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Please take a moment to download
APACC Capacity Building Session 3:
Online Clinical Management Tools
Jonathan Schapiro
Saye Khoo
Tavitiya Sudjaritruk
•iOS App •Android App
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www.druginteractions.orgOur Mission
“To provide clinically useful, reliable, comprehensive, up-to-date,
evidence-based drug-drug interactions resources,
freely available to healthcare workers, patients and researchers
worldwide”
www.hiv-druginteractions.org www.hep-druginteractions.org www.cancer-druginteractions.org
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www.druginteractions.org
1. Select HIV Drugs 2. Select Comedications
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1. Select HIV Drugs 2. Select Comedications
www.druginteractions.org
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1. Select HIV Drugs 2. Select Comedications
www.druginteractions.org
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www.druginteractions.org
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www.druginteractions.org
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www.druginteractions.org
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Case study #1Tavitiya Sudjaritruk, MD, ScM, PhD
Division of Infectious Diseases, Department of Pediatrics
Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Email: [email protected]
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Identification data
•An 8-year-old boy with perinatally acquired
HIV infection
•Address: Lamphun province, Thailand
•Date of admission: September 2008
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Medical History
At age 3 years – first presentation at the local
hospital
• Presentation:
• Oral candidiasis
• Recurrent pneumonia
• Wasting syndrome (weight and height <3rd percentiles)
• Lab investigations:
• Anti HIV test: positive
• CD4 0% (2 cells/mm3)
• Plasma HIV RNA 318,156 copies/ml
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Medical History
At age 3 years – first presentation at the local
hospital
• Management:
• Started the first-line cART regimen: zidovudine,
lamivudine, nevirapine (according to the Thai national
HIV treatment guidelines at that time)
• Progression:
• Clinical status was improved
• Opportunistic infections were subsided
• Weight gained 3 kg/year
• Height gained 10 cm/year
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Progression
At age 5 years – followed up at the local hospital
• Presentation: anemia suspected from zidovudine
• Lab investigations:
• Hemoglobin 2.5 g/dL
• Hematocrit 7%
• CD4 12.8% (202 cells/mm3)
• Plasma HIV RNA – not done
• Management:
• Blood transfusion
• Switched zidovudine to stavudine (plus lamivudine and
nevirapine)
• Progression: anemia was improved
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Progression
At age 7 years – followed up at the local hospital
• Presentation: poor adherence to antiretroviral medications
• Lab investigations:
• CD4 8% (142 cells/mm3)
• Plasma HIV RNA 78,727 copies/mL
• HIV drug resistance mutations:
• NRTI: K65R, K70KT, M184V
• NNRTI: V108I, Y181C, H221Y
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Discussion #1
What is the second-line cART regimen
will you choose for this patient?
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Discussion #1
What is the second-line cART regimen
will you choose for this patient?
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Progression
At age 7 years – followed up at the local hospital
• Presentation: poor adherence to antiretroviral medications
• Lab investigations:
• CD4 8% (142 cells/mm3)
• plasma HIV RNA 78,727 copies/mL
• HIV drug resistance mutations:
• NRTI: K65R, K70KT, M184V
• NNRTI: V108I, Y181C, H221Y
• Management:
• Switch cART to the second-line regimen
• Stavudine (2 MKDay), lamivudine (10 MKDay),
lopinavir/ritonavir (LPV 185 mg/m2 + RTV 45 mg/m2 every
12 hours)
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Present illness
At age 8 years – followed up at the local hospital
• Presentation:
• Prolong fever for 2 weeks
• Chronic cough for 1 month
• Weight loss (2 kg during the past month)
• Multiple neck mass with spontaneous ruptured for 2 months
• Additional history: his grandmother was diagnosed with
drug susceptible pulmonary TB (sputum AFB 2+) 4 months
ago, and was currently on anti-TB treatment
• He was referred to our hospital
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Present illness
• Physical exam:
• Temp 38.0-38.5°C
• Respiratory rate 24 /min
• Mild pale conjunctivae
• Multiple cervical
lymphadenopathies (2-3
cm in diameter) with
spontaneous ruptured
• Lungs: clear
• Hepatomegaly (liver 5 cm
below right costal margin)
• No splenomegaly
The photographs were consented by the patient
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Work up
• Lab investigations:
• CBC: hemoglobin 8.8 g/dL; hematocrit 26.2%, platelet
295,000 /mm3
• LFT: albumin 2.4 g/dL, globulin 6.8 g/dL, AST/ALT
35/13 U/L, TB/DB 0.46/0.24 mg/dL
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Work up
• Chest X-ray:
Findings: coarse reticulonodular densities on the right upper and middle lung fields with right pleural thickening
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Work up
• Lymph node excisional biopsy:
• Pus – AFB staining 1+, but no Mycobacterium
tuberculosis growth in 8 weeks
• Pathology: caseous and suppurative granulomatous
inflammation
• Sputum AFB for 3 days: not found
• Sputum culture: Mycobacterium tuberculosis grown
• Drug susceptibility test: sensitive to isoniazid,
rifampicin, streptomycin
• Hemoculture for Mycobacterium spp: no growth
in 8 weeks
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Diagnosis
Drug susceptible, smear positive,
pulmonary TB with TB lymphadenitis
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Management
• Started anti-TB drugs
• Isoniazid (10 MKDay)
• Rifampicin (18 MKDay)
• Pyrazinamide (30 MKDay)
• Ethambutol (15 MKday)
• Continued cART regimen:
• Stavudine (2 MKDay),
• Lamivudine (10 MKDay)
• Increased dose of lopinavir/ritonavir to LPV 270 mg/m2
+ RTV 70 mg/m2 every 12 hours
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Discussion #2
What issues should be concerned in this
patient?
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Progression
• Concern about drug-drug interaction: rifampicin and lopinavir/ritonavir
• Measured drug level (trough level) for lopinavirand ritonavir
• Impression: Drug-drug interaction
Day of anti-TB
treatment
Lopinavir
(ng/mL)
Ritonavir
(ng/mL)
Day 0 20,021 857
Day 7 <50 undetectable
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Discussion #2
What should we do next?
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Progression
• Management: Anti-TB regimen modification
• Taken off rifampicin
• Added ofloxacin (15 MKDay)
• New anti-TB regimen: HZEQ
• Continue cART regimen:
• Stavudine (2 MKDay),
• Lamivudine (10 MKDay)
• Lopinavir/ritonavir (LPV 270 mg/m2 + RTV 70 mg/m2
every 12 hours)
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Progression
• Measured drug level (trough level) for lopinavir
and ritonavir again after anti-TB modification
• Management: continue anti-TB for 14 months
(4HZEQ + 10HEQ)
• Clinical status was improved
Day of anti-TB
treatment
Lopinavir
(ng/mL)
Ritonavir
(ng/mL)
Day 0 20,021 857
Day 7 <50 undetectable
Day 14
(Day 7 after off RF)
15,625 738
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Lesson learned
• Poor adherence to antiretroviral medication is one of the major concerns during the course of HIV treatment
• HIV drug resistance testing can guide us to select the appropriate treatment regimen for the patients
• Tuberculosis is the most common co-infection in HIV-infected patients
• Drug-drug interaction between anti-TB and antiretroviral medications should be considered when concomitantly provide treatment for both diseases