![Page 1: Introduction to Stem Cells - Bharathidasan UniversityCourse :Stem Cell Biology & Tissue Engineering 1998 - Researchers first extract stem cells from human embryos 1999 - First Successful](https://reader033.vdocument.in/reader033/viewer/2022053021/5f8b805279984c535922cf45/html5/thumbnails/1.jpg)
Introduction to Stem Cells
Dr. K. PremkumarAssociate Professor
Dept of Biomedical ScienceBharathidasan University
Course :Stem Cell Biology & Tissue Engineering
![Page 2: Introduction to Stem Cells - Bharathidasan UniversityCourse :Stem Cell Biology & Tissue Engineering 1998 - Researchers first extract stem cells from human embryos 1999 - First Successful](https://reader033.vdocument.in/reader033/viewer/2022053021/5f8b805279984c535922cf45/html5/thumbnails/2.jpg)
1998 - Researchers first extract stem cells from human
embryos
1999 - First Successful human transplant of insulin-making
cells from cadavers
2001 - President Bush restricts federal funding for
embryonic stem-cell research
2002 - Juvenile Diabetes Research Foundation
International creates $20 million fund-raising effort
to support stem-cell research
2002 - California ok stem cell research
2004 - Harvard researchers grow stem cells from embryos
using private funding
2004 - Ballot measure for $3 Billion bond for stem cells
Stem Cell History
![Page 3: Introduction to Stem Cells - Bharathidasan UniversityCourse :Stem Cell Biology & Tissue Engineering 1998 - Researchers first extract stem cells from human embryos 1999 - First Successful](https://reader033.vdocument.in/reader033/viewer/2022053021/5f8b805279984c535922cf45/html5/thumbnails/3.jpg)
Stem Cells
• A cell that has the ability to continuously divideand differentiate (develop) into various otherkind(s) of cells/tissues.
• ‘Blank cells’ (unspecialized)
• Capable of dividing and renewing themselves for long periods of time (proliferation and renewal)
• Have the potential to give rise to specialized cell types (differentiation)
![Page 4: Introduction to Stem Cells - Bharathidasan UniversityCourse :Stem Cell Biology & Tissue Engineering 1998 - Researchers first extract stem cells from human embryos 1999 - First Successful](https://reader033.vdocument.in/reader033/viewer/2022053021/5f8b805279984c535922cf45/html5/thumbnails/4.jpg)
![Page 5: Introduction to Stem Cells - Bharathidasan UniversityCourse :Stem Cell Biology & Tissue Engineering 1998 - Researchers first extract stem cells from human embryos 1999 - First Successful](https://reader033.vdocument.in/reader033/viewer/2022053021/5f8b805279984c535922cf45/html5/thumbnails/5.jpg)
Types of Stem Cells
![Page 6: Introduction to Stem Cells - Bharathidasan UniversityCourse :Stem Cell Biology & Tissue Engineering 1998 - Researchers first extract stem cells from human embryos 1999 - First Successful](https://reader033.vdocument.in/reader033/viewer/2022053021/5f8b805279984c535922cf45/html5/thumbnails/6.jpg)
Stem cell
Nature Description Examples
TotipotentEach cell can develop
into a new individual
Cells from early
(1-3 days)
embryos
PluripotentCells can form any (over
200) cell types
Some cells of
blastocyst (5 to 14
days)
Multipotent
Cells differentiated, but
can form a number of
other tissues
Fetal tissue, cord
blood, and adult
stem cells
![Page 7: Introduction to Stem Cells - Bharathidasan UniversityCourse :Stem Cell Biology & Tissue Engineering 1998 - Researchers first extract stem cells from human embryos 1999 - First Successful](https://reader033.vdocument.in/reader033/viewer/2022053021/5f8b805279984c535922cf45/html5/thumbnails/7.jpg)
![Page 8: Introduction to Stem Cells - Bharathidasan UniversityCourse :Stem Cell Biology & Tissue Engineering 1998 - Researchers first extract stem cells from human embryos 1999 - First Successful](https://reader033.vdocument.in/reader033/viewer/2022053021/5f8b805279984c535922cf45/html5/thumbnails/8.jpg)
Dr. Hariom Yadav
Stem Cell Differentiation
![Page 9: Introduction to Stem Cells - Bharathidasan UniversityCourse :Stem Cell Biology & Tissue Engineering 1998 - Researchers first extract stem cells from human embryos 1999 - First Successful](https://reader033.vdocument.in/reader033/viewer/2022053021/5f8b805279984c535922cf45/html5/thumbnails/9.jpg)
Stages of Embryogenesis
Day 1Fertilized egg
Day 22-cell embryo
Day 3-4Multi-cell embryo
Day 5-6BlastocystDay 11-14
Tissue Differentiation
![Page 10: Introduction to Stem Cells - Bharathidasan UniversityCourse :Stem Cell Biology & Tissue Engineering 1998 - Researchers first extract stem cells from human embryos 1999 - First Successful](https://reader033.vdocument.in/reader033/viewer/2022053021/5f8b805279984c535922cf45/html5/thumbnails/10.jpg)
Derivation and Use of Embryonic Stem Cell Lines
Isolate inner cell mass(destroys embryo)
Heart muscleKidney
“Special sauce”(largely unknown)
Day 5-6Blastocyst
Inner cells(forms fetus)
Outer cells(forms placenta)
Heartrepaired
Culture cells
![Page 11: Introduction to Stem Cells - Bharathidasan UniversityCourse :Stem Cell Biology & Tissue Engineering 1998 - Researchers first extract stem cells from human embryos 1999 - First Successful](https://reader033.vdocument.in/reader033/viewer/2022053021/5f8b805279984c535922cf45/html5/thumbnails/11.jpg)
Embryonic Stem cells Potency
![Page 12: Introduction to Stem Cells - Bharathidasan UniversityCourse :Stem Cell Biology & Tissue Engineering 1998 - Researchers first extract stem cells from human embryos 1999 - First Successful](https://reader033.vdocument.in/reader033/viewer/2022053021/5f8b805279984c535922cf45/html5/thumbnails/12.jpg)
Hematopoietic Stem Cell Differentiation
![Page 13: Introduction to Stem Cells - Bharathidasan UniversityCourse :Stem Cell Biology & Tissue Engineering 1998 - Researchers first extract stem cells from human embryos 1999 - First Successful](https://reader033.vdocument.in/reader033/viewer/2022053021/5f8b805279984c535922cf45/html5/thumbnails/13.jpg)
Adult Stem Cells Potency
![Page 14: Introduction to Stem Cells - Bharathidasan UniversityCourse :Stem Cell Biology & Tissue Engineering 1998 - Researchers first extract stem cells from human embryos 1999 - First Successful](https://reader033.vdocument.in/reader033/viewer/2022053021/5f8b805279984c535922cf45/html5/thumbnails/14.jpg)
![Page 15: Introduction to Stem Cells - Bharathidasan UniversityCourse :Stem Cell Biology & Tissue Engineering 1998 - Researchers first extract stem cells from human embryos 1999 - First Successful](https://reader033.vdocument.in/reader033/viewer/2022053021/5f8b805279984c535922cf45/html5/thumbnails/15.jpg)
Potential of Adult Stem Cells
![Page 16: Introduction to Stem Cells - Bharathidasan UniversityCourse :Stem Cell Biology & Tissue Engineering 1998 - Researchers first extract stem cells from human embryos 1999 - First Successful](https://reader033.vdocument.in/reader033/viewer/2022053021/5f8b805279984c535922cf45/html5/thumbnails/16.jpg)
Applications of Stem cells
Disease
• Diabetes, Spinal cord injury, Parkinson’s disease, heart disease
Genetic based Disease
• Cystic fibrosis, Huntington’s
![Page 17: Introduction to Stem Cells - Bharathidasan UniversityCourse :Stem Cell Biology & Tissue Engineering 1998 - Researchers first extract stem cells from human embryos 1999 - First Successful](https://reader033.vdocument.in/reader033/viewer/2022053021/5f8b805279984c535922cf45/html5/thumbnails/17.jpg)
7/12/2018 Dr. Hariom Yadav
Stem cells to treat Heart Disease