugaku Zasshi. Dec 2005;125(12):981-988.
![Page 47: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/47.jpg)
OTHER TREATMENTS• Nutritional support
• Omegas 3 and 6 (cell wall stability, decreased inflammation, improved gonadotropic activity1)
• Magnesium and Calcium (noradrenaline, acetylcholine production, activity and recycling)
• B complex (management of stress) • Diet: low in inflammatory foods such as refined
flours and sugar to reduce insulin secretion and insulin resistance, androgen activity2
• Stress relief: cognitive behavioral therapy, meditation, yoga, massage therapy, acupuncture
• 1) Sidani M, Campbell J. Gynecology: select topics. Prim Care. Jun 2002;29(2):297-321, vi; 2) Smith R, Mann N, Makelainen H, Roper J, Braue A, Varigos G. A pilot study to determine the short-term effects of a low glycemic load diet on hormonal markers of acne: a nonrandomized, parallel, controlled feeding trial. Mol Nutr Food Res. Jun 2008;52(6):718-726.
![Page 48: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/48.jpg)
CONCLUSIONS
![Page 49: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/49.jpg)
CONCLUSIONS• Endobiogeny is the study of the internal milieu of the
organism within itself and in its relationship with its environment, stressors, etc. from the standpoint of the endocrine system as the manager of human life
• It combines in an integrative understanding:• a philosophical consideration of the ontology of
structures and functions of the body, • a rational approach to understanding physiology• an empirical assessment of history and symptoms• utilization of a dynamic, integrative and integrated
metabolic assessment of endocrine management of the organism called the “Biology of Functions”
• an integrated assessment of all clinical data to obtain a precise understanding of maladaptive physiology
• In order to create a rational, individualized treatment plan
![Page 50: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/50.jpg)
CONCLUSIONS• The Biology of Functions is an algorithmic
assessment of the qualitative and quantitative relationships of hormones in terms of metabolic activity from nuclear, cellular, tissue, organ and system-wide perspectives
• The Biology of Functions allows for an objective, longitudinal assessment of the effects of therapy over time
• Endobiogeny relies on phytotherapy, oligotherapy, and diet as well as lifestyle modification as its preferred methods of ameliorating physiological imbalances
• It reserves the use of synthetic drugs for urgent cases, or when the body is not able to establish an equilibrium by the effects of functional regulation
![Page 51: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/51.jpg)
RESOURCES
• To learn more about Endobiogeny:• Web:
• Genearal information: • www.endobiogeny.com
• Biology of Functions demonstration: • http://extranet.endobiogenics.com/en/
![Page 52: Introduction to Endobiogeny](https://reader033.vdocument.in/reader033/viewer/2022042815/558439e6d8b42ad8268b4a72/html5/thumbnails/52.jpg)
CONTACT
• Kamyar M. Hedayat, MD, President, American Society for Endobiogenic Medicine and Integrative Physiology
• Contact: [email protected] • Web: www.endobiogeny.com